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Fusion gene ID: 15580 |
FusionGeneSummary for GSS_TTI1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GSS_TTI1 | Fusion gene ID: 15580 | Hgene | Tgene | Gene symbol | GSS | TTI1 | Gene ID | 5621 | 9675 |
| Gene name | prion protein | TELO2 interacting protein 1 | |
| Synonyms | ASCR|AltPrP|CD230|CJD|GSS|KURU|PRIP|PrP|PrP27-30|PrP33-35C|PrPc|p27-30 | KIAA0406|smg-10 | |
| Cytomap | 20p13 | 20q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | major prion proteinalternative prion proteinCD230 antigenprion-related protein | TELO2-interacting protein 1 homologTEL2-interacting protein 1 homologTel two interacting protein 1smg-10 homolog, nonsense mediated mRNA decay factor | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P48637 | O43156 | |
| Ensembl transtripts involved in fusion gene | ENST00000216951, ENST00000541098, ENST00000451957, | ENST00000373448, ENST00000373447, ENST00000449821, ENST00000487362, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 3 X 3 X 3=27 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/50*10)=0.485426827170242 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GSS [Title/Abstract] AND TTI1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GSS | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 22820466 |
| Hgene | GSS | GO:0071280 | cellular response to copper ion | 16254249 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-55-8097-01A | GSS | chr20 | 33529516 | - | TTI1 | chr20 | 36627730 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000216951 | ENST00000373448 | GSS | chr20 | 33529516 | - | TTI1 | chr20 | 36627730 | - |
| In-frame | ENST00000216951 | ENST00000373447 | GSS | chr20 | 33529516 | - | TTI1 | chr20 | 36627730 | - |
| In-frame | ENST00000216951 | ENST00000449821 | GSS | chr20 | 33529516 | - | TTI1 | chr20 | 36627730 | - |
| 5CDS-intron | ENST00000216951 | ENST00000487362 | GSS | chr20 | 33529516 | - | TTI1 | chr20 | 36627730 | - |
| Frame-shift | ENST00000541098 | ENST00000373448 | GSS | chr20 | 33529516 | - | TTI1 | chr20 | 36627730 | - |
| Frame-shift | ENST00000541098 | ENST00000373447 | GSS | chr20 | 33529516 | - | TTI1 | chr20 | 36627730 | - |
| Frame-shift | ENST00000541098 | ENST00000449821 | GSS | chr20 | 33529516 | - | TTI1 | chr20 | 36627730 | - |
| 5CDS-intron | ENST00000541098 | ENST00000487362 | GSS | chr20 | 33529516 | - | TTI1 | chr20 | 36627730 | - |
| intron-3CDS | ENST00000451957 | ENST00000373448 | GSS | chr20 | 33529516 | - | TTI1 | chr20 | 36627730 | - |
| intron-3CDS | ENST00000451957 | ENST00000373447 | GSS | chr20 | 33529516 | - | TTI1 | chr20 | 36627730 | - |
| intron-3CDS | ENST00000451957 | ENST00000449821 | GSS | chr20 | 33529516 | - | TTI1 | chr20 | 36627730 | - |
| intron-intron | ENST00000451957 | ENST00000487362 | GSS | chr20 | 33529516 | - | TTI1 | chr20 | 36627730 | - |
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FusionProtFeatures for GSS_TTI1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GSS | TTI1 |
| Regulator of the DNA damage response (DDR). Part of theTTT complex that is required to stabilize protein levels of thephosphatidylinositol 3-kinase-related protein kinase (PIKK) familyproteins. The TTT complex is involved in the cellular resistanceto DNA damage stresses, like ionizing radiation (IR), ultraviolet(UV) and mitomycin C (MMC). Together with the TTT complex andHSP90 may participate in the proper folding of newly synthesizedPIKKs. Promotes assembly, stabilizes and maintains the activity ofmTORC1 and mTORC2 complexes, which regulate cell growth andsurvival in response to nutrient and hormonal signals.{ECO:0000269|PubMed:20427287, ECO:0000269|PubMed:20801936,ECO:0000269|PubMed:20810650}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GSS | chr20:33529516 | chr20:36627730 | ENST00000216951 | - | 6 | 13 | 148_151 | 202 | 475 | Region | Note=Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GSS | chr20:33529516 | chr20:36627730 | ENST00000216951 | - | 6 | 13 | 364_373 | 202 | 475 | Nucleotide binding | Note=ATP |
| Hgene | >GSS | chr20:33529516 | chr20:36627730 | ENST00000216951 | - | 6 | 13 | 398_401 | 202 | 475 | Nucleotide binding | Note=ATP |
| Hgene | >GSS | chr20:33529516 | chr20:36627730 | ENST00000451957 | - | 1 | 9 | 364_373 | 0 | 364 | Nucleotide binding | Note=ATP |
| Hgene | >GSS | chr20:33529516 | chr20:36627730 | ENST00000451957 | - | 1 | 9 | 398_401 | 0 | 364 | Nucleotide binding | Note=ATP |
| Hgene | >GSS | chr20:33529516 | chr20:36627730 | ENST00000216951 | - | 6 | 13 | 214_216 | 202 | 475 | Region | Note=Substrate binding |
| Hgene | >GSS | chr20:33529516 | chr20:36627730 | ENST00000216951 | - | 6 | 13 | 267_270 | 202 | 475 | Region | Note=Substrate binding |
| Hgene | >GSS | chr20:33529516 | chr20:36627730 | ENST00000216951 | - | 6 | 13 | 461_462 | 202 | 475 | Region | Note=Substrate binding |
| Hgene | >GSS | chr20:33529516 | chr20:36627730 | ENST00000451957 | - | 1 | 9 | 148_151 | 0 | 364 | Region | Note=Substrate binding |
| Hgene | >GSS | chr20:33529516 | chr20:36627730 | ENST00000451957 | - | 1 | 9 | 214_216 | 0 | 364 | Region | Note=Substrate binding |
| Hgene | >GSS | chr20:33529516 | chr20:36627730 | ENST00000451957 | - | 1 | 9 | 267_270 | 0 | 364 | Region | Note=Substrate binding |
| Hgene | >GSS | chr20:33529516 | chr20:36627730 | ENST00000451957 | - | 1 | 9 | 461_462 | 0 | 364 | Region | Note=Substrate binding |
| Tgene | TTI1 | chr20:33529516 | chr20:36627730 | ENST00000373447 | - | 3 | 8 | 833_836 | 884 | 1090 | Compositional bias | Note=Poly-Glu |
| Tgene | TTI1 | chr20:33529516 | chr20:36627730 | ENST00000373448 | - | 4 | 9 | 833_836 | 884 | 1090 | Compositional bias | Note=Poly-Glu |
| Tgene | TTI1 | chr20:33529516 | chr20:36627730 | ENST00000449821 | - | 2 | 7 | 833_836 | 884 | 1090 | Compositional bias | Note=Poly-Glu |
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FusionGeneSequence for GSS_TTI1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GSS_ENST00000216951_chr20_33529516_-_TTI1_ENST00000373448_chr20_36627730_-_408aa MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAFLEQTL SSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKIL SNNPSKGLALGIAKAWELYGSPKSWMCWICVWLFFSPTKTSCFPWLIRPGPRSFTDSHGTPPWQCLEPSRFYVPWEASVVTFFAAGSAKM SCQSWLAPXSPRPPSVPGLDQFTRTRWPSSCSWLSYRAWAPSVRDWTXVRVTXIKWLMPAXFTSVSNSPXNYKRLPGASSSTXXRWTQTP >In-frame_GSS_ENST00000216951_chr20_33529516_-_TTI1_ENST00000373447_chr20_36627730_-_408aa MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAFLEQTL SSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKIL SNNPSKGLALGIAKAWELYGSPKSWMCWICVWLFFSPTKTSCFPWLIRPGPRSFTDSHGTPPWQCLEPSRFYVPWEASVVTFFAAGSAKM SCQSWLAPXSPRPPSVPGLDQFTRTRWPSSCSWLSYRAWAPSVRDWTXVRVTXIKWLMPAXFTSVSNSPXNYKRLPGASSSTXXRWTQTP >In-frame_GSS_ENST00000216951_chr20_33529516_-_TTI1_ENST00000449821_chr20_36627730_-_408aa MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAFLEQTL SSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKIL SNNPSKGLALGIAKAWELYGSPKSWMCWICVWLFFSPTKTSCFPWLIRPGPRSFTDSHGTPPWQCLEPSRFYVPWEASVVTFFAAGSAKM SCQSWLAPXSPRPPSVPGLDQFTRTRWPSSCSWLSYRAWAPSVRDWTXVRVTXIKWLMPAXFTSVSNSPXNYKRLPGASSSTXXRWTQTP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GSS_ENST00000216951_chr20_33529516_-_TTI1_ENST00000373448_chr20_36627730_-_1226nt ATGGCCACCAACTGGGGGAGCCTCTTGCAGGATAAACAGCAGCTAGAGGAGCTGGCACGGCAGGCCGTGGACCGGGCCCTGGCTGAGGGA GTATTGCTGAGGACCTCACAGGAGCCCACTTCCTCGGAGGTGGTGAGCTATGCCCCATTCACGCTCTTCCCCTCACTGGTCCCCAGTGCC CTGCTGGAGCAAGCCTATGCTGTGCAGATGGACTTCAACCTGCTAGTGGATGCTGTCAGCCAGAACGCTGCCTTCCTGGAGCAAACTCTT TCCAGCACCATCAAACAGGATGACTTTACCGCTCGTCTCTTTGACATCCACAAGCAAGTCCTAAAAGAGGGCATTGCCCAGACTGTGTTC CTGGGCCTGAATCGCTCAGACTACATGTTCCAGCGCAGCGCAGATGGCTCCCCAGCCCTGAAACAGATCGAAATCAACACCATCTCTGCC AGCTTTGGGGGCCTGGCCTCCCGGACCCCAGCTGTGCACCGACATGTTCTCAGTGTCCTGAGTAAGACCAAAGAAGCTGGCAAGATCCTC TCTAATAATCCCAGCAAGGGACTGGCCCTGGGAATTGCCAAAGCCTGGGAGCTCTACGGCTCACCCAAGTCTTGGATGTGCTGGATCTGT GTGTGGTTGTTCTTCAGTCCCACAAAAACCAGCTGCTTCCCTTGGCTCATCAGGCCTGGCCCTCGCTCGTTCACCGACTCACACGGGACG CCCCCCTGGCAGTGCTTAGAGCCTTCAAGGTTTTACGTACCCTGGGAAGCAAGTGTGGTGACTTTCTTCGCAGCCGGTTCTGCAAAGATG TCCTGCCAAAGCTGGCTGGCTCCCTAGTCACCCAGGCCCCCATCAGTGCCAGGGCTGGACCAGTTTACTCGCACACGCTGGCCTTCAAGT TGCAGCTGGCTGTCTTACAGGGCCTGGGCCCCCTCTGTGAGAGACTGGACCTAGGTGAGGGTGACCTGAATAAAGTGGCTGATGCCTGCT TGATTTACCTCAGTGTCAAACAGCCCGTGAAATTACAAGAGGCTGCCAGGAGCGTCTTCCTCCACTTGATGAAGGTGGACCCAGACTCCA CCTGGTTCCTCCTGAACGAGCTTTACTGCCCCGTGCAGTTCACACCTCCCCACCCCAGCCTCCACCCTGTGCAGCTGCACGGGGCCAGCG >In-frame_GSS_ENST00000216951_chr20_33529516_-_TTI1_ENST00000373447_chr20_36627730_-_1226nt ATGGCCACCAACTGGGGGAGCCTCTTGCAGGATAAACAGCAGCTAGAGGAGCTGGCACGGCAGGCCGTGGACCGGGCCCTGGCTGAGGGA GTATTGCTGAGGACCTCACAGGAGCCCACTTCCTCGGAGGTGGTGAGCTATGCCCCATTCACGCTCTTCCCCTCACTGGTCCCCAGTGCC CTGCTGGAGCAAGCCTATGCTGTGCAGATGGACTTCAACCTGCTAGTGGATGCTGTCAGCCAGAACGCTGCCTTCCTGGAGCAAACTCTT TCCAGCACCATCAAACAGGATGACTTTACCGCTCGTCTCTTTGACATCCACAAGCAAGTCCTAAAAGAGGGCATTGCCCAGACTGTGTTC CTGGGCCTGAATCGCTCAGACTACATGTTCCAGCGCAGCGCAGATGGCTCCCCAGCCCTGAAACAGATCGAAATCAACACCATCTCTGCC AGCTTTGGGGGCCTGGCCTCCCGGACCCCAGCTGTGCACCGACATGTTCTCAGTGTCCTGAGTAAGACCAAAGAAGCTGGCAAGATCCTC TCTAATAATCCCAGCAAGGGACTGGCCCTGGGAATTGCCAAAGCCTGGGAGCTCTACGGCTCACCCAAGTCTTGGATGTGCTGGATCTGT GTGTGGTTGTTCTTCAGTCCCACAAAAACCAGCTGCTTCCCTTGGCTCATCAGGCCTGGCCCTCGCTCGTTCACCGACTCACACGGGACG CCCCCCTGGCAGTGCTTAGAGCCTTCAAGGTTTTACGTACCCTGGGAAGCAAGTGTGGTGACTTTCTTCGCAGCCGGTTCTGCAAAGATG TCCTGCCAAAGCTGGCTGGCTCCCTAGTCACCCAGGCCCCCATCAGTGCCAGGGCTGGACCAGTTTACTCGCACACGCTGGCCTTCAAGT TGCAGCTGGCTGTCTTACAGGGCCTGGGCCCCCTCTGTGAGAGACTGGACCTAGGTGAGGGTGACCTGAATAAAGTGGCTGATGCCTGCT TGATTTACCTCAGTGTCAAACAGCCCGTGAAATTACAAGAGGCTGCCAGGAGCGTCTTCCTCCACTTGATGAAGGTGGACCCAGACTCCA CCTGGTTCCTCCTGAACGAGCTTTACTGCCCCGTGCAGTTCACACCTCCCCACCCCAGCCTCCACCCTGTGCAGCTGCACGGGGCCAGCG >In-frame_GSS_ENST00000216951_chr20_33529516_-_TTI1_ENST00000449821_chr20_36627730_-_1226nt ATGGCCACCAACTGGGGGAGCCTCTTGCAGGATAAACAGCAGCTAGAGGAGCTGGCACGGCAGGCCGTGGACCGGGCCCTGGCTGAGGGA GTATTGCTGAGGACCTCACAGGAGCCCACTTCCTCGGAGGTGGTGAGCTATGCCCCATTCACGCTCTTCCCCTCACTGGTCCCCAGTGCC CTGCTGGAGCAAGCCTATGCTGTGCAGATGGACTTCAACCTGCTAGTGGATGCTGTCAGCCAGAACGCTGCCTTCCTGGAGCAAACTCTT TCCAGCACCATCAAACAGGATGACTTTACCGCTCGTCTCTTTGACATCCACAAGCAAGTCCTAAAAGAGGGCATTGCCCAGACTGTGTTC CTGGGCCTGAATCGCTCAGACTACATGTTCCAGCGCAGCGCAGATGGCTCCCCAGCCCTGAAACAGATCGAAATCAACACCATCTCTGCC AGCTTTGGGGGCCTGGCCTCCCGGACCCCAGCTGTGCACCGACATGTTCTCAGTGTCCTGAGTAAGACCAAAGAAGCTGGCAAGATCCTC TCTAATAATCCCAGCAAGGGACTGGCCCTGGGAATTGCCAAAGCCTGGGAGCTCTACGGCTCACCCAAGTCTTGGATGTGCTGGATCTGT GTGTGGTTGTTCTTCAGTCCCACAAAAACCAGCTGCTTCCCTTGGCTCATCAGGCCTGGCCCTCGCTCGTTCACCGACTCACACGGGACG CCCCCCTGGCAGTGCTTAGAGCCTTCAAGGTTTTACGTACCCTGGGAAGCAAGTGTGGTGACTTTCTTCGCAGCCGGTTCTGCAAAGATG TCCTGCCAAAGCTGGCTGGCTCCCTAGTCACCCAGGCCCCCATCAGTGCCAGGGCTGGACCAGTTTACTCGCACACGCTGGCCTTCAAGT TGCAGCTGGCTGTCTTACAGGGCCTGGGCCCCCTCTGTGAGAGACTGGACCTAGGTGAGGGTGACCTGAATAAAGTGGCTGATGCCTGCT TGATTTACCTCAGTGTCAAACAGCCCGTGAAATTACAAGAGGCTGCCAGGAGCGTCTTCCTCCACTTGATGAAGGTGGACCCAGACTCCA CCTGGTTCCTCCTGAACGAGCTTTACTGCCCCGTGCAGTTCACACCTCCCCACCCCAGCCTCCACCCTGTGCAGCTGCACGGGGCCAGCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GSS_ENST00000216951_chr20_33529516_-_TTI1_ENST00000373448_chr20_36627730_-_1774nt AAGCGCACTGGGTCGCATCGAGGCCCCGCCCCCTGAGCCTGGGTAGCGGCGCGAGGGCCGGGAGAACCGTTCGCGGAGGAAAGGCGAACT AGTGTTGGGATGGCCACCAACTGGGGGAGCCTCTTGCAGGATAAACAGCAGCTAGAGGAGCTGGCACGGCAGGCCGTGGACCGGGCCCTG GCTGAGGGAGTATTGCTGAGGACCTCACAGGAGCCCACTTCCTCGGAGGTGGTGAGCTATGCCCCATTCACGCTCTTCCCCTCACTGGTC CCCAGTGCCCTGCTGGAGCAAGCCTATGCTGTGCAGATGGACTTCAACCTGCTAGTGGATGCTGTCAGCCAGAACGCTGCCTTCCTGGAG CAAACTCTTTCCAGCACCATCAAACAGGATGACTTTACCGCTCGTCTCTTTGACATCCACAAGCAAGTCCTAAAAGAGGGCATTGCCCAG ACTGTGTTCCTGGGCCTGAATCGCTCAGACTACATGTTCCAGCGCAGCGCAGATGGCTCCCCAGCCCTGAAACAGATCGAAATCAACACC ATCTCTGCCAGCTTTGGGGGCCTGGCCTCCCGGACCCCAGCTGTGCACCGACATGTTCTCAGTGTCCTGAGTAAGACCAAAGAAGCTGGC AAGATCCTCTCTAATAATCCCAGCAAGGGACTGGCCCTGGGAATTGCCAAAGCCTGGGAGCTCTACGGCTCACCCAAGTCTTGGATGTGC TGGATCTGTGTGTGGTTGTTCTTCAGTCCCACAAAAACCAGCTGCTTCCCTTGGCTCATCAGGCCTGGCCCTCGCTCGTTCACCGACTCA CACGGGACGCCCCCCTGGCAGTGCTTAGAGCCTTCAAGGTTTTACGTACCCTGGGAAGCAAGTGTGGTGACTTTCTTCGCAGCCGGTTCT GCAAAGATGTCCTGCCAAAGCTGGCTGGCTCCCTAGTCACCCAGGCCCCCATCAGTGCCAGGGCTGGACCAGTTTACTCGCACACGCTGG CCTTCAAGTTGCAGCTGGCTGTCTTACAGGGCCTGGGCCCCCTCTGTGAGAGACTGGACCTAGGTGAGGGTGACCTGAATAAAGTGGCTG ATGCCTGCTTGATTTACCTCAGTGTCAAACAGCCCGTGAAATTACAAGAGGCTGCCAGGAGCGTCTTCCTCCACTTGATGAAGGTGGACC CAGACTCCACCTGGTTCCTCCTGAACGAGCTTTACTGCCCCGTGCAGTTCACACCTCCCCACCCCAGCCTCCACCCTGTGCAGCTGCACG GGGCCAGCGGGCAGCAGAACCCCTACACGACCAACGTGCTCCAGCTGCTCAAGGAGCTGCAGTGACCCTGCTCCCCCACCACAGAGGCCA CCGATCCCTCCCCTACTGCCAGCCAGAAGCTGGGCTGACCCCACCCCGGCCATAGGCGGTGGCAGCGGCAGCAGAGAAGGTGAATTAGTT AGCCAATCGATTTATAAATTGATCGATCACACAACTGCTTAGAAATGGATTGAAGGAAAGTAGCTGACTATTATTTATGTTTCATACCTT GTGTTGTCAAGTGACATTGTCTGGTGGCTCTAAGGGTTTAACCCCTTAGCCTACCATCTCTATAGCCCCAGCTCCCTCACAGGCCACACA CACACACACACAAGAGGTCAGTTCCCCTCCATCTGCATACACCTCCCTGTCTTCAAATAATGAGATGGAACTAATTTGTTTTACCTAACC >In-frame_GSS_ENST00000216951_chr20_33529516_-_TTI1_ENST00000373447_chr20_36627730_-_1774nt AAGCGCACTGGGTCGCATCGAGGCCCCGCCCCCTGAGCCTGGGTAGCGGCGCGAGGGCCGGGAGAACCGTTCGCGGAGGAAAGGCGAACT AGTGTTGGGATGGCCACCAACTGGGGGAGCCTCTTGCAGGATAAACAGCAGCTAGAGGAGCTGGCACGGCAGGCCGTGGACCGGGCCCTG GCTGAGGGAGTATTGCTGAGGACCTCACAGGAGCCCACTTCCTCGGAGGTGGTGAGCTATGCCCCATTCACGCTCTTCCCCTCACTGGTC CCCAGTGCCCTGCTGGAGCAAGCCTATGCTGTGCAGATGGACTTCAACCTGCTAGTGGATGCTGTCAGCCAGAACGCTGCCTTCCTGGAG CAAACTCTTTCCAGCACCATCAAACAGGATGACTTTACCGCTCGTCTCTTTGACATCCACAAGCAAGTCCTAAAAGAGGGCATTGCCCAG ACTGTGTTCCTGGGCCTGAATCGCTCAGACTACATGTTCCAGCGCAGCGCAGATGGCTCCCCAGCCCTGAAACAGATCGAAATCAACACC ATCTCTGCCAGCTTTGGGGGCCTGGCCTCCCGGACCCCAGCTGTGCACCGACATGTTCTCAGTGTCCTGAGTAAGACCAAAGAAGCTGGC AAGATCCTCTCTAATAATCCCAGCAAGGGACTGGCCCTGGGAATTGCCAAAGCCTGGGAGCTCTACGGCTCACCCAAGTCTTGGATGTGC TGGATCTGTGTGTGGTTGTTCTTCAGTCCCACAAAAACCAGCTGCTTCCCTTGGCTCATCAGGCCTGGCCCTCGCTCGTTCACCGACTCA CACGGGACGCCCCCCTGGCAGTGCTTAGAGCCTTCAAGGTTTTACGTACCCTGGGAAGCAAGTGTGGTGACTTTCTTCGCAGCCGGTTCT GCAAAGATGTCCTGCCAAAGCTGGCTGGCTCCCTAGTCACCCAGGCCCCCATCAGTGCCAGGGCTGGACCAGTTTACTCGCACACGCTGG CCTTCAAGTTGCAGCTGGCTGTCTTACAGGGCCTGGGCCCCCTCTGTGAGAGACTGGACCTAGGTGAGGGTGACCTGAATAAAGTGGCTG ATGCCTGCTTGATTTACCTCAGTGTCAAACAGCCCGTGAAATTACAAGAGGCTGCCAGGAGCGTCTTCCTCCACTTGATGAAGGTGGACC CAGACTCCACCTGGTTCCTCCTGAACGAGCTTTACTGCCCCGTGCAGTTCACACCTCCCCACCCCAGCCTCCACCCTGTGCAGCTGCACG GGGCCAGCGGGCAGCAGAACCCCTACACGACCAACGTGCTCCAGCTGCTCAAGGAGCTGCAGTGACCCTGCTCCCCCACCACAGAGGCCA CCGATCCCTCCCCTACTGCCAGCCAGAAGCTGGGCTGACCCCACCCCGGCCATAGGCGGTGGCAGCGGCAGCAGAGAAGGTGAATTAGTT AGCCAATCGATTTATAAATTGATCGATCACACAACTGCTTAGAAATGGATTGAAGGAAAGTAGCTGACTATTATTTATGTTTCATACCTT GTGTTGTCAAGTGACATTGTCTGGTGGCTCTAAGGGTTTAACCCCTTAGCCTACCATCTCTATAGCCCCAGCTCCCTCACAGGCCACACA CACACACACACAAGAGGTCAGTTCCCCTCCATCTGCATACACCTCCCTGTCTTCAAATAATGAGATGGAACTAATTTGTTTTACCTAACC >In-frame_GSS_ENST00000216951_chr20_33529516_-_TTI1_ENST00000449821_chr20_36627730_-_1759nt AAGCGCACTGGGTCGCATCGAGGCCCCGCCCCCTGAGCCTGGGTAGCGGCGCGAGGGCCGGGAGAACCGTTCGCGGAGGAAAGGCGAACT AGTGTTGGGATGGCCACCAACTGGGGGAGCCTCTTGCAGGATAAACAGCAGCTAGAGGAGCTGGCACGGCAGGCCGTGGACCGGGCCCTG GCTGAGGGAGTATTGCTGAGGACCTCACAGGAGCCCACTTCCTCGGAGGTGGTGAGCTATGCCCCATTCACGCTCTTCCCCTCACTGGTC CCCAGTGCCCTGCTGGAGCAAGCCTATGCTGTGCAGATGGACTTCAACCTGCTAGTGGATGCTGTCAGCCAGAACGCTGCCTTCCTGGAG CAAACTCTTTCCAGCACCATCAAACAGGATGACTTTACCGCTCGTCTCTTTGACATCCACAAGCAAGTCCTAAAAGAGGGCATTGCCCAG ACTGTGTTCCTGGGCCTGAATCGCTCAGACTACATGTTCCAGCGCAGCGCAGATGGCTCCCCAGCCCTGAAACAGATCGAAATCAACACC ATCTCTGCCAGCTTTGGGGGCCTGGCCTCCCGGACCCCAGCTGTGCACCGACATGTTCTCAGTGTCCTGAGTAAGACCAAAGAAGCTGGC AAGATCCTCTCTAATAATCCCAGCAAGGGACTGGCCCTGGGAATTGCCAAAGCCTGGGAGCTCTACGGCTCACCCAAGTCTTGGATGTGC TGGATCTGTGTGTGGTTGTTCTTCAGTCCCACAAAAACCAGCTGCTTCCCTTGGCTCATCAGGCCTGGCCCTCGCTCGTTCACCGACTCA CACGGGACGCCCCCCTGGCAGTGCTTAGAGCCTTCAAGGTTTTACGTACCCTGGGAAGCAAGTGTGGTGACTTTCTTCGCAGCCGGTTCT GCAAAGATGTCCTGCCAAAGCTGGCTGGCTCCCTAGTCACCCAGGCCCCCATCAGTGCCAGGGCTGGACCAGTTTACTCGCACACGCTGG CCTTCAAGTTGCAGCTGGCTGTCTTACAGGGCCTGGGCCCCCTCTGTGAGAGACTGGACCTAGGTGAGGGTGACCTGAATAAAGTGGCTG ATGCCTGCTTGATTTACCTCAGTGTCAAACAGCCCGTGAAATTACAAGAGGCTGCCAGGAGCGTCTTCCTCCACTTGATGAAGGTGGACC CAGACTCCACCTGGTTCCTCCTGAACGAGCTTTACTGCCCCGTGCAGTTCACACCTCCCCACCCCAGCCTCCACCCTGTGCAGCTGCACG GGGCCAGCGGGCAGCAGAACCCCTACACGACCAACGTGCTCCAGCTGCTCAAGGAGCTGCAGTGACCCTGCTCCCCCACCACAGAGGCCA CCGATCCCTCCCCTACTGCCAGCCAGAAGCTGGGCTGACCCCACCCCGGCCATAGGCGGTGGCAGCGGCAGCAGAGAAGGTGAATTAGTT AGCCAATCGATTTATAAATTGATCGATCACACAACTGCTTAGAAATGGATTGAAGGAAAGTAGCTGACTATTATTTATGTTTCATACCTT GTGTTGTCAAGTGACATTGTCTGGTGGCTCTAAGGGTTTAACCCCTTAGCCTACCATCTCTATAGCCCCAGCTCCCTCACAGGCCACACA CACACACACACAAGAGGTCAGTTCCCCTCCATCTGCATACACCTCCCTGTCTTCAAATAATGAGATGGAACTAATTTGTTTTACCTAACC |
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FusionGenePPI for GSS_TTI1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GSS | TERF1, CDK9, GSS, ABHD14A, ASS1, ECHS1, GINS3, ASNS, DCPS, HMGB3, MSN, PPP5C, RRAGB, VCL, MVK, OLA1, PAFAH1B2, PDIA4, RAP1GDS1, TBCB, USP14, YWHAB, YWHAE, YWHAG, YWHAH, GBE1, ZFAND6 | TTI1 | RUVBL2, RUVBL1, MTOR, TELO2, ATM, ATR, PRKDC, SMG1, TRRAP, TTI2, HSPA4, PIH1D1, POLR2E, RPAP3, URI1, TUBA1A, RBM8A, EGFR, FBXO6, PSME4, COPB2, COPG1, COPZ1, NUP50, RUFY1, TSC22D1, TMEM51, CD274, VSIG2, CD68, LPAR6, ARL13B, SCN2B, HTR6, API5, NTRK1, NCSTN, POU5F1, PTPRF, VSIG1, SIGLECL1, CD70, CHRM3, STOM, ZNHIT2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GSS_TTI1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | GSS | P48637 | DB06151 | Acetylcysteine | Glutathione synthetase | small molecule | approved|investigational |
| Hgene | GSS | P48637 | DB00143 | Glutathione | Glutathione synthetase | small molecule | approved|investigational|nutraceutical |
| Hgene | GSS | P48637 | DB00145 | Glycine | Glutathione synthetase | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for GSS_TTI1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GSS | C0011616 | Contact Dermatitis | 1 | CTD_human |
| Hgene | GSS | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | GSS | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | GSS | C0026636 | Mouth Diseases | 1 | CTD_human |
| Hgene | GSS | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | GSS | C0398746 | Gluthathione synthetase deficiency | 1 | CTD_human;HPO;ORPHANET;UNIPROT |
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