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Fusion gene ID: 15513 |
FusionGeneSummary for GSE1_FAR1 |
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Fusion gene information | Fusion gene name: GSE1_FAR1 | Fusion gene ID: 15513 | Hgene | Tgene | Gene symbol | GSE1 | FAR1 | Gene ID | 23199 | 84188 |
Gene name | Gse1 coiled-coil protein | fatty acyl-CoA reductase 1 | |
Synonyms | CRHSP24|KIAA0182 | MLSTD2|PFCRD|SDR10E1 | |
Cytomap | 16q24.1 | 11p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | genetic suppressor element 1CTC-786C10.1Gse1 coiled-coil protein homolog | fatty acyl-CoA reductase 1male sterility domain-containing protein 2short chain dehydrogenase/reductase family 10E, member 1 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q14687 | Q8WVX9 | |
Ensembl transtripts involved in fusion gene | ENST00000405402, ENST00000253458, ENST00000393243, ENST00000471070, | ENST00000354817, ENST00000527202, ENST00000532502, | |
Fusion gene scores | * DoF score | 13 X 9 X 7=819 | 28 X 8 X 12=2688 |
# samples | 13 | 31 | |
** MAII score | log2(13/819*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(31/2688*10)=-3.11619301750452 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GSE1 [Title/Abstract] AND FAR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FAR1 | GO:0008611 | ether lipid biosynthetic process | 24108123 |
Tgene | FAR1 | GO:0035336 | long-chain fatty-acyl-CoA metabolic process | 15220348 |
Tgene | FAR1 | GO:0046474 | glycerophospholipid biosynthetic process | 20071337 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AU117141 | GSE1 | chr16 | 85709522 | + | FAR1 | chr11 | 13752533 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000405402 | ENST00000354817 | GSE1 | chr16 | 85709522 | + | FAR1 | chr11 | 13752533 | + |
intron-intron | ENST00000405402 | ENST00000527202 | GSE1 | chr16 | 85709522 | + | FAR1 | chr11 | 13752533 | + |
intron-3UTR | ENST00000405402 | ENST00000532502 | GSE1 | chr16 | 85709522 | + | FAR1 | chr11 | 13752533 | + |
3UTR-3UTR | ENST00000253458 | ENST00000354817 | GSE1 | chr16 | 85709522 | + | FAR1 | chr11 | 13752533 | + |
3UTR-intron | ENST00000253458 | ENST00000527202 | GSE1 | chr16 | 85709522 | + | FAR1 | chr11 | 13752533 | + |
3UTR-3UTR | ENST00000253458 | ENST00000532502 | GSE1 | chr16 | 85709522 | + | FAR1 | chr11 | 13752533 | + |
3UTR-3UTR | ENST00000393243 | ENST00000354817 | GSE1 | chr16 | 85709522 | + | FAR1 | chr11 | 13752533 | + |
3UTR-intron | ENST00000393243 | ENST00000527202 | GSE1 | chr16 | 85709522 | + | FAR1 | chr11 | 13752533 | + |
3UTR-3UTR | ENST00000393243 | ENST00000532502 | GSE1 | chr16 | 85709522 | + | FAR1 | chr11 | 13752533 | + |
intron-3UTR | ENST00000471070 | ENST00000354817 | GSE1 | chr16 | 85709522 | + | FAR1 | chr11 | 13752533 | + |
intron-intron | ENST00000471070 | ENST00000527202 | GSE1 | chr16 | 85709522 | + | FAR1 | chr11 | 13752533 | + |
intron-3UTR | ENST00000471070 | ENST00000532502 | GSE1 | chr16 | 85709522 | + | FAR1 | chr11 | 13752533 | + |
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FusionProtFeatures for GSE1_FAR1 |
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Hgene | Tgene |
GSE1 | FAR1 |
Catalyzes the reduction of saturated and unsaturated C16or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348,PubMed:24108123). It plays an essential role in the production ofether lipids/plasmalogens which synthesis requires fatty alcohols(PubMed:20071337, PubMed:24108123). In parallel, it is alsorequired for wax monoesters production since fatty alcohols alsoconstitute a substrate for their synthesis (By similarity).{ECO:0000250|UniProtKB:Q922J9, ECO:0000269|PubMed:15220348,ECO:0000269|PubMed:20071337, ECO:0000269|PubMed:24108123}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GSE1_FAR1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GSE1_FAR1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GSE1_FAR1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GSE1_FAR1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | FAR1 | C4015344 | PEROXISOMAL FATTY ACYL-CoA REDUCTASE 1 DISORDER | 1 | ORPHANET;UNIPROT |