|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 15409 |
FusionGeneSummary for GRHPR_GATA3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GRHPR_GATA3 | Fusion gene ID: 15409 | Hgene | Tgene | Gene symbol | GRHPR | GATA3 | Gene ID | 9380 | 2625 |
| Gene name | glyoxylate and hydroxypyruvate reductase | GATA binding protein 3 | |
| Synonyms | GLXR|GLYD|PH2 | HDR|HDRS | |
| Cytomap | 9p13.2 | 10p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glyoxylate reductase/hydroxypyruvate reductaseglycerate-2-dehydrogenaseglyoxylate reductase and hydroxypyruvate reductase | trans-acting T-cell-specific transcription factor GATA-3GATA-binding factor 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UBQ7 | P23771 | |
| Ensembl transtripts involved in fusion gene | ENST00000493368, ENST00000318158, ENST00000607784, | ENST00000379328, ENST00000346208, ENST00000461472, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: GRHPR [Title/Abstract] AND GATA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GRHPR | GO:0046487 | glyoxylate metabolic process | 10524214 |
| Hgene | GRHPR | GO:0051259 | protein complex oligomerization | 16756993 |
| Hgene | GRHPR | GO:0055114 | oxidation-reduction process | 10484776|10524214 |
| Tgene | GATA3 | GO:0033600 | negative regulation of mammary gland epithelial cell proliferation | 19483726 |
| Tgene | GATA3 | GO:0045893 | positive regulation of transcription, DNA-templated | 19723756|19805038 |
| Tgene | GATA3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19232384|20189993|20484083 |
| Tgene | GATA3 | GO:0060231 | mesenchymal to epithelial transition | 20189993 |
| Tgene | GATA3 | GO:0072676 | lymphocyte migration | 19805038 |
| Tgene | GATA3 | GO:2000664 | positive regulation of interleukin-5 secretion | 20554961 |
| Tgene | GATA3 | GO:2000667 | positive regulation of interleukin-13 secretion | 20554961 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AO-A12A-01A | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000493368 | ENST00000379328 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| intron-3CDS | ENST00000493368 | ENST00000346208 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| intron-3UTR | ENST00000493368 | ENST00000461472 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| Frame-shift | ENST00000318158 | ENST00000379328 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| Frame-shift | ENST00000318158 | ENST00000346208 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| 5CDS-3UTR | ENST00000318158 | ENST00000461472 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| Frame-shift | ENST00000607784 | ENST00000379328 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| Frame-shift | ENST00000607784 | ENST00000346208 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
| 5CDS-3UTR | ENST00000607784 | ENST00000461472 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
Top |
FusionProtFeatures for GRHPR_GATA3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRHPR | GATA3 |
| Enzyme with hydroxy-pyruvate reductase, glyoxylatereductase and D-glycerate dehydrogenase enzymatic activities.Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolateoxidizes D-glycerate to hydroxypyruvate. | Transcriptional activator which binds to the enhancer ofthe T-cell receptor alpha and delta genes. Binds to the consensussequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2)differentiation process following immune and inflammatoryresponses. {ECO:0000269|PubMed:23824597}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for GRHPR_GATA3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for GRHPR_GATA3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GRHPR | LSM1, SUCLA2, HSD17B4, SLC25A5, CXADR, PGM1, ACOX1, LIG4, PTH2R, FOS, CDC7, GLS2, MOV10, NXF1, AKR1B1, ETFA, ETFB, AGL, AKR1A1, CARKD, CTSD, GFER, GLO1, HSPE1, PIR, PRDX6, RFK, RTN4, VPS29, PCBP1, TJP1, UFM1 | GATA3 | LMO1, LMO2, TAL1, BMI1, MDM2, HDAC3, HDAC5, TBX21, RARB, HDAC4, SP1, REPIN1, MYB, SPI1, BRCA1, USP21, FOXP3, PSMA3, CDK2, FBXW7, MAPK14, WEE1, FOXA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for GRHPR_GATA3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for GRHPR_GATA3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GRHPR | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | GATA3 | C1840333 | Barakat syndrome | 3 | CTD_human;ORPHANET;UNIPROT |
| Tgene | GATA3 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Tgene | GATA3 | C0019829 | Hodgkin Disease | 1 | CTD_human |
| Tgene | GATA3 | C0021368 | Inflammation | 1 | CTD_human |
| Tgene | GATA3 | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human |
| Tgene | GATA3 | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
| Tgene | GATA3 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Tgene | GATA3 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|