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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15498

FusionGeneSummary for GRTP1_GRSF1

check button Fusion gene summary
Fusion gene informationFusion gene name: GRTP1_GRSF1
Fusion gene ID: 15498
HgeneTgene
Gene symbol

GRTP1

GRSF1

Gene ID

79774

2926

Gene namegrowth hormone regulated TBC protein 1G-rich RNA sequence binding factor 1
SynonymsTBC1D6-
Cytomap

13q34

4q13.3

Type of geneprotein-codingprotein-coding
Descriptiongrowth hormone-regulated TBC protein 1TBC1 domain family member 6G-rich sequence factor 1GRSF-1
Modification date2018052320180519
UniProtAcc

Q5TC63

Q12849

Ensembl transtripts involved in fusion geneENST00000375431, ENST00000326039, 
ENST00000375430, ENST00000476439, 
ENST00000254799, ENST00000439371, 
ENST00000502323, ENST00000545193, 
ENST00000508091, 
Fusion gene scores* DoF score5 X 4 X 4=805 X 4 X 2=40
# samples 55
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GRTP1 [Title/Abstract] AND GRSF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN407654GRTP1chr13

113994067

-GRSF1chr4

71691095

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000375431ENST00000254799GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-3CDSENST00000375431ENST00000439371GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-3CDSENST00000375431ENST00000502323GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-3CDSENST00000375431ENST00000545193GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-intronENST00000375431ENST00000508091GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-3CDSENST00000326039ENST00000254799GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-3CDSENST00000326039ENST00000439371GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-3CDSENST00000326039ENST00000502323GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-3CDSENST00000326039ENST00000545193GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-intronENST00000326039ENST00000508091GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-3CDSENST00000375430ENST00000254799GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-3CDSENST00000375430ENST00000439371GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-3CDSENST00000375430ENST00000502323GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-3CDSENST00000375430ENST00000545193GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-intronENST00000375430ENST00000508091GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-3CDSENST00000476439ENST00000254799GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-3CDSENST00000476439ENST00000439371GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-3CDSENST00000476439ENST00000502323GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-3CDSENST00000476439ENST00000545193GRTP1chr13

113994067

-GRSF1chr4

71691095

-
intron-intronENST00000476439ENST00000508091GRTP1chr13

113994067

-GRSF1chr4

71691095

-

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FusionProtFeatures for GRTP1_GRSF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRTP1

Q5TC63

GRSF1

Q12849

May act as a GTPase-activating protein for Rab familyprotein(s). Regulator of post-transcriptional mitochondrial geneexpression, required for assembly of the mitochondrial ribosomeand for recruitment of mRNA and lncRNA. Binds RNAs containing the14 base G-rich element. Preferentially binds RNAs transcribed fromthree contiguous genes on the light strand of mtDNA, the ND6 mRNA,and the long non-coding RNAs for MT-CYB and MT-ND5, each of whichcontains multiple consensus binding sequences.{ECO:0000269|PubMed:23473033, ECO:0000269|PubMed:23473034}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GRTP1_GRSF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GRTP1_GRSF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GRTP1_GRSF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GRTP1_GRSF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource