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Fusion gene ID: 15497 |
FusionGeneSummary for GRTP1_COL4A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRTP1_COL4A2 | Fusion gene ID: 15497 | Hgene | Tgene | Gene symbol | GRTP1 | COL4A2 | Gene ID | 79774 | 1284 |
| Gene name | growth hormone regulated TBC protein 1 | collagen type IV alpha 2 chain | |
| Synonyms | TBC1D6 | ICH|POREN2 | |
| Cytomap | 13q34 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | growth hormone-regulated TBC protein 1TBC1 domain family member 6 | collagen alpha-2(IV) chaincanstatin | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q5TC63 | P08572 | |
| Ensembl transtripts involved in fusion gene | ENST00000375431, ENST00000326039, ENST00000375430, ENST00000476439, | ENST00000360467, ENST00000462309, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 6 X 6 X 3=108 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/108*10)=-1.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GRTP1 [Title/Abstract] AND COL4A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | COL4A2 | GO:0016525 | negative regulation of angiogenesis | 10625665 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-69-7979-01A | GRTP1 | chr13 | 113999178 | - | COL4A2 | chr13 | 111154015 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000375431 | ENST00000360467 | GRTP1 | chr13 | 113999178 | - | COL4A2 | chr13 | 111154015 | + |
| 5CDS-intron | ENST00000375431 | ENST00000462309 | GRTP1 | chr13 | 113999178 | - | COL4A2 | chr13 | 111154015 | + |
| In-frame | ENST00000326039 | ENST00000360467 | GRTP1 | chr13 | 113999178 | - | COL4A2 | chr13 | 111154015 | + |
| 5CDS-intron | ENST00000326039 | ENST00000462309 | GRTP1 | chr13 | 113999178 | - | COL4A2 | chr13 | 111154015 | + |
| In-frame | ENST00000375430 | ENST00000360467 | GRTP1 | chr13 | 113999178 | - | COL4A2 | chr13 | 111154015 | + |
| 5CDS-intron | ENST00000375430 | ENST00000462309 | GRTP1 | chr13 | 113999178 | - | COL4A2 | chr13 | 111154015 | + |
| intron-3CDS | ENST00000476439 | ENST00000360467 | GRTP1 | chr13 | 113999178 | - | COL4A2 | chr13 | 111154015 | + |
| intron-intron | ENST00000476439 | ENST00000462309 | GRTP1 | chr13 | 113999178 | - | COL4A2 | chr13 | 111154015 | + |
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FusionProtFeatures for GRTP1_COL4A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRTP1 | COL4A2 |
| May act as a GTPase-activating protein for Rab familyprotein(s). | Type IV collagen is the major structural component ofglomerular basement membranes (GBM), forming a 'chicken-wire'meshwork together with laminins, proteoglycans andentactin/nidogen. Canstatin, a cleavage product corresponding to thecollagen alpha 2(IV) NC1 domain, possesses both anti-angiogenicand anti-tumor cell activity. It inhibits proliferation andmigration of endothelial cells, reduces mitochondrial membranepotential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity.Ligand for alphavbeta3 and alphavbeta5 integrins. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >COL4A2 | chr13:113999178 | chr13:111154015 | ENST00000360467 | + | 39 | 48 | 1489_1712 | 1253 | 1713 | Domain | Collagen IV NC1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GRTP1 | chr13:113999178 | chr13:111154015 | ENST00000326039 | - | 3 | 5 | 68_258 | 109 | 267 | Domain | Rab-GAP TBC |
| Hgene | >GRTP1 | chr13:113999178 | chr13:111154015 | ENST00000375431 | - | 5 | 8 | 68_258 | 187 | 337 | Domain | Rab-GAP TBC |
| Tgene | COL4A2 | chr13:113999178 | chr13:111154015 | ENST00000360467 | + | 39 | 48 | 184_1484 | 1253 | 1713 | Region | Note=Triple-helical region |
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FusionGeneSequence for GRTP1_COL4A2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GRTP1_ENST00000375431_chr13_113999178_-_COL4A2_ENST00000360467_chr13_111154015_+_647aa MQPAERSRVPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQ NPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDA LVGRILPGERGPPGSPGLQGFPGITPPSNISGAPGDKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGTKGWAGDSGPQGR PGVFGLPGEKGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIAGIPQKIAVQPGTVGPQGRRGPPGAPGEMGPQGPPG EPGFRGAPGKAGPQGRGGVSAVPGFRGDEGPIGHQGPIGQEGAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMCPVGMNKLWSGYS LLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPVAEDEIKPYISRCSVCEAPAIAIAVHSQD VSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPEQSFQGSPSADTLKAG >In-frame_GRTP1_ENST00000326039_chr13_113999178_-_COL4A2_ENST00000360467_chr13_111154015_+_569aa MVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILIT NNEEESFWLLDALVGRILPGERGPPGSPGLQGFPGITPPSNISGAPGDKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGT KGWAGDSGPQGRPGVFGLPGEKGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIAGIPQKIAVQPGTVGPQGRRGPPG APGEMGPQGPPGEPGFRGAPGKAGPQGRGGVSAVPGFRGDEGPIGHQGPIGQEGAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMC PVGMNKLWSGYSLLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPVAEDEIKPYISRCSVCE APAIAIAVHSQDVSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPEQSF >In-frame_GRTP1_ENST00000375430_chr13_113999178_-_COL4A2_ENST00000360467_chr13_111154015_+_647aa MQPAERSRVPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQ NPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDA LVGRILPGERGPPGSPGLQGFPGITPPSNISGAPGDKGAPGIFGLKGYRGPPGPPGSAALPGSKGDTGNPGAPGTPGTKGWAGDSGPQGR PGVFGLPGEKGPRGEQGFMGNTGPTGAVGDRGPKGPKGDPGFPGAPGTVGAPGIAGIPQKIAVQPGTVGPQGRRGPPGAPGEMGPQGPPG EPGFRGAPGKAGPQGRGGVSAVPGFRGDEGPIGHQGPIGQEGAPGRPGSPGLPGMPGRSVSIGYLLVKHSQTDQEPMCPVGMNKLWSGYS LLYFEGQEKAHNQDLGLAGSCLARFSTMPFLYCNPGDVCYYASRNDKSYWLSTTAPLPMMPVAEDEIKPYISRCSVCEAPAIAIAVHSQD VSIPHCPAGWRSLWIGYSFLMHTAAGDEGGGQSLVSPGSCLEDFRATPFIECNGGRGTCHYYANKYSFWLTTIPEQSFQGSPSADTLKAG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GRTP1_ENST00000375431_chr13_113999178_-_COL4A2_ENST00000360467_chr13_111154015_+_1941nt ATGCAGCCCGCCGAGCGCTCGCGGGTCCCCAGGATCGACCCGTACGGATTCGAGCGGCCTGAGGACTTCGACGACGCCGCCTACGAGAAG TTTTTCTCCAGCTACCTGGTCACGCTCACCCGCAGGGCGATCAAATGGTCCCGGCTGCTGCAGGGCGGGGGCGTCCCCAGGAGCCGGACA GTGAAGCGCTATGTCCGGAAAGGGGTCCCGCTGGAGCACCGTGCCCGCGTCTGGATGGTGCTGAGTGGGGCCCAGGCGCAGATGGACCAG AATCCCGGCTACTACCACCAGCTTCTCCAGGGAGAGAGAAACCCCAGGCTGGAGGACGCCATCAGGACAGACCTGAACCGGACCTTCCCC GACAACGTGAAGTTCCGGAAGACCACGGACCCCTGCTTACAGAGGACCCTGTACAATGTGCTGCTGGCATATGGGCACCATAACCAGGGA GTGGGCTACTGCCAGGGAATGAATTTTATAGCAGGATATCTGATTCTTATAACAAATAATGAAGAAGAATCTTTTTGGCTGTTAGATGCT CTTGTTGGAAGAATACTACCAGGGGAACGAGGCCCACCTGGGAGCCCAGGACTTCAGGGGTTCCCTGGTATCACACCCCCTTCCAACATC TCTGGGGCACCTGGTGACAAAGGGGCGCCAGGGATATTTGGCCTGAAAGGTTATCGGGGCCCACCAGGGCCACCAGGTTCTGCTGCTCTT CCTGGAAGCAAAGGTGACACAGGGAACCCAGGAGCTCCAGGAACCCCAGGGACCAAAGGATGGGCCGGGGACTCCGGGCCCCAGGGCAGG CCTGGTGTGTTTGGTCTCCCAGGAGAAAAAGGGCCCAGGGGTGAACAAGGCTTCATGGGGAACACTGGACCCACTGGGGCGGTGGGCGAC AGAGGCCCCAAGGGACCCAAGGGAGACCCAGGATTCCCTGGTGCCCCCGGGACTGTGGGAGCCCCCGGGATTGCAGGAATCCCCCAGAAG ATTGCCGTCCAACCAGGGACAGTGGGTCCCCAGGGGAGGCGAGGCCCCCCTGGGGCACCGGGGGAGATGGGGCCCCAGGGCCCCCCCGGA GAACCAGGTTTCCGTGGGGCTCCAGGGAAAGCTGGGCCCCAAGGAAGAGGTGGTGTGTCTGCTGTTCCCGGCTTCCGGGGAGATGAAGGA CCCATAGGCCACCAGGGGCCGATTGGCCAAGAAGGTGCACCAGGCCGTCCAGGGAGCCCGGGCCTGCCGGGTATGCCAGGCCGCAGCGTC AGCATCGGCTACCTCCTGGTGAAGCACAGCCAGACGGACCAGGAGCCCATGTGCCCAGTGGGCATGAACAAACTCTGGAGTGGATACAGC CTGCTGTACTTCGAGGGCCAGGAGAAGGCGCACAACCAGGACCTGGGGCTGGCGGGCTCCTGCCTGGCGCGGTTCAGCACCATGCCCTTC CTGTACTGCAACCCTGGTGATGTCTGCTACTATGCCAGCCGGAACGACAAGTCCTACTGGCTCTCTACCACTGCGCCGCTGCCCATGATG CCCGTGGCCGAGGACGAGATCAAGCCCTACATCAGCCGCTGTTCTGTGTGTGAGGCCCCGGCCATCGCCATCGCGGTCCACAGTCAGGAT GTCTCCATCCCACACTGCCCAGCTGGGTGGCGGAGTTTGTGGATCGGATATTCCTTCCTCATGCACACGGCGGCGGGAGACGAAGGCGGT GGCCAATCACTGGTGTCACCGGGCAGCTGTCTAGAGGACTTCCGCGCCACACCATTCATCGAATGCAATGGAGGCCGCGGCACCTGCCAC TACTACGCCAACAAGTACAGCTTCTGGCTGACCACCATTCCCGAGCAGAGCTTCCAGGGCTCGCCCTCCGCCGACACGCTCAAGGCCGGC >In-frame_GRTP1_ENST00000326039_chr13_113999178_-_COL4A2_ENST00000360467_chr13_111154015_+_1707nt ATGGTGCTGAGTGGGGCCCAGGCGCAGATGGACCAGAATCCCGGCTACTACCACCAGCTTCTCCAGGGAGAGAGAAACCCCAGGCTGGAG GACGCCATCAGGACAGACCTGAACCGGACCTTCCCCGACAACGTGAAGTTCCGGAAGACCACGGACCCCTGCTTACAGAGGACCCTGTAC AATGTGCTGCTGGCATATGGGCACCATAACCAGGGAGTGGGCTACTGCCAGGGAATGAATTTTATAGCAGGATATCTGATTCTTATAACA AATAATGAAGAAGAATCTTTTTGGCTGTTAGATGCTCTTGTTGGAAGAATACTACCAGGGGAACGAGGCCCACCTGGGAGCCCAGGACTT CAGGGGTTCCCTGGTATCACACCCCCTTCCAACATCTCTGGGGCACCTGGTGACAAAGGGGCGCCAGGGATATTTGGCCTGAAAGGTTAT CGGGGCCCACCAGGGCCACCAGGTTCTGCTGCTCTTCCTGGAAGCAAAGGTGACACAGGGAACCCAGGAGCTCCAGGAACCCCAGGGACC AAAGGATGGGCCGGGGACTCCGGGCCCCAGGGCAGGCCTGGTGTGTTTGGTCTCCCAGGAGAAAAAGGGCCCAGGGGTGAACAAGGCTTC ATGGGGAACACTGGACCCACTGGGGCGGTGGGCGACAGAGGCCCCAAGGGACCCAAGGGAGACCCAGGATTCCCTGGTGCCCCCGGGACT GTGGGAGCCCCCGGGATTGCAGGAATCCCCCAGAAGATTGCCGTCCAACCAGGGACAGTGGGTCCCCAGGGGAGGCGAGGCCCCCCTGGG GCACCGGGGGAGATGGGGCCCCAGGGCCCCCCCGGAGAACCAGGTTTCCGTGGGGCTCCAGGGAAAGCTGGGCCCCAAGGAAGAGGTGGT GTGTCTGCTGTTCCCGGCTTCCGGGGAGATGAAGGACCCATAGGCCACCAGGGGCCGATTGGCCAAGAAGGTGCACCAGGCCGTCCAGGG AGCCCGGGCCTGCCGGGTATGCCAGGCCGCAGCGTCAGCATCGGCTACCTCCTGGTGAAGCACAGCCAGACGGACCAGGAGCCCATGTGC CCAGTGGGCATGAACAAACTCTGGAGTGGATACAGCCTGCTGTACTTCGAGGGCCAGGAGAAGGCGCACAACCAGGACCTGGGGCTGGCG GGCTCCTGCCTGGCGCGGTTCAGCACCATGCCCTTCCTGTACTGCAACCCTGGTGATGTCTGCTACTATGCCAGCCGGAACGACAAGTCC TACTGGCTCTCTACCACTGCGCCGCTGCCCATGATGCCCGTGGCCGAGGACGAGATCAAGCCCTACATCAGCCGCTGTTCTGTGTGTGAG GCCCCGGCCATCGCCATCGCGGTCCACAGTCAGGATGTCTCCATCCCACACTGCCCAGCTGGGTGGCGGAGTTTGTGGATCGGATATTCC TTCCTCATGCACACGGCGGCGGGAGACGAAGGCGGTGGCCAATCACTGGTGTCACCGGGCAGCTGTCTAGAGGACTTCCGCGCCACACCA TTCATCGAATGCAATGGAGGCCGCGGCACCTGCCACTACTACGCCAACAAGTACAGCTTCTGGCTGACCACCATTCCCGAGCAGAGCTTC >In-frame_GRTP1_ENST00000375430_chr13_113999178_-_COL4A2_ENST00000360467_chr13_111154015_+_1941nt ATGCAGCCCGCCGAGCGCTCGCGGGTCCCCAGGATCGACCCGTACGGATTCGAGCGGCCTGAGGACTTCGACGACGCCGCCTACGAGAAG TTTTTCTCCAGCTACCTGGTCACGCTCACCCGCAGGGCGATCAAATGGTCCCGGCTGCTGCAGGGCGGGGGCGTCCCCAGGAGCCGGACA GTGAAGCGCTATGTCCGGAAAGGGGTCCCGCTGGAGCACCGTGCCCGCGTCTGGATGGTGCTGAGTGGGGCCCAGGCGCAGATGGACCAG AATCCCGGCTACTACCACCAGCTTCTCCAGGGAGAGAGAAACCCCAGGCTGGAGGACGCCATCAGGACAGACCTGAACCGGACCTTCCCC GACAACGTGAAGTTCCGGAAGACCACGGACCCCTGCTTACAGAGGACCCTGTACAATGTGCTGCTGGCATATGGGCACCATAACCAGGGA GTGGGCTACTGCCAGGGAATGAATTTTATAGCAGGATATCTGATTCTTATAACAAATAATGAAGAAGAATCTTTTTGGCTGTTAGATGCT CTTGTTGGAAGAATACTACCAGGGGAACGAGGCCCACCTGGGAGCCCAGGACTTCAGGGGTTCCCTGGTATCACACCCCCTTCCAACATC TCTGGGGCACCTGGTGACAAAGGGGCGCCAGGGATATTTGGCCTGAAAGGTTATCGGGGCCCACCAGGGCCACCAGGTTCTGCTGCTCTT CCTGGAAGCAAAGGTGACACAGGGAACCCAGGAGCTCCAGGAACCCCAGGGACCAAAGGATGGGCCGGGGACTCCGGGCCCCAGGGCAGG CCTGGTGTGTTTGGTCTCCCAGGAGAAAAAGGGCCCAGGGGTGAACAAGGCTTCATGGGGAACACTGGACCCACTGGGGCGGTGGGCGAC AGAGGCCCCAAGGGACCCAAGGGAGACCCAGGATTCCCTGGTGCCCCCGGGACTGTGGGAGCCCCCGGGATTGCAGGAATCCCCCAGAAG ATTGCCGTCCAACCAGGGACAGTGGGTCCCCAGGGGAGGCGAGGCCCCCCTGGGGCACCGGGGGAGATGGGGCCCCAGGGCCCCCCCGGA GAACCAGGTTTCCGTGGGGCTCCAGGGAAAGCTGGGCCCCAAGGAAGAGGTGGTGTGTCTGCTGTTCCCGGCTTCCGGGGAGATGAAGGA CCCATAGGCCACCAGGGGCCGATTGGCCAAGAAGGTGCACCAGGCCGTCCAGGGAGCCCGGGCCTGCCGGGTATGCCAGGCCGCAGCGTC AGCATCGGCTACCTCCTGGTGAAGCACAGCCAGACGGACCAGGAGCCCATGTGCCCAGTGGGCATGAACAAACTCTGGAGTGGATACAGC CTGCTGTACTTCGAGGGCCAGGAGAAGGCGCACAACCAGGACCTGGGGCTGGCGGGCTCCTGCCTGGCGCGGTTCAGCACCATGCCCTTC CTGTACTGCAACCCTGGTGATGTCTGCTACTATGCCAGCCGGAACGACAAGTCCTACTGGCTCTCTACCACTGCGCCGCTGCCCATGATG CCCGTGGCCGAGGACGAGATCAAGCCCTACATCAGCCGCTGTTCTGTGTGTGAGGCCCCGGCCATCGCCATCGCGGTCCACAGTCAGGAT GTCTCCATCCCACACTGCCCAGCTGGGTGGCGGAGTTTGTGGATCGGATATTCCTTCCTCATGCACACGGCGGCGGGAGACGAAGGCGGT GGCCAATCACTGGTGTCACCGGGCAGCTGTCTAGAGGACTTCCGCGCCACACCATTCATCGAATGCAATGGAGGCCGCGGCACCTGCCAC TACTACGCCAACAAGTACAGCTTCTGGCTGACCACCATTCCCGAGCAGAGCTTCCAGGGCTCGCCCTCCGCCGACACGCTCAAGGCCGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GRTP1_ENST00000375431_chr13_113999178_-_COL4A2_ENST00000360467_chr13_111154015_+_2852nt GGACTTAAGCGCCCCGGAGCCGGGAGGCGAACTTGGGACCCGCTGGCCTCGCTCGGTGCGCGCCTCCCTCCCCGCATGCAGCCCGCCGAG CGCTCGCGGGTCCCCAGGATCGACCCGTACGGATTCGAGCGGCCTGAGGACTTCGACGACGCCGCCTACGAGAAGTTTTTCTCCAGCTAC CTGGTCACGCTCACCCGCAGGGCGATCAAATGGTCCCGGCTGCTGCAGGGCGGGGGCGTCCCCAGGAGCCGGACAGTGAAGCGCTATGTC CGGAAAGGGGTCCCGCTGGAGCACCGTGCCCGCGTCTGGATGGTGCTGAGTGGGGCCCAGGCGCAGATGGACCAGAATCCCGGCTACTAC CACCAGCTTCTCCAGGGAGAGAGAAACCCCAGGCTGGAGGACGCCATCAGGACAGACCTGAACCGGACCTTCCCCGACAACGTGAAGTTC CGGAAGACCACGGACCCCTGCTTACAGAGGACCCTGTACAATGTGCTGCTGGCATATGGGCACCATAACCAGGGAGTGGGCTACTGCCAG GGAATGAATTTTATAGCAGGATATCTGATTCTTATAACAAATAATGAAGAAGAATCTTTTTGGCTGTTAGATGCTCTTGTTGGAAGAATA CTACCAGGGGAACGAGGCCCACCTGGGAGCCCAGGACTTCAGGGGTTCCCTGGTATCACACCCCCTTCCAACATCTCTGGGGCACCTGGT GACAAAGGGGCGCCAGGGATATTTGGCCTGAAAGGTTATCGGGGCCCACCAGGGCCACCAGGTTCTGCTGCTCTTCCTGGAAGCAAAGGT GACACAGGGAACCCAGGAGCTCCAGGAACCCCAGGGACCAAAGGATGGGCCGGGGACTCCGGGCCCCAGGGCAGGCCTGGTGTGTTTGGT CTCCCAGGAGAAAAAGGGCCCAGGGGTGAACAAGGCTTCATGGGGAACACTGGACCCACTGGGGCGGTGGGCGACAGAGGCCCCAAGGGA CCCAAGGGAGACCCAGGATTCCCTGGTGCCCCCGGGACTGTGGGAGCCCCCGGGATTGCAGGAATCCCCCAGAAGATTGCCGTCCAACCA GGGACAGTGGGTCCCCAGGGGAGGCGAGGCCCCCCTGGGGCACCGGGGGAGATGGGGCCCCAGGGCCCCCCCGGAGAACCAGGTTTCCGT GGGGCTCCAGGGAAAGCTGGGCCCCAAGGAAGAGGTGGTGTGTCTGCTGTTCCCGGCTTCCGGGGAGATGAAGGACCCATAGGCCACCAG GGGCCGATTGGCCAAGAAGGTGCACCAGGCCGTCCAGGGAGCCCGGGCCTGCCGGGTATGCCAGGCCGCAGCGTCAGCATCGGCTACCTC CTGGTGAAGCACAGCCAGACGGACCAGGAGCCCATGTGCCCAGTGGGCATGAACAAACTCTGGAGTGGATACAGCCTGCTGTACTTCGAG GGCCAGGAGAAGGCGCACAACCAGGACCTGGGGCTGGCGGGCTCCTGCCTGGCGCGGTTCAGCACCATGCCCTTCCTGTACTGCAACCCT GGTGATGTCTGCTACTATGCCAGCCGGAACGACAAGTCCTACTGGCTCTCTACCACTGCGCCGCTGCCCATGATGCCCGTGGCCGAGGAC GAGATCAAGCCCTACATCAGCCGCTGTTCTGTGTGTGAGGCCCCGGCCATCGCCATCGCGGTCCACAGTCAGGATGTCTCCATCCCACAC TGCCCAGCTGGGTGGCGGAGTTTGTGGATCGGATATTCCTTCCTCATGCACACGGCGGCGGGAGACGAAGGCGGTGGCCAATCACTGGTG TCACCGGGCAGCTGTCTAGAGGACTTCCGCGCCACACCATTCATCGAATGCAATGGAGGCCGCGGCACCTGCCACTACTACGCCAACAAG TACAGCTTCTGGCTGACCACCATTCCCGAGCAGAGCTTCCAGGGCTCGCCCTCCGCCGACACGCTCAAGGCCGGCCTCATCCGCACACAC ATCAGCCGCTGCCAGGTGTGCATGAAGAACCTGTGAGCCGGCGCGTGCCAGGAAGGGCCATTTTGGTGCTTATTCTTAACTTATTACCTC AGGTGCCAACCCAAAAATTGGTTTTATTTTTTTCTTAAAAAAAAAAAAGTCTACCAAAGGAATTTGCATCCAGCAGCAGCACTTAGACCT GCCAGCCACTGTCACCGAGCGGGTGCAAGCACTCGGGGTCCCTGGAGGGCAAGCCCTGCCCACAGAAAGCCAGGAGCAGCCCTGGCCCCC ATCAGCCCTGCTAGACGCACCGCCTGAAGGCACAGCTAACCACTTCGCACACACCCATGTAACCACTGCACTTTCCAATGCCACAGACAA CTCACATTGTTCAACTCCCTTCTCGGGGTGGGACAGACGAGACAACAGCACACAGGCAGCCAGCCGTGGCCAGAGGCTCGAGGGGCTCAG GGCCTCAGGCACCCGTCCCCACACGAGGGCCCCGTGGGTGGGCCTGGCCCTGCTTTCTACGCCAATGTTATGCCAGCTCCATGTTCTCCC AAATACCGTTGATGTGAATTATTTTAAAGGCAAAACCGTGCTCTTTATTTTAAAAAACACTGATAATCACACTGCGGTAGGTCATTCTTT TGCCACATCCCTATAGACCACTGGGTTTGGCAAAACTCAGGCAGAAGTGGAGACCTTTCTAGACATCATTGTCAGCCTTGCTACTTGAAG GTACACCCCATAGGGTCGGAGGTGCTGTCCCCACTGCCCCACGTTGTCCCTGAGATTTAACCCCTCCACTGCTGGGGGTGAGCTGTACTC >In-frame_GRTP1_ENST00000326039_chr13_113999178_-_COL4A2_ENST00000360467_chr13_111154015_+_2551nt GCGTCTGGATGGTGCTGAGTGGGGCCCAGGCGCAGATGGACCAGAATCCCGGCTACTACCACCAGCTTCTCCAGGGAGAGAGAAACCCCA GGCTGGAGGACGCCATCAGGACAGACCTGAACCGGACCTTCCCCGACAACGTGAAGTTCCGGAAGACCACGGACCCCTGCTTACAGAGGA CCCTGTACAATGTGCTGCTGGCATATGGGCACCATAACCAGGGAGTGGGCTACTGCCAGGGAATGAATTTTATAGCAGGATATCTGATTC TTATAACAAATAATGAAGAAGAATCTTTTTGGCTGTTAGATGCTCTTGTTGGAAGAATACTACCAGGGGAACGAGGCCCACCTGGGAGCC CAGGACTTCAGGGGTTCCCTGGTATCACACCCCCTTCCAACATCTCTGGGGCACCTGGTGACAAAGGGGCGCCAGGGATATTTGGCCTGA AAGGTTATCGGGGCCCACCAGGGCCACCAGGTTCTGCTGCTCTTCCTGGAAGCAAAGGTGACACAGGGAACCCAGGAGCTCCAGGAACCC CAGGGACCAAAGGATGGGCCGGGGACTCCGGGCCCCAGGGCAGGCCTGGTGTGTTTGGTCTCCCAGGAGAAAAAGGGCCCAGGGGTGAAC AAGGCTTCATGGGGAACACTGGACCCACTGGGGCGGTGGGCGACAGAGGCCCCAAGGGACCCAAGGGAGACCCAGGATTCCCTGGTGCCC CCGGGACTGTGGGAGCCCCCGGGATTGCAGGAATCCCCCAGAAGATTGCCGTCCAACCAGGGACAGTGGGTCCCCAGGGGAGGCGAGGCC CCCCTGGGGCACCGGGGGAGATGGGGCCCCAGGGCCCCCCCGGAGAACCAGGTTTCCGTGGGGCTCCAGGGAAAGCTGGGCCCCAAGGAA GAGGTGGTGTGTCTGCTGTTCCCGGCTTCCGGGGAGATGAAGGACCCATAGGCCACCAGGGGCCGATTGGCCAAGAAGGTGCACCAGGCC GTCCAGGGAGCCCGGGCCTGCCGGGTATGCCAGGCCGCAGCGTCAGCATCGGCTACCTCCTGGTGAAGCACAGCCAGACGGACCAGGAGC CCATGTGCCCAGTGGGCATGAACAAACTCTGGAGTGGATACAGCCTGCTGTACTTCGAGGGCCAGGAGAAGGCGCACAACCAGGACCTGG GGCTGGCGGGCTCCTGCCTGGCGCGGTTCAGCACCATGCCCTTCCTGTACTGCAACCCTGGTGATGTCTGCTACTATGCCAGCCGGAACG ACAAGTCCTACTGGCTCTCTACCACTGCGCCGCTGCCCATGATGCCCGTGGCCGAGGACGAGATCAAGCCCTACATCAGCCGCTGTTCTG TGTGTGAGGCCCCGGCCATCGCCATCGCGGTCCACAGTCAGGATGTCTCCATCCCACACTGCCCAGCTGGGTGGCGGAGTTTGTGGATCG GATATTCCTTCCTCATGCACACGGCGGCGGGAGACGAAGGCGGTGGCCAATCACTGGTGTCACCGGGCAGCTGTCTAGAGGACTTCCGCG CCACACCATTCATCGAATGCAATGGAGGCCGCGGCACCTGCCACTACTACGCCAACAAGTACAGCTTCTGGCTGACCACCATTCCCGAGC AGAGCTTCCAGGGCTCGCCCTCCGCCGACACGCTCAAGGCCGGCCTCATCCGCACACACATCAGCCGCTGCCAGGTGTGCATGAAGAACC TGTGAGCCGGCGCGTGCCAGGAAGGGCCATTTTGGTGCTTATTCTTAACTTATTACCTCAGGTGCCAACCCAAAAATTGGTTTTATTTTT TTCTTAAAAAAAAAAAAGTCTACCAAAGGAATTTGCATCCAGCAGCAGCACTTAGACCTGCCAGCCACTGTCACCGAGCGGGTGCAAGCA CTCGGGGTCCCTGGAGGGCAAGCCCTGCCCACAGAAAGCCAGGAGCAGCCCTGGCCCCCATCAGCCCTGCTAGACGCACCGCCTGAAGGC ACAGCTAACCACTTCGCACACACCCATGTAACCACTGCACTTTCCAATGCCACAGACAACTCACATTGTTCAACTCCCTTCTCGGGGTGG GACAGACGAGACAACAGCACACAGGCAGCCAGCCGTGGCCAGAGGCTCGAGGGGCTCAGGGCCTCAGGCACCCGTCCCCACACGAGGGCC CCGTGGGTGGGCCTGGCCCTGCTTTCTACGCCAATGTTATGCCAGCTCCATGTTCTCCCAAATACCGTTGATGTGAATTATTTTAAAGGC AAAACCGTGCTCTTTATTTTAAAAAACACTGATAATCACACTGCGGTAGGTCATTCTTTTGCCACATCCCTATAGACCACTGGGTTTGGC AAAACTCAGGCAGAAGTGGAGACCTTTCTAGACATCATTGTCAGCCTTGCTACTTGAAGGTACACCCCATAGGGTCGGAGGTGCTGTCCC CACTGCCCCACGTTGTCCCTGAGATTTAACCCCTCCACTGCTGGGGGTGAGCTGTACTCTTCTGACTGCCCCCTCCTGTGTAACGACTAC >In-frame_GRTP1_ENST00000375430_chr13_113999178_-_COL4A2_ENST00000360467_chr13_111154015_+_2824nt GAACTTGGGACCCGCTGGCCTCGCTCGGTGCGCGCCTCCCTCCCCGCATGCAGCCCGCCGAGCGCTCGCGGGTCCCCAGGATCGACCCGT ACGGATTCGAGCGGCCTGAGGACTTCGACGACGCCGCCTACGAGAAGTTTTTCTCCAGCTACCTGGTCACGCTCACCCGCAGGGCGATCA AATGGTCCCGGCTGCTGCAGGGCGGGGGCGTCCCCAGGAGCCGGACAGTGAAGCGCTATGTCCGGAAAGGGGTCCCGCTGGAGCACCGTG CCCGCGTCTGGATGGTGCTGAGTGGGGCCCAGGCGCAGATGGACCAGAATCCCGGCTACTACCACCAGCTTCTCCAGGGAGAGAGAAACC CCAGGCTGGAGGACGCCATCAGGACAGACCTGAACCGGACCTTCCCCGACAACGTGAAGTTCCGGAAGACCACGGACCCCTGCTTACAGA GGACCCTGTACAATGTGCTGCTGGCATATGGGCACCATAACCAGGGAGTGGGCTACTGCCAGGGAATGAATTTTATAGCAGGATATCTGA TTCTTATAACAAATAATGAAGAAGAATCTTTTTGGCTGTTAGATGCTCTTGTTGGAAGAATACTACCAGGGGAACGAGGCCCACCTGGGA GCCCAGGACTTCAGGGGTTCCCTGGTATCACACCCCCTTCCAACATCTCTGGGGCACCTGGTGACAAAGGGGCGCCAGGGATATTTGGCC TGAAAGGTTATCGGGGCCCACCAGGGCCACCAGGTTCTGCTGCTCTTCCTGGAAGCAAAGGTGACACAGGGAACCCAGGAGCTCCAGGAA CCCCAGGGACCAAAGGATGGGCCGGGGACTCCGGGCCCCAGGGCAGGCCTGGTGTGTTTGGTCTCCCAGGAGAAAAAGGGCCCAGGGGTG AACAAGGCTTCATGGGGAACACTGGACCCACTGGGGCGGTGGGCGACAGAGGCCCCAAGGGACCCAAGGGAGACCCAGGATTCCCTGGTG CCCCCGGGACTGTGGGAGCCCCCGGGATTGCAGGAATCCCCCAGAAGATTGCCGTCCAACCAGGGACAGTGGGTCCCCAGGGGAGGCGAG GCCCCCCTGGGGCACCGGGGGAGATGGGGCCCCAGGGCCCCCCCGGAGAACCAGGTTTCCGTGGGGCTCCAGGGAAAGCTGGGCCCCAAG GAAGAGGTGGTGTGTCTGCTGTTCCCGGCTTCCGGGGAGATGAAGGACCCATAGGCCACCAGGGGCCGATTGGCCAAGAAGGTGCACCAG GCCGTCCAGGGAGCCCGGGCCTGCCGGGTATGCCAGGCCGCAGCGTCAGCATCGGCTACCTCCTGGTGAAGCACAGCCAGACGGACCAGG AGCCCATGTGCCCAGTGGGCATGAACAAACTCTGGAGTGGATACAGCCTGCTGTACTTCGAGGGCCAGGAGAAGGCGCACAACCAGGACC TGGGGCTGGCGGGCTCCTGCCTGGCGCGGTTCAGCACCATGCCCTTCCTGTACTGCAACCCTGGTGATGTCTGCTACTATGCCAGCCGGA ACGACAAGTCCTACTGGCTCTCTACCACTGCGCCGCTGCCCATGATGCCCGTGGCCGAGGACGAGATCAAGCCCTACATCAGCCGCTGTT CTGTGTGTGAGGCCCCGGCCATCGCCATCGCGGTCCACAGTCAGGATGTCTCCATCCCACACTGCCCAGCTGGGTGGCGGAGTTTGTGGA TCGGATATTCCTTCCTCATGCACACGGCGGCGGGAGACGAAGGCGGTGGCCAATCACTGGTGTCACCGGGCAGCTGTCTAGAGGACTTCC GCGCCACACCATTCATCGAATGCAATGGAGGCCGCGGCACCTGCCACTACTACGCCAACAAGTACAGCTTCTGGCTGACCACCATTCCCG AGCAGAGCTTCCAGGGCTCGCCCTCCGCCGACACGCTCAAGGCCGGCCTCATCCGCACACACATCAGCCGCTGCCAGGTGTGCATGAAGA ACCTGTGAGCCGGCGCGTGCCAGGAAGGGCCATTTTGGTGCTTATTCTTAACTTATTACCTCAGGTGCCAACCCAAAAATTGGTTTTATT TTTTTCTTAAAAAAAAAAAAGTCTACCAAAGGAATTTGCATCCAGCAGCAGCACTTAGACCTGCCAGCCACTGTCACCGAGCGGGTGCAA GCACTCGGGGTCCCTGGAGGGCAAGCCCTGCCCACAGAAAGCCAGGAGCAGCCCTGGCCCCCATCAGCCCTGCTAGACGCACCGCCTGAA GGCACAGCTAACCACTTCGCACACACCCATGTAACCACTGCACTTTCCAATGCCACAGACAACTCACATTGTTCAACTCCCTTCTCGGGG TGGGACAGACGAGACAACAGCACACAGGCAGCCAGCCGTGGCCAGAGGCTCGAGGGGCTCAGGGCCTCAGGCACCCGTCCCCACACGAGG GCCCCGTGGGTGGGCCTGGCCCTGCTTTCTACGCCAATGTTATGCCAGCTCCATGTTCTCCCAAATACCGTTGATGTGAATTATTTTAAA GGCAAAACCGTGCTCTTTATTTTAAAAAACACTGATAATCACACTGCGGTAGGTCATTCTTTTGCCACATCCCTATAGACCACTGGGTTT GGCAAAACTCAGGCAGAAGTGGAGACCTTTCTAGACATCATTGTCAGCCTTGCTACTTGAAGGTACACCCCATAGGGTCGGAGGTGCTGT CCCCACTGCCCCACGTTGTCCCTGAGATTTAACCCCTCCACTGCTGGGGGTGAGCTGTACTCTTCTGACTGCCCCCTCCTGTGTAACGAC |
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FusionGenePPI for GRTP1_COL4A2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GRTP1 | NES, PCDHGC3, GJB7, FAM63A, UBB, ATP2A1 | COL4A2 | COL4A2, COL4A1, CSNK2B, DAZAP2, TK1, SMN1, ANXA7, VHL, SKIL, FAM46A, FBXO6, C1QB, C1QTNF2, CELA2B, FGL1, ITLN2, COL9A1, C1QTNF9, STBD1, SERPINA6, TMEM25, SEMG1, PTPRK, COL8A2, CLPSL1, TNPO3, PLOD1, COLGALT2, MMP9, MMP2, FKBP9, LYG2, COL10A1, COLQ, CRP, MSR1, IFNA21 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GRTP1_COL4A2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GRTP1_COL4A2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | COL4A2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | COL4A2 | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
| Tgene | COL4A2 | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
| Tgene | COL4A2 | C3280970 | PORENCEPHALY 2 | 1 | UNIPROT |
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