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Fusion gene ID: 15356 |
FusionGeneSummary for GRB10_STEAP1B |
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Fusion gene information | Fusion gene name: GRB10_STEAP1B | Fusion gene ID: 15356 | Hgene | Tgene | Gene symbol | GRB10 | STEAP1B | Gene ID | 2887 | 256227 |
Gene name | growth factor receptor bound protein 10 | STEAP family member 1B | |
Synonyms | GRB-IR|Grb-10|IRBP|MEG1|RSS | - | |
Cytomap | 7p12.1 | 7p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | growth factor receptor-bound protein 10GRB10 adapter proteinGRB10 adaptor proteininsulin receptor-binding protein Grb-IRmaternally expressed gene 1 | STEAP family member 1BSTEAP family protein MGC87042 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q13322 | Q6NZ63 | |
Ensembl transtripts involved in fusion gene | ENST00000398810, ENST00000439599, ENST00000398812, ENST00000335866, ENST00000402578, ENST00000403097, ENST00000406641, ENST00000357271, ENST00000407526, ENST00000401949, ENST00000402497, ENST00000483819, | ENST00000406890, ENST00000404369, | |
Fusion gene scores | * DoF score | 10 X 6 X 8=480 | 2 X 2 X 2=8 |
# samples | 10 | 2 | |
** MAII score | log2(10/480*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: GRB10 [Title/Abstract] AND STEAP1B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GRB10 | GO:0030178 | negative regulation of Wnt signaling pathway | 17376403 |
Hgene | GRB10 | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway | 15060076 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BLCA | TCGA-CU-A0YN-01A | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000398810 | ENST00000406890 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
intron-5UTR | ENST00000398810 | ENST00000404369 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
intron-5UTR | ENST00000439599 | ENST00000406890 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
intron-5UTR | ENST00000439599 | ENST00000404369 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
intron-5UTR | ENST00000398812 | ENST00000406890 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
intron-5UTR | ENST00000398812 | ENST00000404369 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
5UTR-5UTR | ENST00000335866 | ENST00000406890 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
5UTR-5UTR | ENST00000335866 | ENST00000404369 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
intron-5UTR | ENST00000402578 | ENST00000406890 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
intron-5UTR | ENST00000402578 | ENST00000404369 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
5UTR-5UTR | ENST00000403097 | ENST00000406890 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
5UTR-5UTR | ENST00000403097 | ENST00000404369 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
5UTR-5UTR | ENST00000406641 | ENST00000406890 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
5UTR-5UTR | ENST00000406641 | ENST00000404369 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
intron-5UTR | ENST00000357271 | ENST00000406890 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
intron-5UTR | ENST00000357271 | ENST00000404369 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
5UTR-5UTR | ENST00000407526 | ENST00000406890 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
5UTR-5UTR | ENST00000407526 | ENST00000404369 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
5UTR-5UTR | ENST00000401949 | ENST00000406890 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
5UTR-5UTR | ENST00000401949 | ENST00000404369 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
intron-5UTR | ENST00000402497 | ENST00000406890 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
intron-5UTR | ENST00000402497 | ENST00000404369 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
5CDS-5UTR | ENST00000483819 | ENST00000406890 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
5CDS-5UTR | ENST00000483819 | ENST00000404369 | GRB10 | chr7 | 50823584 | - | STEAP1B | chr7 | 22534505 | - |
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FusionProtFeatures for GRB10_STEAP1B |
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Hgene | Tgene |
GRB10 | STEAP1B |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GRB10_STEAP1B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GRB10_STEAP1B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GRB10 | GIGYF2, GIGYF1, IGF1R, SRC, FYN, INSR, IRS1, RAF1, KDR, EGFR, KIT, MAP2K1, RET, EPHB1, GHR, JAK2, ABL1, NEDD4, NOA1, MEGF10, ELAVL1, PIK3R1, IRS2, APP, DENND5B, IQCB1, RQCD1, HECW2, AKT1, YWHAE, ZDHHC17, CHFR, NARS, BAIAP2, RCAN3, XPO1, NEDD4L, WDR59 | STEAP1B | STEAP1, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GRB10_STEAP1B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GRB10_STEAP1B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GRB10 | C0036341 | Schizophrenia | 1 | PSYGENET |