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Fusion gene ID: 15469 |
FusionGeneSummary for GRM3_ABCB1 |
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Fusion gene information | Fusion gene name: GRM3_ABCB1 | Fusion gene ID: 15469 | Hgene | Tgene | Gene symbol | GRM3 | ABCB1 | Gene ID | 2913 | 5243 |
Gene name | glutamate metabotropic receptor 3 | ATP binding cassette subfamily B member 1 | |
Synonyms | GLUR3|GPRC1C|MGLUR3|mGlu3 | ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1 | |
Cytomap | 7q21.11-q21.12 | 7q21.12 | |
Type of gene | protein-coding | protein-coding | |
Description | metabotropic glutamate receptor 3glutamate receptor, metabotropic 3 | multidrug resistance protein 1ATP-binding cassette, sub-family B (MDR/TAP), member 1P glycoproteinP-glycoprotein 1colchicin sensitivitydoxorubicin resistance | |
Modification date | 20180524 | 20180527 | |
UniProtAcc | Q14832 | P08183 | |
Ensembl transtripts involved in fusion gene | ENST00000361669, ENST00000546348, ENST00000536043, ENST00000439827, ENST00000394720, | ENST00000265724, ENST00000543898, ENST00000488737, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 3=48 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GRM3 [Title/Abstract] AND ABCB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ABCB1 | GO:0000086 | G2/M transition of mitotic cell cycle | 19384922 |
Tgene | ABCB1 | GO:0045332 | phospholipid translocation | 8898203 |
Tgene | ABCB1 | GO:0099040 | ceramide translocation | 8898203 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AF345337 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000361669 | ENST00000265724 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
intron-intron | ENST00000361669 | ENST00000543898 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
intron-intron | ENST00000361669 | ENST00000488737 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
intron-5UTR | ENST00000546348 | ENST00000265724 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
intron-intron | ENST00000546348 | ENST00000543898 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
intron-intron | ENST00000546348 | ENST00000488737 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
intron-5UTR | ENST00000536043 | ENST00000265724 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
intron-intron | ENST00000536043 | ENST00000543898 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
intron-intron | ENST00000536043 | ENST00000488737 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
intron-5UTR | ENST00000439827 | ENST00000265724 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
intron-intron | ENST00000439827 | ENST00000543898 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
intron-intron | ENST00000439827 | ENST00000488737 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
intron-5UTR | ENST00000394720 | ENST00000265724 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
intron-intron | ENST00000394720 | ENST00000543898 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
intron-intron | ENST00000394720 | ENST00000488737 | GRM3 | chr7 | 86331484 | - | ABCB1 | chr7 | 87230396 | - |
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FusionProtFeatures for GRM3_ABCB1 |
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Hgene | Tgene |
GRM3 | ABCB1 |
G-protein coupled receptor for glutamate. Ligand bindingcauses a conformation change that triggers signaling via guaninenucleotide-binding proteins (G proteins) and modulates theactivity of down-stream effectors. Signaling inhibits adenylatecyclase activity. {ECO:0000269|PubMed:8840013}. | Energy-dependent efflux pump responsible for decreaseddrug accumulation in multidrug-resistant cells. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GRM3_ABCB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GRM3_ABCB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GRM3_ABCB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | ABCB1 | P08183 | DB09031 | Miltefosine | Multidrug resistance protein 1 | small molecule | approved|investigational |
Tgene | ABCB1 | P08183 | DB00778 | Roxithromycin | Multidrug resistance protein 1 | small molecule | approved|investigational|withdrawn |
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RelatedDiseases for GRM3_ABCB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GRM3 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
Hgene | GRM3 | C0025202 | melanoma | 2 | CTD_human |
Hgene | GRM3 | C0525045 | Mood Disorders | 2 | PSYGENET |
Hgene | GRM3 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | GRM3 | C0014556 | Epilepsy, Temporal Lobe | 1 | CTD_human |
Hgene | GRM3 | C0036341 | Schizophrenia | 1 | CTD_human |
Hgene | GRM3 | C0858355 | addicted to cocaine | 1 | PSYGENET |
Tgene | ABCB1 | C0011570 | Mental Depression | 5 | PSYGENET |
Tgene | ABCB1 | C0011581 | Depressive disorder | 5 | PSYGENET |
Tgene | ABCB1 | C0041696 | Unipolar Depression | 5 | PSYGENET |
Tgene | ABCB1 | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
Tgene | ABCB1 | C0036341 | Schizophrenia | 4 | PSYGENET |
Tgene | ABCB1 | C0041755 | Adverse reaction to drug | 4 | CTD_human |
Tgene | ABCB1 | C0003873 | Rheumatoid Arthritis | 2 | CTD_human |
Tgene | ABCB1 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Tgene | ABCB1 | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
Tgene | ABCB1 | C0014544 | Epilepsy | 2 | CTD_human |
Tgene | ABCB1 | C0027765 | nervous system disorder | 2 | CTD_human |
Tgene | ABCB1 | C0027947 | Neutropenia | 2 | CTD_human |
Tgene | ABCB1 | C0004936 | Mental disorders | 1 | CTD_human |
Tgene | ABCB1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Tgene | ABCB1 | C0014836 | Escherichia coli Infections | 1 | CTD_human |
Tgene | ABCB1 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Tgene | ABCB1 | C0018798 | Congenital Heart Defects | 1 | CTD_human |
Tgene | ABCB1 | C0020651 | Hypotension, Orthostatic | 1 | CTD_human |
Tgene | ABCB1 | C0022665 | Kidney Neoplasm | 1 | CTD_human |
Tgene | ABCB1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | ABCB1 | C0024809 | Marijuana Abuse | 1 | CTD_human |
Tgene | ABCB1 | C0027497 | Nausea | 1 | CTD_human |
Tgene | ABCB1 | C0027609 | Neonatal Abstinence Syndrome | 1 | PSYGENET |
Tgene | ABCB1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | ABCB1 | C0027819 | Neuroblastoma | 1 | CTD_human |
Tgene | ABCB1 | C0030201 | Pain, Postoperative | 1 | CTD_human |
Tgene | ABCB1 | C0030567 | Parkinson Disease | 1 | CTD_human |
Tgene | ABCB1 | C0030569 | Secondary Parkinson Disease | 1 | CTD_human |
Tgene | ABCB1 | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
Tgene | ABCB1 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Tgene | ABCB1 | C0040715 | Chromosomal translocation | 1 | CTD_human |
Tgene | ABCB1 | C0042963 | Vomiting | 1 | CTD_human |
Tgene | ABCB1 | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
Tgene | ABCB1 | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
Tgene | ABCB1 | C0235032 | Neurotoxicity Syndromes | 1 | CTD_human |
Tgene | ABCB1 | C0338831 | Manic | 1 | PSYGENET |
Tgene | ABCB1 | C0376545 | Hematologic Neoplasms | 1 | CTD_human |
Tgene | ABCB1 | C0993582 | Arthritis, Experimental | 1 | CTD_human |
Tgene | ABCB1 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
Tgene | ABCB1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | ABCB1 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
Tgene | ABCB1 | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | ABCB1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |