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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15378

FusionGeneSummary for GRB7_ITGB3

check button Fusion gene summary
Fusion gene informationFusion gene name: GRB7_ITGB3
Fusion gene ID: 15378
HgeneTgene
Gene symbol

GRB7

ITGB3

Gene ID

2886

3690

Gene namegrowth factor receptor bound protein 7integrin subunit beta 3
Synonyms-BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT
Cytomap

17q12

17q21.32

Type of geneprotein-codingprotein-coding
Descriptiongrowth factor receptor-bound protein 7B47GRB7 adapter proteinepidermal growth factor receptor GRB-7integrin beta-3antigen CD61integrin beta 3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)platelet membrane glycoprotein IIIa
Modification date2018051920180527
UniProtAcc

Q14451

P05106

Ensembl transtripts involved in fusion geneENST00000309156, ENST00000309185, 
ENST00000394211, ENST00000578702, 
ENST00000445327, ENST00000394209, 
ENST00000394204, 		ENST00000559488, 
ENST00000571680, ENST00000435993, 
ENST00000560629, 
Fusion gene scores* DoF score11 X 8 X 7=6165 X 4 X 3=60
# samples 137
** MAII scorelog2(13/616*10)=-2.24441872766645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GRB7 [Title/Abstract] AND ITGB3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGRB7

GO:0030335

positive regulation of cell migration

10893408|12021278

TgeneITGB3

GO:0033627

cell adhesion mediated by integrin

12807887

TgeneITGB3

GO:0034446

substrate adhesion-dependent cell spreading

24658351


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A0CX-01AGRB7chr17

37900460

+ITGB3chr17

45351785

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000309156ENST00000559488GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000309156ENST00000571680GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000309156ENST00000435993GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000309156ENST00000560629GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000309185ENST00000559488GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000309185ENST00000571680GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000309185ENST00000435993GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000309185ENST00000560629GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000394211ENST00000559488GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000394211ENST00000571680GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000394211ENST00000435993GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000394211ENST00000560629GRB7chr17

37900460

+ITGB3chr17

45351785

+
intron-3CDSENST00000578702ENST00000559488GRB7chr17

37900460

+ITGB3chr17

45351785

+
intron-3CDSENST00000578702ENST00000571680GRB7chr17

37900460

+ITGB3chr17

45351785

+
intron-5UTRENST00000578702ENST00000435993GRB7chr17

37900460

+ITGB3chr17

45351785

+
intron-5UTRENST00000578702ENST00000560629GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000445327ENST00000559488GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000445327ENST00000571680GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000445327ENST00000435993GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000445327ENST00000560629GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000394209ENST00000559488GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000394209ENST00000571680GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000394209ENST00000435993GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000394209ENST00000560629GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000394204ENST00000559488GRB7chr17

37900460

+ITGB3chr17

45351785

+
Frame-shiftENST00000394204ENST00000571680GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000394204ENST00000435993GRB7chr17

37900460

+ITGB3chr17

45351785

+
5CDS-5UTRENST00000394204ENST00000560629GRB7chr17

37900460

+ITGB3chr17

45351785

+

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FusionProtFeatures for GRB7_ITGB3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRB7

Q14451

ITGB3

P05106

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor forcytotactin, fibronectin, laminin, matrix metalloproteinase-2,osteopontin, osteomodulin, prothrombin, thrombospondin,vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3(ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen,plasminogen, prothrombin, thrombospondin and vitronectin.Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize thesequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V infibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction throughbinding of soluble fibrinogen. This step leads to rapid plateletaggregation which physically plugs ruptured endothelial surface.Fibrinogen binding enhances SELP expression in activated platelets(By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) andacts as its coreceptor in CX3CR1-dependent fractalkine signaling(PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (viaEGF domain) and this binding is essential for NRG1-ERBB signaling(PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding isessential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 bindsto FGF2 and this binding is essential for FGF2 signaling(PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding isessential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 bindsto IGF2 and this binding is essential for IGF2 signaling(PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding isessential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 bindsto PLA2G2A via a site (site 2) which is distinct from theclassical ligand-binding site (site 1) and this induces integrinconformational changes and enhanced ligand binding to site 1(PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptorfor fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesionto FBN1 (PubMed:12807887). {ECO:0000250|UniProtKB:O54890,ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:18441324,ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119,ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:23125415,ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:25398877,ECO:0000269|PubMed:28302677, ECO:0000269|PubMed:28873464,ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:9195946,ECO:0000303|PubMed:16322781, ECO:0000303|PubMed:17635696}. (Microbial infection) Integrin ITGAV:ITGB3 acts as areceptor for Herpes virus 8/HHV-8. {ECO:0000269|PubMed:18045938}. (Microbial infection) Integrin ITGAV:ITGB3 acts as areceptor for Coxsackievirus A9. {ECO:0000269|PubMed:7519807}. (Microbial infection) Acts as a receptor for Hantaanvirus. {ECO:0000269|PubMed:9618541}. (Microbial infection) Integrin ITGAV:ITGB3 acts as areceptor for Cytomegalovirus/HHV-5. {ECO:0000269|PubMed:15834425}. (Microbial infection) Integrin ITGA5:ITGB3 acts as areceptor for Human metapneumovirus. {ECO:0000269|PubMed:24478423}. (Microbial infection) Integrin ITGAV:ITGB3 acts aP05556sa receptor for Human parechovirus 1.{ECO:0000269|PubMed:11160695}. (Microbial infection) Integrin ITGAV:ITGB3 acts as areceptor for West nile virus. {ECO:0000269|PubMed:23658209}. (Microbial infection) In case of HIV-1 infection, theinteraction with extracellular viral Tat protein seems to enhanceangiogenesis in Kaposi's sarcoma lesions.{ECO:0000269|PubMed:10397733}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GRB7_ITGB3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GRB7_ITGB3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GRB7SFN, LY6G6F, ERBB3, KIT, RND1, RET, ERBB2, PTK2, EPHB1, INSR, NPM1, RPS2, ZBTB16, A1BG, ATP5B, CPNE6, PKM, DYNC1I1, AGAP1, GNB2, TMSB4X, PDHB, FLAD1, DOCK7, MSH2, HADHB, TLE1, KMT2B, FGB, PHAX, SETDB1, CALM1, LAX1, TRIM36, KCTD6, OLIG1, ZNHIT1ITGB3ITGAV, PTK2, FLNB, FLNA, ITGB3BP, TLN1, ILK, PECAM1, PDGFRB, THBS1, PTK2B, PXN, PDGFRA, CD36, SYK, EPHA2, ITGA5, P4HB, PLA2G4A, VIM, PRKCB, MAPK3, SHC1, PLA2G2A, ITGA2B, KDR, PAK4, MMP2, ITGA4, ITGB1, DOK1, FGA, CIB1, FERMT3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GRB7_ITGB3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneITGB3P05106DB00054AbciximabIntegrin beta-3biotechapproved
TgeneITGB3P05106DB00098Antithymocyte immunoglobulin (rabbit)Integrin beta-3biotechapproved
TgeneITGB3P05106DB00775TirofibanIntegrin beta-3small moleculeapproved
TgeneITGB3P05106DB00063EptifibatideIntegrin beta-3biotechapproved|investigational

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RelatedDiseases for GRB7_ITGB3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRB7C1458155Mammary Neoplasms2CTD_human
HgeneGRB7C0001418Adenocarcinoma1CTD_human
HgeneGRB7C0007134Renal Cell Carcinoma1CTD_human
HgeneGRB7C0024121Lung Neoplasms1CTD_human
HgeneGRB7C0033578Prostatic Neoplasms1CTD_human
TgeneITGB3C0040015Thrombasthenia18CTD_human;HPO;ORPHANET;UNIPROT
TgeneITGB3C0004352Autistic Disorder3CTD_human
TgeneITGB3C3853779Neonatal Alloimmune Thrombocytopenia2CTD_human
TgeneITGB3C0007274Carotid Artery Thrombosis1CTD_human
TgeneITGB3C0010072Coronary Thrombosis1CTD_human
TgeneITGB3C0017639Gliosis1CTD_human
TgeneITGB3C0019080Hemorrhage1CTD_human
TgeneITGB3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneITGB3C0027051Myocardial Infarction1CTD_human
TgeneITGB3C0033578Prostatic Neoplasms1CTD_human
TgeneITGB3C0036341Schizophrenia1PSYGENET
TgeneITGB3C0038454Cerebrovascular accident1CTD_human
TgeneITGB3C0040034Thrombocytopenia1CTD_human
TgeneITGB3C0948089Acute Coronary Syndrome1CTD_human
TgeneITGB3C1510586Autism Spectrum Disorders1CTD_human
TgeneITGB3C1861195Glanzmann Thrombasthenia, Autosomal Dominant1ORPHANET;UNIPROT
TgeneITGB3C2937358Cerebral Hemorrhage1CTD_human