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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15531

FusionGeneSummary for GSK3B_ATP11B

check button Fusion gene summary
Fusion gene informationFusion gene name: GSK3B_ATP11B
Fusion gene ID: 15531
HgeneTgene
Gene symbol

GSK3B

ATP11B

Gene ID

2932

23200

Gene nameglycogen synthase kinase 3 betaATPase phospholipid transporting 11B (putative)
Synonyms-ATPIF|ATPIR
Cytomap

3q13.33

3q26.33

Type of geneprotein-codingprotein-coding
Descriptionglycogen synthase kinase-3 betaGSK-3 betaGSK3beta isoformserine/threonine-protein kinase GSK3Bprobable phospholipid-transporting ATPase IFATPase IRATPase, class VI, type 11BP4-ATPase flippase complex alpha subunit ATP11Btruncated ATPase 11B protein
Modification date2018052720180523
UniProtAcc

P49841

Q9Y2G3

Ensembl transtripts involved in fusion geneENST00000264235, ENST00000316626, 
ENST00000473886, 
ENST00000323116, 
ENST00000493826, ENST00000482794, 
Fusion gene scores* DoF score24 X 16 X 8=30727 X 5 X 4=140
# samples 267
** MAII scorelog2(26/3072*10)=-3.5625946876927
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GSK3B [Title/Abstract] AND ATP11B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGSK3B

GO:0005977

glycogen metabolic process

8638126

HgeneGSK3B

GO:0006468

protein phosphorylation

11035810|16315267|20937854

HgeneGSK3B

GO:0006983

ER overload response

14744935

HgeneGSK3B

GO:0018105

peptidyl-serine phosphorylation

8638126|11104755|11955436|14744935|17139249

HgeneGSK3B

GO:0018107

peptidyl-threonine phosphorylation

11955436|17139249|25897075

HgeneGSK3B

GO:0031175

neuron projection development

19830702

HgeneGSK3B

GO:0031334

positive regulation of protein complex assembly

8638126

HgeneGSK3B

GO:0032091

negative regulation of protein binding

16890161

HgeneGSK3B

GO:0035556

intracellular signal transduction

14749367

HgeneGSK3B

GO:0043066

negative regulation of apoptotic process

14744935

HgeneGSK3B

GO:0046777

protein autophosphorylation

23184662

HgeneGSK3B

GO:0046827

positive regulation of protein export from nucleus

14744935

HgeneGSK3B

GO:0060070

canonical Wnt signaling pathway

18787224

HgeneGSK3B

GO:1901215

negative regulation of neuron death

19830702

HgeneGSK3B

GO:1901216

positive regulation of neuron death

18508033


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-G9-6333-01AGSK3Bchr3

119720893

-ATP11Bchr3

182631649

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000264235ENST00000323116GSK3Bchr3

119720893

-ATP11Bchr3

182631649

+
5CDS-intronENST00000264235ENST00000493826GSK3Bchr3

119720893

-ATP11Bchr3

182631649

+
5CDS-intronENST00000264235ENST00000482794GSK3Bchr3

119720893

-ATP11Bchr3

182631649

+
In-frameENST00000316626ENST00000323116GSK3Bchr3

119720893

-ATP11Bchr3

182631649

+
5CDS-intronENST00000316626ENST00000493826GSK3Bchr3

119720893

-ATP11Bchr3

182631649

+
5CDS-intronENST00000316626ENST00000482794GSK3Bchr3

119720893

-ATP11Bchr3

182631649

+
intron-3CDSENST00000473886ENST00000323116GSK3Bchr3

119720893

-ATP11Bchr3

182631649

+
intron-intronENST00000473886ENST00000493826GSK3Bchr3

119720893

-ATP11Bchr3

182631649

+
intron-intronENST00000473886ENST00000482794GSK3Bchr3

119720893

-ATP11Bchr3

182631649

+

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FusionProtFeatures for GSK3B_ATP11B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSK3B

P49841

ATP11B

Q9Y2G3

Constitutively active protein kinase that acts as anegative regulator in the hormonal control of glucose homeostasis,Wnt signaling and regulation of transcription factors andmicrotubules, by phosphorylating and inactivating glycogensynthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1,DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requiresprimed phosphorylation of the majority of its substrates. Inskeletal muscle, contributes to insulin regulation of glycogensynthesis by phosphorylating and inhibiting GYS1 activity andhence glycogen synthesis. May also mediate the development ofinsulin resistance by regulating activation of transcriptionfactors. Regulates protein synthesis by controlling the activityof initiation factor 2B (EIF2BE/EIF2B5) in the same manner asglycogen synthase. In Wnt signaling, GSK3B forms a multimericcomplex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylatesthe N-terminus of CTNNB1 leading to its degradation mediated byubiquitin/proteasomes. Phosphorylates JUN at sites proximal to itsDNA-binding domain, thereby reducing its affinity for DNA.Phosphorylates NFATC1/NFATC on conserved serine residues promotingNFATC1/NFATC nuclear export, shutting off NFATC1/NFATC generegulation, and thereby opposing the action of calcineurin.Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantlyMAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU isthe principal component of neurofibrillary tangles in Alzheimerdisease. Plays an important role in ERBB2-dependent stabilizationof microtubules at the cell cortex. Phosphorylates MACF1,inhibiting its binding to microtubules which is critical for itsrole in bulge stem cell migration and skin wound repair. Probablyregulates NF-kappa-B (NFKB1) at the transcriptional level and isrequired for the NF-kappa-B-mediated anti-apoptotic response toTNF-alpha (TNF/TNFA). Negatively regulates replication inpancreatic beta-cells, resulting in apoptosis, loss of beta-cellsand diabetes. Through phosphorylation of the anti-apoptoticprotein MCL1, may control cell apoptosis in response to growthfactors deprivation. Phosphorylates MUC1 in breast cancer cells,decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Isnecessary for the establishment of neuronal polarity and axonoutgrowth. Phosphorylates MARK2, leading to inhibit its activity.Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity.Phosphorylates ZC3HAV1 which enhances its antiviral activity.Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitinationand proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' uponT-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59'and stabilizes it by protecting it from proteasomal degradation.Regulates the circadian clock via phosphorylation of the majorclock components including ARNTL/BMAL1, CLOCK and PER2.Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomaldegradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21'and primes it for ubiquitination and proteasomal degradation.Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positivelyregulates its activity. Phosphorylates MYCN in neuroblastoma cellswhich may promote its degradation (PubMed:24391509).{ECO:0000269|PubMed:11430833, ECO:0000269|PubMed:12554650,ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15448698,ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16484495,ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:1846781,ECO:0000269|PubMed:19946213, ECO:0000269|PubMed:20932480,ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:22514281,ECO:0000269|PubMed:24391509, ECO:0000269|PubMed:8397507,ECO:0000269|PubMed:9072970, ECO:0000269|PubMed:9819408}. Catalytic component of a P4-ATPase flippase complexwhich catalyzes the hydrolysis of ATP coupled to the transport ofaminophospholipids from the outer to the inner leaflet of variousmembranes and ensures the maintenance of asymmetric distributionof phospholipids. Phospholipid translocation seems also to beimplicated in vesicle formation and in uptake of lipid signalingmolecules (Probable). Involved in regulation of sensitivity tocisplatin; may contribute to secretory vesicle transport ofcisplatin from Golgi to plasma membrane.{ECO:0000269|PubMed:23585472, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGSK3Bchr3:119720893chr3:182631649ENST00000264235-21162_7094421Nucleotide bindingATP
HgeneGSK3Bchr3:119720893chr3:182631649ENST00000316626-21262_7094434Nucleotide bindingATP
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+061021_1025-86196Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+061048_1065-86196Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+06105_289-86196Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+061091_1177-86196Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+061_55-86196Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+06312_341-86196Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+06360_876-86196Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+0678_82-86196Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+06899_910-86196Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+06931_960-86196Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+06983_997-86196Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+061026_1047-86196TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+061066_1090-86196TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+06290_311-86196TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+06342_359-86196TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+0656_77-86196TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+0683_104-86196TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+06877_898-86196TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+06911_930-86196TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+06961_982-86196TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826+06998_1020-86196TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGSK3Bchr3:119720893chr3:182631649ENST00000264235-21156_34094421DomainProtein kinase
HgeneGSK3Bchr3:119720893chr3:182631649ENST00000316626-21256_34094434DomainProtein kinase
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+27301021_102511061178Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+27301048_106511061178Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+2730105_28911061178Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+27301091_117711061178Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+27301_5511061178Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+2730312_34111061178Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+2730360_87611061178Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+273078_8211061178Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+2730899_91011061178Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+2730931_96011061178Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+2730983_99711061178Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+27301026_104711061178TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+27301066_109011061178TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+2730290_31111061178TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+2730342_35911061178TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+273056_7711061178TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+273083_10411061178TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+2730877_89811061178TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+2730911_93011061178TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+2730961_98211061178TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116+2730998_102011061178TransmembraneHelical


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FusionGeneSequence for GSK3B_ATP11B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GSK3B_ENST00000264235_chr3_119720893_-_ATP11B_ENST00000323116_chr3_182631649_+_166aa
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD

>In-frame_GSK3B_ENST00000316626_chr3_119720893_-_ATP11B_ENST00000323116_chr3_182631649_+_166aa
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GSK3B_ENST00000264235_chr3_119720893_-_ATP11B_ENST00000323116_chr3_182631649_+_498nt
ATGTCAGGGCGGCCCAGAACCACCTCCTTTGCGGAGAGCTGCAAGCCGGTGCAGCAGCCTTCAGCTTTTGGCAGCATGAAAGTTAGCAGA
GACAAGGACGGCAGCAAGGTGACAACAGTGGTGGCAACTCCTGGGCAGGGTCCAGACAGGCCACAAGAAGTCAGCTATACAGACACTAAA
GTGATTGGAAATGGATCATTTGGTGTGGTATATCAAGCCAAACTTTGTGATTCAGGAGAACTGGTCGCCATCAAGAAAGTATTGCAGGAC
AAGAGATTTAAGCTTACTGAAACAAATGCAGGTATCAAGTGCTTGGACTCCATGTGCTGTTTCCCGGAAGGAGAAGCAGCGTGTGCATCT
GTTGGAAGAATGCTGGAACGAGTTATAGGAAGATGTAGTCCAACCCACATCAGCAGATCATGGAGTGCATCGGATCCTTTCTATACCAAC

>In-frame_GSK3B_ENST00000316626_chr3_119720893_-_ATP11B_ENST00000323116_chr3_182631649_+_498nt
ATGTCAGGGCGGCCCAGAACCACCTCCTTTGCGGAGAGCTGCAAGCCGGTGCAGCAGCCTTCAGCTTTTGGCAGCATGAAAGTTAGCAGA
GACAAGGACGGCAGCAAGGTGACAACAGTGGTGGCAACTCCTGGGCAGGGTCCAGACAGGCCACAAGAAGTCAGCTATACAGACACTAAA
GTGATTGGAAATGGATCATTTGGTGTGGTATATCAAGCCAAACTTTGTGATTCAGGAGAACTGGTCGCCATCAAGAAAGTATTGCAGGAC
AAGAGATTTAAGCTTACTGAAACAAATGCAGGTATCAAGTGCTTGGACTCCATGTGCTGTTTCCCGGAAGGAGAAGCAGCGTGTGCATCT
GTTGGAAGAATGCTGGAACGAGTTATAGGAAGATGTAGTCCAACCCACATCAGCAGATCATGGAGTGCATCGGATCCTTTCTATACCAAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_GSK3B_ENST00000264235_chr3_119720893_-_ATP11B_ENST00000323116_chr3_182631649_+_5012nt
CGGGCTTGTGCCGCCGCCGCCGCCGCCGCCGCCCGGGCCAAGTGACAAAGGAAGGAAGGAAGCGAGGAGGAGCCGGCCCCGCAGCCGCTG
ACAGGGCTCTGGGCTGGGGCAAAGCGCGGACACTTCCTGAGCGGGCACCGAGCAGAGCCGAGGGGCGGGAGGGCGGCCGAGCTGTTGCCG
CGGACGGGGGAGGGGGCCCCGAGGGACGGAAGCGGTTGCCGGGTTCCCATGTCCCCGGCGAATGGGGAACAGTCGAGGAGCCGCTGCCTG
GGGTCTGAAGGGAGCTGCCTCCGCCACCGCCATGGCCGCTGGATCCAGCCGCCGCCTGCAGCTGCTCCTGGCGCAATGAGGAGAGGAGCC
GCCGCCACCGCCACCGCCCGCCTCTGACTGACTCGCGACTCCGCCGCCCTCTAGTTCGCCGGGCCCCTGCCGTCAGCCCGCCGGATCCCG
CGGCTTGCCGGAGCTGCAGCGTTTCCCGTCGCATCTCCGAGCCACCCCCTCCCTCCCTCTCCCTCCCTCCTACCCATCCCCCTTTCTCTT
CAAGCGTGAGACTCGTGATCCTTCCGCCGCTTCCCTTCTTCATTGACTCGGAAAAAAAATCCCCGAGGAAAATATAATATTCGAAGTACT
CATTTTCAATCAAGTATTTGCCCCCGTTTCACGTGATACATATTTTTTTAGGATTTGCCCTCTCTTTTCTCTCCTCCCAGGAAAGGGAGG
GGAAAGAATTGTATTTTTTCCCAAGTCCTAAATCATCTATATGTTAAATATCCGTGCCGATCTGTCTTGAAGGAGAAATATATCGCTTGT
TTTGTTTTTTATAGTATACAAAAGGAGTGAAAAGCCAAGAGGACGAAGTCTTTTTCTTTTTCTTCTGTGGGAGAACTTAATGCTGCATTT
ATCGTTAACCTAACACCCCAACATAAAGACAAAAGGAAGAAAAGGAGGAAGGAAGGAAAAGGTGATTCGCGAAGAGAGTGATCATGTCAG
GGCGGCCCAGAACCACCTCCTTTGCGGAGAGCTGCAAGCCGGTGCAGCAGCCTTCAGCTTTTGGCAGCATGAAAGTTAGCAGAGACAAGG
ACGGCAGCAAGGTGACAACAGTGGTGGCAACTCCTGGGCAGGGTCCAGACAGGCCACAAGAAGTCAGCTATACAGACACTAAAGTGATTG
GAAATGGATCATTTGGTGTGGTATATCAAGCCAAACTTTGTGATTCAGGAGAACTGGTCGCCATCAAGAAAGTATTGCAGGACAAGAGAT
TTAAGCTTACTGAAACAAATGCAGGTATCAAGTGCTTGGACTCCATGTGCTGTTTCCCGGAAGGAGAAGCAGCGTGTGCATCTGTTGGAA
GAATGCTGGAACGAGTTATAGGAAGATGTAGTCCAACCCACATCAGCAGATCATGGAGTGCATCGGATCCTTTCTATACCAACGACAGGA
GCATCTTGACTCTCTCCACAATGGACTCATCTACTTGTTAAAGGGGCAGTAGTACTTTGTGGGAGCCAGTTCACCTCCTTTCCTAAAATT
CAGTGTGATCACCCTGTTAATGGCCACACTAGCTCTGAAATTAATTTCCAAAATCTTTGTAGTAGTTCATACCCACTCAGAGTTATAATG
GCAAACAAACAGAAAGCATTAGTACAAGCCCCTCCCAACACCCTTAATTTGAATCTGAACATGTTAAAATTTGAGAATAAAGAGACATTT
TTCATCTCTTTGTCTGGTTTGTCCCTTGTGCTTATGGGACTCCTAATGGCATTTCAGTCTGTTGCTGAGGCCATTATATTTTAATATAAA
TGTAGAAAAAAGAGAGAAATCTTAGTAAAGAGTATTTTTTAGTATTAGCTTGATTATTGACTCTTCTATTTAAATCTGCTTCTGTAAATT
ATGCTGAAAGTTTGCCTTGAGAACTCTATTTTTTTATTAGAGTTATATTTAAAGCTTTTCATGGGAAAAGTTAATGTGAATACTGAGGAA
TTTTGGTCCCTCAGTGACCTGTGTTGTTAATTCATTAATGCATTCTGAGTTCACAGAGCAAATTAGGAGAATCATTTCCAACCATTATTT
ACTGCAGTATGGGGAGTAAATTTATACCAATTCCTCTAACTGTACTGTAACACAGCCTGTAAAGTTAGCCATATAAATGCAAGGGTATAT
CATATATACAAATCAGGAATCAGGTCCGTTCACCGAACTTCAAATTGATGTTTACTAATATTTTTGTGACAGAGTATAAAGACCCTATAG
TGGGTAAATTAGATACTATTAGCATATTATTAATTTAATGTCTTTATCATTGGATCTTTTGCATGCTTTAATCTGGTTAACATATTTAAA
TTTGCTTTTTTTCTCTTTACCTGAAGGCTCTGTGTATAGTATTTCATGACATCGTTGTACAGTTTAACTATATCAATAAAAAGTTTGGAC
AGTATTTAAATATTGCAAATATGTTTAATTATACAAATCAGAATAGTATGGGTAATTAAATGAATACAAAAAGAAGAGCCTCTTTCTGCA
GCCGACTTAGACATGCTCTTCCCTTTCTATAAGCTAGATTTTAGAATAAAGGGTTTCAGTTAATAATCTTATTTTCAGGTTATGTCATCT
AACTTATAGCAAACTACCACAATACAGTGAGTTCTGCCAGTGTCCCAGTACAAGGCATATTTCAGGTGTGGCTGTGGAATGTAAAAATGC
TCAACTTGTATCAGGTAATGTTAGCAATAAATTAAATGCTAAGAATGATTAATCGGGTACATGTTACTGTAATTAACTCATTGCACTTCA
AAACCTAACTTCCATCCTGAATTTATCAAGTAGTTCAGTATTGTCATTTGTTTTTGTTTTATTGAAAAGTAATGTTGTCTTAAGATTTAG
AAGTGATTATTAGCTTGAGAACTATTACCCAGCTCTAAGCAAATAATGATTGTATACATATTAAGATAATGGTTAAATGCGGTTTTACCA
AGTTTTCCCTTGAAAATGTAATTCCTTTATGGAGATTTATTGTGCAGCCCTAAGCTTCCTTCCCATTTCATGAATATAAGGCTTCTAGAA
TTGGACTGGCAGGGGAAAGAATGGTAGAGACAGAAATTAAGACTTTATCCTTGTTTGCTTGTAAACTATTATTTTCTTGCTAATGTAACA
TTTGTCTGTTCCAGTGATGTAAGGATATTAAGTTATTAAGCTAAATATTAATTTTCAAAAATAGTCCTTCTTTAACTTAGATATTTCATA
GCTGGATTTAGGAAGATCTGTTATTCTGGAAGTACTAAAAAGAATAATACAACGTACAATGTCTGCATTCACTAATTCATGTTCCAGAAG
AGGAAATAATGAAGATATACTCAGTAGAGTACTAGGTGGGAGGATATGGAAATTTGCTCATAAAATCTCTTATAAAACGTGCATATAACA
AAATGACACCCAGTAGGCCTGCATTACATTTACATGACCGTGTTTATTTGCCATCAAATAAACTGAGTACTGACACCAGACAAAGACTCC
AAAGTCATAAAATAGCCTATGACCAACTGCAGCAAGACAGGAGGTCAGCTCGCCTATAATGGTGCTTAAAGTGTGATTGATGTAATTTTC
TGTACTCACCATTTGAAGTTAGTTAAGGAGAACTTTATTTTTTTAAAAAAAGTAAATGGCAACCACTAGTGTGCTCATCCTGAACTGTTA
CTCCAAATCCACTCCGTTTTTAAAGCAAAATTATCTTGTGATTTTAAGAAAAGAGTTTTCTATTTATTTAAGAAAGTAACAATGCAGTCT
GCAAGCTTTCAGTAGTTTTCTAGTGCTATATTCATCCTGTAAAACTCTTACTACGTAACCAGTAATCACAAGGAAAGTGTCCCCTTTGCA
TATTTCTTTAAAATTCTTTCTTTGGAAAGTATGATGTTGATAATTAACTTACCCTTATCTGCCAAAACCAGAGCAAAATGCTAAATACGT
TATTGCTAATCAGTGGTCTCAAATCGATTTGCCTCCCTTTGCCTCGTCTGAGGGCTGTAAGCCTGAAGATAGTGGCAAGCACCAAGTCAG
TTTCCAAAATTGCCCCTCAGCTGCTTTAAGTGACTCAGCACCCTGCCTCAGCTTCAGCAGGCGTAGGCTCACCCTGGGCGGAGCAAAGTA
TGGGCCAGGGAGAACTACAGCTACGAAGACCTGCTGTCGAGTTGAGAAAAGGGGAGAATTTATGGTCTGAATTTTCTAACTGTCCTCTTT
CTTGGGTCTAAAGCTCATAATACACAAAGGCTTCCAGACCTGAGCCACACCCAGGCCCTATCCTGAACAGGAGACTAAACAGAGGCAAAT
CAACCCTAGGAAATACTTGCATTCTGCCCTACGGTTAGTACCAGGACTGAGGTCATTTCTACTGGAAAAGATTGTGAGATTGAACTTATC
TGATCGCTTGAGACTCCTAATAGGCAGGAGTCAAGGCCACTAGAAAATTGACAGTTAAGAGCCAAAAGTTTTTAAAATATGCTACTCTGA
AAAATCTCGTGAAGGCTGTAGGAAAAGGGAGAATCTTCCATGTTGGTGTTTTTCCTGTAAAGATCAGTTTGGGGTATGATATAAGCAGGT
ATTAATAAAAATAACACACCAAAGAGTTACGTAAAACATGTTTTATTAATTTTGGTCCCCACGTACAGACATTTTATTTCTATTTTGAAA
TGAGTTATCTATTTTCATAAAAGTAAAACACTATTAAAGTGCTGTTTTATGTGAAATAACTTGAATGTTGTTCCTATAAAAAATAGATCA
TAACTCATGATATGTTTGTAATCATGGTAATTTAGATTTTTATGAGGAATGAGTATCTGGAAATATTGTAGCAATACTTGGTTTAAAATT
TTGGACCTGAGACACTGTGGCTGTCTAATGTAATCCTTTAAAAATTCTCTGCATTGTCAGTAAATGTAGTATATTATTGTACAGCTACTC

>In-frame_GSK3B_ENST00000316626_chr3_119720893_-_ATP11B_ENST00000323116_chr3_182631649_+_4261nt
ATCATCTATATGTTAAATATCCGTGCCGATCTGTCTTGAAGGAGAAATATATCGCTTGTTTTGTTTTTTATAGTATACAAAAGGAGTGAA
AAGCCAAGAGGACGAAGTCTTTTTCTTTTTCTTCTGTGGGAGAACTTAATGCTGCATTTATCGTTAACCTAACACCCCAACATAAAGACA
AAAGGAAGAAAAGGAGGAAGGAAGGAAAAGGTGATTCGCGAAGAGAGTGATCATGTCAGGGCGGCCCAGAACCACCTCCTTTGCGGAGAG
CTGCAAGCCGGTGCAGCAGCCTTCAGCTTTTGGCAGCATGAAAGTTAGCAGAGACAAGGACGGCAGCAAGGTGACAACAGTGGTGGCAAC
TCCTGGGCAGGGTCCAGACAGGCCACAAGAAGTCAGCTATACAGACACTAAAGTGATTGGAAATGGATCATTTGGTGTGGTATATCAAGC
CAAACTTTGTGATTCAGGAGAACTGGTCGCCATCAAGAAAGTATTGCAGGACAAGAGATTTAAGCTTACTGAAACAAATGCAGGTATCAA
GTGCTTGGACTCCATGTGCTGTTTCCCGGAAGGAGAAGCAGCGTGTGCATCTGTTGGAAGAATGCTGGAACGAGTTATAGGAAGATGTAG
TCCAACCCACATCAGCAGATCATGGAGTGCATCGGATCCTTTCTATACCAACGACAGGAGCATCTTGACTCTCTCCACAATGGACTCATC
TACTTGTTAAAGGGGCAGTAGTACTTTGTGGGAGCCAGTTCACCTCCTTTCCTAAAATTCAGTGTGATCACCCTGTTAATGGCCACACTA
GCTCTGAAATTAATTTCCAAAATCTTTGTAGTAGTTCATACCCACTCAGAGTTATAATGGCAAACAAACAGAAAGCATTAGTACAAGCCC
CTCCCAACACCCTTAATTTGAATCTGAACATGTTAAAATTTGAGAATAAAGAGACATTTTTCATCTCTTTGTCTGGTTTGTCCCTTGTGC
TTATGGGACTCCTAATGGCATTTCAGTCTGTTGCTGAGGCCATTATATTTTAATATAAATGTAGAAAAAAGAGAGAAATCTTAGTAAAGA
GTATTTTTTAGTATTAGCTTGATTATTGACTCTTCTATTTAAATCTGCTTCTGTAAATTATGCTGAAAGTTTGCCTTGAGAACTCTATTT
TTTTATTAGAGTTATATTTAAAGCTTTTCATGGGAAAAGTTAATGTGAATACTGAGGAATTTTGGTCCCTCAGTGACCTGTGTTGTTAAT
TCATTAATGCATTCTGAGTTCACAGAGCAAATTAGGAGAATCATTTCCAACCATTATTTACTGCAGTATGGGGAGTAAATTTATACCAAT
TCCTCTAACTGTACTGTAACACAGCCTGTAAAGTTAGCCATATAAATGCAAGGGTATATCATATATACAAATCAGGAATCAGGTCCGTTC
ACCGAACTTCAAATTGATGTTTACTAATATTTTTGTGACAGAGTATAAAGACCCTATAGTGGGTAAATTAGATACTATTAGCATATTATT
AATTTAATGTCTTTATCATTGGATCTTTTGCATGCTTTAATCTGGTTAACATATTTAAATTTGCTTTTTTTCTCTTTACCTGAAGGCTCT
GTGTATAGTATTTCATGACATCGTTGTACAGTTTAACTATATCAATAAAAAGTTTGGACAGTATTTAAATATTGCAAATATGTTTAATTA
TACAAATCAGAATAGTATGGGTAATTAAATGAATACAAAAAGAAGAGCCTCTTTCTGCAGCCGACTTAGACATGCTCTTCCCTTTCTATA
AGCTAGATTTTAGAATAAAGGGTTTCAGTTAATAATCTTATTTTCAGGTTATGTCATCTAACTTATAGCAAACTACCACAATACAGTGAG
TTCTGCCAGTGTCCCAGTACAAGGCATATTTCAGGTGTGGCTGTGGAATGTAAAAATGCTCAACTTGTATCAGGTAATGTTAGCAATAAA
TTAAATGCTAAGAATGATTAATCGGGTACATGTTACTGTAATTAACTCATTGCACTTCAAAACCTAACTTCCATCCTGAATTTATCAAGT
AGTTCAGTATTGTCATTTGTTTTTGTTTTATTGAAAAGTAATGTTGTCTTAAGATTTAGAAGTGATTATTAGCTTGAGAACTATTACCCA
GCTCTAAGCAAATAATGATTGTATACATATTAAGATAATGGTTAAATGCGGTTTTACCAAGTTTTCCCTTGAAAATGTAATTCCTTTATG
GAGATTTATTGTGCAGCCCTAAGCTTCCTTCCCATTTCATGAATATAAGGCTTCTAGAATTGGACTGGCAGGGGAAAGAATGGTAGAGAC
AGAAATTAAGACTTTATCCTTGTTTGCTTGTAAACTATTATTTTCTTGCTAATGTAACATTTGTCTGTTCCAGTGATGTAAGGATATTAA
GTTATTAAGCTAAATATTAATTTTCAAAAATAGTCCTTCTTTAACTTAGATATTTCATAGCTGGATTTAGGAAGATCTGTTATTCTGGAA
GTACTAAAAAGAATAATACAACGTACAATGTCTGCATTCACTAATTCATGTTCCAGAAGAGGAAATAATGAAGATATACTCAGTAGAGTA
CTAGGTGGGAGGATATGGAAATTTGCTCATAAAATCTCTTATAAAACGTGCATATAACAAAATGACACCCAGTAGGCCTGCATTACATTT
ACATGACCGTGTTTATTTGCCATCAAATAAACTGAGTACTGACACCAGACAAAGACTCCAAAGTCATAAAATAGCCTATGACCAACTGCA
GCAAGACAGGAGGTCAGCTCGCCTATAATGGTGCTTAAAGTGTGATTGATGTAATTTTCTGTACTCACCATTTGAAGTTAGTTAAGGAGA
ACTTTATTTTTTTAAAAAAAGTAAATGGCAACCACTAGTGTGCTCATCCTGAACTGTTACTCCAAATCCACTCCGTTTTTAAAGCAAAAT
TATCTTGTGATTTTAAGAAAAGAGTTTTCTATTTATTTAAGAAAGTAACAATGCAGTCTGCAAGCTTTCAGTAGTTTTCTAGTGCTATAT
TCATCCTGTAAAACTCTTACTACGTAACCAGTAATCACAAGGAAAGTGTCCCCTTTGCATATTTCTTTAAAATTCTTTCTTTGGAAAGTA
TGATGTTGATAATTAACTTACCCTTATCTGCCAAAACCAGAGCAAAATGCTAAATACGTTATTGCTAATCAGTGGTCTCAAATCGATTTG
CCTCCCTTTGCCTCGTCTGAGGGCTGTAAGCCTGAAGATAGTGGCAAGCACCAAGTCAGTTTCCAAAATTGCCCCTCAGCTGCTTTAAGT
GACTCAGCACCCTGCCTCAGCTTCAGCAGGCGTAGGCTCACCCTGGGCGGAGCAAAGTATGGGCCAGGGAGAACTACAGCTACGAAGACC
TGCTGTCGAGTTGAGAAAAGGGGAGAATTTATGGTCTGAATTTTCTAACTGTCCTCTTTCTTGGGTCTAAAGCTCATAATACACAAAGGC
TTCCAGACCTGAGCCACACCCAGGCCCTATCCTGAACAGGAGACTAAACAGAGGCAAATCAACCCTAGGAAATACTTGCATTCTGCCCTA
CGGTTAGTACCAGGACTGAGGTCATTTCTACTGGAAAAGATTGTGAGATTGAACTTATCTGATCGCTTGAGACTCCTAATAGGCAGGAGT
CAAGGCCACTAGAAAATTGACAGTTAAGAGCCAAAAGTTTTTAAAATATGCTACTCTGAAAAATCTCGTGAAGGCTGTAGGAAAAGGGAG
AATCTTCCATGTTGGTGTTTTTCCTGTAAAGATCAGTTTGGGGTATGATATAAGCAGGTATTAATAAAAATAACACACCAAAGAGTTACG
TAAAACATGTTTTATTAATTTTGGTCCCCACGTACAGACATTTTATTTCTATTTTGAAATGAGTTATCTATTTTCATAAAAGTAAAACAC
TATTAAAGTGCTGTTTTATGTGAAATAACTTGAATGTTGTTCCTATAAAAAATAGATCATAACTCATGATATGTTTGTAATCATGGTAAT
TTAGATTTTTATGAGGAATGAGTATCTGGAAATATTGTAGCAATACTTGGTTTAAAATTTTGGACCTGAGACACTGTGGCTGTCTAATGT
AATCCTTTAAAAATTCTCTGCATTGTCAGTAAATGTAGTATATTATTGTACAGCTACTCATAATTTTTTAAAGTTTATGAAGTTATATTT


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FusionGenePPI for GSK3B_ATP11B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GSK3BDNM1L, UPF3A, GEMIN4, SMYD2, DDX20, GSKIP, XPO6, DHX36, RPF2, SMN2, IGF2BP1, SNRNP70, EWSR1, ACLY, STRAP, SF3B1, AXIN1, CTNNB1, AR, MUC1, APC, CCNE1, NOTCH2, AKAP11, PRKAR2A, PPP1CA, AKT2, TP53, NFKB1, PTPN1, PTK2, AKT1, TSC2, TSC1, SGK3, NOTCH1, PRKCA, AXIN2, NIN, E2F1, PPARGC1A, ANKRD6, SMAD3, PSEN1, PHLPP1, TRAF2, SNCAIP, EPM2A, SNAI1, MYC, GSK3B, CIITA, KLF5, BTRC, CEBPB, ATF3, SMURF2, SREBF1, UBR5, BCL3, YBX1, YBX3, NOTCH3, MKL1, NAT9, ATXN3, TMEM44, MTOR, ENTPD6, RXRA, ADIRF, CSAD, CST6, GIPC1, SYNE4, BRIX1, EEF1G, GNB2, DNAJC13, C14orf1, PMAIP1, UBR1, LMO4, NSFL1C, GBP2, BAG6, UBE2D1, DNMT1, FEN1, CAMSAP3, GAPDH, TUBA1A, MICAL1, VIM, ZNF227, RSU1, SAP30BP, SPTBN4, MID1IP1, CHD3, TONSL, EIF4EBP1, MAP4, CEBPZ, RPLP1, TLE1, XPNPEP1, MTF2, GJB5, MASP1, PTN, DCTN3, RPS2, DNMT3L, WSB1, IGSF21, CENPB, RAI1, SLA, BZW2, EEF1A1, IGHM, FBN3, KIF5B, VPS51, ACSBG1, ADAP1, IQCG, ZNF746, EFTUD2, MGEA5, MED24, FIBP, FKBP14, LUC7L2, KIAA1191, PFKFB4, ATPIF1, ACTL6B, ASRGL1, RPL36AL, UBXN6, MPP1, DHX34, BEX1, UFM1, DEFA1, ZHX1, QARS, DBI, FAM83D, ZNF135, KHSRP, GPR39, RBPJ, PIM2, NRBP1, CLEC3B, FZD5, ARRB1, MAPT, NCOA3, COPS5, HDAC6, ELAVL1, APP, STK11, RASSF1, TAZ, NFE2L2, PDE4D, MDM2, TOP2A, HSPA4, HSP90AA1, AURKA, FBXW7, PPP2R5D, CREB1, MAP3K1, XIAP, BIRC2, BIRC3, NUB1, SNAI2, GYS1, SNCA, MAPK1, PRKACA, FZD1, PTPN11, PRKDC, AKT3, DDIT4, RELB, RELA, DEAF1, SPICE1, VTA1, MAP3K11, ARHGEF11, KRBA1, FAM193B, RPS6KA1, SMAD1, KLF2, NFE2L1, LRP6, CSF3R, ZFPM1, DUSP9, PRKAR1A, PPP1R2, FRAT1, HECW2, CLASP2, FRAT2, DYNLL1, PRUNE, EPB41L3, EYA1, NBR1, HDAC4, JUN, RNF220, MAP3K4, RICTOR, DEC1, BHLHE41, CSNK2B, FBXW11, TRAK2, HAX1, NUFIP1, ITLN1, PPP3CC, RCAN2, SP7, MAP2K7, ILKAP, XPO1, CDH1, IKBKG, CCND1, FOXO1, PRKCB, PRKCZ, NFE2L3, CREB3L3, CCDC6, PIAS1, UBXN2B, LPCAT1, SOX10, MAP3K2, NFATC1, NFATC2, FOXM1, AREL1, TBK1, UBE3A, CD274, CDX2, SOX9, CTNND1, PPP1CB, PPP1CC, SAMHD1, DEFA5, RCAN1, DKK3, U2AF1, TSKS, BCL2L1, DISC1ATP11BTMEM30A, IFNA21


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GSK3B_ATP11B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGSK3BP49841DB01356LithiumGlycogen synthase kinase-3 betasmall moleculeapproved

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RelatedDiseases for GSK3B_ATP11B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGSK3BC0005586Bipolar Disorder6CTD_human;PSYGENET
HgeneGSK3BC0011581Depressive disorder5CTD_human;PSYGENET
HgeneGSK3BC1269683Major Depressive Disorder5PSYGENET
HgeneGSK3BC0011570Mental Depression3PSYGENET
HgeneGSK3BC0002395Alzheimer's Disease2CTD_human
HgeneGSK3BC0033578Prostatic Neoplasms2CTD_human
HgeneGSK3BC0525045Mood Disorders2PSYGENET
HgeneGSK3BC0018800Cardiomegaly1CTD_human
HgeneGSK3BC0018801Heart failure1CTD_human
HgeneGSK3BC0020538Hypertensive disease1CTD_human
HgeneGSK3BC0026846Muscular Atrophy1CTD_human
HgeneGSK3BC0027051Myocardial Infarction1CTD_human
HgeneGSK3BC0031154Peritonitis1CTD_human
HgeneGSK3BC0036341Schizophrenia1CTD_human
HgeneGSK3BC0334634Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse1CTD_human
HgeneGSK3BC0993582Arthritis, Experimental1CTD_human
HgeneGSK3BC1866282CEROID LIPOFUSCINOSIS, NEURONAL, 61CTD_human
HgeneGSK3BC2609414Acute kidney injury1CTD_human