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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15588

FusionGeneSummary for GSTO2_GSTO2

check button Fusion gene summary
Fusion gene informationFusion gene name: GSTO2_GSTO2
Fusion gene ID: 15588
HgeneTgene
Gene symbol

GSTO2

GSTO2

Gene ID

119391

119391

Gene nameglutathione S-transferase omega 2glutathione S-transferase omega 2
SynonymsGSTO 2-2|bA127L20.1GSTO 2-2|bA127L20.1
Cytomap

10q25.1

10q25.1

Type of geneprotein-codingprotein-coding
Descriptionglutathione S-transferase omega-2GSTO-2MMA(V) reductasebA127L20.1 (novel glutathione-S-transferase)glutathione S-transferase omega 2-2glutathione-S-transferase-like proteinglutathione-dependent dehydroascorbate reductasemonomethylarsonic acid reducglutathione S-transferase omega-2GSTO-2MMA(V) reductasebA127L20.1 (novel glutathione-S-transferase)glutathione S-transferase omega 2-2glutathione-S-transferase-like proteinglutathione-dependent dehydroascorbate reductasemonomethylarsonic acid reduc
Modification date2018052320180523
UniProtAcc

Q9H4Y5

Q9H4Y5

Ensembl transtripts involved in fusion geneENST00000450629, ENST00000338595, 
ENST00000401888, ENST00000477078, 
ENST00000369707, ENST00000429569, 
ENST00000450629, ENST00000338595, 
ENST00000401888, ENST00000477078, 
ENST00000369707, ENST00000429569, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: GSTO2 [Title/Abstract] AND GSTO2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGSTO2

GO:0006805

xenobiotic metabolic process

15970797

HgeneGSTO2

GO:0019852

L-ascorbic acid metabolic process

15970797

HgeneGSTO2

GO:0055114

oxidation-reduction process

15970797

HgeneGSTO2

GO:0071243

cellular response to arsenic-containing substance

15970797

TgeneGSTO2

GO:0006805

xenobiotic metabolic process

15970797

TgeneGSTO2

GO:0019852

L-ascorbic acid metabolic process

15970797

TgeneGSTO2

GO:0055114

oxidation-reduction process

15970797

TgeneGSTO2

GO:0071243

cellular response to arsenic-containing substance

15970797


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE771867GSTO2chr10

106059051

-GSTO2chr10

106058886

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000450629ENST00000450629GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-3CDSENST00000450629ENST00000338595GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-intronENST00000450629ENST00000401888GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-intronENST00000450629ENST00000477078GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-intronENST00000450629ENST00000369707GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-intronENST00000450629ENST00000429569GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-3CDSENST00000338595ENST00000450629GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-3CDSENST00000338595ENST00000338595GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-intronENST00000338595ENST00000401888GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-intronENST00000338595ENST00000477078GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-intronENST00000338595ENST00000369707GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-intronENST00000338595ENST00000429569GSTO2chr10

106059051

-GSTO2chr10

106058886

+
intron-3CDSENST00000401888ENST00000450629GSTO2chr10

106059051

-GSTO2chr10

106058886

+
intron-3CDSENST00000401888ENST00000338595GSTO2chr10

106059051

-GSTO2chr10

106058886

+
intron-intronENST00000401888ENST00000401888GSTO2chr10

106059051

-GSTO2chr10

106058886

+
intron-intronENST00000401888ENST00000477078GSTO2chr10

106059051

-GSTO2chr10

106058886

+
intron-intronENST00000401888ENST00000369707GSTO2chr10

106059051

-GSTO2chr10

106058886

+
intron-intronENST00000401888ENST00000429569GSTO2chr10

106059051

-GSTO2chr10

106058886

+
intron-3CDSENST00000477078ENST00000450629GSTO2chr10

106059051

-GSTO2chr10

106058886

+
intron-3CDSENST00000477078ENST00000338595GSTO2chr10

106059051

-GSTO2chr10

106058886

+
intron-intronENST00000477078ENST00000401888GSTO2chr10

106059051

-GSTO2chr10

106058886

+
intron-intronENST00000477078ENST00000477078GSTO2chr10

106059051

-GSTO2chr10

106058886

+
intron-intronENST00000477078ENST00000369707GSTO2chr10

106059051

-GSTO2chr10

106058886

+
intron-intronENST00000477078ENST00000429569GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-3CDSENST00000369707ENST00000450629GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-3CDSENST00000369707ENST00000338595GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-intronENST00000369707ENST00000401888GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-intronENST00000369707ENST00000477078GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-intronENST00000369707ENST00000369707GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-intronENST00000369707ENST00000429569GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-3CDSENST00000429569ENST00000450629GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-3CDSENST00000429569ENST00000338595GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-intronENST00000429569ENST00000401888GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-intronENST00000429569ENST00000477078GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-intronENST00000429569ENST00000369707GSTO2chr10

106059051

-GSTO2chr10

106058886

+
3UTR-intronENST00000429569ENST00000429569GSTO2chr10

106059051

-GSTO2chr10

106058886

+

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FusionProtFeatures for GSTO2_GSTO2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSTO2

Q9H4Y5

GSTO2

Q9H4Y5

Exhibits glutathione-dependent thiol transferaseactivity. Has high dehydroascorbate reductase activity and maycontribute to the recycling of ascorbic acid. Participates in thebiotransformation of inorganic arsenic and reducesmonomethylarsonic acid (MMA). {ECO:0000269|PubMed:15970797}. Exhibits glutathione-dependent thiol transferaseactivity. Has high dehydroascorbate reductase activity and maycontribute to the recycling of ascorbic acid. Participates in thebiotransformation of inorganic arsenic and reducesmonomethylarsonic acid (MMA). {ECO:0000269|PubMed:15970797}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GSTO2_GSTO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GSTO2_GSTO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GSTO2_GSTO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGSTO2Q9H4Y5DB00143GlutathioneGlutathione S-transferase omega-2small moleculeapproved|investigational|nutraceutical
TgeneGSTO2Q9H4Y5DB00143GlutathioneGlutathione S-transferase omega-2small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for GSTO2_GSTO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGSTO2C0005695Bladder Neoplasm1CTD_human
TgeneGSTO2C0005695Bladder Neoplasm1CTD_human