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Fusion gene ID: 15409 |
FusionGeneSummary for GRHPR_GATA3 |
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Fusion gene information | Fusion gene name: GRHPR_GATA3 | Fusion gene ID: 15409 | Hgene | Tgene | Gene symbol | GRHPR | GATA3 | Gene ID | 9380 | 2625 |
Gene name | glyoxylate and hydroxypyruvate reductase | GATA binding protein 3 | |
Synonyms | GLXR|GLYD|PH2 | HDR|HDRS | |
Cytomap | 9p13.2 | 10p14 | |
Type of gene | protein-coding | protein-coding | |
Description | glyoxylate reductase/hydroxypyruvate reductaseglycerate-2-dehydrogenaseglyoxylate reductase and hydroxypyruvate reductase | trans-acting T-cell-specific transcription factor GATA-3GATA-binding factor 3 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UBQ7 | P23771 | |
Ensembl transtripts involved in fusion gene | ENST00000493368, ENST00000318158, ENST00000607784, | ENST00000379328, ENST00000346208, ENST00000461472, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 1 X 1 X 1=1 |
# samples | 4 | 1 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: GRHPR [Title/Abstract] AND GATA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GRHPR | GO:0046487 | glyoxylate metabolic process | 10524214 |
Hgene | GRHPR | GO:0051259 | protein complex oligomerization | 16756993 |
Hgene | GRHPR | GO:0055114 | oxidation-reduction process | 10484776|10524214 |
Tgene | GATA3 | GO:0033600 | negative regulation of mammary gland epithelial cell proliferation | 19483726 |
Tgene | GATA3 | GO:0045893 | positive regulation of transcription, DNA-templated | 19723756|19805038 |
Tgene | GATA3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19232384|20189993|20484083 |
Tgene | GATA3 | GO:0060231 | mesenchymal to epithelial transition | 20189993 |
Tgene | GATA3 | GO:0072676 | lymphocyte migration | 19805038 |
Tgene | GATA3 | GO:2000664 | positive regulation of interleukin-5 secretion | 20554961 |
Tgene | GATA3 | GO:2000667 | positive regulation of interleukin-13 secretion | 20554961 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AO-A12A-01A | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000493368 | ENST00000379328 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
intron-3CDS | ENST00000493368 | ENST00000346208 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
intron-3UTR | ENST00000493368 | ENST00000461472 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
Frame-shift | ENST00000318158 | ENST00000379328 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
Frame-shift | ENST00000318158 | ENST00000346208 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
5CDS-3UTR | ENST00000318158 | ENST00000461472 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
Frame-shift | ENST00000607784 | ENST00000379328 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
Frame-shift | ENST00000607784 | ENST00000346208 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
5CDS-3UTR | ENST00000607784 | ENST00000461472 | GRHPR | chr9 | 37422830 | + | GATA3 | chr10 | 8115702 | + |
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FusionProtFeatures for GRHPR_GATA3 |
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Hgene | Tgene |
GRHPR | GATA3 |
Enzyme with hydroxy-pyruvate reductase, glyoxylatereductase and D-glycerate dehydrogenase enzymatic activities.Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolateoxidizes D-glycerate to hydroxypyruvate. | Transcriptional activator which binds to the enhancer ofthe T-cell receptor alpha and delta genes. Binds to the consensussequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2)differentiation process following immune and inflammatoryresponses. {ECO:0000269|PubMed:23824597}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GRHPR_GATA3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GRHPR_GATA3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GRHPR | LSM1, SUCLA2, HSD17B4, SLC25A5, CXADR, PGM1, ACOX1, LIG4, PTH2R, FOS, CDC7, GLS2, MOV10, NXF1, AKR1B1, ETFA, ETFB, AGL, AKR1A1, CARKD, CTSD, GFER, GLO1, HSPE1, PIR, PRDX6, RFK, RTN4, VPS29, PCBP1, TJP1, UFM1 | GATA3 | LMO1, LMO2, TAL1, BMI1, MDM2, HDAC3, HDAC5, TBX21, RARB, HDAC4, SP1, REPIN1, MYB, SPI1, BRCA1, USP21, FOXP3, PSMA3, CDK2, FBXW7, MAPK14, WEE1, FOXA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GRHPR_GATA3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GRHPR_GATA3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GRHPR | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | GATA3 | C1840333 | Barakat syndrome | 3 | CTD_human;ORPHANET;UNIPROT |
Tgene | GATA3 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Tgene | GATA3 | C0019829 | Hodgkin Disease | 1 | CTD_human |
Tgene | GATA3 | C0021368 | Inflammation | 1 | CTD_human |
Tgene | GATA3 | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human |
Tgene | GATA3 | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
Tgene | GATA3 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | GATA3 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |