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Fusion gene ID: 15624 |
FusionGeneSummary for GTF2F2_CTIF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GTF2F2_CTIF | Fusion gene ID: 15624 | Hgene | Tgene | Gene symbol | GTF2F2 | CTIF | Gene ID | 2963 | 9811 |
| Gene name | general transcription factor IIF subunit 2 | cap binding complex dependent translation initiation factor | |
| Synonyms | BTF4|RAP30|TF2F2|TFIIF | Gm672|KIAA0427 | |
| Cytomap | 13q14.12-q14.13 | 18q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | general transcription factor IIF subunit 2ATP-dependent helicase GTF2F2TFIIF-betageneral transcription factor IIF 30 kDa subunitgeneral transcription factor IIF, polypeptide 2, 30kDatranscription initiation factor IIF subunit betatranscription initi | CBP80/20-dependent translation initiation factor | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P13984 | O43310 | |
| Ensembl transtripts involved in fusion gene | ENST00000340473, ENST00000494087, | ENST00000256413, ENST00000382998, ENST00000592658, | |
| Fusion gene scores | * DoF score | 8 X 4 X 6=192 | 6 X 4 X 5=120 |
| # samples | 7 | 6 | |
| ** MAII score | log2(7/192*10)=-1.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GTF2F2 [Title/Abstract] AND CTIF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-44-7667-01A | GTF2F2 | chr13 | 45781640 | + | CTIF | chr18 | 46284290 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000340473 | ENST00000256413 | GTF2F2 | chr13 | 45781640 | + | CTIF | chr18 | 46284290 | + |
| In-frame | ENST00000340473 | ENST00000382998 | GTF2F2 | chr13 | 45781640 | + | CTIF | chr18 | 46284290 | + |
| 5CDS-intron | ENST00000340473 | ENST00000592658 | GTF2F2 | chr13 | 45781640 | + | CTIF | chr18 | 46284290 | + |
| 3UTR-3CDS | ENST00000494087 | ENST00000256413 | GTF2F2 | chr13 | 45781640 | + | CTIF | chr18 | 46284290 | + |
| 3UTR-3CDS | ENST00000494087 | ENST00000382998 | GTF2F2 | chr13 | 45781640 | + | CTIF | chr18 | 46284290 | + |
| 3UTR-intron | ENST00000494087 | ENST00000592658 | GTF2F2 | chr13 | 45781640 | + | CTIF | chr18 | 46284290 | + |
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FusionProtFeatures for GTF2F2_CTIF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GTF2F2 | CTIF |
| TFIIF is a general transcription initiation factor thatbinds to RNA polymerase II and helps to recruit it to theinitiation complex in collaboration with TFIIB. It promotestranscription elongation. This subunit shows ATP-dependent DNA-helicase activity. {ECO:0000269|PubMed:2477704}. | Specifically required for the pioneer round of mRNAtranslation mediated by the cap-binding complex (CBC), that takesplace during or right after mRNA export via the nuclear porecomplex (NPC). Acts via its interaction with the NCBP1/CBP80component of the CBC complex and recruits the 40S small subunit ofthe ribosome via eIF3. In contrast, it is not involved in steadystate translation, that takes place when the CBC complex isreplaced by cytoplasmic cap-binding protein eIF4E. Also requiredfor nonsense-mediated mRNA decay (NMD), the pioneer round of mRNAtranslation mediated by the cap-binding complex playing a centralrole in nonsense-mediated mRNA decay (NMD).{ECO:0000269|PubMed:19648179}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GTF2F2 | chr13:45781640 | chr18:46284290 | ENST00000340473 | + | 5 | 8 | 36_43 | 128 | 250 | Nucleotide binding | ATP |
| Tgene | >CTIF | chr13:45781640 | chr18:46284290 | ENST00000256413 | + | 6 | 12 | 376_577 | 194 | 599 | Domain | Note=MIF4G |
| Tgene | >CTIF | chr13:45781640 | chr18:46284290 | ENST00000382998 | + | 7 | 13 | 376_577 | 194 | 601 | Domain | Note=MIF4G |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GTF2F2_CTIF |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GTF2F2_ENST00000340473_chr13_45781640_+_CTIF_ENST00000256413_chr18_46284290_+_533aa MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKASGRGEVGKLRIAKTQGRTEVSFTLNEDLANIHDIGGKPASVSAPREHPFVLQSVGG QTLTVFTESSSDKLSLEGIVVQRAECRPAASENYMRLKRRQQRPPGGNKPQQHGDHQPGSAKHNRDHQKSYQGGSAPHPSGRPTHHGYSQ NRRWHHGNMKHPPGDKGEAGAHRNAKETMTIENPKLEDTAGDTGHSSLEAPRSPDTLAPVASERLPPQQSGGPEVETKRKDSILPERIGE RPKITLLQSSKDRLRRRLKEKDEVAVETTTPQQNKMDKLIEILNSMRNNSSDVDTKLTTFMEEAQNSTNSEEMLGEIVRTIYQKAVSDRS FAFTAAKLCDKMALFMVEGTKFRSLLLNMLQKDFTVREELQQQDVERWLGFITFLCEVFGTMRSSTGEPFRVLVCPIYTCLRELLQSQDV >In-frame_GTF2F2_ENST00000340473_chr13_45781640_+_CTIF_ENST00000382998_chr18_46284290_+_535aa MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKASGRGEVGKLRIAKTQGRTEVSFTLNEDLANIHDIGGKPASVSAPREHPFVLQSVGG QTLTVFTESSSDKLSLEGIVVQRAECRPAASENYMRLKRRQQRPPGGNKPQQHGDHQPGSAKHNRDHQKSYQGGSAPHPSGRPTHHGYSQ NRRWHHGNMKHPPGDKGEAGAHRNAKETMTIENPKLEDTAGDTGHSSLEAPRSPDTLAPVASERLPPQQSGGPEVETKRKDSILPERIGE RPKITLLQSSKDRLRRRLKEKVPDEVAVETTTPQQNKMDKLIEILNSMRNNSSDVDTKLTTFMEEAQNSTNSEEMLGEIVRTIYQKAVSD RSFAFTAAKLCDKMALFMVEGTKFRSLLLNMLQKDFTVREELQQQDVERWLGFITFLCEVFGTMRSSTGEPFRVLVCPIYTCLRELLQSQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GTF2F2_ENST00000340473_chr13_45781640_+_CTIF_ENST00000256413_chr18_46284290_+_1599nt ATGGCCGAGCGCGGGGAACTCGACTTGACCGGCGCCAAACAGAACACAGGAGTGTGGCTAGTCAAGGTTCCTAAATATTTGTCACAGCAA TGGGCTAAAGCCTCTGGAAGAGGTGAAGTTGGGAAACTGCGGATTGCCAAGACTCAAGGAAGGACTGAGGTGTCATTTACTTTGAATGAG GATCTTGCAAATATTCATGATATTGGTGGAAAACCAGCTTCAGTCAGTGCTCCTAGAGAACATCCATTTGTCTTGCAAAGTGTTGGAGGA CAGACATTAACAGTATTTACTGAGAGCTCATCAGATAAGCTGTCATTGGAAGGAATAGTGGTACAAAGAGCTGAATGCCGACCAGCTGCC AGTGAAAACTACATGCGATTAAAAAGGCGGCAGCAGAGACCTCCGGGGGGCAACAAGCCCCAACAGCATGGTGACCACCAGCCAGGCAGT GCCAAACACAACAGGGACCACCAGAAATCCTACCAGGGGGGCTCAGCACCCCACCCCTCAGGGAGGCCCACTCACCATGGCTACAGCCAG AACCGGCGCTGGCACCATGGCAACATGAAGCACCCACCAGGCGACAAGGGGGAGGCAGGCGCACACCGCAATGCCAAAGAGACCATGACC ATCGAGAACCCAAAACTGGAGGACACTGCAGGGGACACCGGGCACAGCAGCCTTGAGGCCCCCCGCAGCCCTGACACCCTGGCCCCGGTG GCTTCTGAGCGGCTGCCCCCACAGCAGTCAGGGGGGCCAGAGGTTGAGACAAAACGTAAAGACAGTATTCTTCCCGAGCGCATCGGGGAG CGGCCCAAAATTACCCTGCTCCAGTCTTCCAAAGACAGACTGCGGCGAAGGCTAAAGGAAAAGGATGAAGTGGCCGTGGAGACGACCACT CCCCAGCAGAACAAGATGGACAAGCTGATCGAGATCCTGAACAGCATGCGGAACAACAGCAGCGACGTGGACACCAAGCTCACCACCTTC ATGGAGGAGGCCCAGAACTCCACCAACTCCGAGGAGATGCTGGGCGAGATCGTGCGCACAATCTACCAGAAGGCTGTGTCCGACCGCAGC TTCGCCTTCACCGCTGCCAAGCTCTGCGACAAGATGGCGCTCTTTATGGTGGAGGGGACCAAGTTCCGGAGCCTGCTCCTCAACATGCTG CAGAAGGACTTCACGGTGCGCGAGGAGCTGCAGCAGCAGGACGTGGAGCGCTGGCTGGGCTTCATCACCTTCCTGTGCGAGGTCTTCGGC ACCATGCGCAGCAGCACAGGCGAGCCCTTCCGTGTGCTCGTGTGCCCCATCTACACCTGCCTCAGGGAGCTCTTGCAATCTCAGGATGTG AAGGAAGATGCTGTCCTTTGCTGCTCTATGGAGCTGCAGAGTACAGGCCGGCTGCTGGAGGAACAGCTGCCTGAGATGATGACAGAGCTC CTGGCCAGCGCACGGGACAAGATGCTGTGCCCCTCGGAGTCCATGCTGACCCGGTCGCTGCTCCTAGAGGTCATCGAGCTCCACGCTAAC >In-frame_GTF2F2_ENST00000340473_chr13_45781640_+_CTIF_ENST00000382998_chr18_46284290_+_1605nt ATGGCCGAGCGCGGGGAACTCGACTTGACCGGCGCCAAACAGAACACAGGAGTGTGGCTAGTCAAGGTTCCTAAATATTTGTCACAGCAA TGGGCTAAAGCCTCTGGAAGAGGTGAAGTTGGGAAACTGCGGATTGCCAAGACTCAAGGAAGGACTGAGGTGTCATTTACTTTGAATGAG GATCTTGCAAATATTCATGATATTGGTGGAAAACCAGCTTCAGTCAGTGCTCCTAGAGAACATCCATTTGTCTTGCAAAGTGTTGGAGGA CAGACATTAACAGTATTTACTGAGAGCTCATCAGATAAGCTGTCATTGGAAGGAATAGTGGTACAAAGAGCTGAATGCCGACCAGCTGCC AGTGAAAACTACATGCGATTAAAAAGGCGGCAGCAGAGACCTCCGGGGGGCAACAAGCCCCAACAGCATGGTGACCACCAGCCAGGCAGT GCCAAACACAACAGGGACCACCAGAAATCCTACCAGGGGGGCTCAGCACCCCACCCCTCAGGGAGGCCCACTCACCATGGCTACAGCCAG AACCGGCGCTGGCACCATGGCAACATGAAGCACCCACCAGGCGACAAGGGGGAGGCAGGCGCACACCGCAATGCCAAAGAGACCATGACC ATCGAGAACCCAAAACTGGAGGACACTGCAGGGGACACCGGGCACAGCAGCCTTGAGGCCCCCCGCAGCCCTGACACCCTGGCCCCGGTG GCTTCTGAGCGGCTGCCCCCACAGCAGTCAGGGGGGCCAGAGGTTGAGACAAAACGTAAAGACAGTATTCTTCCCGAGCGCATCGGGGAG CGGCCCAAAATTACCCTGCTCCAGTCTTCCAAAGACAGACTGCGGCGAAGGCTAAAGGAAAAGGTACCGGATGAAGTGGCCGTGGAGACG ACCACTCCCCAGCAGAACAAGATGGACAAGCTGATCGAGATCCTGAACAGCATGCGGAACAACAGCAGCGACGTGGACACCAAGCTCACC ACCTTCATGGAGGAGGCCCAGAACTCCACCAACTCCGAGGAGATGCTGGGCGAGATCGTGCGCACAATCTACCAGAAGGCTGTGTCCGAC CGCAGCTTCGCCTTCACCGCTGCCAAGCTCTGCGACAAGATGGCGCTCTTTATGGTGGAGGGGACCAAGTTCCGGAGCCTGCTCCTCAAC ATGCTGCAGAAGGACTTCACGGTGCGCGAGGAGCTGCAGCAGCAGGACGTGGAGCGCTGGCTGGGCTTCATCACCTTCCTGTGCGAGGTC TTCGGCACCATGCGCAGCAGCACAGGCGAGCCCTTCCGTGTGCTCGTGTGCCCCATCTACACCTGCCTCAGGGAGCTCTTGCAATCTCAG GATGTGAAGGAAGATGCTGTCCTTTGCTGCTCTATGGAGCTGCAGAGTACAGGCCGGCTGCTGGAGGAACAGCTGCCTGAGATGATGACA GAGCTCCTGGCCAGCGCACGGGACAAGATGCTGTGCCCCTCGGAGTCCATGCTGACCCGGTCGCTGCTCCTAGAGGTCATCGAGCTCCAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GTF2F2_ENST00000340473_chr13_45781640_+_CTIF_ENST00000256413_chr18_46284290_+_5398nt TTCCCAGTGTTCTGGCAGGTAAGGAACGCCGGCTCTTCGCCTCTCAGCGCGGCTTGTCCTTTGTTCCGGACGCCCGCTCCTCAGCCCTGC GGCTCCTGGGGTCGCTGCTGCATCCCGCACGCCTCCACCGGCTGCAGACCCATGGCCGAGCGCGGGGAACTCGACTTGACCGGCGCCAAA CAGAACACAGGAGTGTGGCTAGTCAAGGTTCCTAAATATTTGTCACAGCAATGGGCTAAAGCCTCTGGAAGAGGTGAAGTTGGGAAACTG CGGATTGCCAAGACTCAAGGAAGGACTGAGGTGTCATTTACTTTGAATGAGGATCTTGCAAATATTCATGATATTGGTGGAAAACCAGCT TCAGTCAGTGCTCCTAGAGAACATCCATTTGTCTTGCAAAGTGTTGGAGGACAGACATTAACAGTATTTACTGAGAGCTCATCAGATAAG CTGTCATTGGAAGGAATAGTGGTACAAAGAGCTGAATGCCGACCAGCTGCCAGTGAAAACTACATGCGATTAAAAAGGCGGCAGCAGAGA CCTCCGGGGGGCAACAAGCCCCAACAGCATGGTGACCACCAGCCAGGCAGTGCCAAACACAACAGGGACCACCAGAAATCCTACCAGGGG GGCTCAGCACCCCACCCCTCAGGGAGGCCCACTCACCATGGCTACAGCCAGAACCGGCGCTGGCACCATGGCAACATGAAGCACCCACCA GGCGACAAGGGGGAGGCAGGCGCACACCGCAATGCCAAAGAGACCATGACCATCGAGAACCCAAAACTGGAGGACACTGCAGGGGACACC GGGCACAGCAGCCTTGAGGCCCCCCGCAGCCCTGACACCCTGGCCCCGGTGGCTTCTGAGCGGCTGCCCCCACAGCAGTCAGGGGGGCCA GAGGTTGAGACAAAACGTAAAGACAGTATTCTTCCCGAGCGCATCGGGGAGCGGCCCAAAATTACCCTGCTCCAGTCTTCCAAAGACAGA CTGCGGCGAAGGCTAAAGGAAAAGGATGAAGTGGCCGTGGAGACGACCACTCCCCAGCAGAACAAGATGGACAAGCTGATCGAGATCCTG AACAGCATGCGGAACAACAGCAGCGACGTGGACACCAAGCTCACCACCTTCATGGAGGAGGCCCAGAACTCCACCAACTCCGAGGAGATG CTGGGCGAGATCGTGCGCACAATCTACCAGAAGGCTGTGTCCGACCGCAGCTTCGCCTTCACCGCTGCCAAGCTCTGCGACAAGATGGCG CTCTTTATGGTGGAGGGGACCAAGTTCCGGAGCCTGCTCCTCAACATGCTGCAGAAGGACTTCACGGTGCGCGAGGAGCTGCAGCAGCAG GACGTGGAGCGCTGGCTGGGCTTCATCACCTTCCTGTGCGAGGTCTTCGGCACCATGCGCAGCAGCACAGGCGAGCCCTTCCGTGTGCTC GTGTGCCCCATCTACACCTGCCTCAGGGAGCTCTTGCAATCTCAGGATGTGAAGGAAGATGCTGTCCTTTGCTGCTCTATGGAGCTGCAG AGTACAGGCCGGCTGCTGGAGGAACAGCTGCCTGAGATGATGACAGAGCTCCTGGCCAGCGCACGGGACAAGATGCTGTGCCCCTCGGAG TCCATGCTGACCCGGTCGCTGCTCCTAGAGGTCATCGAGCTCCACGCTAACAGCTGGAACCCTCTGACGCCCCCCATCACGCAGTACTAC AACAGAACCATCCAGAAACTGACAGCCTGACAGCCAGGGGGCCTGGCAGGCGGCCCACGGGCAGCTGGGGCCCTGGTGCACAGGGCCAGA TGGACAGGCGGGAGGACAGGGGTGGCCCTGGCGGGAGAAAGAAATGGGGAGGAGGGCAGGCAGAGTCGGTGGCCAGTCTGGAGCCAGACG GGGAAGGGAGCAAATCCCTGAGAGGAGTGCCCCCGCACAAGCCCCCCAGCCCGAGCATGCAAGCTCACACCAATAAGGGAAGCATGTTTC TTTTTCCTGGTGGCCCTGGCCCTCCCCTTCCTCACTCCCGCCTCTCCCCTCCCCATCAGACCCATCCCCCACGGAGCTTTGTGTGAGGGA TCTCATCGCTGTGACTCCTCGGAGACCTTGGCAGCCTCGCACGCCGGGGCACCGCTTGGGTCAGAAAGGACCTCGGAAGGCTGAAAAAGT GGGTCGGAGACGGGCTCGCATTGTTCCCGCATGCTGTCAGCCGCAGTCGCCAACTGGCAGCAGGCGACGTGTAGCAGATGTCCGGGAGGA CAAAGGCAGGCACGGTCCCCACCAGCCGCCCGTAATTGACGGCCTTTGTCAGCCATGGCAGAGCTGACGCTCCACCTCCCACCTCCAAGT CCTCCTCACTGCAGCCCCCACAGCCTCAGGCCTAGGGGGTCAGGCGCAGCGGGGGAGATGGAGTTTGCAGTTCCACTTGCACTCTTTTGT TTATTGTGTTTTATTTTTCAAAAGTCGGTTGCTTTGAAGTCTCTTTGGCCAATGAAAATGCCCGTGATGTGATCACACAGTCAGCACTGT TGAGGACCCCCGGATTAGTGGGAGATCAAACCCAGCTCCCCTCTAGAAGAAGGATTCGAGCCACAGACAGCTTGCCAGTAGCCAATTAGG GTAATTGGAAACTTCTGCCCCGGCGGGGGGTCCCCGCTGGAATCCTGTGTTCCTCGCCACTGGCTTCCAGCGCCTCTGTTTTCTCAAAGG GCTGATACTGTCACCACTGGGACCAAGTTAAACCTGGTCCTGGCCCCAGGGGCCTTGTGGCAAACAGGGCACAGAACGAGACTGGCAAAT TAAAACCAAAATTCTAGATGGTGTCTTGCGCTCCACACGCAGGTCTTACTGGGGAAAAGGATGGGAGTGGGGGCTCCCCAGGACTCGATT TTAGCTAATGCGCTGTGTCACTGCCCCAGCTCGGACGTAGAAGCCCAGCCCTCCGTGAGCTCTTGGGAAAGGGGTGAATTCACTGGGTCA TGGAAGGGACAGTCAGGTGACCAGCGGGGTCGCCAGATGAAGCTTCCCAGCCGGGAAACAAGACGGGGTTTCTTGGCAGGCCCTGGTCCT GGGGAGCAGGCCCTGTTGTTGGCTGGAGAGGAAGGTGTGGGGTGGAACAGGTGTCCACATAGCTCCATCTCTGGGGGCTGGAGCACACAC TTTGATGAGCCCCCCCGGAAATGATGTCAGAGCCTAGCCGCTTCCTTATTTGCTCTTTTATTGAGGCCGGGCAGGCCCTGGGTCACTTTG GAGGCCCCTCTTGGTCCACACTGGACTGGCCGGGAGGTGATGGGCGGGGAAGGTTCTCGTGATTGATTGATTCTGAGTCTGAGAGTGGCG AGTGGGGAGAGGCTTCCCCAGTTCTCTCCAGCTTTCCCTGCAGCTGCAACCTGCCCTCTGGTCCCAGGTGTGGAGCCTTTGCCTGTCTCT AAAAAGAGCCTGTTGGCGACAAGGTGTAGGGGGCACAAGTTTACCTGAAACAGGTCAGTGGTCTCTCCCAAGAAGCGCACGCCACCTCTG GTCCCTGGCCCTGAACCCTGCCTTCTTCCTCCCTCCACGGTTTCTTCCCAGACTTTCTCAAGCTCCTCCTCACTGCCCTTCCTCCCCAGC CCAGCCTGGGAACACAGATGCCCCGCGGGTAGGAGGCCTCGAGGGAGGAGCCGGGCTGATGCGGGGCTGCTCAGGGCAGGCCCCAGGGCG AGCTTGCCATCGTGGCCAGGCAGCCTCCACCTGTGCTTCAGTGGCCCCTGCCCCCCTGAAGCATGTGGGGTTTGTCCGCTAGGAGGAGGC AAGGCCCCCGAAGAGAGGAGAGACCTGGGAGTGGGAGCTCAGGTCAGGGAGGAGGCAGGGGAGTGGGGTCTCCCAGACCCAACGGTGAGC TCAGAGCAAGCTTCACGCAGGACGCTCCGAAACACTGTGTGGAGGGGGCTGTGTTGTGGGCACCTTGGGGCCTGATTCTCCTTCCTCCGA ACGGGCTCCTTGATGGCCTGGCCACAGGGGCAGCTCCCCATTGGCTGTTAGGACCAGAGTGTGAAGAAGAAGTGAAATATAAATATGTAT ACATATATAAATATATTTTTAATTACATGTCGTGTCACGGTGGCTCCAGACATACTGTTTGCCTAGTTTATTCCACTGCTTGAAAGCGCT TCCTAGCCAATCTGAACAACAACACTTTAAGCTGTTTTTCTAAATGCAGGTTGCTGCTCCTTTTTCAGATATGGAAGGAAAACGTTAAGA CTATTTTTTTTTTAAAGAAACAACAGTCAAGCCTAAAATTTGAGACCCCGAGGCAGCTTCCCGAGGGAGACTGCTCAGACAGGAACTGCA GGACAGAAGTGGATGCCCCACAGACCCTGGCCCCCTCCCCAAGTCCATCCCCTCTCTGTGGCATGAGGAAGGCCGCGTCCGAGTTGACCT CTGAATGTATGTGATGAGAGGCAGAGCTGGATATTGCATTTCTAAGGCTTGCATTGCTTTCCCCTCGCCCGCGGTTCTTGGCGCATGGAA GAGGCGGTCCAGCCATCTGATGTTGATCCTGTCTCAGTCTCCCCACTGCCTGTCAGGATGAGTTAGTCATTGTTTTTCTCCGAGGCGGCC TGCTTGCCACAGCCCTGCTCCCCAAGGCCTGGTGGCTTTGCCGAAGCTCTGGGACCGCAGCCCCAGCGAGGCCCCCAACCTCACCCAGAC GAGGCCAGGAGCCCCGCCACCCTCCACGGGATGTGCACCCTCAGACCCCATTCTCTCTGTTCGTCCTTCCTTGACCAGTCTGTAAACCTT CACTGTTTGGGGATCGTCCTGTCCATCCATGTAAATGTAAATGTTGGCCGAGTCGGTATTTATTCTGATTGATTTTTATTTTATTCTATT ATTTTCTCCGAGGGATGAGGGTGGGGGGTGTGGGAAGGGTACCACAGATCAGGCCGGGGCAGCTGTAGGGGCGGGGGCCCAGACAGCCAG GCCGCCACCAGAGCAGCCCCATGGGGTGCCCCAGACGCGGGCCTCCAAGAAGCCAAGTCCCAGTCTGTTTTCTGGCATCAGACACCGGCC CGTGTTCCTTGTCAGACAGACAGACTCTCAGGCCTGCCTGGGGAGTCGTGTCCCTCAGCTGCAGGGCACTGTGTTGGGAAACCATTGGCT GGGCCTTTGAGGACACAGATCAGAAGAAAGAAAGACAACTTTCCTCTGCGCGGAACACTCACACGGAAGGGCTGGCCGCCTCCCTGAGCC GGCTGGGAGTGGACGACAGGACCTACCTCCCCAGAGCAAGGGCCTGGGGCTTCCCGCCAAAGCTGCCGCGGAACCCCGCTAGTGCGACCA >In-frame_GTF2F2_ENST00000340473_chr13_45781640_+_CTIF_ENST00000382998_chr18_46284290_+_4093nt TTCCCAGTGTTCTGGCAGGTAAGGAACGCCGGCTCTTCGCCTCTCAGCGCGGCTTGTCCTTTGTTCCGGACGCCCGCTCCTCAGCCCTGC GGCTCCTGGGGTCGCTGCTGCATCCCGCACGCCTCCACCGGCTGCAGACCCATGGCCGAGCGCGGGGAACTCGACTTGACCGGCGCCAAA CAGAACACAGGAGTGTGGCTAGTCAAGGTTCCTAAATATTTGTCACAGCAATGGGCTAAAGCCTCTGGAAGAGGTGAAGTTGGGAAACTG CGGATTGCCAAGACTCAAGGAAGGACTGAGGTGTCATTTACTTTGAATGAGGATCTTGCAAATATTCATGATATTGGTGGAAAACCAGCT TCAGTCAGTGCTCCTAGAGAACATCCATTTGTCTTGCAAAGTGTTGGAGGACAGACATTAACAGTATTTACTGAGAGCTCATCAGATAAG CTGTCATTGGAAGGAATAGTGGTACAAAGAGCTGAATGCCGACCAGCTGCCAGTGAAAACTACATGCGATTAAAAAGGCGGCAGCAGAGA CCTCCGGGGGGCAACAAGCCCCAACAGCATGGTGACCACCAGCCAGGCAGTGCCAAACACAACAGGGACCACCAGAAATCCTACCAGGGG GGCTCAGCACCCCACCCCTCAGGGAGGCCCACTCACCATGGCTACAGCCAGAACCGGCGCTGGCACCATGGCAACATGAAGCACCCACCA GGCGACAAGGGGGAGGCAGGCGCACACCGCAATGCCAAAGAGACCATGACCATCGAGAACCCAAAACTGGAGGACACTGCAGGGGACACC GGGCACAGCAGCCTTGAGGCCCCCCGCAGCCCTGACACCCTGGCCCCGGTGGCTTCTGAGCGGCTGCCCCCACAGCAGTCAGGGGGGCCA GAGGTTGAGACAAAACGTAAAGACAGTATTCTTCCCGAGCGCATCGGGGAGCGGCCCAAAATTACCCTGCTCCAGTCTTCCAAAGACAGA CTGCGGCGAAGGCTAAAGGAAAAGGTACCGGATGAAGTGGCCGTGGAGACGACCACTCCCCAGCAGAACAAGATGGACAAGCTGATCGAG ATCCTGAACAGCATGCGGAACAACAGCAGCGACGTGGACACCAAGCTCACCACCTTCATGGAGGAGGCCCAGAACTCCACCAACTCCGAG GAGATGCTGGGCGAGATCGTGCGCACAATCTACCAGAAGGCTGTGTCCGACCGCAGCTTCGCCTTCACCGCTGCCAAGCTCTGCGACAAG ATGGCGCTCTTTATGGTGGAGGGGACCAAGTTCCGGAGCCTGCTCCTCAACATGCTGCAGAAGGACTTCACGGTGCGCGAGGAGCTGCAG CAGCAGGACGTGGAGCGCTGGCTGGGCTTCATCACCTTCCTGTGCGAGGTCTTCGGCACCATGCGCAGCAGCACAGGCGAGCCCTTCCGT GTGCTCGTGTGCCCCATCTACACCTGCCTCAGGGAGCTCTTGCAATCTCAGGATGTGAAGGAAGATGCTGTCCTTTGCTGCTCTATGGAG CTGCAGAGTACAGGCCGGCTGCTGGAGGAACAGCTGCCTGAGATGATGACAGAGCTCCTGGCCAGCGCACGGGACAAGATGCTGTGCCCC TCGGAGTCCATGCTGACCCGGTCGCTGCTCCTAGAGGTCATCGAGCTCCACGCTAACAGCTGGAACCCTCTGACGCCCCCCATCACGCAG TACTACAACAGAACCATCCAGAAACTGACAGCCTGACAGCCAGGGGGCCTGGCAGGCGGCCCACGGGCAGCTGGGGCCCTGGTGCACAGG GCCAGATGGACAGGCGGGAGGACAGGGGTGGCCCTGGCGGGAGAAAGAAATGGGGAGGAGGGCAGGCAGAGTCGGTGGCCAGTCTGGAGC CAGACGGGGAAGGGAGCAAATCCCTGAGAGGAGTGCCCCCGCACAAGCCCCCCAGCCCGAGCATGCAAGCTCACACCAATAAGGGAAGCA TGTTTCTTTTTCCTGGTGGCCCTGGCCCTCCCCTTCCTCACTCCCGCCTCTCCCCTCCCCATCAGACCCATCCCCCACGGAGCTTTGTGT GAGGGATCTCATCGCTGTGACTCCTCGGAGACCTTGGCAGCCTCGCACGCCGGGGCACCGCTTGGGTCAGAAAGGACCTCGGAAGGCTGA AAAAGTGGGTCGGAGACGGGCTCGCATTGTTCCCGCATGCTGTCAGCCGCAGTCGCCAACTGGCAGCAGGCGACGTGTAGCAGATGTCCG GGAGGACAAAGGCAGGCACGGTCCCCACCAGCCGCCCGTAATTGACGGCCTTTGTCAGCCATGGCAGAGCTGACGCTCCACCTCCCACCT CCAAGTCCTCCTCACTGCAGCCCCCACAGCCTCAGGCCTAGGGGGTCAGGCGCAGCGGGGGAGATGGAGTTTGCAGTTCCACTTGCACTC TTTTGTTTATTGTGTTTTATTTTTCAAAAGTCGGTTGCTTTGAAGTCTCTTTGGCCAATGAAAATGCCCGTGATGTGATCACACAGTCAG CACTGTTGAGGACCCCCGGATTAGTGGGAGATCAAACCCAGCTCCCCTCTAGAAGAAGGATTCGAGCCACAGACAGCTTGCCAGTAGCCA ATTAGGGTAATTGGAAACTTCTGCCCCGGCGGGGGGTCCCCGCTGGAATCCTGTGTTCCTCGCCACTGGCTTCCAGCGCCTCTGTTTTCT CAAAGGGCTGATACTGTCACCACTGGGACCAAGTTAAACCTGGTCCTGGCCCCAGGGGCCTTGTGGCAAACAGGGCACAGAACGAGACTG GCAAATTAAAACCAAAATTCTAGATGGTGTCTTGCGCTCCACACGCAGGTCTTACTGGGGAAAAGGATGGGAGTGGGGGCTCCCCAGGAC TCGATTTTAGCTAATGCGCTGTGTCACTGCCCCAGCTCGGACGTAGAAGCCCAGCCCTCCGTGAGCTCTTGGGAAAGGGGTGAATTCACT GGGTCATGGAAGGGACAGTCAGGTGACCAGCGGGGTCGCCAGATGAAGCTTCCCAGCCGGGAAACAAGACGGGGTTTCTTGGCAGGCCCT GGTCCTGGGGAGCAGGCCCTGTTGTTGGCTGGAGAGGAAGGTGTGGGGTGGAACAGGTGTCCACATAGCTCCATCTCTGGGGGCTGGAGC ACACACTTTGATGAGCCCCCCCGGAAATGATGTCAGAGCCTAGCCGCTTCCTTATTTGCTCTTTTATTGAGGCCGGGCAGGCCCTGGGTC ACTTTGGAGGCCCCTCTTGGTCCACACTGGACTGGCCGGGAGGTGATGGGCGGGGAAGGTTCTCGTGATTGATTGATTCTGAGTCTGAGA GTGGCGAGTGGGGAGAGGCTTCCCCAGTTCTCTCCAGCTTTCCCTGCAGCTGCAACCTGCCCTCTGGTCCCAGGTGTGGAGCCTTTGCCT GTCTCTAAAAAGAGCCTGTTGGCGACAAGGTGTAGGGGGCACAAGTTTACCTGAAACAGGTCAGTGGTCTCTCCCAAGAAGCGCACGCCA CCTCTGGTCCCTGGCCCTGAACCCTGCCTTCTTCCTCCCTCCACGGTTTCTTCCCAGACTTTCTCAAGCTCCTCCTCACTGCCCTTCCTC CCCAGCCCAGCCTGGGAACACAGATGCCCCGCGGGTAGGAGGCCTCGAGGGAGGAGCCGGGCTGATGCGGGGCTGCTCAGGGCAGGCCCC AGGGCGAGCTTGCCATCGTGGCCAGGCAGCCTCCACCTGTGCTTCAGTGGCCCCTGCCCCCCTGAAGCATGTGGGGTTTGTCCGCTAGGA GGAGGCAAGGCCCCCGAAGAGAGGAGAGACCTGGGAGTGGGAGCTCAGGTCAGGGAGGAGGCAGGGGAGTGGGGTCTCCCAGACCCAACG GTGAGCTCAGAGCAAGCTTCACGCAGGACGCTCCGAAACACTGTGTGGAGGGGGCTGTGTTGTGGGCACCTTGGGGCCTGATTCTCCTTC CTCCGAACGGGCTCCTTGATGGCCTGGCCACAGGGGCAGCTCCCCATTGGCTGTTAGGACCAGAGTGTGAAGAAGAAGTGAAATATAAAT |
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FusionGenePPI for GTF2F2_CTIF |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GTF2F2 | GTF2B, HTATSF1, GTF2E1, TBP, AHR, ARNT, FOS, JUN, POLR2E, MSX2, ATF4, TCEA1, GTF2E2, AR, POLR2A, POLR2B, POLR2J, POLR2G, POLR2H, CTDP1, BAG6, MED29, SUPT5H, GPRC5A, POLR2C, GTF2F1, TAF10, TAF5, TAF4, HMGA1, LMNA, RPL27A, TCTEX1D2, HECW2, EFTUD2, SH3GL1, SHMT1, FAM177A1, UBR5, SRRT, SUPT4H1, NTRK1, KLF5, EWSR1, XPO1, POLR2F, CBLN4, TMEM184A | CTIF | ELAVL1, MIF4GD, DDX19A, FBXW7, SLBP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | CTIF | chr13:45781640 | chr18:46284290 | ENST00000256413 | + | 6 | 12 | 1_305 | 194 | 599 | NCBP1/CBP80 |
| Tgene | CTIF | chr13:45781640 | chr18:46284290 | ENST00000382998 | + | 7 | 13 | 1_305 | 194 | 601 | NCBP1/CBP80 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GTF2F2_CTIF |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GTF2F2_CTIF |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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