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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15494

FusionGeneSummary for GRSF1_ELFN2

check button Fusion gene summary
Fusion gene informationFusion gene name: GRSF1_ELFN2
Fusion gene ID: 15494
HgeneTgene
Gene symbol

GRSF1

ELFN2

Gene ID

2926

114794

Gene nameG-rich RNA sequence binding factor 1extracellular leucine rich repeat and fibronectin type III domain containing 2
Synonyms-LRRC62|PPP1R29
Cytomap

4q13.3

22q13.1

Type of geneprotein-codingprotein-coding
DescriptionG-rich sequence factor 1GRSF-1protein phosphatase 1 regulatory subunit 29dJ63G5.3 (putative Leucine rich protein)leucine-rich repeat and fibronectin type-III domain-containing protein 6leucine-rich repeat-containing protein 62
Modification date2018051920180523
UniProtAcc

Q12849

Q5R3F8

Ensembl transtripts involved in fusion geneENST00000254799, ENST00000439371, 
ENST00000502323, ENST00000545193, 
ENST00000508091, 
ENST00000402918, 
ENST00000435824, 
Fusion gene scores* DoF score4 X 4 X 2=321 X 1 X 1=1
# samples 41
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: GRSF1 [Title/Abstract] AND ELFN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneELFN2

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCOADTCGA-RU-A8FL-01AGRSF1chr4

71698024

-ELFN2chr22

37772036

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000254799ENST00000402918GRSF1chr4

71698024

-ELFN2chr22

37772036

-
5CDS-5UTRENST00000254799ENST00000435824GRSF1chr4

71698024

-ELFN2chr22

37772036

-
5CDS-5UTRENST00000439371ENST00000402918GRSF1chr4

71698024

-ELFN2chr22

37772036

-
5CDS-5UTRENST00000439371ENST00000435824GRSF1chr4

71698024

-ELFN2chr22

37772036

-
5CDS-5UTRENST00000502323ENST00000402918GRSF1chr4

71698024

-ELFN2chr22

37772036

-
5CDS-5UTRENST00000502323ENST00000435824GRSF1chr4

71698024

-ELFN2chr22

37772036

-
5CDS-5UTRENST00000545193ENST00000402918GRSF1chr4

71698024

-ELFN2chr22

37772036

-
5CDS-5UTRENST00000545193ENST00000435824GRSF1chr4

71698024

-ELFN2chr22

37772036

-
intron-5UTRENST00000508091ENST00000402918GRSF1chr4

71698024

-ELFN2chr22

37772036

-
intron-5UTRENST00000508091ENST00000435824GRSF1chr4

71698024

-ELFN2chr22

37772036

-

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FusionProtFeatures for GRSF1_ELFN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRSF1

Q12849

ELFN2

Q5R3F8

Regulator of post-transcriptional mitochondrial geneexpression, required for assembly of the mitochondrial ribosomeand for recruitment of mRNA and lncRNA. Binds RNAs containing the14 base G-rich element. Preferentially binds RNAs transcribed fromthree contiguous genes on the light strand of mtDNA, the ND6 mRNA,and the long non-coding RNAs for MT-CYB and MT-ND5, each of whichcontains multiple consensus binding sequences.{ECO:0000269|PubMed:23473033, ECO:0000269|PubMed:23473034}. Inhibits phosphatase activity of protein phosphatase 1(PP1) complexes. {ECO:0000269|PubMed:19389623}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GRSF1_ELFN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GRSF1_ELFN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GRSF1ICT1, CUL3, CUL5, CUL2, CUL1, CAND1, TARDBP, TRMT10C, HSD17B10, MRPS26, MRPL11, TFAM, NME4, MRPS25, HSPA9, RPL28, RPL14, MRPS34, MRPS22, MRPL47, RNMTL1, MRPL48, MRPS7, ATP5B, ATP5O, HADHA, C1QBP, HARS2, MRPS15, MRPS2, DHX30, PTCD3, MRPL24, MRPS27, MTPAP, MRPL2, MRPL21, DAP3, MRPL4, PNPT1, MRPL28, MDH2, MRPS28, MRPS31, ACOT9, PSMD10, NXF1, RPS6KA2, IARS2, NF2, CHCHD2, CISD3, PTP4A1, IGHMBP2, PTPN2, CYLD, TRIM25ELFN2CDH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GRSF1_ELFN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GRSF1_ELFN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource