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Fusion gene ID: 15586 |
FusionGeneSummary for GSTO1_INA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GSTO1_INA | Fusion gene ID: 15586 | Hgene | Tgene | Gene symbol | GSTO1 | INA | Gene ID | 9446 | 9118 |
| Gene name | glutathione S-transferase omega 1 | internexin neuronal intermediate filament protein alpha | |
| Synonyms | GSTO 1-1|GSTTLp28|HEL-S-21|P28|SPG-R | NEF5|NF-66|TXBP-1 | |
| Cytomap | 10q25.1 | 10q24.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glutathione S-transferase omega-1MMA(V) reductaseS-(Phenacyl)glutathione reductaseepididymis secretory protein Li 21glutathione S-transferase omega 1-1glutathione-S-transferase likeglutathione-dependent dehydroascorbate reductasemonomethylarsonic a | alpha-internexin66 kDa neurofilament proteinalpha-Inxneurofilament 5 (66kD)neurofilament-66, tax-binding protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P78417 | Q16352 | |
| Ensembl transtripts involved in fusion gene | ENST00000493946, ENST00000539281, ENST00000369710, ENST00000369713, | ENST00000369849, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 1 X 3=12 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GSTO1 [Title/Abstract] AND INA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GSTO1 | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 11035031 |
| Hgene | GSTO1 | GO:0019852 | L-ascorbic acid metabolic process | 11511179 |
| Hgene | GSTO1 | GO:0042178 | xenobiotic catabolic process | 12928150 |
| Hgene | GSTO1 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 11035031 |
| Hgene | GSTO1 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 11035031 |
| Hgene | GSTO1 | GO:0071243 | cellular response to arsenic-containing substance | 11511179 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-EJ-8474-01A | GSTO1 | chr10 | 106022835 | + | INA | chr10 | 105046792 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000493946 | ENST00000369849 | GSTO1 | chr10 | 106022835 | + | INA | chr10 | 105046792 | + |
| In-frame | ENST00000539281 | ENST00000369849 | GSTO1 | chr10 | 106022835 | + | INA | chr10 | 105046792 | + |
| intron-3CDS | ENST00000369710 | ENST00000369849 | GSTO1 | chr10 | 106022835 | + | INA | chr10 | 105046792 | + |
| In-frame | ENST00000369713 | ENST00000369849 | GSTO1 | chr10 | 106022835 | + | INA | chr10 | 105046792 | + |
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FusionProtFeatures for GSTO1_INA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GSTO1 | INA |
| Exhibits glutathione-dependent thiol transferase anddehydroascorbate reductase activities. Has S-(phenacyl)glutathionereductase activity. Has also glutathione S-transferase activity.Participates in the biotransformation of inorganic arsenic andreduces monomethylarsonic acid (MMA) and dimethylarsonic acid.{ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:11511179,ECO:0000269|PubMed:17226937, ECO:0000269|PubMed:18028863,ECO:0000269|PubMed:21106529}. | Class-IV neuronal intermediate filament that is able toself-assemble. It is involved in the morphogenesis of neurons. Itmay form an independent structural network without the involvementof other neurofilaments or it may cooperate with NF-L to form thefilamentous backbone to which NF-M and NF-H attach to form thecross-bridges. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GSTO1_INA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GSTO1_ENST00000539281_chr10_106022835_+_INA_ENST00000369849_chr10_105046792_+_272aa MRFCPFAERTRLVLKAKGIRHEVININLKNKPEWFFKKNPFGLVPVLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILE LFSKVPSLVGSFIRSQNKEDYAGLKEEFRKEFTKLEEDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFS TSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSLKKEEEEEEASKVASKKTSQIGESFEEILEETVISTKKTEKSNIEETTISSQK >In-frame_GSTO1_ENST00000369713_chr10_106022835_+_INA_ENST00000369849_chr10_105046792_+_300aa MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININLKNKPEWFFKKNPFGLVPVLENSQGQLIYESAITC EYLDEAYPGKKLLPDDPYEKACQKMILELFSKVPSLVGSFIRSQNKEDYAGLKEEFRKEFTKLEEDSIGQLENDLRNTKSEMARHLREYQ DLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSLKKEEEEEEASKVASKKTSQIGESF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GSTO1_ENST00000539281_chr10_106022835_+_INA_ENST00000369849_chr10_105046792_+_816nt ATGAGGTTCTGCCCGTTTGCTGAGAGGACGCGTCTAGTCCTGAAGGCCAAGGGAATCAGGCATGAAGTCATCAATATCAACCTGAAAAAT AAGCCTGAGTGGTTCTTTAAGAAAAATCCCTTTGGTCTGGTGCCAGTTCTGGAAAACAGTCAGGGTCAGCTGATCTACGAGTCTGCCATC ACCTGTGAGTACCTGGATGAAGCATACCCAGGGAAGAAGCTGTTGCCGGATGACCCCTATGAGAAAGCTTGCCAGAAGATGATCTTAGAG TTGTTTTCTAAGGTGCCATCCTTGGTAGGAAGCTTTATTAGAAGCCAAAATAAAGAAGACTATGCTGGCCTAAAAGAAGAATTTCGTAAA GAATTTACCAAGCTAGAGGAGGATAGCATTGGGCAGCTGGAGAATGATCTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAA TACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCAGCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGC ACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGTTACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAA GTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAGGCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAA AGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACCGAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAA >In-frame_GSTO1_ENST00000369713_chr10_106022835_+_INA_ENST00000369849_chr10_105046792_+_900nt ATGTCCGGGGAGTCAGCCAGGAGCTTGGGGAAGGGAAGCGCGCCCCCGGGGCCGGTCCCGGAGGGCTCGATCCGCATCTACAGCATGAGG TTCTGCCCGTTTGCTGAGAGGACGCGTCTAGTCCTGAAGGCCAAGGGAATCAGGCATGAAGTCATCAATATCAACCTGAAAAATAAGCCT GAGTGGTTCTTTAAGAAAAATCCCTTTGGTCTGGTGCCAGTTCTGGAAAACAGTCAGGGTCAGCTGATCTACGAGTCTGCCATCACCTGT GAGTACCTGGATGAAGCATACCCAGGGAAGAAGCTGTTGCCGGATGACCCCTATGAGAAAGCTTGCCAGAAGATGATCTTAGAGTTGTTT TCTAAGGTGCCATCCTTGGTAGGAAGCTTTATTAGAAGCCAAAATAAAGAAGACTATGCTGGCCTAAAAGAAGAATTTCGTAAAGAATTT ACCAAGCTAGAGGAGGATAGCATTGGGCAGCTGGAGAATGATCTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAG GACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCAGCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGT GGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGTTACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCA TCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAGGCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTT GAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACCGAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATATAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GSTO1_ENST00000539281_chr10_106022835_+_INA_ENST00000369849_chr10_105046792_+_2854nt AAGGATGACTCCTAGACCTGTCTTTGTCCCATACTTGGGAAGATAAGCTGTTAGTTTACATTGCCAAGATGAAATTCAACTGATCTGTTT TAGAGTAAAGATCTTGCGGGCCAACAAGGAATTTCCTTGGGGAGGTGTGTGGCCTTTGATCTTTGTAGCTATTTAGCAACAAAATGGGAG GCAGTGTTGCCTGACTCAGTTTCCAAGCTTGACTCTTCCCTTTGGCATAGTGAGTTTGGAGTCAAGAGATTTTTATTTTCCCTTCACAAG CTGAACAGGAGCCTTTGGAGAGAACGCTCTGGACCGGAAGCGCGCCCCCGGGGCCGGTCCCGGAGGGCTCGATCCGCATCTACAGCATGA GGTTCTGCCCGTTTGCTGAGAGGACGCGTCTAGTCCTGAAGGCCAAGGGAATCAGGCATGAAGTCATCAATATCAACCTGAAAAATAAGC CTGAGTGGTTCTTTAAGAAAAATCCCTTTGGTCTGGTGCCAGTTCTGGAAAACAGTCAGGGTCAGCTGATCTACGAGTCTGCCATCACCT GTGAGTACCTGGATGAAGCATACCCAGGGAAGAAGCTGTTGCCGGATGACCCCTATGAGAAAGCTTGCCAGAAGATGATCTTAGAGTTGT TTTCTAAGGTGCCATCCTTGGTAGGAAGCTTTATTAGAAGCCAAAATAAAGAAGACTATGCTGGCCTAAAAGAAGAATTTCGTAAAGAAT TTACCAAGCTAGAGGAGGATAGCATTGGGCAGCTGGAGAATGATCTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACC AGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCAGCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCA GTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGTTACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCT CATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAGGCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTT TTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACCGAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATAT AATTCCATTGCTTTGAAAAAGTTAATGCTTAAGAGGGAATGATATGCATTTGACTTGTTAAACAGCCTATTCCTGAACTATAACACCTGC CACCACTATAAAATGTCTTCAAGGCTTCAGTCTCATATTTAGTATTGAATACTTACATTCTCTAATAAGAAAACCACCCCTTAGATTGAA GTAAACTGCAGTCCTGGAGCAATCACAGATGAGTTATCTAAGAATACAGCTTTCTGACCTTCAGCTCACGCTTCACAGTGATCGATGATT CAGGTGCAGAGGAAGTACAAACTAAGGTGCTAAATCTGCGATCATCGTCATTTGCTGTGAACTGAAATTAAAACTATTCATGCTACCCAG CCATTACCCAGCTAAATAATCTTACTCTAGATACCTAAAACATAAGATCACTGCCAGAGATAAACTAATGGTCCACACCCAATTCCACTC TGATAGAATTATTTCACAAATAATAGGTGTTTGTTTAATGGACACTTTTCACCTCCTTCAATTCCATATATCCTTTTCTTCTATGTAGGA AAAAAATAGTCTAGTGTAGTATTCTTCCCTTTTAAACACATTTTGGTTCTTCTCAAAAGAACTTACCCCCATTCGCGCTCTGCTCAGTGG GTAAAATTAGATGCATGTTGACCATGTCTATGATTCGTGTAATTACTTATCCCTGCCCATTTCATATTCTTTCAATTCTGTAGGTTAAAA AAATGGCAGTGATGAATTTTAAGGGTTTCCCCCAACATATAAAATAATGCAAAGAATCCCTAGACTTTAGGCTTTCAGCTTACACAAATC TATTTAATTAGGAAAAAAACTATTAAGGATGTAGCTTTTCACCTTTACTTTAGAAGCACAGTAAATATCCCAAACTGTGATGAAGCCGAC CTTAGATTTAGTAGTGTAAGCTAGAAGAAGTGAGTGTTTCTATGAGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAGTTCATTTGTGGT GATATAGAATTAGCTTTTTCATCCCCTTACCCTTAGAATCCACGTATTCCCCTTCCCACTAGCCTAGGTCATAAAGAGGCGTTGCTTTCA CTCTCCTATGCCTTTTACGAGTGCTAAGTGTAGGATATTTTGTCACCAGAACACAATGCTACCGCCCCAAAGTAAAAGAAACCACTTCTG GTCAATCAACACTACCAGCGTATATATAAGAAAGACATCTTTCTCTTTTCTAAAAGACTTCCCTAACACTTACCCCATGGCTGCACAGTT GGTGGGGTCCTGCCGGAGAGGAAGAGACACTCAGACCAGAGAAGGGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTAGATTCTGGACAG TCAGCTCTTCATCTGCCCAACTGTGTAGCATCTGCATTGCCCAGTCTTTCATGTGTGCCAAGGCTGATGCAGGATTTGTTCTCTGTCCAG CAGTCACTTCGGCCAGAGCTGAAGAGTTGCCCCGTCTCTGTTCCATGTCTCCTTTAAGAGCTCTGGTGATAAGGACATGATGCTTTTACT GAACTTTCTTATCCTAGCACATGCTTCAATAGTTCAAGGAACTTGAAAAATACTTTTCCTTACCTTTACCCCATCCCTGTCTTTACTCCT >In-frame_GSTO1_ENST00000369713_chr10_106022835_+_INA_ENST00000369849_chr10_105046792_+_2776nt ACAGCCCCTTAAGATGTTTTAAGGGCTATCCCATAAAGCCGGGAAGGCACAACGGGTGGAGCTGGCGGCCGCCGGGGGCAGGCACTTTTG AGCTAAGGAGGAAGCGGGGGAGGGAAGGAGGGCGGGAAGGACGCGCCACCTACTTCCTGAATCCCCTGCAAACCCCAGAGGAGCTCGGCC TGCGCTGCGCCACGATGTCCGGGGAGTCAGCCAGGAGCTTGGGGAAGGGAAGCGCGCCCCCGGGGCCGGTCCCGGAGGGCTCGATCCGCA TCTACAGCATGAGGTTCTGCCCGTTTGCTGAGAGGACGCGTCTAGTCCTGAAGGCCAAGGGAATCAGGCATGAAGTCATCAATATCAACC TGAAAAATAAGCCTGAGTGGTTCTTTAAGAAAAATCCCTTTGGTCTGGTGCCAGTTCTGGAAAACAGTCAGGGTCAGCTGATCTACGAGT CTGCCATCACCTGTGAGTACCTGGATGAAGCATACCCAGGGAAGAAGCTGTTGCCGGATGACCCCTATGAGAAAGCTTGCCAGAAGATGA TCTTAGAGTTGTTTTCTAAGGTGCCATCCTTGGTAGGAAGCTTTATTAGAAGCCAAAATAAAGAAGACTATGCTGGCCTAAAAGAAGAAT TTCGTAAAGAATTTACCAAGCTAGAGGAGGATAGCATTGGGCAGCTGGAGAATGATCTGAGGAACACCAAGAGTGAGATGGCACGCCACC TTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCAGCTTACAGGAAACTGCTGGAAGGCGAGGAGACAC GTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGTTACCTGCTCCCACCTAGAATCCTCAGTGCTACAA CCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAGGCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGA TAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACCGAGAAATCAAATATAGAAGAAACCACCATTTCAA GCCAAAAAATATAATTCCATTGCTTTGAAAAAGTTAATGCTTAAGAGGGAATGATATGCATTTGACTTGTTAAACAGCCTATTCCTGAAC TATAACACCTGCCACCACTATAAAATGTCTTCAAGGCTTCAGTCTCATATTTAGTATTGAATACTTACATTCTCTAATAAGAAAACCACC CCTTAGATTGAAGTAAACTGCAGTCCTGGAGCAATCACAGATGAGTTATCTAAGAATACAGCTTTCTGACCTTCAGCTCACGCTTCACAG TGATCGATGATTCAGGTGCAGAGGAAGTACAAACTAAGGTGCTAAATCTGCGATCATCGTCATTTGCTGTGAACTGAAATTAAAACTATT CATGCTACCCAGCCATTACCCAGCTAAATAATCTTACTCTAGATACCTAAAACATAAGATCACTGCCAGAGATAAACTAATGGTCCACAC CCAATTCCACTCTGATAGAATTATTTCACAAATAATAGGTGTTTGTTTAATGGACACTTTTCACCTCCTTCAATTCCATATATCCTTTTC TTCTATGTAGGAAAAAAATAGTCTAGTGTAGTATTCTTCCCTTTTAAACACATTTTGGTTCTTCTCAAAAGAACTTACCCCCATTCGCGC TCTGCTCAGTGGGTAAAATTAGATGCATGTTGACCATGTCTATGATTCGTGTAATTACTTATCCCTGCCCATTTCATATTCTTTCAATTC TGTAGGTTAAAAAAATGGCAGTGATGAATTTTAAGGGTTTCCCCCAACATATAAAATAATGCAAAGAATCCCTAGACTTTAGGCTTTCAG CTTACACAAATCTATTTAATTAGGAAAAAAACTATTAAGGATGTAGCTTTTCACCTTTACTTTAGAAGCACAGTAAATATCCCAAACTGT GATGAAGCCGACCTTAGATTTAGTAGTGTAAGCTAGAAGAAGTGAGTGTTTCTATGAGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAG TTCATTTGTGGTGATATAGAATTAGCTTTTTCATCCCCTTACCCTTAGAATCCACGTATTCCCCTTCCCACTAGCCTAGGTCATAAAGAG GCGTTGCTTTCACTCTCCTATGCCTTTTACGAGTGCTAAGTGTAGGATATTTTGTCACCAGAACACAATGCTACCGCCCCAAAGTAAAAG AAACCACTTCTGGTCAATCAACACTACCAGCGTATATATAAGAAAGACATCTTTCTCTTTTCTAAAAGACTTCCCTAACACTTACCCCAT GGCTGCACAGTTGGTGGGGTCCTGCCGGAGAGGAAGAGACACTCAGACCAGAGAAGGGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTA GATTCTGGACAGTCAGCTCTTCATCTGCCCAACTGTGTAGCATCTGCATTGCCCAGTCTTTCATGTGTGCCAAGGCTGATGCAGGATTTG TTCTCTGTCCAGCAGTCACTTCGGCCAGAGCTGAAGAGTTGCCCCGTCTCTGTTCCATGTCTCCTTTAAGAGCTCTGGTGATAAGGACAT GATGCTTTTACTGAACTTTCTTATCCTAGCACATGCTTCAATAGTTCAAGGAACTTGAAAAATACTTTTCCTTACCTTTACCCCATCCCT |
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FusionGenePPI for GSTO1_INA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GSTO1 | KAT5, SETDB1, RBM48, EEF1G, KIAA1377, UBA5, APP, GSTT1, FN1, BAG3, HSPB1, C11orf54, CAPN1, CAPN9, DUT, ECH1, FKBP1B, GSTA4, ATP5J, FKBP7, LDHA, P4HB, TXN, HSPE1, LYPLA2, NUDT9, PRDX6, TAGLN, TAGLN2, TAGLN3, UQCRFS1, YTHDC2, NTRK1, MED20, PPME1, SERPINB5 | INA | SQSTM1, ARRB1, SIRT7, PPP1CA, PAN2, PARK2, STAU1, CUL7, OBSL1, CCDC183, CENPP, ERGIC1, PRMT8, MAB21L2, CTBP1, NTRK1, CNTROB, ODF2, GAN, NEFM, VIM, SYNC, CCDC120, RSPRY1, NEFH, GFAP, MIPEP, CAPN1, VSIG8, VWA3B, BFSP2, BMP1, GJB7, BAZ2B, KLHL36, TIAL1, DLST, PDHA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GSTO1_INA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | GSTO1 | P78417 | DB00143 | Glutathione | Glutathione S-transferase omega-1 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for GSTO1_INA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GSTO1 | C0023418 | leukemia | 1 | CTD_human |
| Hgene | GSTO1 | C0024115 | Lung diseases | 1 | CTD_human |
| Hgene | GSTO1 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Hgene | GSTO1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | GSTO1 | C0037274 | Dermatologic disorders | 1 | CTD_human |
| Hgene | GSTO1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Hgene | GSTO1 | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
| Tgene | INA | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
| Tgene | INA | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
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