FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 15571

FusionGeneSummary for GSPT1_HPGD

check button Fusion gene summary
Fusion gene informationFusion gene name: GSPT1_HPGD
Fusion gene ID: 15571
HgeneTgene
Gene symbol

GSPT1

HPGD

Gene ID

2935

3248

Gene nameG1 to S phase transition 115-hydroxyprostaglandin dehydrogenase
Synonyms551G9.2|ETF3A|GST1|eRF3a15-PGDH|PGDH|PGDH1|PHOAR1|SDR36C1
Cytomap

16p13.13

4q34.1

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic peptide chain release factor GTP-binding subunit ERF3AG1 to S phase transition protein 1 homologeukaryotic peptide chain release factor subunit 3aeukaryotic release factor 3a15-hydroxyprostaglandin dehydrogenase [NAD(+)]15-hydroxyprostaglandin dehydrogenase (NAD(+))NAD+-dependent 15-hydroxyprostaglandin dehydrogenasehydroxyprostaglandin dehydrogenase 15-(NAD)prostaglandin dehydrogenase 1short chain dehydrogenase/reductas
Modification date2018052320180524
UniProtAcc

P15170

P15428

Ensembl transtripts involved in fusion geneENST00000434724, ENST00000439887, 
ENST00000563468, ENST00000420576, 
ENST00000564790, 
ENST00000296522, 
ENST00000296521, ENST00000510901, 
ENST00000422112, ENST00000541923, 
ENST00000542498, ENST00000504433, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 3 X 2=18
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GSPT1 [Title/Abstract] AND HPGD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGSPT1

GO:0006479

protein methylation

18539146

TgeneHPGD

GO:0006693

prostaglandin metabolic process

16828555

TgeneHPGD

GO:0007179

transforming growth factor beta receptor signaling pathway

15574495

TgeneHPGD

GO:0007565

female pregnancy

15531523

TgeneHPGD

GO:0007567

parturition

15531523

TgeneHPGD

GO:0045786

negative regulation of cell cycle

15574495


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF736330GSPT1chr16

11991740

+HPGDchr4

175443155

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000434724ENST00000296522GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-3CDSENST00000434724ENST00000296521GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000434724ENST00000510901GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000434724ENST00000422112GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000434724ENST00000541923GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000434724ENST00000542498GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000434724ENST00000504433GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-3CDSENST00000439887ENST00000296522GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-3CDSENST00000439887ENST00000296521GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000439887ENST00000510901GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000439887ENST00000422112GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000439887ENST00000541923GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000439887ENST00000542498GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000439887ENST00000504433GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-3CDSENST00000563468ENST00000296522GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-3CDSENST00000563468ENST00000296521GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000563468ENST00000510901GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000563468ENST00000422112GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000563468ENST00000541923GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000563468ENST00000542498GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000563468ENST00000504433GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-3CDSENST00000420576ENST00000296522GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-3CDSENST00000420576ENST00000296521GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000420576ENST00000510901GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000420576ENST00000422112GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000420576ENST00000541923GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000420576ENST00000542498GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000420576ENST00000504433GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-3CDSENST00000564790ENST00000296522GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-3CDSENST00000564790ENST00000296521GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000564790ENST00000510901GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000564790ENST00000422112GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000564790ENST00000541923GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000564790ENST00000542498GSPT1chr16

11991740

+HPGDchr4

175443155

-
intron-5UTRENST00000564790ENST00000504433GSPT1chr16

11991740

+HPGDchr4

175443155

-

Top

FusionProtFeatures for GSPT1_HPGD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSPT1

P15170

HPGD

P15428

Involved in translation termination in response to thetermination codons UAA, UAG and UGA. Stimulates the activity ofERF1. Involved in regulation of mammalian cell growth. Componentof the transient SURF complex which recruits UPF1 to stalledribosomes in the context of nonsense-mediated decay (NMD) of mRNAscontaining premature stop codons.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GSPT1_HPGD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GSPT1_HPGD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GSPT1_HPGD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for GSPT1_HPGD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHPGDC0029411Osteoarthropathy, Primary Hypertrophic2CTD_human;ORPHANET;UNIPROT
TgeneHPGDC0033578Prostatic Neoplasms1CTD_human
TgeneHPGDC0040136Thyroid Neoplasm1CTD_human
TgeneHPGDC0206693Medullary carcinoma1CTD_human
TgeneHPGDC0345408Hereditary clubbing1ORPHANET;UNIPROT