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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15467

FusionGeneSummary for GRK6_ZNF346

check button Fusion gene summary
Fusion gene informationFusion gene name: GRK6_ZNF346
Fusion gene ID: 15467
HgeneTgene
Gene symbol

GRK6

ZNF346

Gene ID

2870

23567

Gene nameG protein-coupled receptor kinase 6zinc finger protein 346
SynonymsGPRK6JAZ|Zfp346
Cytomap

5q35.3

5q35.2

Type of geneprotein-codingprotein-coding
DescriptionG protein-coupled receptor kinase 6zinc finger protein 346double-stranded RNA-binding zinc finger protein JAZjust another zinc finger protein
Modification date2018051920180523
UniProtAcc

P43250

Q9UL40

Ensembl transtripts involved in fusion geneENST00000355472, ENST00000507633, 
ENST00000393576, ENST00000355958, 
ENST00000528793, 		ENST00000506693, 
ENST00000358149, ENST00000512315, 
ENST00000503425, ENST00000261948, 
ENST00000511834, ENST00000503039, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 4 X 4=48
# samples 35
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GRK6 [Title/Abstract] AND ZNF346 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-A5FT-01AGRK6chr5

176863531

+ZNF346chr5

176471390

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000355472ENST00000506693GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000355472ENST00000358149GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000355472ENST00000512315GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000355472ENST00000503425GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000355472ENST00000261948GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000355472ENST00000511834GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000355472ENST00000503039GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000507633ENST00000506693GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000507633ENST00000358149GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000507633ENST00000512315GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000507633ENST00000503425GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000507633ENST00000261948GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000507633ENST00000511834GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000507633ENST00000503039GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000393576ENST00000506693GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000393576ENST00000358149GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000393576ENST00000512315GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000393576ENST00000503425GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000393576ENST00000261948GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000393576ENST00000511834GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000393576ENST00000503039GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000355958ENST00000506693GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000355958ENST00000358149GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000355958ENST00000512315GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000355958ENST00000503425GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000355958ENST00000261948GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000355958ENST00000511834GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000355958ENST00000503039GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000528793ENST00000506693GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000528793ENST00000358149GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000528793ENST00000512315GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000528793ENST00000503425GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000528793ENST00000261948GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000528793ENST00000511834GRK6chr5

176863531

+ZNF346chr5

176471390

+
5CDS-intronENST00000528793ENST00000503039GRK6chr5

176863531

+ZNF346chr5

176471390

+

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FusionProtFeatures for GRK6_ZNF346


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRK6

P43250

ZNF346

Q9UL40

Specifically phosphorylates the activated forms of Gprotein-coupled receptors. Such receptor phosphorylation initiatesbeta-arrestin-mediated receptor desensitization, internalization,and signaling events leading to their desensitization. Seems to beinvolved in the desensitization of D2-like dopamine receptors instriatum and chemokine receptor CXCR4 which is critical forCXCL12-induced cell chemotaxis (By similarity). Phosphorylatesrhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor:LRP6 during Wnt signaling (in vitro). {ECO:0000250,ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20048153}. Binds with low affinity to dsDNA and ssRNA, and withhigh affinity to dsRNA, with no detectable sequence specificity(PubMed:24521053). May bind to specific miRNA hairpins(PubMed:28431233). {ECO:0000269|PubMed:24521053,ECO:0000269|PubMed:28431233}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GRK6_ZNF346


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GRK6_ZNF346


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GRK6PRSS23, FSHR, SNCA, SNCB, SNCG, RCVRN, ADRB2, HSP90AA1, HSP90AB1, KCNIP3, DDB1, MMS19, ITGA5, TBXA2R, SHMT2, CCDC8, GPR183, GRK5, KIAA0226L, NOLC1, TNFRSF1A, MANSC1, ENDOG, NCR3LG1, CD83, C7orf31, GOPC, MRAP2, NR4A1ZNF346EIF2AK2, XPO5, ILF3, CAND1, SIRT1, ANKHD1, TARDBP, AGO3, PRKRA, STAU2, BRIX1, CCDC124, NOA1, HP1BP3, KRR1, NCBP1, PHAX, SNRPG, OLA1, EBNA1BP2, SNRPB2, SNRPA1, RRP9, PPP2CA, SNORA7A, TARBP2, RNF2, NAT2, THOC2, HIST1H1E, ZNF512, ELAVL2, CCDC59


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GRK6_ZNF346


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GRK6_ZNF346


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRK6C0036341Schizophrenia2PSYGENET
HgeneGRK6C0003873Rheumatoid Arthritis1CTD_human