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Fusion gene ID: 15418 |
FusionGeneSummary for GRID1_CXCL12 |
Fusion gene summary |
Fusion gene information | Fusion gene name: GRID1_CXCL12 | Fusion gene ID: 15418 | Hgene | Tgene | Gene symbol | GRID1 | CXCL12 | Gene ID | 2894 | 6387 |
Gene name | glutamate ionotropic receptor delta type subunit 1 | C-X-C motif chemokine ligand 12 | |
Synonyms | GluD1 | IRH|PBSF|SCYB12|SDF1|TLSF|TPAR1 | |
Cytomap | 10q23.1-q23.2 | 10q11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | glutamate receptor ionotropic, delta-1gluR delta-1 subunitglutamate receptor delta-1 subunit | stromal cell-derived factor 1chemokine (C-X-C motif) ligand 12intercrine reduced in hepatomaspre-B cell growth-stimulating factor | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q9ULK0 | P48061 | |
Ensembl transtripts involved in fusion gene | ENST00000327946, ENST00000536331, ENST00000552278, | ENST00000395795, ENST00000374429, ENST00000395793, ENST00000374426, ENST00000343575, ENST00000395794, ENST00000496375, | |
Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 4 X 2 X 4=32 |
# samples | 6 | 4 | |
** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: GRID1 [Title/Abstract] AND CXCL12 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CXCL12 | GO:0033622 | integrin activation | 29301984 |
Tgene | CXCL12 | GO:0045785 | positive regulation of cell adhesion | 23620790 |
Tgene | CXCL12 | GO:0060326 | cell chemotaxis | 18308860 |
Tgene | CXCL12 | GO:0070098 | chemokine-mediated signaling pathway | 20388803 |
Tgene | CXCL12 | GO:0090026 | positive regulation of monocyte chemotaxis | 18802065 |
Tgene | CXCL12 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | 20388803 |
Tgene | CXCL12 | GO:1903237 | negative regulation of leukocyte tethering or rolling | 18308860 |
Tgene | CXCL12 | GO:2000406 | positive regulation of T cell migration | 23620790 |
Tgene | CXCL12 | GO:2000669 | negative regulation of dendritic cell apoptotic process | 15059845 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-ER-A19L-06A | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000327946 | ENST00000395795 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
5CDS-intron | ENST00000327946 | ENST00000374429 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
5CDS-intron | ENST00000327946 | ENST00000395793 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
5CDS-intron | ENST00000327946 | ENST00000374426 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
5CDS-intron | ENST00000327946 | ENST00000343575 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
5CDS-intron | ENST00000327946 | ENST00000395794 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
5CDS-intron | ENST00000327946 | ENST00000496375 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
intron-3CDS | ENST00000536331 | ENST00000395795 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
intron-intron | ENST00000536331 | ENST00000374429 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
intron-intron | ENST00000536331 | ENST00000395793 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
intron-intron | ENST00000536331 | ENST00000374426 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
intron-intron | ENST00000536331 | ENST00000343575 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
intron-intron | ENST00000536331 | ENST00000395794 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
intron-intron | ENST00000536331 | ENST00000496375 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
intron-3CDS | ENST00000552278 | ENST00000395795 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
intron-intron | ENST00000552278 | ENST00000374429 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
intron-intron | ENST00000552278 | ENST00000395793 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
intron-intron | ENST00000552278 | ENST00000374426 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
intron-intron | ENST00000552278 | ENST00000343575 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
intron-intron | ENST00000552278 | ENST00000395794 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
intron-intron | ENST00000552278 | ENST00000496375 | GRID1 | chr10 | 87675943 | - | CXCL12 | chr10 | 44793345 | - |
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FusionProtFeatures for GRID1_CXCL12 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
GRID1 | CXCL12 |
Receptor for glutamate. L-glutamate acts as anexcitatory neurotransmitter at many synapses in the centralnervous system. The postsynaptic actions of Glu are mediated by avariety of receptors that are named according to their selectiveagonists. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000343575 | - | 0 | 3 | 29_33 | -29 | 90 | Region | Receptor and heparin binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000343575 | - | 0 | 3 | 39_41 | -29 | 90 | Region | Note=Receptor binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000343575 | - | 0 | 3 | 41_51 | -29 | 90 | Region | Note=Heparin binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000343575 | - | 0 | 3 | 48_50 | -29 | 90 | Region | Note=Receptor binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000343575 | - | 0 | 3 | 60_70 | -29 | 90 | Region | Note=Receptor binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000374426 | - | 0 | 4 | 29_33 | -13 | 120 | Region | Receptor and heparin binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000374426 | - | 0 | 4 | 39_41 | -13 | 120 | Region | Note=Receptor binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000374426 | - | 0 | 4 | 41_51 | -13 | 120 | Region | Note=Heparin binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000374426 | - | 0 | 4 | 48_50 | -13 | 120 | Region | Note=Receptor binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000374426 | - | 0 | 4 | 60_70 | -13 | 120 | Region | Note=Receptor binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000374429 | - | 0 | 4 | 29_33 | -29 | 94 | Region | Receptor and heparin binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000374429 | - | 0 | 4 | 39_41 | -29 | 94 | Region | Note=Receptor binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000374429 | - | 0 | 4 | 41_51 | -29 | 94 | Region | Note=Heparin binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000374429 | - | 0 | 4 | 48_50 | -29 | 94 | Region | Note=Receptor binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000374429 | - | 0 | 4 | 60_70 | -29 | 94 | Region | Note=Receptor binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000395794 | - | 0 | 4 | 29_33 | -15 | 141 | Region | Receptor and heparin binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000395794 | - | 0 | 4 | 39_41 | -15 | 141 | Region | Note=Receptor binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000395794 | - | 0 | 4 | 41_51 | -15 | 141 | Region | Note=Heparin binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000395794 | - | 0 | 4 | 48_50 | -15 | 141 | Region | Note=Receptor binding |
Tgene | >CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000395794 | - | 0 | 4 | 60_70 | -15 | 141 | Region | Note=Receptor binding |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >GRID1 | chr10:87675943 | chr10:44793345 | ENST00000327946 | - | 5 | 16 | 21_562 | 260 | 1010 | Topological domain | Extracellular |
Hgene | >GRID1 | chr10:87675943 | chr10:44793345 | ENST00000327946 | - | 5 | 16 | 584_637 | 260 | 1010 | Topological domain | Cytoplasmic |
Hgene | >GRID1 | chr10:87675943 | chr10:44793345 | ENST00000327946 | - | 5 | 16 | 659_830 | 260 | 1010 | Topological domain | Extracellular |
Hgene | >GRID1 | chr10:87675943 | chr10:44793345 | ENST00000327946 | - | 5 | 16 | 852_1009 | 260 | 1010 | Topological domain | Cytoplasmic |
Hgene | >GRID1 | chr10:87675943 | chr10:44793345 | ENST00000327946 | - | 5 | 16 | 563_583 | 260 | 1010 | Transmembrane | Helical |
Hgene | >GRID1 | chr10:87675943 | chr10:44793345 | ENST00000327946 | - | 5 | 16 | 638_658 | 260 | 1010 | Transmembrane | Helical |
Hgene | >GRID1 | chr10:87675943 | chr10:44793345 | ENST00000327946 | - | 5 | 16 | 831_851 | 260 | 1010 | Transmembrane | Helical |
Tgene | CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000395795 | - | 2 | 4 | 29_33 | 88 | 91 | Region | Receptor and heparin binding |
Tgene | CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000395795 | - | 2 | 4 | 39_41 | 88 | 91 | Region | Note=Receptor binding |
Tgene | CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000395795 | - | 2 | 4 | 41_51 | 88 | 91 | Region | Note=Heparin binding |
Tgene | CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000395795 | - | 2 | 4 | 48_50 | 88 | 91 | Region | Note=Receptor binding |
Tgene | CXCL12 | chr10:87675943 | chr10:44793345 | ENST00000395795 | - | 2 | 4 | 60_70 | 88 | 91 | Region | Note=Receptor binding |
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FusionGeneSequence for GRID1_CXCL12 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_GRID1_ENST00000327946_chr10_87675943_-_CXCL12_ENST00000395795_chr10_44793345_-_262aa MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILAL VTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_GRID1_ENST00000327946_chr10_87675943_-_CXCL12_ENST00000395795_chr10_44793345_-_787nt ATGGAAGCGCTGACGCTGTGGCTTCTCCCCTGGATATGCCAGTGCGTGTCGGTGCGGGCCGACTCCATCATCCACATCGGTGCCATCTTC GAGGAGAACGCGGCCAAGGACGACAGGGTGTTCCAGTTGGCGGTATCCGACCTGAGCCTCAACGATGACATCCTGCAGAGCGAGAAGATC ACCTACTCCATCAAGGTCATCGAGGCCAACAACCCATTCCAGGCTGTGCAGGAAGCCTGTGACCTCATGACCCAGGGGATTTTGGCCTTG GTCACGTCCACTGGCTGTGCATCTGCCAATGCCCTGCAGTCCCTCACGGATGCCATGCACATCCCACACCTCTTTGTCCAGCGCAACCCG GGAGGGTCGCCACGCACCGCATGCCACCTGAACCCCAGCCCCGATGGTGAGGCCTACACACTGGCTTCGAGACCACCCGTCCGCCTCAAT GATGTCATGCTCAGGCTGGTGACGGAGCTGCGCTGGCAGAAGTTCGTCATGTTCTACGACAGCGAGTATGATATCCGTGGGCTTCAAAGC TTTCTGGACCAGGCCTCGCGGCTGGGCCTTGACGTCTCTTTACAAAAGGTGGACAAGAACATTAGCCACGTATTCACCAGCCTCTTCACC ACGATGAAGACAGAGGAGCTGAATCGCTACCGGGACACGCTTCGCCGCGCCATCCTGCTGCTCAGCCCACAGGGAGCCCACTCCTTCATC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_GRID1_ENST00000327946_chr10_87675943_-_CXCL12_ENST00000395795_chr10_44793345_-_1174nt ACTGCACCGGGACCAGCGCCTCCCCGCTTCGCGCTGCCCTCGGCCTCGCCCCGGGCCCGGGTGGATGAGCCGCGCGCCCGGGGGACATGG AAGCGCTGACGCTGTGGCTTCTCCCCTGGATATGCCAGTGCGTGTCGGTGCGGGCCGACTCCATCATCCACATCGGTGCCATCTTCGAGG AGAACGCGGCCAAGGACGACAGGGTGTTCCAGTTGGCGGTATCCGACCTGAGCCTCAACGATGACATCCTGCAGAGCGAGAAGATCACCT ACTCCATCAAGGTCATCGAGGCCAACAACCCATTCCAGGCTGTGCAGGAAGCCTGTGACCTCATGACCCAGGGGATTTTGGCCTTGGTCA CGTCCACTGGCTGTGCATCTGCCAATGCCCTGCAGTCCCTCACGGATGCCATGCACATCCCACACCTCTTTGTCCAGCGCAACCCGGGAG GGTCGCCACGCACCGCATGCCACCTGAACCCCAGCCCCGATGGTGAGGCCTACACACTGGCTTCGAGACCACCCGTCCGCCTCAATGATG TCATGCTCAGGCTGGTGACGGAGCTGCGCTGGCAGAAGTTCGTCATGTTCTACGACAGCGAGTATGATATCCGTGGGCTTCAAAGCTTTC TGGACCAGGCCTCGCGGCTGGGCCTTGACGTCTCTTTACAAAAGGTGGACAAGAACATTAGCCACGTATTCACCAGCCTCTTCACCACGA TGAAGACAGAGGAGCTGAATCGCTACCGGGACACGCTTCGCCGCGCCATCCTGCTGCTCAGCCCACAGGGAGCCCACTCCTTCATCAACG AGGCCGTGGAGACCAACCTGGCTTCCAAGGACAGCCACTGGGTCTTTGTGAATGAGTTGCTAGAATATGGCTGTACGGCAATGCTGAGAC ATCACGCTGAGCGAGAGTGGACATCCTCATTTTATTCCTACCCTTACCGTGGATCTCTCCTGTGCTTCACCACTCAGTATAATGCTGGCT GAGCTCTTCTGACAAATACCTTCCAAGATGTGAGGAAAACACACGTAGGTGCAGTTGTTGAATTGTATGATCTGCCACTGAAGTAATTAG TGTGATAATTACTTGGATTTTCTCCTTTAACAAATTATTGTTATAAATTATATTAATATATGTCATGCTAATAAATTATTTCCATATTCC |
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FusionGenePPI for GRID1_CXCL12 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GRID1 | DEF6, EGFR, TCTN2, HTR3A, HBB | CXCL12 | FN1, CXCL12, PF4, VCAN, CXCR4, DAZAP2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | GRID1 | chr10:87675943 | chr10:44793345 | ENST00000327946 | - | 5 | 16 | 21_436 | 260 | 1010 | CBLN1 |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GRID1_CXCL12 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | GRID1 | Q9ULK0 | DB00142 | Glutamic Acid | Glutamate receptor ionotropic, delta-1 | small molecule | approved|nutraceutical |
Tgene | CXCL12 | P48061 | DB06822 | Tinzaparin | Stromal cell-derived factor 1 | small molecule | approved |
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RelatedDiseases for GRID1_CXCL12 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GRID1 | C0036341 | Schizophrenia | 5 | PSYGENET |
Hgene | GRID1 | C0011570 | Mental Depression | 3 | PSYGENET |
Hgene | GRID1 | C0011581 | Depressive disorder | 3 | PSYGENET |
Hgene | GRID1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | GRID1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | CXCL12 | C0027626 | Neoplasm Invasiveness | 3 | CTD_human |
Tgene | CXCL12 | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
Tgene | CXCL12 | C0022116 | Ischemia | 1 | CTD_human |
Tgene | CXCL12 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | CXCL12 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | CXCL12 | C0266929 | Chronic Periodontitis | 1 | CTD_human |
Tgene | CXCL12 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Tgene | CXCL12 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | CXCL12 | C1956346 | Coronary Artery Disease | 1 | CTD_human |
Tgene | CXCL12 | C2239176 | Liver carcinoma | 1 | CTD_human |