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Fusion gene ID: 15417 |
FusionGeneSummary for GRID1_AFAP1L2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRID1_AFAP1L2 | Fusion gene ID: 15417 | Hgene | Tgene | Gene symbol | GRID1 | AFAP1L2 | Gene ID | 2894 | 84632 |
| Gene name | glutamate ionotropic receptor delta type subunit 1 | actin filament associated protein 1 like 2 | |
| Synonyms | GluD1 | CTB-1144G6.4|KIAA1914|XB130 | |
| Cytomap | 10q23.1-q23.2 | 10q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glutamate receptor ionotropic, delta-1gluR delta-1 subunitglutamate receptor delta-1 subunit | actin filament-associated protein 1-like 2AFAP1-like protein 2CTB-1144G6.6 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9ULK0 | Q8N4X5 | |
| Ensembl transtripts involved in fusion gene | ENST00000327946, ENST00000536331, ENST00000552278, | ENST00000304129, ENST00000369271, ENST00000545353, ENST00000491814, | |
| Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 3 X 2 X 3=18 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GRID1 [Title/Abstract] AND AFAP1L2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | AFAP1L2 | GO:0006954 | inflammatory response | 17412687 |
| Tgene | AFAP1L2 | GO:0007346 | regulation of mitotic cell cycle | 17412687 |
| Tgene | AFAP1L2 | GO:0032675 | regulation of interleukin-6 production | 17412687 |
| Tgene | AFAP1L2 | GO:0032757 | positive regulation of interleukin-8 production | 17412687 |
| Tgene | AFAP1L2 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway | 17412687 |
| Tgene | AFAP1L2 | GO:0045893 | positive regulation of transcription, DNA-templated | 17412687 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A6YR-01A | GRID1 | chr10 | 88123698 | - | AFAP1L2 | chr10 | 116100490 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000327946 | ENST00000304129 | GRID1 | chr10 | 88123698 | - | AFAP1L2 | chr10 | 116100490 | - |
| In-frame | ENST00000327946 | ENST00000369271 | GRID1 | chr10 | 88123698 | - | AFAP1L2 | chr10 | 116100490 | - |
| In-frame | ENST00000327946 | ENST00000545353 | GRID1 | chr10 | 88123698 | - | AFAP1L2 | chr10 | 116100490 | - |
| 5CDS-intron | ENST00000327946 | ENST00000491814 | GRID1 | chr10 | 88123698 | - | AFAP1L2 | chr10 | 116100490 | - |
| intron-3CDS | ENST00000536331 | ENST00000304129 | GRID1 | chr10 | 88123698 | - | AFAP1L2 | chr10 | 116100490 | - |
| intron-3CDS | ENST00000536331 | ENST00000369271 | GRID1 | chr10 | 88123698 | - | AFAP1L2 | chr10 | 116100490 | - |
| intron-3CDS | ENST00000536331 | ENST00000545353 | GRID1 | chr10 | 88123698 | - | AFAP1L2 | chr10 | 116100490 | - |
| intron-intron | ENST00000536331 | ENST00000491814 | GRID1 | chr10 | 88123698 | - | AFAP1L2 | chr10 | 116100490 | - |
| intron-3CDS | ENST00000552278 | ENST00000304129 | GRID1 | chr10 | 88123698 | - | AFAP1L2 | chr10 | 116100490 | - |
| intron-3CDS | ENST00000552278 | ENST00000369271 | GRID1 | chr10 | 88123698 | - | AFAP1L2 | chr10 | 116100490 | - |
| intron-3CDS | ENST00000552278 | ENST00000545353 | GRID1 | chr10 | 88123698 | - | AFAP1L2 | chr10 | 116100490 | - |
| intron-intron | ENST00000552278 | ENST00000491814 | GRID1 | chr10 | 88123698 | - | AFAP1L2 | chr10 | 116100490 | - |
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FusionProtFeatures for GRID1_AFAP1L2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRID1 | AFAP1L2 |
| Receptor for glutamate. L-glutamate acts as anexcitatory neurotransmitter at many synapses in the centralnervous system. The postsynaptic actions of Glu are mediated by avariety of receptors that are named according to their selectiveagonists. | May play a role in a signaling cascade by enhancing thekinase activity of SRC. Contributes to SRC-regulated transcriptionactivation. {ECO:0000269|PubMed:17412687}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >AFAP1L2 | chr10:88123698 | chr10:116100490 | ENST00000304129 | - | 0 | 19 | 652_749 | 5 | 819 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >AFAP1L2 | chr10:88123698 | chr10:116100490 | ENST00000369271 | - | 0 | 19 | 652_749 | 5 | 815 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >AFAP1L2 | chr10:88123698 | chr10:116100490 | ENST00000304129 | - | 0 | 19 | 175_271 | 5 | 819 | Domain | PH 1 |
| Tgene | >AFAP1L2 | chr10:88123698 | chr10:116100490 | ENST00000304129 | - | 0 | 19 | 353_447 | 5 | 819 | Domain | PH 2 |
| Tgene | >AFAP1L2 | chr10:88123698 | chr10:116100490 | ENST00000369271 | - | 0 | 19 | 175_271 | 5 | 815 | Domain | PH 1 |
| Tgene | >AFAP1L2 | chr10:88123698 | chr10:116100490 | ENST00000369271 | - | 0 | 19 | 353_447 | 5 | 815 | Domain | PH 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GRID1 | chr10:88123698 | chr10:116100490 | ENST00000327946 | - | 2 | 16 | 21_562 | 78 | 1010 | Topological domain | Extracellular |
| Hgene | >GRID1 | chr10:88123698 | chr10:116100490 | ENST00000327946 | - | 2 | 16 | 584_637 | 78 | 1010 | Topological domain | Cytoplasmic |
| Hgene | >GRID1 | chr10:88123698 | chr10:116100490 | ENST00000327946 | - | 2 | 16 | 659_830 | 78 | 1010 | Topological domain | Extracellular |
| Hgene | >GRID1 | chr10:88123698 | chr10:116100490 | ENST00000327946 | - | 2 | 16 | 852_1009 | 78 | 1010 | Topological domain | Cytoplasmic |
| Hgene | >GRID1 | chr10:88123698 | chr10:116100490 | ENST00000327946 | - | 2 | 16 | 563_583 | 78 | 1010 | Transmembrane | Helical |
| Hgene | >GRID1 | chr10:88123698 | chr10:116100490 | ENST00000327946 | - | 2 | 16 | 638_658 | 78 | 1010 | Transmembrane | Helical |
| Hgene | >GRID1 | chr10:88123698 | chr10:116100490 | ENST00000327946 | - | 2 | 16 | 831_851 | 78 | 1010 | Transmembrane | Helical |
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FusionGeneSequence for GRID1_AFAP1L2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GRID1_ENST00000327946_chr10_88123698_-_AFAP1L2_ENST00000304129_chr10_116100490_-_892aa MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEALEQLLTELDDF LKILDQENLSSTALVKKSCLAELLRLYTKSSSSDEEYIYMNKVTINKQQNAESQGKAPEEQGLLPNGEPSQHSSAPQKSLPDLPPPKMIP ERKQLAIPKTESPEGYYEEAEPYDTSLNEDGEAVSSSYESYDEEDGSKGKSAPYQWPSPEAGIELMRDARICAFLWRKKWLGQWAKQLCV IKDNRLLCYKSSKDHSPQLDVNLLGSSVIHKEKQVRKKEHKLKITPMNADVIVLGLQSKDQAEQWLRVIQEVSGLPSEGASEGNQYTPDA QRFNCQKPDIAEKYLSASEYGSSVDGHPEVPETKDVKKKCSAGLKLSNLMNLGRKKSTSLEPVERSLETSSYLNVLVNSQWKSRWCSVRD NHLHFYQDRNRSKVAQQPLSLVGCEVVPDPSPDHLYSFRILHKGEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFTYDYVDADRVSC IVSAAKNSLLLMQRKFSEPNTYIDGLPSQDRQEELYDDVDLSELTAAVEPTEEATPVADDPNERESDRVYLDLTPVKSFLHGPSSAQAQA SSPTLSCLDNATEALPADSGPGPTPDEPCIKCPENLGEQQLESLEPEDPSLRITTVKIQTEQQRISFPPSCPDAVVATPPGASPPVKDRL RVTSAEIKLGKNRTEAEVKRYTEEKERLEKKKEEIRGHLAQLRKEKRELKETLLKCTDKEVLASLEQKLKEIDEECRGEESRRVDLELSI >In-frame_GRID1_ENST00000327946_chr10_88123698_-_AFAP1L2_ENST00000369271_chr10_116100490_-_888aa MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEALEQLLTELDDF LKILDQENLSSTALVKKSCLAELLRLYTKSSSSDEEYIYMNKVTINKQQNAESQGKAPEEQGLLPNGEPSQHSSAPQKSLPDLPPPKMIP ERKQLAIPKTESPEGYYEEAEPYDTSLNEDGEAVSSSYESYDEEDGSKGKSAPYQWPSPEAGIELMRDARICAFLWRKKWLGQWAKQLCV IKDNRLLCYKSSKDHSPQLDVNLLGSSVIHKEKQVRKKEHKLKITPMNADVIVLGLQSKDQAEQWLRVIQEVSGLPSEGASEGNQYTPDA QRFNCQKPDIAEKYLSASEYGSSVDGHPEVPETKDVKKKCSAGLKLSNLMNLGRKKSTSLEPVERSLETSSYLNVLVNSQWKSRWCSVRD NHLHFYQDRNRSKVAQQPLSLVGCEVVPDPSPDHLYSFRILHKGEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFTYDYVDADRVSC IVSAAKNSLLLMQRKFSEPNTYIDGLPSQDRQEELYDDVDLSELTAAVEPTEEATPVADDPNERESDRVYLDLTPVKSFLHGPSSAQAQA SSPTLSCLDNATEALPADSGPGPTPDEPCIKCPENLGEQQLESLEPEDPSLRITTVKIQTEQQRISFPPSCPDAVVATPPGASPPVKDRL RVTSAEIKLGKNRTEAEVKRYTEEKERLEKKKEEIRGHLAQLRKEKRELKETLLKCTDKEVLASLEQKLKEIDEECRGEESRRVDLELSI >In-frame_GRID1_ENST00000327946_chr10_88123698_-_AFAP1L2_ENST00000545353_chr10_116100490_-_945aa MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEALEQLLTELDDF LKILDQENLSSTALVKKSCLAELLRLYTKSSSSDEEYIYMNKVTINKQQNAESQGKAPEEQGLLPNGEPSQHSSAPQKSLPDLPPPKMRI LTLGQISGAQSFSPDGTHLTGTEFLGGWSWRPSQIRLMSPGTHWGDLTATEIPERKQLAIPKTESPEGYYEEAEPYDTSLNEDGEAVSSS YESYDEEDGSKGKSAPYQWPSPEAGIELMRDARICAFLWRKKWLGQWAKQLCVIKDNRLLCYKSSKDHSPQLDVNLLGSSVIHKEKQVRK KEHKLKITPMNADVIVLGLQSKDQAEQWLRVIQEVSGLPSEGASEGNQYTPDAQRFNCQKPDIAEKYLSASEYGSSVDGHPEVPETKDVK KKCSAGLKLSNLMNLGRKKSTSLEPVERSLETSSYLNVLVNSQWKSRWCSVRDNHLHFYQDRNRSKVAQQPLSLVGCEVVPDPSPDHLYS FRILHKGEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFTYDYVDADRVSCIVSAAKNSLLLMQRKFSEPNTYIDGLPSQDRQEELYD DVDLSELTAAVEPTEEATPVADDPNERESDRVYLDLTPVKSFLHGPSSAQAQASSPTLSCLDNATEALPADSGPGPTPDEPCIKCPENLG EQQLESLEPEDPSLRITTVKIQTEQQRISFPPSCPDAVVATPPGASPPVKDRLRVTSAEIKLGKNRTEAEVKRYTEEKERLEKKKEEIRG HLAQLRKEKRELKETLLKCTDKEVLASLEQKLKEIDEECRGEESRRVDLELSIMEVKDNLKKAEAGPVTLGTTVDTTHLENVSPRPKAVT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GRID1_ENST00000327946_chr10_88123698_-_AFAP1L2_ENST00000304129_chr10_116100490_-_2676nt ATGGAAGCGCTGACGCTGTGGCTTCTCCCCTGGATATGCCAGTGCGTGTCGGTGCGGGCCGACTCCATCATCCACATCGGTGCCATCTTC GAGGAGAACGCGGCCAAGGACGACAGGGTGTTCCAGTTGGCGGTATCCGACCTGAGCCTCAACGATGACATCCTGCAGAGCGAGAAGATC ACCTACTCCATCAAGGTCATCGAGGCCAACAACCCATTCCAGGCTGTGCAGGAAGCCCTGGAACAGCTGCTGACAGAGTTGGATGACTTC CTCAAGATTCTTGACCAGGAGAACCTGAGCAGCACAGCACTGGTGAAGAAGAGCTGCCTGGCGGAGCTCCTCCGGCTTTACACCAAAAGC AGCAGCTCTGATGAGGAGTACATTTATATGAACAAAGTGACCATCAACAAGCAACAGAATGCAGAGTCTCAAGGCAAAGCGCCTGAGGAG CAGGGCCTGCTACCCAATGGGGAGCCCAGCCAGCACTCCTCGGCCCCTCAGAAGAGCCTTCCAGACCTCCCGCCACCCAAGATGATTCCA GAACGGAAACAGCTTGCCATCCCAAAGACGGAGTCTCCAGAGGGCTACTATGAAGAGGCTGAGCCATATGACACATCCCTCAATGAGGAC GGAGAGGCTGTGAGCAGCTCCTACGAGTCCTACGATGAAGAGGACGGCAGCAAGGGCAAGTCGGCCCCTTACCAGTGGCCCTCGCCGGAG GCCGGCATCGAGCTGATGCGTGACGCCCGCATCTGCGCCTTCCTGTGGCGCAAGAAGTGGCTGGGACAGTGGGCCAAGCAGCTCTGTGTC ATCAAGGACAACAGGCTTCTGTGCTACAAATCCTCCAAGGACCACAGCCCTCAGCTGGACGTGAACCTACTGGGCAGCAGCGTCATTCAC AAGGAGAAGCAAGTGCGGAAGAAGGAGCACAAGCTGAAGATCACGCCGATGAATGCCGATGTGATTGTGCTGGGCCTGCAGAGCAAGGAC CAGGCTGAGCAGTGGCTCAGGGTCATCCAGGAAGTGAGCGGCCTGCCTTCCGAAGGAGCATCTGAAGGAAACCAGTACACCCCGGATGCC CAGCGCTTTAACTGCCAGAAACCAGATATAGCTGAGAAGTACCTGTCGGCTTCAGAGTATGGGAGCTCCGTGGATGGCCACCCTGAGGTC CCAGAAACCAAAGACGTCAAGAAGAAATGTTCTGCTGGCCTCAAACTGAGCAACCTAATGAATCTGGGCAGGAAGAAATCCACCTCACTG GAGCCTGTGGAGAGGTCCCTCGAGACATCCAGTTACCTGAACGTGCTGGTGAACAGCCAGTGGAAGTCTCGCTGGTGCTCTGTCAGGGAC AATCACCTGCACTTCTACCAGGACCGGAACCGGAGCAAGGTGGCCCAGCAACCCCTCAGCCTGGTGGGCTGCGAGGTGGTCCCAGACCCC AGCCCCGACCACCTCTACTCCTTCCGCATCCTCCACAAGGGCGAGGAGCTGGCCAAGCTTGAGGCCAAGTCTTCCGAGGAAATGGGCCAC TGGCTGGGTCTCCTGCTCTCTGAGTCAGGCTCCAAGACAGACCCAGAAGAGTTCACCTACGACTATGTGGATGCCGATAGGGTCTCCTGT ATTGTGAGTGCGGCCAAAAACTCTCTCTTACTGATGCAGAGAAAGTTCTCAGAGCCCAACACTTACATCGATGGCCTGCCTAGCCAGGAC CGCCAGGAGGAGCTGTATGACGACGTGGACCTGTCAGAGCTCACAGCTGCGGTGGAGCCTACCGAGGAAGCCACCCCTGTTGCAGATGAC CCAAATGAGAGAGAATCTGACCGAGTGTACCTGGACCTCACACCTGTCAAGTCCTTTCTGCATGGCCCCAGCAGTGCACAGGCCCAGGCC TCCTCCCCGACGTTGTCCTGCCTGGACAATGCAACTGAGGCCCTCCCGGCAGACTCAGGCCCAGGTCCCACCCCAGATGAGCCCTGCATA AAGTGTCCAGAGAACCTGGGAGAACAGCAGCTGGAGAGTTTGGAGCCAGAGGATCCTTCCCTGAGAATCACCACCGTCAAAATCCAGACG GAACAGCAGAGAATCTCCTTCCCACCGAGCTGCCCGGATGCCGTGGTGGCCACCCCACCTGGTGCCAGCCCACCTGTGAAGGACAGGTTG CGCGTGACCAGTGCAGAGATCAAGCTTGGCAAGAATCGGACAGAAGCTGAGGTGAAGCGGTACACAGAGGAGAAGGAGAGGCTTGAAAAG AAGAAGGAAGAAATCCGGGGGCACCTGGCTCAGCTCCGGAAAGAGAAACGGGAGCTAAAGGAAACCCTACTGAAATGCACAGACAAGGAA GTCCTGGCGAGCCTGGAGCAGAAGCTGAAGGAAATTGACGAGGAGTGCCGGGGCGAGGAGAGCAGGCGCGTGGACCTGGAGCTCAGCATC ATGGAGGTGAAGGACAACCTGAAGAAGGCTGAGGCAGGGCCTGTGACGTTAGGCACCACCGTGGACACCACCCACCTGGAGAATGTGAGC CCCCGCCCCAAAGCTGTCACACCTGCCTCTGCCCCAGACTGTACCCCAGTCAACTCTGCAACCACACTCAAGAACAGGCCTCTCTCGGTC >In-frame_GRID1_ENST00000327946_chr10_88123698_-_AFAP1L2_ENST00000369271_chr10_116100490_-_2664nt ATGGAAGCGCTGACGCTGTGGCTTCTCCCCTGGATATGCCAGTGCGTGTCGGTGCGGGCCGACTCCATCATCCACATCGGTGCCATCTTC GAGGAGAACGCGGCCAAGGACGACAGGGTGTTCCAGTTGGCGGTATCCGACCTGAGCCTCAACGATGACATCCTGCAGAGCGAGAAGATC ACCTACTCCATCAAGGTCATCGAGGCCAACAACCCATTCCAGGCTGTGCAGGAAGCCCTGGAACAGCTGCTGACAGAGTTGGATGACTTC CTCAAGATTCTTGACCAGGAGAACCTGAGCAGCACAGCACTGGTGAAGAAGAGCTGCCTGGCGGAGCTCCTCCGGCTTTACACCAAAAGC AGCAGCTCTGATGAGGAGTACATTTATATGAACAAAGTGACCATCAACAAGCAACAGAATGCAGAGTCTCAAGGCAAAGCGCCTGAGGAG CAGGGCCTGCTACCCAATGGGGAGCCCAGCCAGCACTCCTCGGCCCCTCAGAAGAGCCTTCCAGACCTCCCGCCACCCAAGATGATTCCA GAACGGAAACAGCTTGCCATCCCAAAGACGGAGTCTCCAGAGGGCTACTATGAAGAGGCTGAGCCATATGACACATCCCTCAATGAGGAC GGAGAGGCTGTGAGCAGCTCCTACGAGTCCTACGATGAAGAGGACGGCAGCAAGGGCAAGTCGGCCCCTTACCAGTGGCCCTCGCCGGAG GCCGGCATCGAGCTGATGCGTGACGCCCGCATCTGCGCCTTCCTGTGGCGCAAGAAGTGGCTGGGACAGTGGGCCAAGCAGCTCTGTGTC ATCAAGGACAACAGGCTTCTGTGCTACAAATCCTCCAAGGACCACAGCCCTCAGCTGGACGTGAACCTACTGGGCAGCAGCGTCATTCAC AAGGAGAAGCAAGTGCGGAAGAAGGAGCACAAGCTGAAGATCACGCCGATGAATGCCGATGTGATTGTGCTGGGCCTGCAGAGCAAGGAC CAGGCTGAGCAGTGGCTCAGGGTCATCCAGGAAGTGAGCGGCCTGCCTTCCGAAGGAGCATCTGAAGGAAACCAGTACACCCCGGATGCC CAGCGCTTTAACTGCCAGAAACCAGATATAGCTGAGAAGTACCTGTCGGCTTCAGAGTATGGGAGCTCCGTGGATGGCCACCCTGAGGTC CCAGAAACCAAAGACGTCAAGAAGAAATGTTCTGCTGGCCTCAAACTGAGCAACCTAATGAATCTGGGCAGGAAGAAATCCACCTCACTG GAGCCTGTGGAGAGGTCCCTCGAGACATCCAGTTACCTGAACGTGCTGGTGAACAGCCAGTGGAAGTCTCGCTGGTGCTCTGTCAGGGAC AATCACCTGCACTTCTACCAGGACCGGAACCGGAGCAAGGTGGCCCAGCAACCCCTCAGCCTGGTGGGCTGCGAGGTGGTCCCAGACCCC AGCCCCGACCACCTCTACTCCTTCCGCATCCTCCACAAGGGCGAGGAGCTGGCCAAGCTTGAGGCCAAGTCTTCCGAGGAAATGGGCCAC TGGCTGGGTCTCCTGCTCTCTGAGTCAGGCTCCAAGACAGACCCAGAAGAGTTCACCTACGACTATGTGGATGCCGATAGGGTCTCCTGT ATTGTGAGTGCGGCCAAAAACTCTCTCTTACTGATGCAGAGAAAGTTCTCAGAGCCCAACACTTACATCGATGGCCTGCCTAGCCAGGAC CGCCAGGAGGAGCTGTATGACGACGTGGACCTGTCAGAGCTCACAGCTGCGGTGGAGCCTACCGAGGAAGCCACCCCTGTTGCAGATGAC CCAAATGAGAGAGAATCTGACCGAGTGTACCTGGACCTCACACCTGTCAAGTCCTTTCTGCATGGCCCCAGCAGTGCACAGGCCCAGGCC TCCTCCCCGACGTTGTCCTGCCTGGACAATGCAACTGAGGCCCTCCCGGCAGACTCAGGCCCAGGTCCCACCCCAGATGAGCCCTGCATA AAGTGTCCAGAGAACCTGGGAGAACAGCAGCTGGAGAGTTTGGAGCCAGAGGATCCTTCCCTGAGAATCACCACCGTCAAAATCCAGACG GAACAGCAGAGAATCTCCTTCCCACCGAGCTGCCCGGATGCCGTGGTGGCCACCCCACCTGGTGCCAGCCCACCTGTGAAGGACAGGTTG CGCGTGACCAGTGCAGAGATCAAGCTTGGCAAGAATCGGACAGAAGCTGAGGTGAAGCGGTACACAGAGGAGAAGGAGAGGCTTGAAAAG AAGAAGGAAGAAATCCGGGGGCACCTGGCTCAGCTCCGGAAAGAGAAACGGGAGCTAAAGGAAACCCTACTGAAATGCACAGACAAGGAA GTCCTGGCGAGCCTGGAGCAGAAGCTGAAGGAAATTGACGAGGAGTGCCGGGGCGAGGAGAGCAGGCGCGTGGACCTGGAGCTCAGCATC ATGGAGGTGAAGGACAACCTGAAGAAGGCTGAGGCAGGGCCTGTGACGTTAGGCACCACCGTGGACACCACCCACCTGGAGAATCCCAAA GCTGTCACACCTGCCTCTGCCCCAGACTGTACCCCAGTCAACTCTGCAACCACACTCAAGAACAGGCCTCTCTCGGTCGTGGTCACAGGC >In-frame_GRID1_ENST00000327946_chr10_88123698_-_AFAP1L2_ENST00000545353_chr10_116100490_-_2835nt ATGGAAGCGCTGACGCTGTGGCTTCTCCCCTGGATATGCCAGTGCGTGTCGGTGCGGGCCGACTCCATCATCCACATCGGTGCCATCTTC GAGGAGAACGCGGCCAAGGACGACAGGGTGTTCCAGTTGGCGGTATCCGACCTGAGCCTCAACGATGACATCCTGCAGAGCGAGAAGATC ACCTACTCCATCAAGGTCATCGAGGCCAACAACCCATTCCAGGCTGTGCAGGAAGCCCTGGAACAGCTGCTGACAGAGTTGGATGACTTC CTCAAGATTCTTGACCAGGAGAACCTGAGCAGCACAGCACTGGTGAAGAAGAGCTGCCTGGCGGAGCTCCTCCGGCTTTACACCAAAAGC AGCAGCTCTGATGAGGAGTACATTTATATGAACAAAGTGACCATCAACAAGCAACAGAATGCAGAGTCTCAAGGCAAAGCGCCTGAGGAG CAGGGCCTGCTACCCAATGGGGAGCCCAGCCAGCACTCCTCGGCCCCTCAGAAGAGCCTTCCAGACCTCCCGCCACCCAAGATGAGAATC CTGACCTTGGGCCAGATCTCGGGTGCCCAGAGCTTTTCTCCAGATGGGACCCACCTGACGGGAACGGAGTTTCTTGGAGGCTGGAGCTGG AGGCCCAGCCAGATCAGGCTGATGAGCCCTGGGACCCACTGGGGAGACCTTACTGCCACAGAGATTCCAGAACGGAAACAGCTTGCCATC CCAAAGACGGAGTCTCCAGAGGGCTACTATGAAGAGGCTGAGCCATATGACACATCCCTCAATGAGGACGGAGAGGCTGTGAGCAGCTCC TACGAGTCCTACGATGAAGAGGACGGCAGCAAGGGCAAGTCGGCCCCTTACCAGTGGCCCTCGCCGGAGGCCGGCATCGAGCTGATGCGT GACGCCCGCATCTGCGCCTTCCTGTGGCGCAAGAAGTGGCTGGGACAGTGGGCCAAGCAGCTCTGTGTCATCAAGGACAACAGGCTTCTG TGCTACAAATCCTCCAAGGACCACAGCCCTCAGCTGGACGTGAACCTACTGGGCAGCAGCGTCATTCACAAGGAGAAGCAAGTGCGGAAG AAGGAGCACAAGCTGAAGATCACGCCGATGAATGCCGATGTGATTGTGCTGGGCCTGCAGAGCAAGGACCAGGCTGAGCAGTGGCTCAGG GTCATCCAGGAAGTGAGCGGCCTGCCTTCCGAAGGAGCATCTGAAGGAAACCAGTACACCCCGGATGCCCAGCGCTTTAACTGCCAGAAA CCAGATATAGCTGAGAAGTACCTGTCGGCTTCAGAGTATGGGAGCTCCGTGGATGGCCACCCTGAGGTCCCAGAAACCAAAGACGTCAAG AAGAAATGTTCTGCTGGCCTCAAACTGAGCAACCTAATGAATCTGGGCAGGAAGAAATCCACCTCACTGGAGCCTGTGGAGAGGTCCCTC GAGACATCCAGTTACCTGAACGTGCTGGTGAACAGCCAGTGGAAGTCTCGCTGGTGCTCTGTCAGGGACAATCACCTGCACTTCTACCAG GACCGGAACCGGAGCAAGGTGGCCCAGCAACCCCTCAGCCTGGTGGGCTGCGAGGTGGTCCCAGACCCCAGCCCCGACCACCTCTACTCC TTCCGCATCCTCCACAAGGGCGAGGAGCTGGCCAAGCTTGAGGCCAAGTCTTCCGAGGAAATGGGCCACTGGCTGGGTCTCCTGCTCTCT GAGTCAGGCTCCAAGACAGACCCAGAAGAGTTCACCTACGACTATGTGGATGCCGATAGGGTCTCCTGTATTGTGAGTGCGGCCAAAAAC TCTCTCTTACTGATGCAGAGAAAGTTCTCAGAGCCCAACACTTACATCGATGGCCTGCCTAGCCAGGACCGCCAGGAGGAGCTGTATGAC GACGTGGACCTGTCAGAGCTCACAGCTGCGGTGGAGCCTACCGAGGAAGCCACCCCTGTTGCAGATGACCCAAATGAGAGAGAATCTGAC CGAGTGTACCTGGACCTCACACCTGTCAAGTCCTTTCTGCATGGCCCCAGCAGTGCACAGGCCCAGGCCTCCTCCCCGACGTTGTCCTGC CTGGACAATGCAACTGAGGCCCTCCCGGCAGACTCAGGCCCAGGTCCCACCCCAGATGAGCCCTGCATAAAGTGTCCAGAGAACCTGGGA GAACAGCAGCTGGAGAGTTTGGAGCCAGAGGATCCTTCCCTGAGAATCACCACCGTCAAAATCCAGACGGAACAGCAGAGAATCTCCTTC CCACCGAGCTGCCCGGATGCCGTGGTGGCCACCCCACCTGGTGCCAGCCCACCTGTGAAGGACAGGTTGCGCGTGACCAGTGCAGAGATC AAGCTTGGCAAGAATCGGACAGAAGCTGAGGTGAAGCGGTACACAGAGGAGAAGGAGAGGCTTGAAAAGAAGAAGGAAGAAATCCGGGGG CACCTGGCTCAGCTCCGGAAAGAGAAACGGGAGCTAAAGGAAACCCTACTGAAATGCACAGACAAGGAAGTCCTGGCGAGCCTGGAGCAG AAGCTGAAGGAAATTGACGAGGAGTGCCGGGGCGAGGAGAGCAGGCGCGTGGACCTGGAGCTCAGCATCATGGAGGTGAAGGACAACCTG AAGAAGGCTGAGGCAGGGCCTGTGACGTTAGGCACCACCGTGGACACCACCCACCTGGAGAATGTGAGCCCCCGCCCCAAAGCTGTCACA CCTGCCTCTGCCCCAGACTGTACCCCAGTCAACTCTGCAACCACACTCAAGAACAGGCCTCTCTCGGTCGTGGTCACAGGCAAAGGCACT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GRID1_ENST00000327946_chr10_88123698_-_AFAP1L2_ENST00000304129_chr10_116100490_-_3980nt ACTGCACCGGGACCAGCGCCTCCCCGCTTCGCGCTGCCCTCGGCCTCGCCCCGGGCCCGGGTGGATGAGCCGCGCGCCCGGGGGACATGG AAGCGCTGACGCTGTGGCTTCTCCCCTGGATATGCCAGTGCGTGTCGGTGCGGGCCGACTCCATCATCCACATCGGTGCCATCTTCGAGG AGAACGCGGCCAAGGACGACAGGGTGTTCCAGTTGGCGGTATCCGACCTGAGCCTCAACGATGACATCCTGCAGAGCGAGAAGATCACCT ACTCCATCAAGGTCATCGAGGCCAACAACCCATTCCAGGCTGTGCAGGAAGCCCTGGAACAGCTGCTGACAGAGTTGGATGACTTCCTCA AGATTCTTGACCAGGAGAACCTGAGCAGCACAGCACTGGTGAAGAAGAGCTGCCTGGCGGAGCTCCTCCGGCTTTACACCAAAAGCAGCA GCTCTGATGAGGAGTACATTTATATGAACAAAGTGACCATCAACAAGCAACAGAATGCAGAGTCTCAAGGCAAAGCGCCTGAGGAGCAGG GCCTGCTACCCAATGGGGAGCCCAGCCAGCACTCCTCGGCCCCTCAGAAGAGCCTTCCAGACCTCCCGCCACCCAAGATGATTCCAGAAC GGAAACAGCTTGCCATCCCAAAGACGGAGTCTCCAGAGGGCTACTATGAAGAGGCTGAGCCATATGACACATCCCTCAATGAGGACGGAG AGGCTGTGAGCAGCTCCTACGAGTCCTACGATGAAGAGGACGGCAGCAAGGGCAAGTCGGCCCCTTACCAGTGGCCCTCGCCGGAGGCCG GCATCGAGCTGATGCGTGACGCCCGCATCTGCGCCTTCCTGTGGCGCAAGAAGTGGCTGGGACAGTGGGCCAAGCAGCTCTGTGTCATCA AGGACAACAGGCTTCTGTGCTACAAATCCTCCAAGGACCACAGCCCTCAGCTGGACGTGAACCTACTGGGCAGCAGCGTCATTCACAAGG AGAAGCAAGTGCGGAAGAAGGAGCACAAGCTGAAGATCACGCCGATGAATGCCGATGTGATTGTGCTGGGCCTGCAGAGCAAGGACCAGG CTGAGCAGTGGCTCAGGGTCATCCAGGAAGTGAGCGGCCTGCCTTCCGAAGGAGCATCTGAAGGAAACCAGTACACCCCGGATGCCCAGC GCTTTAACTGCCAGAAACCAGATATAGCTGAGAAGTACCTGTCGGCTTCAGAGTATGGGAGCTCCGTGGATGGCCACCCTGAGGTCCCAG AAACCAAAGACGTCAAGAAGAAATGTTCTGCTGGCCTCAAACTGAGCAACCTAATGAATCTGGGCAGGAAGAAATCCACCTCACTGGAGC CTGTGGAGAGGTCCCTCGAGACATCCAGTTACCTGAACGTGCTGGTGAACAGCCAGTGGAAGTCTCGCTGGTGCTCTGTCAGGGACAATC ACCTGCACTTCTACCAGGACCGGAACCGGAGCAAGGTGGCCCAGCAACCCCTCAGCCTGGTGGGCTGCGAGGTGGTCCCAGACCCCAGCC CCGACCACCTCTACTCCTTCCGCATCCTCCACAAGGGCGAGGAGCTGGCCAAGCTTGAGGCCAAGTCTTCCGAGGAAATGGGCCACTGGC TGGGTCTCCTGCTCTCTGAGTCAGGCTCCAAGACAGACCCAGAAGAGTTCACCTACGACTATGTGGATGCCGATAGGGTCTCCTGTATTG TGAGTGCGGCCAAAAACTCTCTCTTACTGATGCAGAGAAAGTTCTCAGAGCCCAACACTTACATCGATGGCCTGCCTAGCCAGGACCGCC AGGAGGAGCTGTATGACGACGTGGACCTGTCAGAGCTCACAGCTGCGGTGGAGCCTACCGAGGAAGCCACCCCTGTTGCAGATGACCCAA ATGAGAGAGAATCTGACCGAGTGTACCTGGACCTCACACCTGTCAAGTCCTTTCTGCATGGCCCCAGCAGTGCACAGGCCCAGGCCTCCT CCCCGACGTTGTCCTGCCTGGACAATGCAACTGAGGCCCTCCCGGCAGACTCAGGCCCAGGTCCCACCCCAGATGAGCCCTGCATAAAGT GTCCAGAGAACCTGGGAGAACAGCAGCTGGAGAGTTTGGAGCCAGAGGATCCTTCCCTGAGAATCACCACCGTCAAAATCCAGACGGAAC AGCAGAGAATCTCCTTCCCACCGAGCTGCCCGGATGCCGTGGTGGCCACCCCACCTGGTGCCAGCCCACCTGTGAAGGACAGGTTGCGCG TGACCAGTGCAGAGATCAAGCTTGGCAAGAATCGGACAGAAGCTGAGGTGAAGCGGTACACAGAGGAGAAGGAGAGGCTTGAAAAGAAGA AGGAAGAAATCCGGGGGCACCTGGCTCAGCTCCGGAAAGAGAAACGGGAGCTAAAGGAAACCCTACTGAAATGCACAGACAAGGAAGTCC TGGCGAGCCTGGAGCAGAAGCTGAAGGAAATTGACGAGGAGTGCCGGGGCGAGGAGAGCAGGCGCGTGGACCTGGAGCTCAGCATCATGG AGGTGAAGGACAACCTGAAGAAGGCTGAGGCAGGGCCTGTGACGTTAGGCACCACCGTGGACACCACCCACCTGGAGAATGTGAGCCCCC GCCCCAAAGCTGTCACACCTGCCTCTGCCCCAGACTGTACCCCAGTCAACTCTGCAACCACACTCAAGAACAGGCCTCTCTCGGTCGTGG TCACAGGCAAAGGCACTGTACTCCAGAAAGCCAAGGAATGGGAGAAGAAAGGAGCAAGTTAGAAAACAAGCTTCATCTAAAGACTCTCAT GTCAATGTGGACCTTGGTGACAATCCTGCTTTGTTAAAGCAAAAACTATGCGAAAGGGTGAGTCTGTTTAGAAGAAAAAGCAAAGACTGA GGTACTGTGAATGGAGAGCTTCAGCTAAGAGGAGGCTCTGTCCCTTTTCAGAGCCAAAGGAAATAATACAACAAAAAGGAGGCTTCTTTG GAGACCTAAGTCTATTGGATGTAAACAAGACGTTGTATTTAGGGATGTTCTGTGTTTCTTTCTTTTTTGAAGTTGTCATCAATTGCTTTA CTAAGATTTTTAAATAGTGAAAACCTCCTGTTTAGACTTTGGTGGAAGATGAATCAAGGAAGCAGGGCCCTGTCTTATGGGTCACGTGTC TTTGGTGAGTGAGAAGACCTAAACTCCTGGCCATCATCTCTTATCCAATACTTAGCAGTTGGGGATTAAACCATCCTTGCCTTCAGTTCT CTCCAATATTACCAGGCCCAACTCAGTCTTCAGTGATTTTAAACAGCATTGACATCATCTGTAAAACCATCATCTGTAAAACCATCTATG ACATGAGTTTTGAGAAACAATAATGGGGAAAATATTTGGGACCAAGCTGAAGCACTAATCCCACTAAGTTAAAGACTTCTTTCCAGTCCA AGGCAGGCCTGAATCAACTGTCTTTAAATAAAATTTTAAGTGATGCTGTATTATATATAGGAAAAAATGCTTAAAATCCTGTCATTTAGA ACAGTGAAAAGTATCTTTTGAGATTAAAGTGACTCTTTACTGTAGGAAAAATATTACTCTGTGTTTACAGATTCATTGCTGTGGTCAGGC CATTTTTAAGGGAAGAGTTATTTAATATAAATAGTCTCTGATTTTAAGTTCTGTTTAATGTTCATTCTCCTTCCAAGAACAAAGTGGTGA TTTTTGGTTAGGGTGATCGCCCTCTTAAAATTGGCAGTGCTGTTCCTTGTGCTGCCCCTGTCTTTTCCTCTGATGGCATTTTTTTTTTTT TTTTTTTAACACAGGTTGAAACATTTCATCTATTATCTCTGCCTCATTTCTGGAGGGTTGTGTATCAGTTCTCTAACACTTGTTCCTGAG AACTAAATGTCTTTTTTATTCTTATTTCCTCTCTCATAAACATTTGGTGACCTTTTACCAAGTGGTGAGTTAGTTAGGTTTTTTAAAATA >In-frame_GRID1_ENST00000327946_chr10_88123698_-_AFAP1L2_ENST00000369271_chr10_116100490_-_3968nt ACTGCACCGGGACCAGCGCCTCCCCGCTTCGCGCTGCCCTCGGCCTCGCCCCGGGCCCGGGTGGATGAGCCGCGCGCCCGGGGGACATGG AAGCGCTGACGCTGTGGCTTCTCCCCTGGATATGCCAGTGCGTGTCGGTGCGGGCCGACTCCATCATCCACATCGGTGCCATCTTCGAGG AGAACGCGGCCAAGGACGACAGGGTGTTCCAGTTGGCGGTATCCGACCTGAGCCTCAACGATGACATCCTGCAGAGCGAGAAGATCACCT ACTCCATCAAGGTCATCGAGGCCAACAACCCATTCCAGGCTGTGCAGGAAGCCCTGGAACAGCTGCTGACAGAGTTGGATGACTTCCTCA AGATTCTTGACCAGGAGAACCTGAGCAGCACAGCACTGGTGAAGAAGAGCTGCCTGGCGGAGCTCCTCCGGCTTTACACCAAAAGCAGCA GCTCTGATGAGGAGTACATTTATATGAACAAAGTGACCATCAACAAGCAACAGAATGCAGAGTCTCAAGGCAAAGCGCCTGAGGAGCAGG GCCTGCTACCCAATGGGGAGCCCAGCCAGCACTCCTCGGCCCCTCAGAAGAGCCTTCCAGACCTCCCGCCACCCAAGATGATTCCAGAAC GGAAACAGCTTGCCATCCCAAAGACGGAGTCTCCAGAGGGCTACTATGAAGAGGCTGAGCCATATGACACATCCCTCAATGAGGACGGAG AGGCTGTGAGCAGCTCCTACGAGTCCTACGATGAAGAGGACGGCAGCAAGGGCAAGTCGGCCCCTTACCAGTGGCCCTCGCCGGAGGCCG GCATCGAGCTGATGCGTGACGCCCGCATCTGCGCCTTCCTGTGGCGCAAGAAGTGGCTGGGACAGTGGGCCAAGCAGCTCTGTGTCATCA AGGACAACAGGCTTCTGTGCTACAAATCCTCCAAGGACCACAGCCCTCAGCTGGACGTGAACCTACTGGGCAGCAGCGTCATTCACAAGG AGAAGCAAGTGCGGAAGAAGGAGCACAAGCTGAAGATCACGCCGATGAATGCCGATGTGATTGTGCTGGGCCTGCAGAGCAAGGACCAGG CTGAGCAGTGGCTCAGGGTCATCCAGGAAGTGAGCGGCCTGCCTTCCGAAGGAGCATCTGAAGGAAACCAGTACACCCCGGATGCCCAGC GCTTTAACTGCCAGAAACCAGATATAGCTGAGAAGTACCTGTCGGCTTCAGAGTATGGGAGCTCCGTGGATGGCCACCCTGAGGTCCCAG AAACCAAAGACGTCAAGAAGAAATGTTCTGCTGGCCTCAAACTGAGCAACCTAATGAATCTGGGCAGGAAGAAATCCACCTCACTGGAGC CTGTGGAGAGGTCCCTCGAGACATCCAGTTACCTGAACGTGCTGGTGAACAGCCAGTGGAAGTCTCGCTGGTGCTCTGTCAGGGACAATC ACCTGCACTTCTACCAGGACCGGAACCGGAGCAAGGTGGCCCAGCAACCCCTCAGCCTGGTGGGCTGCGAGGTGGTCCCAGACCCCAGCC CCGACCACCTCTACTCCTTCCGCATCCTCCACAAGGGCGAGGAGCTGGCCAAGCTTGAGGCCAAGTCTTCCGAGGAAATGGGCCACTGGC TGGGTCTCCTGCTCTCTGAGTCAGGCTCCAAGACAGACCCAGAAGAGTTCACCTACGACTATGTGGATGCCGATAGGGTCTCCTGTATTG TGAGTGCGGCCAAAAACTCTCTCTTACTGATGCAGAGAAAGTTCTCAGAGCCCAACACTTACATCGATGGCCTGCCTAGCCAGGACCGCC AGGAGGAGCTGTATGACGACGTGGACCTGTCAGAGCTCACAGCTGCGGTGGAGCCTACCGAGGAAGCCACCCCTGTTGCAGATGACCCAA ATGAGAGAGAATCTGACCGAGTGTACCTGGACCTCACACCTGTCAAGTCCTTTCTGCATGGCCCCAGCAGTGCACAGGCCCAGGCCTCCT CCCCGACGTTGTCCTGCCTGGACAATGCAACTGAGGCCCTCCCGGCAGACTCAGGCCCAGGTCCCACCCCAGATGAGCCCTGCATAAAGT GTCCAGAGAACCTGGGAGAACAGCAGCTGGAGAGTTTGGAGCCAGAGGATCCTTCCCTGAGAATCACCACCGTCAAAATCCAGACGGAAC AGCAGAGAATCTCCTTCCCACCGAGCTGCCCGGATGCCGTGGTGGCCACCCCACCTGGTGCCAGCCCACCTGTGAAGGACAGGTTGCGCG TGACCAGTGCAGAGATCAAGCTTGGCAAGAATCGGACAGAAGCTGAGGTGAAGCGGTACACAGAGGAGAAGGAGAGGCTTGAAAAGAAGA AGGAAGAAATCCGGGGGCACCTGGCTCAGCTCCGGAAAGAGAAACGGGAGCTAAAGGAAACCCTACTGAAATGCACAGACAAGGAAGTCC TGGCGAGCCTGGAGCAGAAGCTGAAGGAAATTGACGAGGAGTGCCGGGGCGAGGAGAGCAGGCGCGTGGACCTGGAGCTCAGCATCATGG AGGTGAAGGACAACCTGAAGAAGGCTGAGGCAGGGCCTGTGACGTTAGGCACCACCGTGGACACCACCCACCTGGAGAATCCCAAAGCTG TCACACCTGCCTCTGCCCCAGACTGTACCCCAGTCAACTCTGCAACCACACTCAAGAACAGGCCTCTCTCGGTCGTGGTCACAGGCAAAG GCACTGTACTCCAGAAAGCCAAGGAATGGGAGAAGAAAGGAGCAAGTTAGAAAACAAGCTTCATCTAAAGACTCTCATGTCAATGTGGAC CTTGGTGACAATCCTGCTTTGTTAAAGCAAAAACTATGCGAAAGGGTGAGTCTGTTTAGAAGAAAAAGCAAAGACTGAGGTACTGTGAAT GGAGAGCTTCAGCTAAGAGGAGGCTCTGTCCCTTTTCAGAGCCAAAGGAAATAATACAACAAAAAGGAGGCTTCTTTGGAGACCTAAGTC TATTGGATGTAAACAAGACGTTGTATTTAGGGATGTTCTGTGTTTCTTTCTTTTTTGAAGTTGTCATCAATTGCTTTACTAAGATTTTTA AATAGTGAAAACCTCCTGTTTAGACTTTGGTGGAAGATGAATCAAGGAAGCAGGGCCCTGTCTTATGGGTCACGTGTCTTTGGTGAGTGA GAAGACCTAAACTCCTGGCCATCATCTCTTATCCAATACTTAGCAGTTGGGGATTAAACCATCCTTGCCTTCAGTTCTCTCCAATATTAC CAGGCCCAACTCAGTCTTCAGTGATTTTAAACAGCATTGACATCATCTGTAAAACCATCATCTGTAAAACCATCTATGACATGAGTTTTG AGAAACAATAATGGGGAAAATATTTGGGACCAAGCTGAAGCACTAATCCCACTAAGTTAAAGACTTCTTTCCAGTCCAAGGCAGGCCTGA ATCAACTGTCTTTAAATAAAATTTTAAGTGATGCTGTATTATATATAGGAAAAAATGCTTAAAATCCTGTCATTTAGAACAGTGAAAAGT ATCTTTTGAGATTAAAGTGACTCTTTACTGTAGGAAAAATATTACTCTGTGTTTACAGATTCATTGCTGTGGTCAGGCCATTTTTAAGGG AAGAGTTATTTAATATAAATAGTCTCTGATTTTAAGTTCTGTTTAATGTTCATTCTCCTTCCAAGAACAAAGTGGTGATTTTTGGTTAGG GTGATCGCCCTCTTAAAATTGGCAGTGCTGTTCCTTGTGCTGCCCCTGTCTTTTCCTCTGATGGCATTTTTTTTTTTTTTTTTTTAACAC AGGTTGAAACATTTCATCTATTATCTCTGCCTCATTTCTGGAGGGTTGTGTATCAGTTCTCTAACACTTGTTCCTGAGAACTAAATGTCT TTTTTATTCTTATTTCCTCTCTCATAAACATTTGGTGACCTTTTACCAAGTGGTGAGTTAGTTAGGTTTTTTAAAATAAAATGTTCATTG >In-frame_GRID1_ENST00000327946_chr10_88123698_-_AFAP1L2_ENST00000545353_chr10_116100490_-_3191nt ACTGCACCGGGACCAGCGCCTCCCCGCTTCGCGCTGCCCTCGGCCTCGCCCCGGGCCCGGGTGGATGAGCCGCGCGCCCGGGGGACATGG AAGCGCTGACGCTGTGGCTTCTCCCCTGGATATGCCAGTGCGTGTCGGTGCGGGCCGACTCCATCATCCACATCGGTGCCATCTTCGAGG AGAACGCGGCCAAGGACGACAGGGTGTTCCAGTTGGCGGTATCCGACCTGAGCCTCAACGATGACATCCTGCAGAGCGAGAAGATCACCT ACTCCATCAAGGTCATCGAGGCCAACAACCCATTCCAGGCTGTGCAGGAAGCCCTGGAACAGCTGCTGACAGAGTTGGATGACTTCCTCA AGATTCTTGACCAGGAGAACCTGAGCAGCACAGCACTGGTGAAGAAGAGCTGCCTGGCGGAGCTCCTCCGGCTTTACACCAAAAGCAGCA GCTCTGATGAGGAGTACATTTATATGAACAAAGTGACCATCAACAAGCAACAGAATGCAGAGTCTCAAGGCAAAGCGCCTGAGGAGCAGG GCCTGCTACCCAATGGGGAGCCCAGCCAGCACTCCTCGGCCCCTCAGAAGAGCCTTCCAGACCTCCCGCCACCCAAGATGAGAATCCTGA CCTTGGGCCAGATCTCGGGTGCCCAGAGCTTTTCTCCAGATGGGACCCACCTGACGGGAACGGAGTTTCTTGGAGGCTGGAGCTGGAGGC CCAGCCAGATCAGGCTGATGAGCCCTGGGACCCACTGGGGAGACCTTACTGCCACAGAGATTCCAGAACGGAAACAGCTTGCCATCCCAA AGACGGAGTCTCCAGAGGGCTACTATGAAGAGGCTGAGCCATATGACACATCCCTCAATGAGGACGGAGAGGCTGTGAGCAGCTCCTACG AGTCCTACGATGAAGAGGACGGCAGCAAGGGCAAGTCGGCCCCTTACCAGTGGCCCTCGCCGGAGGCCGGCATCGAGCTGATGCGTGACG CCCGCATCTGCGCCTTCCTGTGGCGCAAGAAGTGGCTGGGACAGTGGGCCAAGCAGCTCTGTGTCATCAAGGACAACAGGCTTCTGTGCT ACAAATCCTCCAAGGACCACAGCCCTCAGCTGGACGTGAACCTACTGGGCAGCAGCGTCATTCACAAGGAGAAGCAAGTGCGGAAGAAGG AGCACAAGCTGAAGATCACGCCGATGAATGCCGATGTGATTGTGCTGGGCCTGCAGAGCAAGGACCAGGCTGAGCAGTGGCTCAGGGTCA TCCAGGAAGTGAGCGGCCTGCCTTCCGAAGGAGCATCTGAAGGAAACCAGTACACCCCGGATGCCCAGCGCTTTAACTGCCAGAAACCAG ATATAGCTGAGAAGTACCTGTCGGCTTCAGAGTATGGGAGCTCCGTGGATGGCCACCCTGAGGTCCCAGAAACCAAAGACGTCAAGAAGA AATGTTCTGCTGGCCTCAAACTGAGCAACCTAATGAATCTGGGCAGGAAGAAATCCACCTCACTGGAGCCTGTGGAGAGGTCCCTCGAGA CATCCAGTTACCTGAACGTGCTGGTGAACAGCCAGTGGAAGTCTCGCTGGTGCTCTGTCAGGGACAATCACCTGCACTTCTACCAGGACC GGAACCGGAGCAAGGTGGCCCAGCAACCCCTCAGCCTGGTGGGCTGCGAGGTGGTCCCAGACCCCAGCCCCGACCACCTCTACTCCTTCC GCATCCTCCACAAGGGCGAGGAGCTGGCCAAGCTTGAGGCCAAGTCTTCCGAGGAAATGGGCCACTGGCTGGGTCTCCTGCTCTCTGAGT CAGGCTCCAAGACAGACCCAGAAGAGTTCACCTACGACTATGTGGATGCCGATAGGGTCTCCTGTATTGTGAGTGCGGCCAAAAACTCTC TCTTACTGATGCAGAGAAAGTTCTCAGAGCCCAACACTTACATCGATGGCCTGCCTAGCCAGGACCGCCAGGAGGAGCTGTATGACGACG TGGACCTGTCAGAGCTCACAGCTGCGGTGGAGCCTACCGAGGAAGCCACCCCTGTTGCAGATGACCCAAATGAGAGAGAATCTGACCGAG TGTACCTGGACCTCACACCTGTCAAGTCCTTTCTGCATGGCCCCAGCAGTGCACAGGCCCAGGCCTCCTCCCCGACGTTGTCCTGCCTGG ACAATGCAACTGAGGCCCTCCCGGCAGACTCAGGCCCAGGTCCCACCCCAGATGAGCCCTGCATAAAGTGTCCAGAGAACCTGGGAGAAC AGCAGCTGGAGAGTTTGGAGCCAGAGGATCCTTCCCTGAGAATCACCACCGTCAAAATCCAGACGGAACAGCAGAGAATCTCCTTCCCAC CGAGCTGCCCGGATGCCGTGGTGGCCACCCCACCTGGTGCCAGCCCACCTGTGAAGGACAGGTTGCGCGTGACCAGTGCAGAGATCAAGC TTGGCAAGAATCGGACAGAAGCTGAGGTGAAGCGGTACACAGAGGAGAAGGAGAGGCTTGAAAAGAAGAAGGAAGAAATCCGGGGGCACC TGGCTCAGCTCCGGAAAGAGAAACGGGAGCTAAAGGAAACCCTACTGAAATGCACAGACAAGGAAGTCCTGGCGAGCCTGGAGCAGAAGC TGAAGGAAATTGACGAGGAGTGCCGGGGCGAGGAGAGCAGGCGCGTGGACCTGGAGCTCAGCATCATGGAGGTGAAGGACAACCTGAAGA AGGCTGAGGCAGGGCCTGTGACGTTAGGCACCACCGTGGACACCACCCACCTGGAGAATGTGAGCCCCCGCCCCAAAGCTGTCACACCTG CCTCTGCCCCAGACTGTACCCCAGTCAACTCTGCAACCACACTCAAGAACAGGCCTCTCTCGGTCGTGGTCACAGGCAAAGGCACTGTAC TCCAGAAAGCCAAGGAATGGGAGAAGAAAGGAGCAAGTTAGAAAACAAGCTTCATCTAAAGACTCTCATGTCAATGTGGACCTTGGTGAC AATCCTGCTTTGTTAAAGCAAAAACTATGCGAAAGGGTGAGTCTGTTTAGAAGAAAAAGCAAAGACTGAGGTACTGTGAATGGAGAGCTT CAGCTAAGAGGAGGCTCTGTCCCTTTTCAGAGCCAAAGGAAATAATACAACAAAAAGGAGGCTTCTTTGGAGACCTAAGTCTATTGGATG |
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FusionGenePPI for GRID1_AFAP1L2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GRID1 | DEF6, EGFR, TCTN2, HTR3A, HBB | AFAP1L2 | TERF1, TINF2, ACD, POT1, TERF2, ATXN1L, APP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | GRID1 | chr10:88123698 | chr10:116100490 | ENST00000327946 | - | 2 | 16 | 21_436 | 78 | 1010 | CBLN1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GRID1_AFAP1L2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | GRID1 | Q9ULK0 | DB00142 | Glutamic Acid | Glutamate receptor ionotropic, delta-1 | small molecule | approved|nutraceutical |
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RelatedDiseases for GRID1_AFAP1L2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GRID1 | C0036341 | Schizophrenia | 5 | PSYGENET |
| Hgene | GRID1 | C0011570 | Mental Depression | 3 | PSYGENET |
| Hgene | GRID1 | C0011581 | Depressive disorder | 3 | PSYGENET |
| Hgene | GRID1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | GRID1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
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