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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15567

FusionGeneSummary for GSN_TRA2A

check button Fusion gene summary
Fusion gene informationFusion gene name: GSN_TRA2A
Fusion gene ID: 15567
HgeneTgene
Gene symbol

GSN

TRA2A

Gene ID

2934

29896

Gene namegelsolintransformer 2 alpha homolog
SynonymsADF|AGELAWMS1|HSU53209
Cytomap

9q33.2

7p15.3

Type of geneprotein-codingprotein-coding
Descriptiongelsolinactin-depolymerizing factorbrevintransformer-2 protein homolog alphaTRA-2 alphaTRA2-alphaTra2alphahtra-2 alphaputative MAPK activating protein PM24transformer-2 alphatransformer-2 protein homolog A
Modification date2018052220180523
UniProtAcc

P06396

Q13595

Ensembl transtripts involved in fusion geneENST00000373823, ENST00000373808, 
ENST00000436847, ENST00000449733, 
ENST00000412819, ENST00000394353, 
ENST00000341272, ENST00000545652, 
ENST00000373818, ENST00000485767, 
ENST00000373807, ENST00000373806, 
ENST00000297071, ENST00000392502, 
ENST00000538367, ENST00000474586, 
Fusion gene scores* DoF score15 X 11 X 7=11555 X 6 X 5=150
# samples 197
** MAII scorelog2(19/1155*10)=-2.60382152797247
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GSN [Title/Abstract] AND TRA2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGSN

GO:0030041

actin filament polymerization

3020431

HgeneGSN

GO:0051014

actin filament severing

3020431

TgeneTRA2A

GO:0000398

mRNA splicing, via spliceosome

9546399


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-7794-01AGSNchr9

124095016

+TRA2Achr7

23571595

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000373823ENST00000297071GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000373823ENST00000392502GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000373823ENST00000538367GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-intronENST00000373823ENST00000474586GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000373808ENST00000297071GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000373808ENST00000392502GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000373808ENST00000538367GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-intronENST00000373808ENST00000474586GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000436847ENST00000297071GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000436847ENST00000392502GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000436847ENST00000538367GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-intronENST00000436847ENST00000474586GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000449733ENST00000297071GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000449733ENST00000392502GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000449733ENST00000538367GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-intronENST00000449733ENST00000474586GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000412819ENST00000297071GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000412819ENST00000392502GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000412819ENST00000538367GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-intronENST00000412819ENST00000474586GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000394353ENST00000297071GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000394353ENST00000392502GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000394353ENST00000538367GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-intronENST00000394353ENST00000474586GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000341272ENST00000297071GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000341272ENST00000392502GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000341272ENST00000538367GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-intronENST00000341272ENST00000474586GSNchr9

124095016

+TRA2Achr7

23571595

-
intron-5UTRENST00000545652ENST00000297071GSNchr9

124095016

+TRA2Achr7

23571595

-
intron-5UTRENST00000545652ENST00000392502GSNchr9

124095016

+TRA2Achr7

23571595

-
intron-5UTRENST00000545652ENST00000538367GSNchr9

124095016

+TRA2Achr7

23571595

-
intron-intronENST00000545652ENST00000474586GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000373818ENST00000297071GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000373818ENST00000392502GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-5UTRENST00000373818ENST00000538367GSNchr9

124095016

+TRA2Achr7

23571595

-
3UTR-intronENST00000373818ENST00000474586GSNchr9

124095016

+TRA2Achr7

23571595

-
intron-5UTRENST00000485767ENST00000297071GSNchr9

124095016

+TRA2Achr7

23571595

-
intron-5UTRENST00000485767ENST00000392502GSNchr9

124095016

+TRA2Achr7

23571595

-
intron-5UTRENST00000485767ENST00000538367GSNchr9

124095016

+TRA2Achr7

23571595

-
intron-intronENST00000485767ENST00000474586GSNchr9

124095016

+TRA2Achr7

23571595

-
intron-5UTRENST00000373807ENST00000297071GSNchr9

124095016

+TRA2Achr7

23571595

-
intron-5UTRENST00000373807ENST00000392502GSNchr9

124095016

+TRA2Achr7

23571595

-
intron-5UTRENST00000373807ENST00000538367GSNchr9

124095016

+TRA2Achr7

23571595

-
intron-intronENST00000373807ENST00000474586GSNchr9

124095016

+TRA2Achr7

23571595

-
intron-5UTRENST00000373806ENST00000297071GSNchr9

124095016

+TRA2Achr7

23571595

-
intron-5UTRENST00000373806ENST00000392502GSNchr9

124095016

+TRA2Achr7

23571595

-
intron-5UTRENST00000373806ENST00000538367GSNchr9

124095016

+TRA2Achr7

23571595

-
intron-intronENST00000373806ENST00000474586GSNchr9

124095016

+TRA2Achr7

23571595

-

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FusionProtFeatures for GSN_TRA2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSN

P06396

TRA2A

Q13595

Sequence-specific RNA-binding protein which participatesin the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GSN_TRA2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GSN_TRA2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GSNCASP4, PPM1B, AR, STK39, PTK2B, TOM1L1, ACTA1, VDAC1, FN1, PIK3CA, PTK2, VCL, PXN, SRC, PTPN12, APP, PLCG1, ACTN4, PSMD4, ESR1, ARRB1, ARRB2, UBE2Q2, FBXO25, MDM2, SDHB, ALB, MPG, CASP3, WASL, CFLAR, ITCH, TP53, CUL7, OBSL1, GAS2L1, LRRC39, TMOD1, PPP1R18, DDX19B, TMOD2, ACTR1B, RBM18, MAP1S, HNRNPA1, CAPZA2, CDK2, DBN1, FLNA, MYH9, IQGAP1, THOC1, ACTR2, SYNPO, LIMA1, MYO19, MYO18A, BCL7C, BCL7A, LSP1, TMOD3, NEXN, SSH1, ACTBL2, FBXO40, PLEKHG6, FBXO34, MYO6, DNALI1, PFN2, EIF3K, SESTD1, COX15, DLST, CCND2TRA2ATADA2A, YWHAG, NUDT21, SELENBP1, CRABP1, TNNT1, CDK2AP2, C11orf58, ELAVL1, CUL3, CUL5, COPS5, SRSF10, RBM25, SRSF5, CDC5L, SEPT2, NFIA, NHP2L1, NCSTN, SF3A1, BUD31, SF3B3, PHGDH, S100A9, HNRNPC, HNRNPU, PRPF40A, SF3B6, HNRNPM, SAP18, PRPF6, IK, HP1BP3, SEPT7, SMARCB1, PLEC, BARD1, PAXIP1, MAGOH, EIF4A3, PPP1CC, DHX15, U2SURP, CDK6, LBP, NXF1, YTHDC1, CLK3, SRPK2, OBSL1, EZH2, SUZ12, EED, RNF2, BMI1, ZNF22, LARP7, SRRM1, MRPS9, MRPS26, THRAP3, LUC7L2, LUC7L, ZNF768, PTCD1, PTCD3, SRRM2, C17orf85, ZFR, PABPC4L, PABPC4, RBBP6, ELAVL2, RPL6, MRPS23, MRPS27, TRUB2, MRPS6, RPL26L1, MTERF3, PAIP1, MRPS18B, MRPL32, C10orf2, MRPS10, DAP3, MEPCE, UPF1, PPIG, LARP1, LARP1B, PHAX, MRPS31, MKRN1, MRPS18C, MRPS5, MRPS7, MRPS22, MRPS15, MRPS35, MRPS25, RRP9, NGRN, MRPS2, MOV10, MRPS33, SRRT, PRPF3, MRPS11, PNN, SRP14, GAR1, MRPS24, CASC3, WDR33, CSNK1E, CSNK1D, MRPS14, GAPDHS, ZCCHC3, MKRN2, ZC3H11A, NOA1, TRA2B, ISY1, SRSF8, CLK1, SRSF7, APOBEC3F, HIST1H2AG, SRSF12, CLK2, MRPL34, MRPS21, SNIP1, NTRK1, SRSF3, SRSF6, EWSR1, CNTRL, CDK2, FEN1, U2AF2, SNRNP70, ZC3H18, C11orf57, SNRPN, NCOA5, PABPC1, SYF2, APOBEC3D, NR3C1, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GSN_TRA2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGSNP06396DB01593ZincGelsolinsmall moleculeapproved|investigational

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RelatedDiseases for GSN_TRA2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGSNC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneGSNC0025500Mesothelioma1CTD_human
HgeneGSNC0029456Osteoporosis1CTD_human
HgeneGSNC0030524Paratuberculosis1CTD_human
HgeneGSNC0036341Schizophrenia1PSYGENET
HgeneGSNC0043094Weight Gain1CTD_human
HgeneGSNC0948089Acute Coronary Syndrome1CTD_human
HgeneGSNC1622345Meretoja syndrome1CTD_human;ORPHANET;UNIPROT
HgeneGSNC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneTRA2AC0037274Dermatologic disorders1CTD_human
TgeneTRA2AC0311375Arsenic Poisoning1CTD_human