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Fusion gene ID: 15583 |
FusionGeneSummary for GSTM2_EVC2 |
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Fusion gene information | Fusion gene name: GSTM2_EVC2 | Fusion gene ID: 15583 | Hgene | Tgene | Gene symbol | GSTM2 | EVC2 | Gene ID | 2946 | 132884 |
Gene name | glutathione S-transferase mu 2 | EvC ciliary complex subunit 2 | |
Synonyms | GST4|GSTM|GSTM2-2|GTHMUS | LBN|WAD | |
Cytomap | 1p13.3 | 4p16.2 | |
Type of gene | protein-coding | protein-coding | |
Description | glutathione S-transferase Mu 2GST class-mu 2GST, muscleS-(hydroxyalkyl)glutathione lyase M2glutathione S-alkyltransferase M2glutathione S-aralkyltransferase M2glutathione S-aryltransferase M2glutathione S-transferase 4glutathione S-transferase M1 | limbinEllis van Creveld syndrome 2ellis-van Creveld syndrome protein 2 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | P28161 | Q86UK5 | |
Ensembl transtripts involved in fusion gene | ENST00000369831, ENST00000460717, ENST00000369827, ENST00000442650, ENST00000464206, ENST00000241337, ENST00000414179, ENST00000369829, | ENST00000344938, ENST00000344408, ENST00000310917, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 2=8 |
# samples | 3 | 2 | |
** MAII score | log2(3/4*10)=2.90689059560852 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: GSTM2 [Title/Abstract] AND EVC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GSTM2 | GO:0006749 | glutathione metabolic process | 2034681|8373352|16549767 |
Hgene | GSTM2 | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 17023043 |
Hgene | GSTM2 | GO:0018916 | nitrobenzene metabolic process | 2034681|8373352 |
Hgene | GSTM2 | GO:0042178 | xenobiotic catabolic process | 2034681|8373352|16549767 |
Hgene | GSTM2 | GO:0043651 | linoleic acid metabolic process | 16624487 |
Hgene | GSTM2 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 17023043|22406107 |
Hgene | GSTM2 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 17023043 |
Hgene | GSTM2 | GO:0070458 | cellular detoxification of nitrogen compound | 2034681|8373352 |
Hgene | GSTM2 | GO:0071313 | cellular response to caffeine | 22406107 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW386100 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000369831 | ENST00000344938 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000369831 | ENST00000344408 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000369831 | ENST00000310917 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000460717 | ENST00000344938 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000460717 | ENST00000344408 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000460717 | ENST00000310917 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000369827 | ENST00000344938 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000369827 | ENST00000344408 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000369827 | ENST00000310917 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000442650 | ENST00000344938 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000442650 | ENST00000344408 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000442650 | ENST00000310917 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000464206 | ENST00000344938 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000464206 | ENST00000344408 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000464206 | ENST00000310917 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000241337 | ENST00000344938 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000241337 | ENST00000344408 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000241337 | ENST00000310917 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000414179 | ENST00000344938 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000414179 | ENST00000344408 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000414179 | ENST00000310917 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000369829 | ENST00000344938 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000369829 | ENST00000344408 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
intron-intron | ENST00000369829 | ENST00000310917 | GSTM2 | chr1 | 110256544 | + | EVC2 | chr4 | 5671338 | + |
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FusionProtFeatures for GSTM2_EVC2 |
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Hgene | Tgene |
GSTM2 | EVC2 |
Conjugation of reduced glutathione to a wide number ofexogenous and endogenous hydrophobic electrophiles.{ECO:0000269|PubMed:16549767}. | Component of the EvC complex that positively regulatesciliary Hedgehog (Hh) signaling. Plays a critical role in boneformation and skeletal development. May be involved in earlyembryonic morphogenesis. {ECO:0000250|UniProtKB:Q8K1G2}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GSTM2_EVC2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GSTM2_EVC2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GSTM2_EVC2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | GSTM2 | P28161 | DB00143 | Glutathione | Glutathione S-transferase Mu 2 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for GSTM2_EVC2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GSTM2 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Hgene | GSTM2 | C0013080 | Down Syndrome | 1 | CTD_human |
Hgene | GSTM2 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | GSTM2 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | GSTM2 | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
Hgene | GSTM2 | C2609414 | Acute kidney injury | 1 | CTD_human |
Hgene | GSTM2 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | EVC2 | C0013903 | Ellis-Van Creveld Syndrome | 2 | CTD_human;ORPHANET;UNIPROT |