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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15383

FusionGeneSummary for GREB1L_PLD3

check button Fusion gene summary
Fusion gene informationFusion gene name: GREB1L_PLD3
Fusion gene ID: 15383
HgeneTgene
Gene symbol

GREB1L

PLD3

Gene ID

80000

23646

Gene nameGREB1 like retinoic acid receptor coactivatorphospholipase D family member 3
SynonymsC18orf6|KIAA1772|RHDA3AD19|HU-K4|HUK4|SCA46
Cytomap

18q11.1-q11.2

19q13.2

Type of geneprotein-codingprotein-coding
DescriptionGREB1-like proteingrowth regulation by estrogen in breast cancer 1 likegrowth regulation by estrogen in breast cancer 1-like proteingrowth regulation by estrogen in breast cancer-likephospholipase D3choline phosphatase 3hindIII K4L homologphosphatidylcholine-hydrolyzing phospholipase D3
Modification date2018051920180519
UniProtAcc

Q9C091

Q8IV08

Ensembl transtripts involved in fusion geneENST00000431264, ENST00000424526, 
ENST00000400483, ENST00000269218, 
ENST00000580732, ENST00000578368, 
ENST00000409419, ENST00000409587, 
ENST00000594085, ENST00000409735, 
ENST00000356508, ENST00000409281, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 4 X 2=24
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GREB1L [Title/Abstract] AND PLD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGREB1L

GO:0001822

kidney development

29100091


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE938399GREB1Lchr18

18983889

-PLD3chr19

40882572

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000431264ENST00000409419GREB1Lchr18

18983889

-PLD3chr19

40882572

-
Frame-shitENST00000431264ENST00000409587GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000431264ENST00000594085GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000431264ENST00000409735GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000431264ENST00000356508GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000431264ENST00000409281GREB1Lchr18

18983889

-PLD3chr19

40882572

-
Frame-shitENST00000424526ENST00000409419GREB1Lchr18

18983889

-PLD3chr19

40882572

-
Frame-shitENST00000424526ENST00000409587GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000424526ENST00000594085GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000424526ENST00000409735GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000424526ENST00000356508GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000424526ENST00000409281GREB1Lchr18

18983889

-PLD3chr19

40882572

-
Frame-shitENST00000400483ENST00000409419GREB1Lchr18

18983889

-PLD3chr19

40882572

-
Frame-shitENST00000400483ENST00000409587GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000400483ENST00000594085GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000400483ENST00000409735GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000400483ENST00000356508GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000400483ENST00000409281GREB1Lchr18

18983889

-PLD3chr19

40882572

-
Frame-shitENST00000269218ENST00000409419GREB1Lchr18

18983889

-PLD3chr19

40882572

-
Frame-shitENST00000269218ENST00000409587GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000269218ENST00000594085GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000269218ENST00000409735GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000269218ENST00000356508GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000269218ENST00000409281GREB1Lchr18

18983889

-PLD3chr19

40882572

-
Frame-shitENST00000580732ENST00000409419GREB1Lchr18

18983889

-PLD3chr19

40882572

-
Frame-shitENST00000580732ENST00000409587GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000580732ENST00000594085GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000580732ENST00000409735GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000580732ENST00000356508GREB1Lchr18

18983889

-PLD3chr19

40882572

-
5CDS-intronENST00000580732ENST00000409281GREB1Lchr18

18983889

-PLD3chr19

40882572

-
3UTR-3CDSENST00000578368ENST00000409419GREB1Lchr18

18983889

-PLD3chr19

40882572

-
3UTR-3CDSENST00000578368ENST00000409587GREB1Lchr18

18983889

-PLD3chr19

40882572

-
3UTR-intronENST00000578368ENST00000594085GREB1Lchr18

18983889

-PLD3chr19

40882572

-
3UTR-intronENST00000578368ENST00000409735GREB1Lchr18

18983889

-PLD3chr19

40882572

-
3UTR-intronENST00000578368ENST00000356508GREB1Lchr18

18983889

-PLD3chr19

40882572

-
3UTR-intronENST00000578368ENST00000409281GREB1Lchr18

18983889

-PLD3chr19

40882572

-

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FusionProtFeatures for GREB1L_PLD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GREB1L

Q9C091

PLD3

Q8IV08

Plays a major role in early metanephros and genitaldevelopment. {ECO:0000269|PubMed:29100091}. May be involved in APP processing.{ECO:0000305|PubMed:24336208}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GREB1L_PLD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GREB1L_PLD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GREB1L_PLD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GREB1L_PLD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource