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Fusion gene ID: 15494 |
FusionGeneSummary for GRSF1_ELFN2 |
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Fusion gene information | Fusion gene name: GRSF1_ELFN2 | Fusion gene ID: 15494 | Hgene | Tgene | Gene symbol | GRSF1 | ELFN2 | Gene ID | 2926 | 114794 |
Gene name | G-rich RNA sequence binding factor 1 | extracellular leucine rich repeat and fibronectin type III domain containing 2 | |
Synonyms | - | LRRC62|PPP1R29 | |
Cytomap | 4q13.3 | 22q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | G-rich sequence factor 1GRSF-1 | protein phosphatase 1 regulatory subunit 29dJ63G5.3 (putative Leucine rich protein)leucine-rich repeat and fibronectin type-III domain-containing protein 6leucine-rich repeat-containing protein 62 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q12849 | Q5R3F8 | |
Ensembl transtripts involved in fusion gene | ENST00000254799, ENST00000439371, ENST00000502323, ENST00000545193, ENST00000508091, | ENST00000402918, ENST00000435824, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 1 X 1 X 1=1 |
# samples | 4 | 1 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: GRSF1 [Title/Abstract] AND ELFN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ELFN2 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | COAD | TCGA-RU-A8FL-01A | GRSF1 | chr4 | 71698024 | - | ELFN2 | chr22 | 37772036 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000254799 | ENST00000402918 | GRSF1 | chr4 | 71698024 | - | ELFN2 | chr22 | 37772036 | - |
5CDS-5UTR | ENST00000254799 | ENST00000435824 | GRSF1 | chr4 | 71698024 | - | ELFN2 | chr22 | 37772036 | - |
5CDS-5UTR | ENST00000439371 | ENST00000402918 | GRSF1 | chr4 | 71698024 | - | ELFN2 | chr22 | 37772036 | - |
5CDS-5UTR | ENST00000439371 | ENST00000435824 | GRSF1 | chr4 | 71698024 | - | ELFN2 | chr22 | 37772036 | - |
5CDS-5UTR | ENST00000502323 | ENST00000402918 | GRSF1 | chr4 | 71698024 | - | ELFN2 | chr22 | 37772036 | - |
5CDS-5UTR | ENST00000502323 | ENST00000435824 | GRSF1 | chr4 | 71698024 | - | ELFN2 | chr22 | 37772036 | - |
5CDS-5UTR | ENST00000545193 | ENST00000402918 | GRSF1 | chr4 | 71698024 | - | ELFN2 | chr22 | 37772036 | - |
5CDS-5UTR | ENST00000545193 | ENST00000435824 | GRSF1 | chr4 | 71698024 | - | ELFN2 | chr22 | 37772036 | - |
intron-5UTR | ENST00000508091 | ENST00000402918 | GRSF1 | chr4 | 71698024 | - | ELFN2 | chr22 | 37772036 | - |
intron-5UTR | ENST00000508091 | ENST00000435824 | GRSF1 | chr4 | 71698024 | - | ELFN2 | chr22 | 37772036 | - |
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FusionProtFeatures for GRSF1_ELFN2 |
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Hgene | Tgene |
GRSF1 | ELFN2 |
Regulator of post-transcriptional mitochondrial geneexpression, required for assembly of the mitochondrial ribosomeand for recruitment of mRNA and lncRNA. Binds RNAs containing the14 base G-rich element. Preferentially binds RNAs transcribed fromthree contiguous genes on the light strand of mtDNA, the ND6 mRNA,and the long non-coding RNAs for MT-CYB and MT-ND5, each of whichcontains multiple consensus binding sequences.{ECO:0000269|PubMed:23473033, ECO:0000269|PubMed:23473034}. | Inhibits phosphatase activity of protein phosphatase 1(PP1) complexes. {ECO:0000269|PubMed:19389623}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GRSF1_ELFN2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GRSF1_ELFN2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GRSF1 | ICT1, CUL3, CUL5, CUL2, CUL1, CAND1, TARDBP, TRMT10C, HSD17B10, MRPS26, MRPL11, TFAM, NME4, MRPS25, HSPA9, RPL28, RPL14, MRPS34, MRPS22, MRPL47, RNMTL1, MRPL48, MRPS7, ATP5B, ATP5O, HADHA, C1QBP, HARS2, MRPS15, MRPS2, DHX30, PTCD3, MRPL24, MRPS27, MTPAP, MRPL2, MRPL21, DAP3, MRPL4, PNPT1, MRPL28, MDH2, MRPS28, MRPS31, ACOT9, PSMD10, NXF1, RPS6KA2, IARS2, NF2, CHCHD2, CISD3, PTP4A1, IGHMBP2, PTPN2, CYLD, TRIM25 | ELFN2 | CDH1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GRSF1_ELFN2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GRSF1_ELFN2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |