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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15515

FusionGeneSummary for GSE1_GPR161

check button Fusion gene summary
Fusion gene informationFusion gene name: GSE1_GPR161
Fusion gene ID: 15515
HgeneTgene
Gene symbol

GSE1

GPR161

Gene ID

23199

23432

Gene nameGse1 coiled-coil proteinG protein-coupled receptor 161
SynonymsCRHSP24|KIAA0182RE2
Cytomap

16q24.1

1q24.2

Type of geneprotein-codingprotein-coding
Descriptiongenetic suppressor element 1CTC-786C10.1Gse1 coiled-coil protein homologG-protein coupled receptor 161G-protein coupled receptor RE2
Modification date2018051920180519
UniProtAcc

Q14687

Q8N6U8

Ensembl transtripts involved in fusion geneENST00000405402, ENST00000253458, 
ENST00000393243, ENST00000471070, 
ENST00000367838, ENST00000271357, 
ENST00000367836, ENST00000539777, 
ENST00000537209, ENST00000361697, 
ENST00000546300, ENST00000367835, 
ENST00000485232, 
Fusion gene scores* DoF score13 X 9 X 7=8194 X 3 X 4=48
# samples 134
** MAII scorelog2(13/819*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GSE1 [Title/Abstract] AND GPR161 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG014025GSE1chr16

85667360

-GPR161chr1

168061667

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000405402ENST00000367838GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000405402ENST00000271357GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000405402ENST00000367836GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000405402ENST00000539777GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000405402ENST00000537209GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000405402ENST00000361697GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000405402ENST00000546300GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000405402ENST00000367835GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000405402ENST00000485232GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000253458ENST00000367838GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000253458ENST00000271357GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000253458ENST00000367836GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000253458ENST00000539777GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000253458ENST00000537209GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000253458ENST00000361697GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000253458ENST00000546300GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000253458ENST00000367835GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000253458ENST00000485232GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000393243ENST00000367838GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000393243ENST00000271357GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000393243ENST00000367836GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000393243ENST00000539777GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000393243ENST00000537209GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000393243ENST00000361697GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000393243ENST00000546300GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000393243ENST00000367835GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000393243ENST00000485232GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000471070ENST00000367838GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000471070ENST00000271357GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000471070ENST00000367836GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000471070ENST00000539777GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000471070ENST00000537209GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000471070ENST00000361697GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000471070ENST00000546300GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000471070ENST00000367835GSE1chr16

85667360

-GPR161chr1

168061667

-
intron-intronENST00000471070ENST00000485232GSE1chr16

85667360

-GPR161chr1

168061667

-

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FusionProtFeatures for GSE1_GPR161


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSE1

Q14687

GPR161

Q8N6U8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GSE1_GPR161


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GSE1_GPR161


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GSE1_GPR161


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GSE1_GPR161


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource