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Fusion gene ID: 15423 |
FusionGeneSummary for GRID2_PRDX6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRID2_PRDX6 | Fusion gene ID: 15423 | Hgene | Tgene | Gene symbol | GRID2 | PRDX6 | Gene ID | 2895 | 25824 |
| Gene name | glutamate ionotropic receptor delta type subunit 2 | peroxiredoxin 5 | |
| Synonyms | GluD2|SCAR18 | ACR1|AOEB166|B166|HEL-S-55|PLP|PMP20|PRDX6|PRXV|SBBI10|prx-V | |
| Cytomap | 4q22.1-q22.2 | 11q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glutamate receptor ionotropic, delta-2gluR delta-2 subunitglutamate receptor delta-2 subunitglutamate receptor, ionotropic, delta 2 | peroxiredoxin-5, mitochondrialAlu co-repressor 1TPx type VIantioxidant enzyme B166epididymis secretory protein Li 55liver tissue 2D-page spot 71Bperoxiredoxin Vperoxisomal antioxidant enzymethioredoxin peroxidase PMP20thioredoxin reductase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O43424 | P30041 | |
| Ensembl transtripts involved in fusion gene | ENST00000282020, ENST00000505687, ENST00000510992, | ENST00000340385, ENST00000470017, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 1=9 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GRID2 [Title/Abstract] AND PRDX6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PRDX6 | GO:0006979 | response to oxidative stress | 10521424 |
| Tgene | PRDX6 | GO:0016480 | negative regulation of transcription by RNA polymerase III | 10095767 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF972933 | GRID2 | chr4 | 94123007 | - | PRDX6 | chr1 | 173455450 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000282020 | ENST00000340385 | GRID2 | chr4 | 94123007 | - | PRDX6 | chr1 | 173455450 | + |
| intron-3UTR | ENST00000282020 | ENST00000470017 | GRID2 | chr4 | 94123007 | - | PRDX6 | chr1 | 173455450 | + |
| intron-3CDS | ENST00000505687 | ENST00000340385 | GRID2 | chr4 | 94123007 | - | PRDX6 | chr1 | 173455450 | + |
| intron-3UTR | ENST00000505687 | ENST00000470017 | GRID2 | chr4 | 94123007 | - | PRDX6 | chr1 | 173455450 | + |
| intron-3CDS | ENST00000510992 | ENST00000340385 | GRID2 | chr4 | 94123007 | - | PRDX6 | chr1 | 173455450 | + |
| intron-3UTR | ENST00000510992 | ENST00000470017 | GRID2 | chr4 | 94123007 | - | PRDX6 | chr1 | 173455450 | + |
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FusionProtFeatures for GRID2_PRDX6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRID2 | PRDX6 |
| Receptor for glutamate. L-glutamate acts as anexcitatory neurotransmitter at many synapses in the centralnervous system. The postsynaptic actions of Glu are mediated by avariety of receptors that are named according to their selectiveagonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptorendocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC)synapses through the beta-NRX1-CBLN1-GRID2 triad complex(PubMed:27418511). {ECO:0000269|PubMed:27418511}. | Thiol-specific peroxidase that catalyzes the reductionof hydrogen peroxide and organic hydroperoxides to water andalcohols, respectively. Can reduce H(2)O(2) and short chainorganic, fatty acid, and phospholipid hydroperoxides. Also hasphospholipase activity, and can therefore either reduce theoxidized sn-2 fatty acyl grup of phospholipids (peroxidaseactivity) or hydrolyze the sn-2 ester bond of phospholipids(phospholipase activity). These activities are dependent onbinding to phospholipids at acidic pH and to oxidized phospholipdsat cytosolic pH. Plays a role in cell protection against oxidativestress by detoxifying peroxides and in phospholipid homeostasis.{ECO:0000269|PubMed:10893423, ECO:0000269|PubMed:9497358}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GRID2_PRDX6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GRID2_PRDX6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GRID2_PRDX6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | GRID2 | O43424 | DB00142 | Glutamic Acid | Glutamate receptor ionotropic, delta-2 | small molecule | approved|nutraceutical |
| Tgene | PRDX6 | P30041 | DB02325 | Isopropyl Alcohol | Peroxiredoxin-6 | small molecule | approved|investigational |
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RelatedDiseases for GRID2_PRDX6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GRID2 | C4015505 | SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 18 | 1 | ORPHANET;UNIPROT |
| Tgene | PRDX6 | C0011616 | Contact Dermatitis | 1 | CTD_human |
| Tgene | PRDX6 | C0013080 | Down Syndrome | 1 | CTD_human |
| Tgene | PRDX6 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Tgene | PRDX6 | C0035222 | Respiratory Distress Syndrome, Adult | 1 | CTD_human |
| Tgene | PRDX6 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | PRDX6 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Tgene | PRDX6 | C2239176 | Liver carcinoma | 1 | CTD_human |
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