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Fusion gene ID: 15518 |
FusionGeneSummary for GSE1_LBP |
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Fusion gene information | Fusion gene name: GSE1_LBP | Fusion gene ID: 15518 | Hgene | Tgene | Gene symbol | GSE1 | LBP | Gene ID | 23199 | 3929 |
Gene name | Gse1 coiled-coil protein | lipopolysaccharide binding protein | |
Synonyms | CRHSP24|KIAA0182 | BPIFD2 | |
Cytomap | 16q24.1 | 20q11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | genetic suppressor element 1CTC-786C10.1Gse1 coiled-coil protein homolog | lipopolysaccharide-binding proteinBPI fold containing family D, member 2LPS-binding protein | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q14687 | P18428 | |
Ensembl transtripts involved in fusion gene | ENST00000405402, ENST00000253458, ENST00000393243, ENST00000471070, | ENST00000217407, | |
Fusion gene scores | * DoF score | 13 X 9 X 7=819 | 3 X 3 X 3=27 |
# samples | 13 | 3 | |
** MAII score | log2(13/819*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: GSE1 [Title/Abstract] AND LBP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | LBP | GO:0015920 | lipopolysaccharide transport | 8985160 |
Tgene | LBP | GO:0031663 | lipopolysaccharide-mediated signaling pathway | 8409400|11739189 |
Tgene | LBP | GO:0032490 | detection of molecule of bacterial origin | 11528597 |
Tgene | LBP | GO:0032496 | response to lipopolysaccharide | 8409400|11739189 |
Tgene | LBP | GO:0032720 | negative regulation of tumor necrosis factor production | 11739189 |
Tgene | LBP | GO:0032755 | positive regulation of interleukin-6 production | 8409400 |
Tgene | LBP | GO:0032757 | positive regulation of interleukin-8 production | 8409400 |
Tgene | LBP | GO:0032760 | positive regulation of tumor necrosis factor production | 8409400|12594207 |
Tgene | LBP | GO:0033036 | macromolecule localization | 15294986 |
Tgene | LBP | GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway | 11528597 |
Tgene | LBP | GO:0043032 | positive regulation of macrophage activation | 8409400 |
Tgene | LBP | GO:0045919 | positive regulation of cytolysis | 15294986 |
Tgene | LBP | GO:0050829 | defense response to Gram-negative bacterium | 11528597 |
Tgene | LBP | GO:0050830 | defense response to Gram-positive bacterium | 12932360 |
Tgene | LBP | GO:0071222 | cellular response to lipopolysaccharide | 12594207 |
Tgene | LBP | GO:0071223 | cellular response to lipoteichoic acid | 12594207 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-X6-A8C7-01A | GSE1 | chr16 | 85205413 | + | LBP | chr20 | 37005267 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000405402 | ENST00000217407 | GSE1 | chr16 | 85205413 | + | LBP | chr20 | 37005267 | + |
intron-3CDS | ENST00000253458 | ENST00000217407 | GSE1 | chr16 | 85205413 | + | LBP | chr20 | 37005267 | + |
intron-3CDS | ENST00000393243 | ENST00000217407 | GSE1 | chr16 | 85205413 | + | LBP | chr20 | 37005267 | + |
intron-3CDS | ENST00000471070 | ENST00000217407 | GSE1 | chr16 | 85205413 | + | LBP | chr20 | 37005267 | + |
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FusionProtFeatures for GSE1_LBP |
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Hgene | Tgene |
GSE1 | LBP |
Plays a role in the innate immune response. Binds to thelipid A moiety of bacterial lipopolysaccharides (LPS), aglycolipid present in the outer membrane of all Gram-negativebacteria (PubMed:7517398, PubMed:24120359). Acts as an affinityenhancer for CD14, facilitating its association with LPS. Promotesthe release of cytokines in response to bacteriallipopolysaccharide (PubMed:7517398, PubMed:24120359).{ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:20133493,ECO:0000269|PubMed:24120359, ECO:0000269|PubMed:7517398,ECO:0000305|PubMed:17481951}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GSE1_LBP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GSE1_LBP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GSE1 | NUDT18, RBPMS, RCOR3, HDAC2, KDM1A, RBM48, XRCC6, NR2E1, CDC5L, CEP63, TNIK, ELAVL1, TCF3, FUS, HDAC1, MTA3, EXOSC6, DGCR6, RUNX1T1, GOLGA2, TRIP6, RALBP1, GSE1, C1orf94, TEKT4, C6orf165, SNAI1, HMG20B, FGF1, DOK4, NTRK1, SRPK2, NINL, MAPK3, HMG20A, TCF4, EYA2, LLGL2, HAO2, FAM136A, NR3C1, AR, TRIM25 | LBP | CFHR1, APOA1, CD14, CBFA2T2, C4BPA, FTH1, BAG6, BST1, HSPB1, SMAD3, PSMA3, SETD1A, PRDX4, TRA2A, PYCRL, TSC22D4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GSE1_LBP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GSE1_LBP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | LBP | C0023893 | Liver Cirrhosis, Experimental | 2 | CTD_human |
Tgene | LBP | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
Tgene | LBP | C0026766 | Multiple Organ Failure | 1 | CTD_human |
Tgene | LBP | C0028754 | Obesity | 1 | CTD_human |
Tgene | LBP | C0043094 | Weight Gain | 1 | CTD_human |
Tgene | LBP | C0243026 | Sepsis | 1 | CTD_human |
Tgene | LBP | C0524620 | Metabolic Syndrome X | 1 | CTD_human |
Tgene | LBP | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |