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Fusion gene ID: 15469 |
FusionGeneSummary for GRM3_ABCB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRM3_ABCB1 | Fusion gene ID: 15469 | Hgene | Tgene | Gene symbol | GRM3 | ABCB1 | Gene ID | 2913 | 5243 |
| Gene name | glutamate metabotropic receptor 3 | ATP binding cassette subfamily B member 1 | |
| Synonyms | GLUR3|GPRC1C|MGLUR3|mGlu3 | ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1 | |
| Cytomap | 7q21.11-q21.12 | 7q21.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | metabotropic glutamate receptor 3glutamate receptor, metabotropic 3 | multidrug resistance protein 1ATP-binding cassette, sub-family B (MDR/TAP), member 1P glycoproteinP-glycoprotein 1colchicin sensitivitydoxorubicin resistance | |
| Modification date | 20180524 | 20180527 | |
| UniProtAcc | Q14832 | P08183 | |
| Ensembl transtripts involved in fusion gene | ENST00000361669, ENST00000546348, ENST00000536043, ENST00000439827, ENST00000394720, | ENST00000265724, ENST00000543898, ENST00000488737, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 3=48 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GRM3 [Title/Abstract] AND ABCB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ABCB1 | GO:0000086 | G2/M transition of mitotic cell cycle | 19384922 |
| Tgene | ABCB1 | GO:0045332 | phospholipid translocation | 8898203 |
| Tgene | ABCB1 | GO:0099040 | ceramide translocation | 8898203 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AF345337 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000361669 | ENST00000265724 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
| intron-intron | ENST00000361669 | ENST00000543898 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
| intron-intron | ENST00000361669 | ENST00000488737 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
| intron-5UTR | ENST00000546348 | ENST00000265724 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
| intron-intron | ENST00000546348 | ENST00000543898 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
| intron-intron | ENST00000546348 | ENST00000488737 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
| intron-5UTR | ENST00000536043 | ENST00000265724 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
| intron-intron | ENST00000536043 | ENST00000543898 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
| intron-intron | ENST00000536043 | ENST00000488737 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
| intron-5UTR | ENST00000439827 | ENST00000265724 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
| intron-intron | ENST00000439827 | ENST00000543898 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
| intron-intron | ENST00000439827 | ENST00000488737 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
| intron-5UTR | ENST00000394720 | ENST00000265724 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
| intron-intron | ENST00000394720 | ENST00000543898 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
| intron-intron | ENST00000394720 | ENST00000488737 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
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FusionProtFeatures for GRM3_ABCB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRM3 | ABCB1 |
| G-protein coupled receptor for glutamate. Ligand bindingcauses a conformation change that triggers signaling via guaninenucleotide-binding proteins (G proteins) and modulates theactivity of down-stream effectors. Signaling inhibits adenylatecyclase activity. {ECO:0000269|PubMed:8840013}. | Energy-dependent efflux pump responsible for decreaseddrug accumulation in multidrug-resistant cells. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GRM3_ABCB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GRM3_ABCB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GRM3_ABCB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | ABCB1 | P08183 | DB09031 | Miltefosine | Multidrug resistance protein 1 | small molecule | approved|investigational |
| Tgene | ABCB1 | P08183 | DB00778 | Roxithromycin | Multidrug resistance protein 1 | small molecule | approved|investigational|withdrawn |
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RelatedDiseases for GRM3_ABCB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GRM3 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| Hgene | GRM3 | C0025202 | melanoma | 2 | CTD_human |
| Hgene | GRM3 | C0525045 | Mood Disorders | 2 | PSYGENET |
| Hgene | GRM3 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Hgene | GRM3 | C0014556 | Epilepsy, Temporal Lobe | 1 | CTD_human |
| Hgene | GRM3 | C0036341 | Schizophrenia | 1 | CTD_human |
| Hgene | GRM3 | C0858355 | addicted to cocaine | 1 | PSYGENET |
| Tgene | ABCB1 | C0011570 | Mental Depression | 5 | PSYGENET |
| Tgene | ABCB1 | C0011581 | Depressive disorder | 5 | PSYGENET |
| Tgene | ABCB1 | C0041696 | Unipolar Depression | 5 | PSYGENET |
| Tgene | ABCB1 | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
| Tgene | ABCB1 | C0036341 | Schizophrenia | 4 | PSYGENET |
| Tgene | ABCB1 | C0041755 | Adverse reaction to drug | 4 | CTD_human |
| Tgene | ABCB1 | C0003873 | Rheumatoid Arthritis | 2 | CTD_human |
| Tgene | ABCB1 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Tgene | ABCB1 | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
| Tgene | ABCB1 | C0014544 | Epilepsy | 2 | CTD_human |
| Tgene | ABCB1 | C0027765 | nervous system disorder | 2 | CTD_human |
| Tgene | ABCB1 | C0027947 | Neutropenia | 2 | CTD_human |
| Tgene | ABCB1 | C0004936 | Mental disorders | 1 | CTD_human |
| Tgene | ABCB1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | ABCB1 | C0014836 | Escherichia coli Infections | 1 | CTD_human |
| Tgene | ABCB1 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| Tgene | ABCB1 | C0018798 | Congenital Heart Defects | 1 | CTD_human |
| Tgene | ABCB1 | C0020651 | Hypotension, Orthostatic | 1 | CTD_human |
| Tgene | ABCB1 | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| Tgene | ABCB1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | ABCB1 | C0024809 | Marijuana Abuse | 1 | CTD_human |
| Tgene | ABCB1 | C0027497 | Nausea | 1 | CTD_human |
| Tgene | ABCB1 | C0027609 | Neonatal Abstinence Syndrome | 1 | PSYGENET |
| Tgene | ABCB1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | ABCB1 | C0027819 | Neuroblastoma | 1 | CTD_human |
| Tgene | ABCB1 | C0030201 | Pain, Postoperative | 1 | CTD_human |
| Tgene | ABCB1 | C0030567 | Parkinson Disease | 1 | CTD_human |
| Tgene | ABCB1 | C0030569 | Secondary Parkinson Disease | 1 | CTD_human |
| Tgene | ABCB1 | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| Tgene | ABCB1 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Tgene | ABCB1 | C0040715 | Chromosomal translocation | 1 | CTD_human |
| Tgene | ABCB1 | C0042963 | Vomiting | 1 | CTD_human |
| Tgene | ABCB1 | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
| Tgene | ABCB1 | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
| Tgene | ABCB1 | C0235032 | Neurotoxicity Syndromes | 1 | CTD_human |
| Tgene | ABCB1 | C0338831 | Manic | 1 | PSYGENET |
| Tgene | ABCB1 | C0376545 | Hematologic Neoplasms | 1 | CTD_human |
| Tgene | ABCB1 | C0993582 | Arthritis, Experimental | 1 | CTD_human |
| Tgene | ABCB1 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
| Tgene | ABCB1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | ABCB1 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
| Tgene | ABCB1 | C2239176 | Liver carcinoma | 1 | CTD_human |
| Tgene | ABCB1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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