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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15469

FusionGeneSummary for GRM3_ABCB1

check button Fusion gene summary
Fusion gene informationFusion gene name: GRM3_ABCB1
Fusion gene ID: 15469
HgeneTgene
Gene symbol

GRM3

ABCB1

Gene ID

2913

5243

Gene nameglutamate metabotropic receptor 3ATP binding cassette subfamily B member 1
SynonymsGLUR3|GPRC1C|MGLUR3|mGlu3ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1
Cytomap

7q21.11-q21.12

7q21.12

Type of geneprotein-codingprotein-coding
Descriptionmetabotropic glutamate receptor 3glutamate receptor, metabotropic 3multidrug resistance protein 1ATP-binding cassette, sub-family B (MDR/TAP), member 1P glycoproteinP-glycoprotein 1colchicin sensitivitydoxorubicin resistance
Modification date2018052420180527
UniProtAcc

Q14832

P08183

Ensembl transtripts involved in fusion geneENST00000361669, ENST00000546348, 
ENST00000536043, ENST00000439827, 
ENST00000394720, 
ENST00000265724, 
ENST00000543898, ENST00000488737, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 3=48
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRM3 [Title/Abstract] AND ABCB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneABCB1

GO:0000086

G2/M transition of mitotic cell cycle

19384922

TgeneABCB1

GO:0045332

phospholipid translocation

8898203

TgeneABCB1

GO:0099040

ceramide translocation

8898203


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF345337GRM3chr7

86331484

-ABCB1chr7

87230396

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000361669ENST00000265724GRM3chr7

86331484

-ABCB1chr7

87230396

-
intron-intronENST00000361669ENST00000543898GRM3chr7

86331484

-ABCB1chr7

87230396

-
intron-intronENST00000361669ENST00000488737GRM3chr7

86331484

-ABCB1chr7

87230396

-
intron-5UTRENST00000546348ENST00000265724GRM3chr7

86331484

-ABCB1chr7

87230396

-
intron-intronENST00000546348ENST00000543898GRM3chr7

86331484

-ABCB1chr7

87230396

-
intron-intronENST00000546348ENST00000488737GRM3chr7

86331484

-ABCB1chr7

87230396

-
intron-5UTRENST00000536043ENST00000265724GRM3chr7

86331484

-ABCB1chr7

87230396

-
intron-intronENST00000536043ENST00000543898GRM3chr7

86331484

-ABCB1chr7

87230396

-
intron-intronENST00000536043ENST00000488737GRM3chr7

86331484

-ABCB1chr7

87230396

-
intron-5UTRENST00000439827ENST00000265724GRM3chr7

86331484

-ABCB1chr7

87230396

-
intron-intronENST00000439827ENST00000543898GRM3chr7

86331484

-ABCB1chr7

87230396

-
intron-intronENST00000439827ENST00000488737GRM3chr7

86331484

-ABCB1chr7

87230396

-
intron-5UTRENST00000394720ENST00000265724GRM3chr7

86331484

-ABCB1chr7

87230396

-
intron-intronENST00000394720ENST00000543898GRM3chr7

86331484

-ABCB1chr7

87230396

-
intron-intronENST00000394720ENST00000488737GRM3chr7

86331484

-ABCB1chr7

87230396

-

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FusionProtFeatures for GRM3_ABCB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRM3

Q14832

ABCB1

P08183

G-protein coupled receptor for glutamate. Ligand bindingcauses a conformation change that triggers signaling via guaninenucleotide-binding proteins (G proteins) and modulates theactivity of down-stream effectors. Signaling inhibits adenylatecyclase activity. {ECO:0000269|PubMed:8840013}. Energy-dependent efflux pump responsible for decreaseddrug accumulation in multidrug-resistant cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GRM3_ABCB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GRM3_ABCB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GRM3_ABCB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneABCB1P08183DB09031MiltefosineMultidrug resistance protein 1small moleculeapproved|investigational
TgeneABCB1P08183DB00778RoxithromycinMultidrug resistance protein 1small moleculeapproved|investigational|withdrawn

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RelatedDiseases for GRM3_ABCB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRM3C0005586Bipolar Disorder5PSYGENET
HgeneGRM3C0025202melanoma2CTD_human
HgeneGRM3C0525045Mood Disorders2PSYGENET
HgeneGRM3C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneGRM3C0014556Epilepsy, Temporal Lobe1CTD_human
HgeneGRM3C0036341Schizophrenia1CTD_human
HgeneGRM3C0858355addicted to cocaine1PSYGENET
TgeneABCB1C0011570Mental Depression5PSYGENET
TgeneABCB1C0011581Depressive disorder5PSYGENET
TgeneABCB1C0041696Unipolar Depression5PSYGENET
TgeneABCB1C1269683Major Depressive Disorder5PSYGENET
TgeneABCB1C0036341Schizophrenia4PSYGENET
TgeneABCB1C0041755Adverse reaction to drug4CTD_human
TgeneABCB1C0003873Rheumatoid Arthritis2CTD_human
TgeneABCB1C0005586Bipolar Disorder2PSYGENET
TgeneABCB1C0009404Colorectal Neoplasms2CTD_human
TgeneABCB1C0014544Epilepsy2CTD_human
TgeneABCB1C0027765nervous system disorder2CTD_human
TgeneABCB1C0027947Neutropenia2CTD_human
TgeneABCB1C0004936Mental disorders1CTD_human
TgeneABCB1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneABCB1C0014836Escherichia coli Infections1CTD_human
TgeneABCB1C0014859Esophageal Neoplasms1CTD_human
TgeneABCB1C0018798Congenital Heart Defects1CTD_human
TgeneABCB1C0020651Hypotension, Orthostatic1CTD_human
TgeneABCB1C0022665Kidney Neoplasm1CTD_human
TgeneABCB1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneABCB1C0024809Marijuana Abuse1CTD_human
TgeneABCB1C0027497Nausea1CTD_human
TgeneABCB1C0027609Neonatal Abstinence Syndrome1PSYGENET
TgeneABCB1C0027627Neoplasm Metastasis1CTD_human
TgeneABCB1C0027819Neuroblastoma1CTD_human
TgeneABCB1C0030201Pain, Postoperative1CTD_human
TgeneABCB1C0030567Parkinson Disease1CTD_human
TgeneABCB1C0030569Secondary Parkinson Disease1CTD_human
TgeneABCB1C0031117Peripheral Neuropathy1CTD_human
TgeneABCB1C0033975Psychotic Disorders1PSYGENET
TgeneABCB1C0040715Chromosomal translocation1CTD_human
TgeneABCB1C0042963Vomiting1CTD_human
TgeneABCB1C0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneABCB1C0206686Adrenocortical carcinoma1CTD_human
TgeneABCB1C0235032Neurotoxicity Syndromes1CTD_human
TgeneABCB1C0338831Manic1PSYGENET
TgeneABCB1C0376545Hematologic Neoplasms1CTD_human
TgeneABCB1C0993582Arthritis, Experimental1CTD_human
TgeneABCB1C1168401Squamous cell carcinoma of the head and neck1CTD_human
TgeneABCB1C1458155Mammary Neoplasms1CTD_human
TgeneABCB1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneABCB1C2239176Liver carcinoma1CTD_human
TgeneABCB1C4277682Chemical and Drug Induced Liver Injury1CTD_human