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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15375

FusionGeneSummary for GRB7_CDK12

check button Fusion gene summary
Fusion gene informationFusion gene name: GRB7_CDK12
Fusion gene ID: 15375
HgeneTgene
Gene symbol

GRB7

CDK12

Gene ID

2886

51755

Gene namegrowth factor receptor bound protein 7cyclin dependent kinase 12
Synonyms-CRK7|CRKR|CRKRS
Cytomap

17q12

17q12

Type of geneprotein-codingprotein-coding
Descriptiongrowth factor receptor-bound protein 7B47GRB7 adapter proteinepidermal growth factor receptor GRB-7cyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12
Modification date2018051920180523
UniProtAcc

Q14451

Q9NYV4

Ensembl transtripts involved in fusion geneENST00000309156, ENST00000309185, 
ENST00000394211, ENST00000578702, 
ENST00000445327, ENST00000394209, 
ENST00000394204, 		ENST00000430627, 
ENST00000447079, ENST00000559545, 
Fusion gene scores* DoF score11 X 8 X 7=61627 X 15 X 12=4860
# samples 1331
** MAII scorelog2(13/616*10)=-2.24441872766645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(31/4860*10)=-3.97061619321891
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRB7 [Title/Abstract] AND CDK12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGRB7

GO:0030335

positive regulation of cell migration

10893408|12021278

TgeneCDK12

GO:0046777

protein autophosphorylation

11683387


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-1736-01BGRB7chr17

37894386

+CDK12chr17

37721013

+
TCGALDREADTCGA-AF-A56L-01AGRB7chr17

37902455

+CDK12chr17

37700502

+
TCGARVSTADTCGA-CG-4449-01AGRB7chr17

37902455

+CDK12chr17

37680927

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000309156ENST00000430627GRB7chr17

37894386

+CDK12chr17

37721013

+
5UTR-intronENST00000309156ENST00000447079GRB7chr17

37894386

+CDK12chr17

37721013

+
5UTR-3UTRENST00000309156ENST00000559545GRB7chr17

37894386

+CDK12chr17

37721013

+
5UTR-intronENST00000309185ENST00000430627GRB7chr17

37894386

+CDK12chr17

37721013

+
5UTR-intronENST00000309185ENST00000447079GRB7chr17

37894386

+CDK12chr17

37721013

+
5UTR-3UTRENST00000309185ENST00000559545GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000394211ENST00000430627GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000394211ENST00000447079GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-3UTRENST00000394211ENST00000559545GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000578702ENST00000430627GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000578702ENST00000447079GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-3UTRENST00000578702ENST00000559545GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000445327ENST00000430627GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000445327ENST00000447079GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-3UTRENST00000445327ENST00000559545GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000394209ENST00000430627GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000394209ENST00000447079GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-3UTRENST00000394209ENST00000559545GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000394204ENST00000430627GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-intronENST00000394204ENST00000447079GRB7chr17

37894386

+CDK12chr17

37721013

+
intron-3UTRENST00000394204ENST00000559545GRB7chr17

37894386

+CDK12chr17

37721013

+
5CDS-intronENST00000309156ENST00000430627GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000309156ENST00000447079GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000309156ENST00000559545GRB7chr17

37902455

+CDK12chr17

37700502

+
3UTR-intronENST00000309185ENST00000430627GRB7chr17

37902455

+CDK12chr17

37700502

+
3UTR-intronENST00000309185ENST00000447079GRB7chr17

37902455

+CDK12chr17

37700502

+
3UTR-intronENST00000309185ENST00000559545GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000394211ENST00000430627GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000394211ENST00000447079GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000394211ENST00000559545GRB7chr17

37902455

+CDK12chr17

37700502

+
intron-intronENST00000578702ENST00000430627GRB7chr17

37902455

+CDK12chr17

37700502

+
intron-intronENST00000578702ENST00000447079GRB7chr17

37902455

+CDK12chr17

37700502

+
intron-intronENST00000578702ENST00000559545GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000445327ENST00000430627GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000445327ENST00000447079GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000445327ENST00000559545GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000394209ENST00000430627GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000394209ENST00000447079GRB7chr17

37902455

+CDK12chr17

37700502

+
5CDS-intronENST00000394209ENST00000559545GRB7chr17

37902455

+CDK12chr17

37700502

+
3UTR-intronENST00000394204ENST00000430627GRB7chr17

37902455

+CDK12chr17

37700502

+
3UTR-intronENST00000394204ENST00000447079GRB7chr17

37902455

+CDK12chr17

37700502

+
3UTR-intronENST00000394204ENST00000559545GRB7chr17

37902455

+CDK12chr17

37700502

+
Frame-shiftENST00000309156ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680927

+
Frame-shiftENST00000309156ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680927

+
5CDS-intronENST00000309156ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680927

+
3UTR-3CDSENST00000309185ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680927

+
3UTR-3CDSENST00000309185ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680927

+
3UTR-intronENST00000309185ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680927

+
Frame-shiftENST00000394211ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680927

+
Frame-shiftENST00000394211ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680927

+
5CDS-intronENST00000394211ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680927

+
intron-3CDSENST00000578702ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680927

+
intron-3CDSENST00000578702ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680927

+
intron-intronENST00000578702ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680927

+
Frame-shiftENST00000445327ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680927

+
Frame-shiftENST00000445327ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680927

+
5CDS-intronENST00000445327ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680927

+
Frame-shiftENST00000394209ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680927

+
Frame-shiftENST00000394209ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680927

+
5CDS-intronENST00000394209ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680927

+
3UTR-3CDSENST00000394204ENST00000430627GRB7chr17

37902455

+CDK12chr17

37680927

+
3UTR-3CDSENST00000394204ENST00000447079GRB7chr17

37902455

+CDK12chr17

37680927

+
3UTR-intronENST00000394204ENST00000559545GRB7chr17

37902455

+CDK12chr17

37680927

+

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FusionProtFeatures for GRB7_CDK12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRB7

Q14451

CDK12

Q9NYV4

Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II(POLR2A), thereby acting as a key regulator of transcriptionelongation. Regulates the expression of genes involved in DNArepair and is required for the maintenance of genomic stability.Preferentially phosphorylates 'Ser-5' in CTD repeats that arealready phosphorylated at 'Ser-7', but can also phosphorylate'Ser-2'. Required for RNA splicing, possibly by phosphorylatingSRSF1/SF2. Involved in regulation of MAP kinase activity, possiblyleading to affect the response to estrogen inhibitors.{ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820,ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619,ECO:0000269|PubMed:24662513}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GRB7_CDK12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GRB7_CDK12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GRB7SFN, LY6G6F, ERBB3, KIT, RND1, RET, ERBB2, PTK2, EPHB1, INSR, NPM1, RPS2, ZBTB16, A1BG, ATP5B, CPNE6, PKM, DYNC1I1, AGAP1, GNB2, TMSB4X, PDHB, FLAD1, DOCK7, MSH2, HADHB, TLE1, KMT2B, FGB, PHAX, SETDB1, CALM1, LAX1, TRIM36, KCTD6, OLIG1, ZNHIT1CDK12MGMT, SRRM2, RBM39, ELAVL1, MYC, PRPF4, CDK13, CCNK, TRIM24, IPPK, VPS51, ZNF606, TCEB3, BARD1, PAXIP1, PRPF40A, EWSR1, CDK20, CDK9, PIN1, RPL14, ACAA1, MAP4K4, SCAF4, SUPT16H, SRPK2, CLK1, BCLAF1, RNPS1, SNW1, PCGF1, CDX1, RPL37A, RRS1, ZNF2, FGF8, RPS14, WEE1, LASP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GRB7_CDK12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GRB7_CDK12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRB7C1458155Mammary Neoplasms2CTD_human
HgeneGRB7C0001418Adenocarcinoma1CTD_human
HgeneGRB7C0007134Renal Cell Carcinoma1CTD_human
HgeneGRB7C0024121Lung Neoplasms1CTD_human
HgeneGRB7C0033578Prostatic Neoplasms1CTD_human