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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15519

FusionGeneSummary for GSE1_METTL23

check button Fusion gene summary
Fusion gene informationFusion gene name: GSE1_METTL23
Fusion gene ID: 15519
HgeneTgene
Gene symbol

GSE1

METTL23

Gene ID

23199

124512

Gene nameGse1 coiled-coil proteinmethyltransferase like 23
SynonymsCRHSP24|KIAA0182C17orf95|MRT44
Cytomap

16q24.1

17q25.1

Type of geneprotein-codingprotein-coding
Descriptiongenetic suppressor element 1CTC-786C10.1Gse1 coiled-coil protein homologmethyltransferase-like protein 23spike binding protein 1
Modification date2018051920180519
UniProtAcc

Q14687

Q86XA0

Ensembl transtripts involved in fusion geneENST00000405402, ENST00000253458, 
ENST00000393243, ENST00000471070, 
ENST00000589977, ENST00000591571, 
ENST00000586738, ENST00000588783, 
ENST00000586752, ENST00000588302, 
ENST00000590964, ENST00000341249, 
ENST00000588822, ENST00000586200, 
Fusion gene scores* DoF score13 X 9 X 7=8193 X 4 X 2=24
# samples 134
** MAII scorelog2(13/819*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GSE1 [Title/Abstract] AND METTL23 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A7-A2KD-01AGSE1chr16

85647004

+METTL23chr17

74729060

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000405402ENST00000589977GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-5UTRENST00000405402ENST00000591571GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-5UTRENST00000405402ENST00000586738GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-5UTRENST00000405402ENST00000588783GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-5UTRENST00000405402ENST00000586752GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-5UTRENST00000405402ENST00000588302GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-5UTRENST00000405402ENST00000590964GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-5UTRENST00000405402ENST00000341249GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-5UTRENST00000405402ENST00000588822GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-intronENST00000405402ENST00000586200GSE1chr16

85647004

+METTL23chr17

74729060

+
Frame-shitENST00000253458ENST00000589977GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-5UTRENST00000253458ENST00000591571GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-5UTRENST00000253458ENST00000586738GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-5UTRENST00000253458ENST00000588783GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-5UTRENST00000253458ENST00000586752GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-5UTRENST00000253458ENST00000588302GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-5UTRENST00000253458ENST00000590964GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-5UTRENST00000253458ENST00000341249GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-5UTRENST00000253458ENST00000588822GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-intronENST00000253458ENST00000586200GSE1chr16

85647004

+METTL23chr17

74729060

+
Frame-shitENST00000393243ENST00000589977GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-5UTRENST00000393243ENST00000591571GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-5UTRENST00000393243ENST00000586738GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-5UTRENST00000393243ENST00000588783GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-5UTRENST00000393243ENST00000586752GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-5UTRENST00000393243ENST00000588302GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-5UTRENST00000393243ENST00000590964GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-5UTRENST00000393243ENST00000341249GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-5UTRENST00000393243ENST00000588822GSE1chr16

85647004

+METTL23chr17

74729060

+
5CDS-intronENST00000393243ENST00000586200GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-3CDSENST00000471070ENST00000589977GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-5UTRENST00000471070ENST00000591571GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-5UTRENST00000471070ENST00000586738GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-5UTRENST00000471070ENST00000588783GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-5UTRENST00000471070ENST00000586752GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-5UTRENST00000471070ENST00000588302GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-5UTRENST00000471070ENST00000590964GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-5UTRENST00000471070ENST00000341249GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-5UTRENST00000471070ENST00000588822GSE1chr16

85647004

+METTL23chr17

74729060

+
intron-intronENST00000471070ENST00000586200GSE1chr16

85647004

+METTL23chr17

74729060

+

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FusionProtFeatures for GSE1_METTL23


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSE1

Q14687

METTL23

Q86XA0

Probable methyltransferase. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GSE1_METTL23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GSE1_METTL23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GSE1NUDT18, RBPMS, RCOR3, HDAC2, KDM1A, RBM48, XRCC6, NR2E1, CDC5L, CEP63, TNIK, ELAVL1, TCF3, FUS, HDAC1, MTA3, EXOSC6, DGCR6, RUNX1T1, GOLGA2, TRIP6, RALBP1, GSE1, C1orf94, TEKT4, C6orf165, SNAI1, HMG20B, FGF1, DOK4, NTRK1, SRPK2, NINL, MAPK3, HMG20A, TCF4, EYA2, LLGL2, HAO2, FAM136A, NR3C1, AR, TRIM25METTL23BCL2L1, TK1, BAG6, CASP14, CCT3, CSTA, DNAJA1, DNAJA2, DNAJB11, GANAB, HSP90B1, HSPA5, CCAR2, VCPKMT, PDIA6, S100A7, S100A9, SEP15, SERPINH1, TUBB2A, TUBB3, TUBB4A, TUBB6, UBB, UBC, UBL4A, UGGT1, UGGT2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GSE1_METTL23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GSE1_METTL23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMETTL23C3714756Intellectual Disability1CTD_human