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Fusion gene ID: 15382 |
FusionGeneSummary for GREB1L_CEP192 |
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Fusion gene information | Fusion gene name: GREB1L_CEP192 | Fusion gene ID: 15382 | Hgene | Tgene | Gene symbol | GREB1L | CEP192 | Gene ID | 80000 | 55125 |
Gene name | GREB1 like retinoic acid receptor coactivator | centrosomal protein 192 | |
Synonyms | C18orf6|KIAA1772|RHDA3 | PPP1R62 | |
Cytomap | 18q11.1-q11.2 | 18p11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | GREB1-like proteingrowth regulation by estrogen in breast cancer 1 likegrowth regulation by estrogen in breast cancer 1-like proteingrowth regulation by estrogen in breast cancer-like | centrosomal protein of 192 kDa192 kDa centrosomal proteincentrosomal protein 192kDaprotein phosphatase 1, regulatory subunit 62 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9C091 | Q8TEP8 | |
Ensembl transtripts involved in fusion gene | ENST00000431264, ENST00000424526, ENST00000400483, ENST00000269218, ENST00000580732, ENST00000578368, | ENST00000506447, ENST00000325971, ENST00000430049, ENST00000540847, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 3=27 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: GREB1L [Title/Abstract] AND CEP192 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GREB1L | GO:0001822 | kidney development | 29100091 |
Tgene | CEP192 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A06Q-01A | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000431264 | ENST00000506447 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
5UTR-3CDS | ENST00000431264 | ENST00000325971 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
5UTR-3CDS | ENST00000431264 | ENST00000430049 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
5UTR-3UTR | ENST00000431264 | ENST00000540847 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
5UTR-3CDS | ENST00000424526 | ENST00000506447 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
5UTR-3CDS | ENST00000424526 | ENST00000325971 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
5UTR-3CDS | ENST00000424526 | ENST00000430049 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
5UTR-3UTR | ENST00000424526 | ENST00000540847 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
5UTR-3CDS | ENST00000400483 | ENST00000506447 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
5UTR-3CDS | ENST00000400483 | ENST00000325971 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
5UTR-3CDS | ENST00000400483 | ENST00000430049 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
5UTR-3UTR | ENST00000400483 | ENST00000540847 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
5UTR-3CDS | ENST00000269218 | ENST00000506447 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
5UTR-3CDS | ENST00000269218 | ENST00000325971 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
5UTR-3CDS | ENST00000269218 | ENST00000430049 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
5UTR-3UTR | ENST00000269218 | ENST00000540847 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
intron-3CDS | ENST00000580732 | ENST00000506447 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
intron-3CDS | ENST00000580732 | ENST00000325971 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
intron-3CDS | ENST00000580732 | ENST00000430049 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
intron-3UTR | ENST00000580732 | ENST00000540847 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
intron-3CDS | ENST00000578368 | ENST00000506447 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
intron-3CDS | ENST00000578368 | ENST00000325971 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
intron-3CDS | ENST00000578368 | ENST00000430049 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
intron-3UTR | ENST00000578368 | ENST00000540847 | GREB1L | chr18 | 18822354 | + | CEP192 | chr18 | 13100304 | + |
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FusionProtFeatures for GREB1L_CEP192 |
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Hgene | Tgene |
GREB1L | CEP192 |
Plays a major role in early metanephros and genitaldevelopment. {ECO:0000269|PubMed:29100091}. | Required for mitotic centrosome maturation and bipolarspindle assembly (PubMed:25042804, PubMed:17980596,PubMed:18207742). Appears to be a major regulator ofpericentriolar material (PCM) recruitment, centrosome maturation,and centriole duplication (PubMed:25042804, PubMed:17980596,PubMed:18207742). Centrosome-specific activating scaffold forAURKA and PLK1 (PubMed:25042804). {ECO:0000269|PubMed:17980596,ECO:0000269|PubMed:18207742, ECO:0000269|PubMed:25042804}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GREB1L_CEP192 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GREB1L_CEP192 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GREB1L | MOV10, NXF1, TSEN2, LYPD4 | CEP192 | CYLD, AURKA, UBC, CEP85, RBM12B, SDCCAG8, BNIP3L, ALMS1, PJA2, ZBTB10, NEDD1, EGLN2, SKP2, ANKRD28, LATS1, LATS2, SLMAP, ENO1, MOV10, NXF1, CARD8, PLK4, CACYBP, PCNT, MAGED1, OFD1, CEP152, CEP131, CEP350, CEP63, KIAA1671, CDK5RAP2, KIZ, USP42, TRIM37, CEP295, SPATA2, MARK3, CCDC67, CENPJ, RPGRIP1L, PCM1, CEP120, CNTROB, CEP128, CEP135, CEP89, CNTRL, FBF1, NINL, NIN, ODF2, CEP19, POC5, SASS6, DIAPH1, EZH2, KIF2A, KPNB1, POLD1, RNF41, PCDHB15, KDM1B, EYA2, SIL1, DCTPP1, FEZ1, HOMER3, GMNN, HEY1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GREB1L_CEP192 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GREB1L_CEP192 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |