FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 15420

FusionGeneSummary for GRID1_HECTD2

check button Fusion gene summary
Fusion gene informationFusion gene name: GRID1_HECTD2
Fusion gene ID: 15420
HgeneTgene
Gene symbol

GRID1

HECTD2

Gene ID

2894

143279

Gene nameglutamate ionotropic receptor delta type subunit 1HECT domain E3 ubiquitin protein ligase 2
SynonymsGluD1-
Cytomap

10q23.1-q23.2

10q23.32

Type of geneprotein-codingprotein-coding
Descriptionglutamate receptor ionotropic, delta-1gluR delta-1 subunitglutamate receptor delta-1 subunitprobable E3 ubiquitin-protein ligase HECTD2HECT domain containing E3 ubiquitin protein ligase 2HECT domain-containing protein 2HECT-type E3 ubiquitin transferase HECTD2
Modification date2018052320180522
UniProtAcc

Q9ULK0

Q5U5R9

Ensembl transtripts involved in fusion geneENST00000327946, ENST00000536331, 
ENST00000552278, 		ENST00000446394, 
ENST00000371681, ENST00000298068, 
ENST00000536715, ENST00000498446, 
ENST00000371667, 
Fusion gene scores* DoF score6 X 4 X 5=1204 X 3 X 4=48
# samples 64
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRID1 [Title/Abstract] AND HECTD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-EB-A42Z-01AGRID1chr10

88123698

-HECTD2chr10

93185038

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000327946ENST00000446394GRID1chr10

88123698

-HECTD2chr10

93185038

+
Frame-shiftENST00000327946ENST00000371681GRID1chr10

88123698

-HECTD2chr10

93185038

+
Frame-shiftENST00000327946ENST00000298068GRID1chr10

88123698

-HECTD2chr10

93185038

+
5CDS-intronENST00000327946ENST00000536715GRID1chr10

88123698

-HECTD2chr10

93185038

+
5CDS-intronENST00000327946ENST00000498446GRID1chr10

88123698

-HECTD2chr10

93185038

+
5CDS-intronENST00000327946ENST00000371667GRID1chr10

88123698

-HECTD2chr10

93185038

+
intron-3CDSENST00000536331ENST00000446394GRID1chr10

88123698

-HECTD2chr10

93185038

+
intron-3CDSENST00000536331ENST00000371681GRID1chr10

88123698

-HECTD2chr10

93185038

+
intron-3CDSENST00000536331ENST00000298068GRID1chr10

88123698

-HECTD2chr10

93185038

+
intron-intronENST00000536331ENST00000536715GRID1chr10

88123698

-HECTD2chr10

93185038

+
intron-intronENST00000536331ENST00000498446GRID1chr10

88123698

-HECTD2chr10

93185038

+
intron-intronENST00000536331ENST00000371667GRID1chr10

88123698

-HECTD2chr10

93185038

+
intron-3CDSENST00000552278ENST00000446394GRID1chr10

88123698

-HECTD2chr10

93185038

+
intron-3CDSENST00000552278ENST00000371681GRID1chr10

88123698

-HECTD2chr10

93185038

+
intron-3CDSENST00000552278ENST00000298068GRID1chr10

88123698

-HECTD2chr10

93185038

+
intron-intronENST00000552278ENST00000536715GRID1chr10

88123698

-HECTD2chr10

93185038

+
intron-intronENST00000552278ENST00000498446GRID1chr10

88123698

-HECTD2chr10

93185038

+
intron-intronENST00000552278ENST00000371667GRID1chr10

88123698

-HECTD2chr10

93185038

+

Top

FusionProtFeatures for GRID1_HECTD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRID1

Q9ULK0

HECTD2

Q5U5R9

Receptor for glutamate. L-glutamate acts as anexcitatory neurotransmitter at many synapses in the centralnervous system. The postsynaptic actions of Glu are mediated by avariety of receptors that are named according to their selectiveagonists. Probable E3 ubiquitin-protein ligase which acceptsubiquitin from an E2 ubiquitin-conjugating enzyme in the form of athioester and then directly transfers the ubiquitin to targetedsubstrates. {ECO:0000250|UniProtKB:Q69ZR2}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GRID1_HECTD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GRID1_HECTD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GRID1DEF6, EGFR, TCTN2, HTR3A, HBBHECTD2ELAVL1, RNF166, ACKR3, PIAS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GRID1_HECTD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGRID1Q9ULK0DB00142Glutamic AcidGlutamate receptor ionotropic, delta-1small moleculeapproved|nutraceutical

Top

RelatedDiseases for GRID1_HECTD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRID1C0036341Schizophrenia5PSYGENET
HgeneGRID1C0011570Mental Depression3PSYGENET
HgeneGRID1C0011581Depressive disorder3PSYGENET
HgeneGRID1C0005586Bipolar Disorder1PSYGENET
HgeneGRID1C0009404Colorectal Neoplasms1CTD_human