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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15583

FusionGeneSummary for GSTM2_EVC2

check button Fusion gene summary
Fusion gene informationFusion gene name: GSTM2_EVC2
Fusion gene ID: 15583
HgeneTgene
Gene symbol

GSTM2

EVC2

Gene ID

2946

132884

Gene nameglutathione S-transferase mu 2EvC ciliary complex subunit 2
SynonymsGST4|GSTM|GSTM2-2|GTHMUSLBN|WAD
Cytomap

1p13.3

4p16.2

Type of geneprotein-codingprotein-coding
Descriptionglutathione S-transferase Mu 2GST class-mu 2GST, muscleS-(hydroxyalkyl)glutathione lyase M2glutathione S-alkyltransferase M2glutathione S-aralkyltransferase M2glutathione S-aryltransferase M2glutathione S-transferase 4glutathione S-transferase M1limbinEllis van Creveld syndrome 2ellis-van Creveld syndrome protein 2
Modification date2018051920180519
UniProtAcc

P28161

Q86UK5

Ensembl transtripts involved in fusion geneENST00000369831, ENST00000460717, 
ENST00000369827, ENST00000442650, 
ENST00000464206, ENST00000241337, 
ENST00000414179, ENST00000369829, 
ENST00000344938, ENST00000344408, 
ENST00000310917, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 2 X 2=8
# samples 32
** MAII scorelog2(3/4*10)=2.90689059560852log2(2/8*10)=1.32192809488736
Context

PubMed: GSTM2 [Title/Abstract] AND EVC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGSTM2

GO:0006749

glutathione metabolic process

2034681|8373352|16549767

HgeneGSTM2

GO:0010880

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

17023043

HgeneGSTM2

GO:0018916

nitrobenzene metabolic process

2034681|8373352

HgeneGSTM2

GO:0042178

xenobiotic catabolic process

2034681|8373352|16549767

HgeneGSTM2

GO:0043651

linoleic acid metabolic process

16624487

HgeneGSTM2

GO:0060315

negative regulation of ryanodine-sensitive calcium-release channel activity

17023043|22406107

HgeneGSTM2

GO:0060316

positive regulation of ryanodine-sensitive calcium-release channel activity

17023043

HgeneGSTM2

GO:0070458

cellular detoxification of nitrogen compound

2034681|8373352

HgeneGSTM2

GO:0071313

cellular response to caffeine

22406107


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW386100GSTM2chr1

110256544

+EVC2chr4

5671338

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000369831ENST00000344938GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000369831ENST00000344408GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000369831ENST00000310917GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000460717ENST00000344938GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000460717ENST00000344408GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000460717ENST00000310917GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000369827ENST00000344938GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000369827ENST00000344408GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000369827ENST00000310917GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000442650ENST00000344938GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000442650ENST00000344408GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000442650ENST00000310917GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000464206ENST00000344938GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000464206ENST00000344408GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000464206ENST00000310917GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000241337ENST00000344938GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000241337ENST00000344408GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000241337ENST00000310917GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000414179ENST00000344938GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000414179ENST00000344408GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000414179ENST00000310917GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000369829ENST00000344938GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000369829ENST00000344408GSTM2chr1

110256544

+EVC2chr4

5671338

+
intron-intronENST00000369829ENST00000310917GSTM2chr1

110256544

+EVC2chr4

5671338

+

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FusionProtFeatures for GSTM2_EVC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSTM2

P28161

EVC2

Q86UK5

Conjugation of reduced glutathione to a wide number ofexogenous and endogenous hydrophobic electrophiles.{ECO:0000269|PubMed:16549767}. Component of the EvC complex that positively regulatesciliary Hedgehog (Hh) signaling. Plays a critical role in boneformation and skeletal development. May be involved in earlyembryonic morphogenesis. {ECO:0000250|UniProtKB:Q8K1G2}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GSTM2_EVC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GSTM2_EVC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GSTM2_EVC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGSTM2P28161DB00143GlutathioneGlutathione S-transferase Mu 2small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for GSTM2_EVC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGSTM2C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneGSTM2C0013080Down Syndrome1CTD_human
HgeneGSTM2C0036341Schizophrenia1PSYGENET
HgeneGSTM2C0151744Myocardial Ischemia1CTD_human
HgeneGSTM2C0524851Neurodegenerative Disorders1CTD_human
HgeneGSTM2C2609414Acute kidney injury1CTD_human
HgeneGSTM2C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneEVC2C0013903Ellis-Van Creveld Syndrome2CTD_human;ORPHANET;UNIPROT