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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15459

FusionGeneSummary for GRK4_GRK4

check button Fusion gene summary
Fusion gene informationFusion gene name: GRK4_GRK4
Fusion gene ID: 15459
HgeneTgene
Gene symbol

GRK4

GRK4

Gene ID

2868

2868

Gene nameG protein-coupled receptor kinase 4G protein-coupled receptor kinase 4
SynonymsGPRK2L|GPRK4|GRK4a|IT11GPRK2L|GPRK4|GRK4a|IT11
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
DescriptionG protein-coupled receptor kinase 4G protein-coupled receptor kinase 2-likeG protein-coupled receptor kinase 4G protein-coupled receptor kinase 2-like
Modification date2018051920180519
UniProtAcc

P32298

P32298

Ensembl transtripts involved in fusion geneENST00000398051, ENST00000398052, 
ENST00000504933, ENST00000345167, 
ENST00000503518, ENST00000442472, 
ENST00000509545, 		ENST00000398051, 
ENST00000398052, ENST00000504933, 
ENST00000345167, ENST00000503518, 
ENST00000442472, ENST00000509545, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 7 X 6=168
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRK4 [Title/Abstract] AND GRK4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGRK4

GO:0031623

receptor internalization

20074556

TgeneGRK4

GO:0031623

receptor internalization

20074556


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF329649GRK4chr4

3023248

+GRK4chr4

3023346

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000398051ENST00000398051GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000398051ENST00000398052GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000398051ENST00000504933GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000398051ENST00000345167GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000398051ENST00000503518GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000398051ENST00000442472GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000398051ENST00000509545GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000398052ENST00000398051GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000398052ENST00000398052GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000398052ENST00000504933GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000398052ENST00000345167GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000398052ENST00000503518GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000398052ENST00000442472GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000398052ENST00000509545GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000504933ENST00000398051GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000504933ENST00000398052GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000504933ENST00000504933GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000504933ENST00000345167GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000504933ENST00000503518GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000504933ENST00000442472GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000504933ENST00000509545GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000345167ENST00000398051GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000345167ENST00000398052GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000345167ENST00000504933GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000345167ENST00000345167GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000345167ENST00000503518GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000345167ENST00000442472GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000345167ENST00000509545GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000503518ENST00000398051GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000503518ENST00000398052GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000503518ENST00000504933GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000503518ENST00000345167GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000503518ENST00000503518GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000503518ENST00000442472GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000503518ENST00000509545GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000442472ENST00000398051GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000442472ENST00000398052GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000442472ENST00000504933GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000442472ENST00000345167GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000442472ENST00000503518GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000442472ENST00000442472GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000442472ENST00000509545GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000509545ENST00000398051GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000509545ENST00000398052GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000509545ENST00000504933GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000509545ENST00000345167GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000509545ENST00000503518GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000509545ENST00000442472GRK4chr4

3023248

+GRK4chr4

3023346

-
intron-intronENST00000509545ENST00000509545GRK4chr4

3023248

+GRK4chr4

3023346

-

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FusionProtFeatures for GRK4_GRK4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRK4

P32298

GRK4

P32298


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GRK4_GRK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GRK4_GRK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GRK4_GRK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GRK4_GRK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource