![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 15492 |
FusionGeneSummary for GRSF1_CIAO1 |
![]() |
Fusion gene information | Fusion gene name: GRSF1_CIAO1 | Fusion gene ID: 15492 | Hgene | Tgene | Gene symbol | GRSF1 | CIAO1 | Gene ID | 2926 | 9391 |
Gene name | G-rich RNA sequence binding factor 1 | cytosolic iron-sulfur assembly component 1 | |
Synonyms | - | CIA1|WDR39 | |
Cytomap | 4q13.3 | 2q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | G-rich sequence factor 1GRSF-1 | probable cytosolic iron-sulfur protein assembly protein CIAO1WD repeat domain 39WD repeat-containing protein 39WD40 protein Ciao1cytosolic iron-sulfur protein assembly 1 homolog | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q12849 | O76071 | |
Ensembl transtripts involved in fusion gene | ENST00000254799, ENST00000439371, ENST00000502323, ENST00000545193, ENST00000508091, | ENST00000488633, ENST00000469320, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 5 X 5 X 2=50 |
# samples | 4 | 5 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/50*10)=0 | |
Context | PubMed: GRSF1 [Title/Abstract] AND CIAO1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW779166 | GRSF1 | chr4 | 71698910 | - | CIAO1 | chr2 | 96938508 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000254799 | ENST00000488633 | GRSF1 | chr4 | 71698910 | - | CIAO1 | chr2 | 96938508 | + |
intron-intron | ENST00000254799 | ENST00000469320 | GRSF1 | chr4 | 71698910 | - | CIAO1 | chr2 | 96938508 | + |
intron-intron | ENST00000439371 | ENST00000488633 | GRSF1 | chr4 | 71698910 | - | CIAO1 | chr2 | 96938508 | + |
intron-intron | ENST00000439371 | ENST00000469320 | GRSF1 | chr4 | 71698910 | - | CIAO1 | chr2 | 96938508 | + |
intron-intron | ENST00000502323 | ENST00000488633 | GRSF1 | chr4 | 71698910 | - | CIAO1 | chr2 | 96938508 | + |
intron-intron | ENST00000502323 | ENST00000469320 | GRSF1 | chr4 | 71698910 | - | CIAO1 | chr2 | 96938508 | + |
intron-intron | ENST00000545193 | ENST00000488633 | GRSF1 | chr4 | 71698910 | - | CIAO1 | chr2 | 96938508 | + |
intron-intron | ENST00000545193 | ENST00000469320 | GRSF1 | chr4 | 71698910 | - | CIAO1 | chr2 | 96938508 | + |
intron-intron | ENST00000508091 | ENST00000488633 | GRSF1 | chr4 | 71698910 | - | CIAO1 | chr2 | 96938508 | + |
intron-intron | ENST00000508091 | ENST00000469320 | GRSF1 | chr4 | 71698910 | - | CIAO1 | chr2 | 96938508 | + |
Top |
FusionProtFeatures for GRSF1_CIAO1 |
![]() |
Hgene | Tgene |
GRSF1 | CIAO1 |
Regulator of post-transcriptional mitochondrial geneexpression, required for assembly of the mitochondrial ribosomeand for recruitment of mRNA and lncRNA. Binds RNAs containing the14 base G-rich element. Preferentially binds RNAs transcribed fromthree contiguous genes on the light strand of mtDNA, the ND6 mRNA,and the long non-coding RNAs for MT-CYB and MT-ND5, each of whichcontains multiple consensus binding sequences.{ECO:0000269|PubMed:23473033, ECO:0000269|PubMed:23473034}. | Key component of the cytosolic iron-sulfur proteinassembly (CIA) complex, a multiprotein complex that mediates theincorporation of iron-sulfur cluster into extramitochondrial Fe/Sproteins. Seems to specifically modulate the transactivationactivity of WT1. As part of the mitotic spindle-associated MMXDcomplex it may play a role in chromosome segregation.{ECO:0000255|HAMAP-Rule:MF_03037, ECO:0000269|PubMed:17937914,ECO:0000269|PubMed:20797633}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for GRSF1_CIAO1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for GRSF1_CIAO1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for GRSF1_CIAO1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for GRSF1_CIAO1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |