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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15364

FusionGeneSummary for GRB2_PCYT1A

check button Fusion gene summary
Fusion gene informationFusion gene name: GRB2_PCYT1A
Fusion gene ID: 15364
HgeneTgene
Gene symbol

GRB2

PCYT1A

Gene ID

2885

5130

Gene namegrowth factor receptor bound protein 2phosphate cytidylyltransferase 1, choline, alpha
SynonymsASH|EGFRBP-GRB2|Grb3-3|MST084|MSTP084|NCKAP2CCTA|CT|CTA|CTPCT|PCYT1|SMDCRD
Cytomap

17q25.1

3q29

Type of geneprotein-codingprotein-coding
Descriptiongrowth factor receptor-bound protein 2HT027SH2/SH3 adapter GRB2abundant SRC homologyepidermal growth factor receptor-binding protein GRB2growth factor receptor-bound protein 3protein Ashcholine-phosphate cytidylyltransferase ACCT ACCT-alphaCT ACTP:phosphocholine cytidylyltransferase Aphosphorylcholine transferase A
Modification date2018052720180523
UniProtAcc

P62993

P49585

Ensembl transtripts involved in fusion geneENST00000392562, ENST00000316804, 
ENST00000316615, ENST00000392563, 
ENST00000392564, ENST00000578961, 
ENST00000462266, 
ENST00000419333, 
ENST00000292823, ENST00000431016, 
ENST00000491544, 
Fusion gene scores* DoF score11 X 4 X 9=3966 X 6 X 5=180
# samples 116
** MAII scorelog2(11/396*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRB2 [Title/Abstract] AND PCYT1A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-46-6025-01AGRB2chr17

73389632

-PCYT1Achr3

195997412

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000392562ENST00000419333GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000392562ENST00000292823GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000392562ENST00000431016GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000392562ENST00000491544GRB2chr17

73389632

-PCYT1Achr3

195997412

-
Frame-shitENST00000316804ENST00000419333GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000316804ENST00000292823GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000316804ENST00000431016GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000316804ENST00000491544GRB2chr17

73389632

-PCYT1Achr3

195997412

-
Frame-shitENST00000316615ENST00000419333GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000316615ENST00000292823GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000316615ENST00000431016GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000316615ENST00000491544GRB2chr17

73389632

-PCYT1Achr3

195997412

-
In-frameENST00000392563ENST00000419333GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000392563ENST00000292823GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000392563ENST00000431016GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000392563ENST00000491544GRB2chr17

73389632

-PCYT1Achr3

195997412

-
In-frameENST00000392564ENST00000419333GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000392564ENST00000292823GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000392564ENST00000431016GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000392564ENST00000491544GRB2chr17

73389632

-PCYT1Achr3

195997412

-
In-frameENST00000578961ENST00000419333GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000578961ENST00000292823GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000578961ENST00000431016GRB2chr17

73389632

-PCYT1Achr3

195997412

-
5CDS-5UTRENST00000578961ENST00000491544GRB2chr17

73389632

-PCYT1Achr3

195997412

-
intron-3CDSENST00000462266ENST00000419333GRB2chr17

73389632

-PCYT1Achr3

195997412

-
intron-5UTRENST00000462266ENST00000292823GRB2chr17

73389632

-PCYT1Achr3

195997412

-
intron-5UTRENST00000462266ENST00000431016GRB2chr17

73389632

-PCYT1Achr3

195997412

-
intron-5UTRENST00000462266ENST00000491544GRB2chr17

73389632

-PCYT1Achr3

195997412

-

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FusionProtFeatures for GRB2_PCYT1A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRB2

P62993

PCYT1A

P49585

Adapter protein that provides a critical link betweencell surface growth factor receptors and the Ras signalingpathway. Isoform 2 does not bind to phosphorylated epidermalgrowth factor receptor (EGFR) but inhibits EGF-inducedtransactivation of a RAS-responsive element. Isoform 2 acts as adominant negative protein over GRB2 and by suppressingproliferative signals, may trigger active programmed cell death. Controls phosphatidylcholine synthesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GRB2_PCYT1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GRB2_ENST00000392563_chr17_73389632_-_PCYT1A_ENST00000419333_chr3_195997412_-_26aa

>In-frame_GRB2_ENST00000392564_chr17_73389632_-_PCYT1A_ENST00000419333_chr3_195997412_-_26aa

>In-frame_GRB2_ENST00000578961_chr17_73389632_-_PCYT1A_ENST00000419333_chr3_195997412_-_26aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GRB2_ENST00000392563_chr17_73389632_-_PCYT1A_ENST00000419333_chr3_195997412_-_78nt

>In-frame_GRB2_ENST00000392564_chr17_73389632_-_PCYT1A_ENST00000419333_chr3_195997412_-_78nt

>In-frame_GRB2_ENST00000578961_chr17_73389632_-_PCYT1A_ENST00000419333_chr3_195997412_-_78nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_GRB2_ENST00000392563_chr17_73389632_-_PCYT1A_ENST00000419333_chr3_195997412_-_1431nt
GGCTGCTGAGCACTGAGCAGCGCTCAGAATGGAAGCCATCGCCAAATATGACTTCAAAGCTACTGCAGACGACGAGCTGAGCTTCAAAAG
GGGGGACATCCTCAAGTTAAAAGAAGATGGATGCACAGTGTTCAGCCAAGGTCAATGCAAGGAAGAGGAGAAAAGAGGCGCCCGGACCCA
ACGGGGCAACAGAAGAAGATGGGGTTCCTTCCAAAGTGCAGCGCTGTGCAGTGGGCTTACGGCAACCAGCTCCTTTTTCTGATGAAATTG
AAGTTGACTTTAGTAAGCCCTATGTCAGGGTAACTATGGAAGAAGCCAGCAGAGGAACTCCTTGTGAGCGACCTGTGAGAGTTTATGCCG
ATGGAATATTTGACTTATTTCACTCTGGTCACGCCCGAGCTCTGATGCAAGCGAAGAACCTTTTCCCTAATACGTACCTCATTGTGGGAG
TTTGCAGTGATGAGCTCACACACAACTTCAAAGGCTTCACGGTGATGAACGAGAATGAGCGCTATGACGCAGTCCAGCACTGCCGCTACG
TGGATGAGGTGGTGAGGAATGCGCCCTGGACGCTGACACCCGAGTTCCTGGCCGAACACCGGATTGATTTTGTAGCCCATGATGATATTC
CTTATTCATCTGCTGGCAGTGATGATGTTTATAAGCACATCAAGGAGGCAGGCATGTTTGCTCCAACACAGAGGACAGAAGGTATCTCCA
CATCAGACATCATCACCCGAATTGTGCGGGATTATGATGTGTATGCGAGGCGGAACCTGCAGAGGGGCTACACAGCAAAGGAGCTCAATG
TCAGCTTTATCAACGAGAAGAAATACCACTTGCAGGAGAGGGTTGACAAAGTAAAGAAGAAAGTGAAAGATGTGGAGGAAAAGTCAAAAG
AATTTGTTCAGAAGGTGGAGGAAAAAAGCATTGACCTCATTCAGAAGTGGGAGGAGAAGTCCCGAGAATTCATTGGAAGTTTTCTGGAAA
TGTTTGGTCCGGAAGGAGCACTGAAACATATGCTGAAAGAGGGGAAGGGCCGGATGCTGCAGGCCATCAGCCCGAAGCAGAGCCCCAGCA
GCAGCCCTACTCGCGAGCGCTCCCCCTCCCCCTCTTTCCGATGGCCCTTCTCCGGCAAGACTTCCCCACCTTGCTCCCCAGCAAATCTCT
CCAGGCACAAGGCTGCAGCCTATGATATCAGGTATAGTTACCTGGAACAGAGCAAATTTGGCTCCCATGTTCTGCTCACCCAGGTGTAGC
CTGGCTTGACGGGAAATGATGCCCAGGGTCCAGAGAGCCAGCAGTGTGGACACGCCAAGGAAAGTGTTGATCCATAGAGCTGTGCTCCCC

>In-frame_GRB2_ENST00000392564_chr17_73389632_-_PCYT1A_ENST00000419333_chr3_195997412_-_1639nt
GAGCCAGGGGGCGTGGGGGCTGGGACAGCAGGCCGATTGGCAGGGCGGGGTTGCCTTCAATCCTGGCCACTGCTCTTAATCGTCCCTCTC
CTGCTTCAGGGTGGCATTGTGTGTCCCAGAGTGCCGGAGCGAGTCCCAGAAGAGAGGCGAGGCTAAGCCCAGAGCGCTGGGTTGCTTCAG
CAGGGAAGACTCCCTTCCCCCTGCTTCAGGCTGCTGAGCACTGAGCAGCGCTCAGAATGGAAGCCATCGCCAAATATGACTTCAAAGCTA
CTGCAGACGACGAGCTGAGCTTCAAAAGGGGGGACATCCTCAAGTTAAAAGAAGATGGATGCACAGTGTTCAGCCAAGGTCAATGCAAGG
AAGAGGAGAAAAGAGGCGCCCGGACCCAACGGGGCAACAGAAGAAGATGGGGTTCCTTCCAAAGTGCAGCGCTGTGCAGTGGGCTTACGG
CAACCAGCTCCTTTTTCTGATGAAATTGAAGTTGACTTTAGTAAGCCCTATGTCAGGGTAACTATGGAAGAAGCCAGCAGAGGAACTCCT
TGTGAGCGACCTGTGAGAGTTTATGCCGATGGAATATTTGACTTATTTCACTCTGGTCACGCCCGAGCTCTGATGCAAGCGAAGAACCTT
TTCCCTAATACGTACCTCATTGTGGGAGTTTGCAGTGATGAGCTCACACACAACTTCAAAGGCTTCACGGTGATGAACGAGAATGAGCGC
TATGACGCAGTCCAGCACTGCCGCTACGTGGATGAGGTGGTGAGGAATGCGCCCTGGACGCTGACACCCGAGTTCCTGGCCGAACACCGG
ATTGATTTTGTAGCCCATGATGATATTCCTTATTCATCTGCTGGCAGTGATGATGTTTATAAGCACATCAAGGAGGCAGGCATGTTTGCT
CCAACACAGAGGACAGAAGGTATCTCCACATCAGACATCATCACCCGAATTGTGCGGGATTATGATGTGTATGCGAGGCGGAACCTGCAG
AGGGGCTACACAGCAAAGGAGCTCAATGTCAGCTTTATCAACGAGAAGAAATACCACTTGCAGGAGAGGGTTGACAAAGTAAAGAAGAAA
GTGAAAGATGTGGAGGAAAAGTCAAAAGAATTTGTTCAGAAGGTGGAGGAAAAAAGCATTGACCTCATTCAGAAGTGGGAGGAGAAGTCC
CGAGAATTCATTGGAAGTTTTCTGGAAATGTTTGGTCCGGAAGGAGCACTGAAACATATGCTGAAAGAGGGGAAGGGCCGGATGCTGCAG
GCCATCAGCCCGAAGCAGAGCCCCAGCAGCAGCCCTACTCGCGAGCGCTCCCCCTCCCCCTCTTTCCGATGGCCCTTCTCCGGCAAGACT
TCCCCACCTTGCTCCCCAGCAAATCTCTCCAGGCACAAGGCTGCAGCCTATGATATCAGGTATAGTTACCTGGAACAGAGCAAATTTGGC
TCCCATGTTCTGCTCACCCAGGTGTAGCCTGGCTTGACGGGAAATGATGCCCAGGGTCCAGAGAGCCAGCAGTGTGGACACGCCAAGGAA
AGTGTTGATCCATAGAGCTGTGCTCCCCTCAGAAATCTGGTGGCAACAGAAAGTAGTCAGTGAGGCAGGCAAGCTCTCTCTCTCTCTCTC

>In-frame_GRB2_ENST00000578961_chr17_73389632_-_PCYT1A_ENST00000419333_chr3_195997412_-_1578nt
CCTGGCCACTGCTCTTAATCGTCCCTCTCCTGCTTCAGGGTGGCATTGTGTGTCCCAGAGTGCCGGAGCGAGTCCCAGAAGAGAGGCGAG
GCTAAGCCCAGAGCGCTGGGTTGCTTCAGCAGGGAAGACTCCCTTCCCCCTGCTTCAGGCTGCTGAGCACTGAGCAGCGCTCAGAATGGA
AGCCATCGCCAAATATGACTTCAAAGCTACTGCAGACGACGAGCTGAGCTTCAAAAGGGGGGACATCCTCAAGTTAAAAGAAGATGGATG
CACAGTGTTCAGCCAAGGTCAATGCAAGGAAGAGGAGAAAAGAGGCGCCCGGACCCAACGGGGCAACAGAAGAAGATGGGGTTCCTTCCA
AAGTGCAGCGCTGTGCAGTGGGCTTACGGCAACCAGCTCCTTTTTCTGATGAAATTGAAGTTGACTTTAGTAAGCCCTATGTCAGGGTAA
CTATGGAAGAAGCCAGCAGAGGAACTCCTTGTGAGCGACCTGTGAGAGTTTATGCCGATGGAATATTTGACTTATTTCACTCTGGTCACG
CCCGAGCTCTGATGCAAGCGAAGAACCTTTTCCCTAATACGTACCTCATTGTGGGAGTTTGCAGTGATGAGCTCACACACAACTTCAAAG
GCTTCACGGTGATGAACGAGAATGAGCGCTATGACGCAGTCCAGCACTGCCGCTACGTGGATGAGGTGGTGAGGAATGCGCCCTGGACGC
TGACACCCGAGTTCCTGGCCGAACACCGGATTGATTTTGTAGCCCATGATGATATTCCTTATTCATCTGCTGGCAGTGATGATGTTTATA
AGCACATCAAGGAGGCAGGCATGTTTGCTCCAACACAGAGGACAGAAGGTATCTCCACATCAGACATCATCACCCGAATTGTGCGGGATT
ATGATGTGTATGCGAGGCGGAACCTGCAGAGGGGCTACACAGCAAAGGAGCTCAATGTCAGCTTTATCAACGAGAAGAAATACCACTTGC
AGGAGAGGGTTGACAAAGTAAAGAAGAAAGTGAAAGATGTGGAGGAAAAGTCAAAAGAATTTGTTCAGAAGGTGGAGGAAAAAAGCATTG
ACCTCATTCAGAAGTGGGAGGAGAAGTCCCGAGAATTCATTGGAAGTTTTCTGGAAATGTTTGGTCCGGAAGGAGCACTGAAACATATGC
TGAAAGAGGGGAAGGGCCGGATGCTGCAGGCCATCAGCCCGAAGCAGAGCCCCAGCAGCAGCCCTACTCGCGAGCGCTCCCCCTCCCCCT
CTTTCCGATGGCCCTTCTCCGGCAAGACTTCCCCACCTTGCTCCCCAGCAAATCTCTCCAGGCACAAGGCTGCAGCCTATGATATCAGGT
ATAGTTACCTGGAACAGAGCAAATTTGGCTCCCATGTTCTGCTCACCCAGGTGTAGCCTGGCTTGACGGGAAATGATGCCCAGGGTCCAG
AGAGCCAGCAGTGTGGACACGCCAAGGAAAGTGTTGATCCATAGAGCTGTGCTCCCCTCAGAAATCTGGTGGCAACAGAAAGTAGTCAGT


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FusionGenePPI for GRB2_PCYT1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GRB2CSF1R, PRRC2A, EGFR, ERBB2, ERBB3, ERBB4, MED28, BCR, GAB2, CBL, ETV6, LY6G6F, NEU3, SRC, PDE6G, DOCK1, FASLG, SHC1, SOS1, VAV2, VAV3, RACGAP1, IQGAP1, KRT7, KRT8, KRT17, KRT18, PLEC, EPPK1, BCAR1, WAS, MAP4K1, BLNK, IL2RB, SYN1, PDGFRB, KHDRBS1, PTPN6, PTPN11, SYK, CD22, GAB1, IRS1, TNFRSF1A, PTK2, SH3BP2, CD28, TNK2, KIT, SOCS1, PTPRA, CBLB, EPHA2, AXL, DAG1, MAP2, PLCG1, MST1R, ITGA2B, NCKIPSD, NTRK1, PTPN1, JAK2, GRB2, USP8, CSF3R, HTT, MET, LCP2, SNTA1, ABL1, LAT, FLT4, PIK3R1, FRS2, GAB3, VAV1, SH2B2, SH2B1, PRKAR1A, DCTN1, RET, CRK, PTPN22, JAK1, ARHGAP17, SHB, REPS2, OCRL, PDGFRA, PXN, PAG1, TRAT1, INSR, RAPGEF1, KDR, SELL, ADRB2, EPOR, SYNCRIP, ZAP70, IRS4, MUC1, ITK, LAT2, SH2B3, ANXA2, ARHGAP35, RASA1, PTPN12, CRKL, ADAM15, ADAM10, WASL, EPS15, IL6ST, SH3KBP1, EPHB1, MAP3K1, FLT3, RALGPS1, USP6NL, SPRY2, PTPRE, DNM1, HNRNPC, MAPK9, DRD3, CDKN1B, ALOX5, PIK3C2B, GHR, HCLS1, DTX1, LAX1, SOS2, DRD4, PTK2B, SKAP1, TOM1L1, SHKBP1, FGFR3, INPP5D, MICAL1, PLXNB1, OTUD5, STAMBP, ALK, NPM1, BTK, CSN2, DAB2, EP300, HNRNPK, HSPA5, MAP1A, ATP8, ND4, MYH9, MYH11, NCL, NFYB, PIK3R2, RBBP6, SLC1A2, SPTBN1, SS18, UBA52, UBC, WIPF1, MAP4K3, ASAP2, SYNJ2, DLGAP1, ARHGAP32, HELZ, PDCD6IP, HIPK3, DCTN2, TCERG1, KIF3A, MAP4K5, KIAA1549L, ABI3BP, PTPN23, ASAP1, ERRFI1, WDR44, USP53, RIF1, SH2D4A, GAREM, RBM33, MSI2, WIPF2, SH3D19, NAP1L5, STK32C, MYO18A, A2M, AEBP1, AGT, AHSG, ALAS2, STRADB, AMBP, APCS, APOH, SNRNP200, B2M, GPANK1, BPGM, CLU, DNAJA3, DNAJB11, ESD, FABP1, FHOD1, FN1, GC, H1F0, HP, IK, PBXIP1, POLR2A, PRKAB1, RNF10, TF, TFG, TSC2, ENO1, ITIH4, AP4S1, CUTA, POMP, C21orf58, CD164, C21orf91, CFH, COX6A1, ECHS1, FH, NADK, FTL, PRAP1, GSTK1, TCEAL8, POLR1D, RBP4, SHBG, WDR1, IRF5, PPP3CA, GIT1, CDC42, CASP2, ELAVL1, SYNM, AP2A2, DNM2, NCK1, UBASH3B, CUL3, DCUN1D1, LRRK1, INPPL1, ARAP1, KRT85, HSPA8, HSPG2, KRT86, KRT1, KRT81, KRT35, CAD, KRT10, KRT2, HSPA9, KRT83, CCT8, KRT9, KRT33B, HSP90AA1, DNM3, DYNC1H1, TUBB, KRT34, RPS19, HSPA1B, HSP90AB1, SKAP2, CCT4, EEF1A1P5, KRT6A, KRT14, TUBB4B, TUBA1C, KRT16, TCP1, CCT2, ACTB, FAM175B, CCT3, KRT5, KRT15, CLPX, EEF1G, PSMD11, CALM3, HSPA1L, KRT32, DARS, HSPD1, EEF1D, CNOT1, UBR4, AHNAK, CLTC, KRT36, KRT82, MFAP4, PSTPIP2, PSMC2, PSME1, PSMD14, CD2AP, FUS, BRE, KRT19, CTTN, KRT4, VASP, CCT7, KRT73, HNRNPU, BABAM1, HNRNPD, DRG1, IMPDH2, SERBP1, PIK3CA, TUBA4B, BRCC3, DOK3, HIST4H4, GAPDH, RUVBL1, PSMD13, RPS20, ACTL6A, RARS, CCT5, HSD17B4, TSG101, IRS2, PDE4D, SPRY1, SPRY4, VCAM1, ELMO2, WDR6, WDR77, SNX18, NISCH, YWHAZ, STARD10, YWHAE, SH3PXD2B, DOCK4, PEAK1, PIK3CB, SLC25A5, YWHAB, YWHAQ, PPP2R2A, SIRPA, SYNJ1, FGD6, PIK3AP1, KIRREL, YWHAG, GAREML, AGER, WIPF3, PTPN18, SLC25A13, CYFIP2, ARHGEF7, PPP1CA, CSK, PTPRJ, YWHAH, CSRP1, SH3PXD2A, TTYH2, PIK3R3, FLNA, ARHGAP12, RADIL, SH2D5, FAU, NCKAP1, DIAPH1, HGS, CLASP2, TEC, SLC25A6, HUNK, MLLT4, C1orf27, PPP1CC, HDGFRP3, SLAIN2, EPS15L1, IGF2BP1, PPP5C, GJA9, TAB1, ITGA4, BAG3, CKS2, FTH1, COPB1, PHACTR4, SF3B4, VIM, UBA1, PHC2, KPNA2, CTAGE5, PON2, ARHGEF5, CASC3, MLXIPL, WBP11, YLPM1, SHANK3, NKD2, SLX1A, ACTG1, CBR1, AP2A1, AP2B1, AP2M1, AP2S1, HIST1H3A, SMU1, SNRPD2, CD59, ABL2, AES, EPS8, LMO2, REL, TRIM27, TP53BP2, DDX17, IKZF3, ZBTB7B, ABI3, NUTM2F, DPPA4, HOMEZ, NIF3L1, ARHGAP9, LZTS2, LNX1, C1orf94, PNMA5, PRR22, INCA1, DOK1, FKBP2, FABP5, ITCH, ROS1, HEXB, ACAP1, PLEKHS1, AUNIP, UQCC2, CRBN, LMX1A, MYOZ1, PACRGL, PARD6A, PCDHB5, PPARA, RB1, SOCS4, TMEM128, TSPAN2, VCP, WDFY3, DBN1, E2F2, ARL6IP4, OLIG1, WBSCR27, ZMAT1, CLNK, CEP170, FBF1, MCM2, USP12, GFAP, NEFH, HNRNPA2B1, RPS27A, LGALS3BP, MYL12A, MYL12B, S100A8, S100A9, ESRRB, LIME1, KRAS, LTK, SHC2, SHC4, DUSP13, DUSP8, CYLD, VPS37B, NKX2-5, SPATA2L, MVB12A, ZMYM6, VPS28, DOCK5, THEMIS, RAC1, TRIM25PCYT1ABARD1, PDIA6, S100A13, NMNAT1, CEP170, CEP170P1, GPRC5C, IP6K3, TMEM206, STX11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GRB2_PCYT1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePCYT1AP49585DB00122CholineCholine-phosphate cytidylyltransferase Asmall moleculeapproved|nutraceutical

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RelatedDiseases for GRB2_PCYT1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGRB2C0036341Schizophrenia2PSYGENET
TgenePCYT1AC1837073Spondylometaphyseal Dysplasia with Cone-Rod Dystrophy2ORPHANET;UNIPROT
TgenePCYT1AC0080178Spina Bifida1CTD_human
TgenePCYT1AC4277682Chemical and Drug Induced Liver Injury1CTD_human