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Fusion gene ID: 15419 |
FusionGeneSummary for GRID1_GLUD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRID1_GLUD1 | Fusion gene ID: 15419 | Hgene | Tgene | Gene symbol | GRID1 | GLUD1 | Gene ID | 2894 | 2746 |
| Gene name | glutamate ionotropic receptor delta type subunit 1 | glutamate dehydrogenase 1 | |
| Synonyms | GluD1 | GDH|GDH1|GLUD | |
| Cytomap | 10q23.1-q23.2 | 10q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glutamate receptor ionotropic, delta-1gluR delta-1 subunitglutamate receptor delta-1 subunit | glutamate dehydrogenase 1, mitochondrialepididymis tissue sperm binding protein Li 18mPglutamate dehydrogenase (NAD(P)+) | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9ULK0 | P00367 | |
| Ensembl transtripts involved in fusion gene | ENST00000327946, ENST00000536331, ENST00000552278, | ENST00000277865, ENST00000537649, ENST00000544149, ENST00000465164, | |
| Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 3 X 3 X 3=27 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GRID1 [Title/Abstract] AND GLUD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GLUD1 | GO:0006537 | glutamate biosynthetic process | 11032875 |
| Tgene | GLUD1 | GO:0006538 | glutamate catabolic process | 6121377|11032875 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-K4-A6MB-01A | GRID1 | chr10 | 88123698 | - | GLUD1 | chr10 | 88836413 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000327946 | ENST00000277865 | GRID1 | chr10 | 88123698 | - | GLUD1 | chr10 | 88836413 | - |
| 5CDS-5UTR | ENST00000327946 | ENST00000537649 | GRID1 | chr10 | 88123698 | - | GLUD1 | chr10 | 88836413 | - |
| 5CDS-5UTR | ENST00000327946 | ENST00000544149 | GRID1 | chr10 | 88123698 | - | GLUD1 | chr10 | 88836413 | - |
| 5CDS-intron | ENST00000327946 | ENST00000465164 | GRID1 | chr10 | 88123698 | - | GLUD1 | chr10 | 88836413 | - |
| intron-3CDS | ENST00000536331 | ENST00000277865 | GRID1 | chr10 | 88123698 | - | GLUD1 | chr10 | 88836413 | - |
| intron-5UTR | ENST00000536331 | ENST00000537649 | GRID1 | chr10 | 88123698 | - | GLUD1 | chr10 | 88836413 | - |
| intron-5UTR | ENST00000536331 | ENST00000544149 | GRID1 | chr10 | 88123698 | - | GLUD1 | chr10 | 88836413 | - |
| intron-intron | ENST00000536331 | ENST00000465164 | GRID1 | chr10 | 88123698 | - | GLUD1 | chr10 | 88836413 | - |
| intron-3CDS | ENST00000552278 | ENST00000277865 | GRID1 | chr10 | 88123698 | - | GLUD1 | chr10 | 88836413 | - |
| intron-5UTR | ENST00000552278 | ENST00000537649 | GRID1 | chr10 | 88123698 | - | GLUD1 | chr10 | 88836413 | - |
| intron-5UTR | ENST00000552278 | ENST00000544149 | GRID1 | chr10 | 88123698 | - | GLUD1 | chr10 | 88836413 | - |
| intron-intron | ENST00000552278 | ENST00000465164 | GRID1 | chr10 | 88123698 | - | GLUD1 | chr10 | 88836413 | - |
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FusionProtFeatures for GRID1_GLUD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRID1 | GLUD1 |
| Receptor for glutamate. L-glutamate acts as anexcitatory neurotransmitter at many synapses in the centralnervous system. The postsynaptic actions of Glu are mediated by avariety of receptors that are named according to their selectiveagonists. | Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamineanaplerosis by producing alpha-ketoglutarate, an importantintermediate in the tricarboxylic acid cycle. May be involved inlearning and memory reactions by increasing the turnover of theexcitatory neurotransmitter glutamate (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GRID1 | chr10:88123698 | chr10:88836413 | ENST00000327946 | - | 2 | 16 | 21_562 | 78 | 1010 | Topological domain | Extracellular |
| Hgene | >GRID1 | chr10:88123698 | chr10:88836413 | ENST00000327946 | - | 2 | 16 | 584_637 | 78 | 1010 | Topological domain | Cytoplasmic |
| Hgene | >GRID1 | chr10:88123698 | chr10:88836413 | ENST00000327946 | - | 2 | 16 | 659_830 | 78 | 1010 | Topological domain | Extracellular |
| Hgene | >GRID1 | chr10:88123698 | chr10:88836413 | ENST00000327946 | - | 2 | 16 | 852_1009 | 78 | 1010 | Topological domain | Cytoplasmic |
| Hgene | >GRID1 | chr10:88123698 | chr10:88836413 | ENST00000327946 | - | 2 | 16 | 563_583 | 78 | 1010 | Transmembrane | Helical |
| Hgene | >GRID1 | chr10:88123698 | chr10:88836413 | ENST00000327946 | - | 2 | 16 | 638_658 | 78 | 1010 | Transmembrane | Helical |
| Hgene | >GRID1 | chr10:88123698 | chr10:88836413 | ENST00000327946 | - | 2 | 16 | 831_851 | 78 | 1010 | Transmembrane | Helical |
| Tgene | GLUD1 | chr10:88123698 | chr10:88836413 | ENST00000277865 | - | 0 | 13 | 141_143 | 148 | 559 | Nucleotide binding | NAD |
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FusionGeneSequence for GRID1_GLUD1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GRID1_ENST00000327946_chr10_88123698_-_GLUD1_ENST00000277865_chr10_88836413_-_489aa MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEGIRYSTDVSVDE VKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDIN AHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNP DGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYL NAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GRID1_ENST00000327946_chr10_88123698_-_GLUD1_ENST00000277865_chr10_88836413_-_1467nt ATGGAAGCGCTGACGCTGTGGCTTCTCCCCTGGATATGCCAGTGCGTGTCGGTGCGGGCCGACTCCATCATCCACATCGGTGCCATCTTC GAGGAGAACGCGGCCAAGGACGACAGGGTGTTCCAGTTGGCGGTATCCGACCTGAGCCTCAACGATGACATCCTGCAGAGCGAGAAGATC ACCTACTCCATCAAGGTCATCGAGGCCAACAACCCATTCCAGGCTGTGCAGGAAGGTATCCGTTACAGCACTGATGTGAGTGTAGATGAA GTAAAAGCTTTGGCTTCTCTGATGACATACAAGTGTGCAGTGGTTGATGTGCCGTTTGGGGGTGCTAAAGCTGGTGTTAAGATCAATCCC AAGAACTATACTGATAATGAATTGGAAAAGATCACAAGGAGGTTCACCATGGAGCTAGCAAAAAAGGGCTTTATTGGTCCTGGCATTGAT GTGCCTGCTCCAGACATGAGCACAGGTGAGCGGGAGATGTCCTGGATCGCTGATACCTATGCCAGCACCATAGGGCACTATGATATTAAT GCACACGCCTGTGTTACTGGTAAACCCATCAGCCAAGGGGGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGGGATT GAAAATTTCATCAATGAAGCTTCTTACATGAGCATTTTAGGAATGACACCAGGGTTTGGAGATAAAACATTTGTTGTTCAGGGATTTGGT AATGTGGGCCTACACTCTATGAGATATTTACATCGTTTTGGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAATCCA GATGGTATTGACCCAAAGGAACTGGAAGACTTCAAATTGCAACATGGGTCCATTCTGGGCTTCCCCAAGGCAAAGCCCTATGAAGGAAGC ATCTTGGAGGCCGACTGTGACATACTGATCCCAGCTGCCAGTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAAGATC ATTGCTGAAGGTGCCAATGGGCCAACAACTCCAGAAGCTGACAAGATCTTCCTGGAGAGAAACATTATGGTTATTCCAGATCTCTACTTG AATGCTGGAGGAGTGACAGTATCTTACTTTGAGTGGCTGAAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGAAAGG GATTCTAACTACCACTTGCTCATGTCTGTTCAAGAGAGTTTAGAAAGAAAATTTGGAAAGCATGGTGGAACTATTCCCATTGTACCCACG GCAGAGTTCCAAGACAGGATATCGGGTGCATCTGAGAAAGACATCGTGCACTCTGGCTTGGCATACACAATGGAGCGTTCTGCCAGGCAA ATTATGCGCACAGCCATGAAGTATAACCTGGGATTGGACCTGAGAACAGCTGCCTATGTTAATGCCATTGAGAAAGTCTTCAAAGTGTAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GRID1_ENST00000327946_chr10_88123698_-_GLUD1_ENST00000277865_chr10_88836413_-_2818nt ACTGCACCGGGACCAGCGCCTCCCCGCTTCGCGCTGCCCTCGGCCTCGCCCCGGGCCCGGGTGGATGAGCCGCGCGCCCGGGGGACATGG AAGCGCTGACGCTGTGGCTTCTCCCCTGGATATGCCAGTGCGTGTCGGTGCGGGCCGACTCCATCATCCACATCGGTGCCATCTTCGAGG AGAACGCGGCCAAGGACGACAGGGTGTTCCAGTTGGCGGTATCCGACCTGAGCCTCAACGATGACATCCTGCAGAGCGAGAAGATCACCT ACTCCATCAAGGTCATCGAGGCCAACAACCCATTCCAGGCTGTGCAGGAAGGTATCCGTTACAGCACTGATGTGAGTGTAGATGAAGTAA AAGCTTTGGCTTCTCTGATGACATACAAGTGTGCAGTGGTTGATGTGCCGTTTGGGGGTGCTAAAGCTGGTGTTAAGATCAATCCCAAGA ACTATACTGATAATGAATTGGAAAAGATCACAAGGAGGTTCACCATGGAGCTAGCAAAAAAGGGCTTTATTGGTCCTGGCATTGATGTGC CTGCTCCAGACATGAGCACAGGTGAGCGGGAGATGTCCTGGATCGCTGATACCTATGCCAGCACCATAGGGCACTATGATATTAATGCAC ACGCCTGTGTTACTGGTAAACCCATCAGCCAAGGGGGAATCCATGGACGCATCTCTGCTACTGGCCGTGGTGTCTTCCATGGGATTGAAA ATTTCATCAATGAAGCTTCTTACATGAGCATTTTAGGAATGACACCAGGGTTTGGAGATAAAACATTTGTTGTTCAGGGATTTGGTAATG TGGGCCTACACTCTATGAGATATTTACATCGTTTTGGTGCTAAATGTATTGCTGTTGGTGAGTCTGATGGGAGTATATGGAATCCAGATG GTATTGACCCAAAGGAACTGGAAGACTTCAAATTGCAACATGGGTCCATTCTGGGCTTCCCCAAGGCAAAGCCCTATGAAGGAAGCATCT TGGAGGCCGACTGTGACATACTGATCCCAGCTGCCAGTGAGAAGCAGTTGACCAAATCCAACGCACCCAGAGTCAAAGCCAAGATCATTG CTGAAGGTGCCAATGGGCCAACAACTCCAGAAGCTGACAAGATCTTCCTGGAGAGAAACATTATGGTTATTCCAGATCTCTACTTGAATG CTGGAGGAGTGACAGTATCTTACTTTGAGTGGCTGAAGAATCTAAATCATGTCAGCTATGGCCGTTTGACCTTCAAATATGAAAGGGATT CTAACTACCACTTGCTCATGTCTGTTCAAGAGAGTTTAGAAAGAAAATTTGGAAAGCATGGTGGAACTATTCCCATTGTACCCACGGCAG AGTTCCAAGACAGGATATCGGGTGCATCTGAGAAAGACATCGTGCACTCTGGCTTGGCATACACAATGGAGCGTTCTGCCAGGCAAATTA TGCGCACAGCCATGAAGTATAACCTGGGATTGGACCTGAGAACAGCTGCCTATGTTAATGCCATTGAGAAAGTCTTCAAAGTGTACAATG AAGCTGGTGTGACCTTCACATAGATGGATCATGGCTGACTTCCTCACTATCCTCTTCACATGTAACTTCTGCAGACCTATCACAAGTTTA CATGTAACCACAGAAATCCCTTTCTCTCCTGACTCATTAATAATGGATACCATTCTCAACAAGTCAATCCAAGTCAGCCCGTTAAGGAGA AAGAAATTAAGGTTAGCGGATCATGTACAAGCTGAGTGTGAAAGTAGAAATCACCTACACCAGAGAGCCATTTTGGTATTTTGCCTTTAA ATAAAAAGCCTCCTTTATCTGGCTGTGCAGCCTTGCTCTGTGGCTTTTCCCAACACAATCAGTGCTAGTGCTGGGGAGGAACAGTCAAGA GCAGTCAGTTGCTTGCTTATTTTTTCTGGATGAGTCTGGGACACACTGTAACTTTAACACATTTAAGAAGTAGGTGTGTGGCCTTTTCAG AAGGTGGCATGGTCCTCAAGTGAGTTCTTAGTATTTTATATCAGCAAAATAATTCAATTTTGCAGGTTGCAAACAAATATAAAACCTGTT TCTGTTTATGAATATTATTCTTTTAGAATAGAATAAGTACATGCTGCTGTAATAAAATTGCCTTTAATCACTTAACAAGCCTAACCTTGA CTCAAACAGTGAATGCCTATAGAAATAATAAATGAAAAAAACTAGTATTTTTATATCATAAAACAATGTCATTTATAGCTTATCATTCAT GTATTGTCCAGCAGACATTAAAAGCCCTGTGGATAATTAAGTTATCTTCATACCTGCAAAATGGTGGAGGCTATTTTCATTAAAACTGTC AGAATTTGCTTACTATAATTATGATACAGTCCAAAGAATGCAGTCACTTTTTATCATGTTAACTAATTGTTCTCTTTTGAAGATCTATGG TTGACTAATTAAACAATAATTCAAGTAGAGTGTCCCAGAAAAAAACCACTTGGGCTCCCTGTTTGGAGTCTGGCTGGCTCTGAGCATTGC CAATGGCCCCTACTCACCTGACTTTGTATCCTCTCCTTTTAGAGGCTTTGCATTCTGCACCCAGCTTCACTAACAGTGGGCTGAAAACAT CCTTGGGTTGAGTGTTTCATTTGGGAGTTATTTGGCCAGGGCCTTTTGAACAGTAGTGTCCCCATGAAGTGCTAGATAATATATGTGTAA GAGTCAGCTTTTTTTTTTTTTTTAACTCTAACACCCTTCAGAAATTTCTAACTACTTTGTAACTGCATGGCTTAACCTGGTGATAAAAGC |
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FusionGenePPI for GRID1_GLUD1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GRID1 | DEF6, EGFR, TCTN2, HTR3A, HBB | GLUD1 | ICT1, HDAC5, ELAVL1, CUL3, FN1, CRP, ORM1, ASGR2, NR4A1, HPX, STAT5A, SEC62, VTN, LSM1, CDK5, ILK, DCP2, KLHL29, FUS, CUL7, GLUD2, BIRC8, UNK, NTRK1, CEP128, PARD6A, MCM2, POU5F1, HSD17B10, U2AF2, CRBN, HYPK, ZNF746, KLHL22, PTPN22 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | GRID1 | chr10:88123698 | chr10:88836413 | ENST00000327946 | - | 2 | 16 | 21_436 | 78 | 1010 | CBLN1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GRID1_GLUD1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | GRID1 | Q9ULK0 | DB00142 | Glutamic Acid | Glutamate receptor ionotropic, delta-1 | small molecule | approved|nutraceutical |
| Tgene | GLUD1 | P00367 | DB11081 | Aluminum chloride | Glutamate dehydrogenase 1, mitochondrial | small molecule | approved |
| Tgene | GLUD1 | P00367 | DB00142 | Glutamic Acid | Glutamate dehydrogenase 1, mitochondrial | small molecule | approved|nutraceutical |
| Tgene | GLUD1 | P00367 | DB00756 | Hexachlorophene | Glutamate dehydrogenase 1, mitochondrial | small molecule | approved|withdrawn |
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RelatedDiseases for GRID1_GLUD1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GRID1 | C0036341 | Schizophrenia | 5 | PSYGENET |
| Hgene | GRID1 | C0011570 | Mental Depression | 3 | PSYGENET |
| Hgene | GRID1 | C0011581 | Depressive disorder | 3 | PSYGENET |
| Hgene | GRID1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | GRID1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Tgene | GLUD1 | C1847555 | Hyperinsulinemic hypoglycemia, familial, 6 | 3 | CTD_human;ORPHANET;UNIPROT |
| Tgene | GLUD1 | C0015934 | Fetal Growth Retardation | 1 | CTD_human |
| Tgene | GLUD1 | C0020459 | Hyperinsulinism | 1 | CTD_human |
| Tgene | GLUD1 | C0220994 | Hyperammonemia | 1 | CTD_human |
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