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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15320

FusionGeneSummary for GPX3_GPX3

check button Fusion gene summary
Fusion gene informationFusion gene name: GPX3_GPX3
Fusion gene ID: 15320
HgeneTgene
Gene symbol

GPX3

GPX3

Gene ID

2878

2878

Gene nameglutathione peroxidase 3glutathione peroxidase 3
SynonymsGPx-P|GSHPx-3|GSHPx-PGPx-P|GSHPx-3|GSHPx-P
Cytomap

5q33.1

5q33.1

Type of geneprotein-codingprotein-coding
Descriptionglutathione peroxidase 3GPx-3extracellular glutathione peroxidaseglutathione peroxidase 3 (plasma)plasma glutathione peroxidaseglutathione peroxidase 3GPx-3extracellular glutathione peroxidaseglutathione peroxidase 3 (plasma)plasma glutathione peroxidase
Modification date2018051920180519
UniProtAcc

P22352

P22352

Ensembl transtripts involved in fusion geneENST00000388825, ENST00000521722, 
ENST00000517973, 		ENST00000388825, 
ENST00000521722, ENST00000517973, 
Fusion gene scores* DoF score8 X 11 X 3=2645 X 9 X 2=90
# samples 1410
** MAII scorelog2(14/264*10)=-0.915111102413487
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/90*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GPX3 [Title/Abstract] AND GPX3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGPX3

GO:0051289

protein homotetramerization

3693360

TgeneGPX3

GO:0051289

protein homotetramerization

3693360


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG430541GPX3chr5

150407832

+GPX3chr5

150406467

+
ChiTaRS3.1BG896291GPX3chr5

150407947

-GPX3chr5

150408072

+
ChiTaRS3.1BG927502GPX3chr5

150407992

+GPX3chr5

150407030

+
ChiTaRS3.1BF878552GPX3chr5

150407052

+GPX3chr5

150404980

-
ChiTaRS3.1W25873GPX3chr5

150407479

-GPX3chr5

150407726

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000388825ENST00000388825GPX3chr5

150407832

+GPX3chr5

150406467

+
3UTR-intronENST00000388825ENST00000521722GPX3chr5

150407832

+GPX3chr5

150406467

+
3UTR-intronENST00000388825ENST00000517973GPX3chr5

150407832

+GPX3chr5

150406467

+
intron-3CDSENST00000521722ENST00000388825GPX3chr5

150407832

+GPX3chr5

150406467

+
intron-intronENST00000521722ENST00000521722GPX3chr5

150407832

+GPX3chr5

150406467

+
intron-intronENST00000521722ENST00000517973GPX3chr5

150407832

+GPX3chr5

150406467

+
intron-3CDSENST00000517973ENST00000388825GPX3chr5

150407832

+GPX3chr5

150406467

+
intron-intronENST00000517973ENST00000521722GPX3chr5

150407832

+GPX3chr5

150406467

+
intron-intronENST00000517973ENST00000517973GPX3chr5

150407832

+GPX3chr5

150406467

+
3UTR-3UTRENST00000388825ENST00000388825GPX3chr5

150407947

-GPX3chr5

150408072

+
3UTR-intronENST00000388825ENST00000521722GPX3chr5

150407947

-GPX3chr5

150408072

+
3UTR-intronENST00000388825ENST00000517973GPX3chr5

150407947

-GPX3chr5

150408072

+
intron-3UTRENST00000521722ENST00000388825GPX3chr5

150407947

-GPX3chr5

150408072

+
intron-intronENST00000521722ENST00000521722GPX3chr5

150407947

-GPX3chr5

150408072

+
intron-intronENST00000521722ENST00000517973GPX3chr5

150407947

-GPX3chr5

150408072

+
intron-3UTRENST00000517973ENST00000388825GPX3chr5

150407947

-GPX3chr5

150408072

+
intron-intronENST00000517973ENST00000521722GPX3chr5

150407947

-GPX3chr5

150408072

+
intron-intronENST00000517973ENST00000517973GPX3chr5

150407947

-GPX3chr5

150408072

+
3UTR-3CDSENST00000388825ENST00000388825GPX3chr5

150407992

+GPX3chr5

150407030

+
3UTR-intronENST00000388825ENST00000521722GPX3chr5

150407992

+GPX3chr5

150407030

+
3UTR-intronENST00000388825ENST00000517973GPX3chr5

150407992

+GPX3chr5

150407030

+
intron-3CDSENST00000521722ENST00000388825GPX3chr5

150407992

+GPX3chr5

150407030

+
intron-intronENST00000521722ENST00000521722GPX3chr5

150407992

+GPX3chr5

150407030

+
intron-intronENST00000521722ENST00000517973GPX3chr5

150407992

+GPX3chr5

150407030

+
intron-3CDSENST00000517973ENST00000388825GPX3chr5

150407992

+GPX3chr5

150407030

+
intron-intronENST00000517973ENST00000521722GPX3chr5

150407992

+GPX3chr5

150407030

+
intron-intronENST00000517973ENST00000517973GPX3chr5

150407992

+GPX3chr5

150407030

+
In-frameENST00000388825ENST00000388825GPX3chr5

150407052

+GPX3chr5

150404980

-
5CDS-3UTRENST00000388825ENST00000521722GPX3chr5

150407052

+GPX3chr5

150404980

-
5CDS-intronENST00000388825ENST00000517973GPX3chr5

150407052

+GPX3chr5

150404980

-
intron-3CDSENST00000521722ENST00000388825GPX3chr5

150407052

+GPX3chr5

150404980

-
intron-3UTRENST00000521722ENST00000521722GPX3chr5

150407052

+GPX3chr5

150404980

-
intron-intronENST00000521722ENST00000517973GPX3chr5

150407052

+GPX3chr5

150404980

-
Frame-shitENST00000517973ENST00000388825GPX3chr5

150407052

+GPX3chr5

150404980

-
5CDS-3UTRENST00000517973ENST00000521722GPX3chr5

150407052

+GPX3chr5

150404980

-
5CDS-intronENST00000517973ENST00000517973GPX3chr5

150407052

+GPX3chr5

150404980

-
5CDS-3UTRENST00000388825ENST00000388825GPX3chr5

150407479

-GPX3chr5

150407726

+
5CDS-intronENST00000388825ENST00000521722GPX3chr5

150407479

-GPX3chr5

150407726

+
5CDS-intronENST00000388825ENST00000517973GPX3chr5

150407479

-GPX3chr5

150407726

+
intron-3UTRENST00000521722ENST00000388825GPX3chr5

150407479

-GPX3chr5

150407726

+
intron-intronENST00000521722ENST00000521722GPX3chr5

150407479

-GPX3chr5

150407726

+
intron-intronENST00000521722ENST00000517973GPX3chr5

150407479

-GPX3chr5

150407726

+
3UTR-3UTRENST00000517973ENST00000388825GPX3chr5

150407479

-GPX3chr5

150407726

+
3UTR-intronENST00000517973ENST00000521722GPX3chr5

150407479

-GPX3chr5

150407726

+
3UTR-intronENST00000517973ENST00000517973GPX3chr5

150407479

-GPX3chr5

150407726

+

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FusionProtFeatures for GPX3_GPX3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPX3

P22352

GPX3

P22352

Protects cells and enzymes from oxidative damage, bycatalyzing the reduction of hydrogen peroxide, lipid peroxides andorganic hydroperoxide, by glutathione. Protects cells and enzymes from oxidative damage, bycatalyzing the reduction of hydrogen peroxide, lipid peroxides andorganic hydroperoxide, by glutathione.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPX3_GPX3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPX3_GPX3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPX3_GPX3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGPX3P22352DB00143GlutathioneGlutathione peroxidase 3small moleculeapproved|investigational|nutraceutical
TgeneGPX3P22352DB00143GlutathioneGlutathione peroxidase 3small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for GPX3_GPX3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGPX3C0014175Endometriosis2CTD_human
HgeneGPX3C0024121Lung Neoplasms2CTD_human
HgeneGPX3C0028754Obesity2CTD_human
HgeneGPX3C0001418Adenocarcinoma1CTD_human
HgeneGPX3C0015624Fanconi Syndrome1CTD_human
HgeneGPX3C0021655Insulin Resistance1CTD_human
HgeneGPX3C0023903Liver neoplasms1CTD_human
HgeneGPX3C0033578Prostatic Neoplasms1CTD_human
HgeneGPX3C0524851Neurodegenerative Disorders1CTD_human
TgeneGPX3C0014175Endometriosis2CTD_human
TgeneGPX3C0024121Lung Neoplasms2CTD_human
TgeneGPX3C0028754Obesity2CTD_human
TgeneGPX3C0001418Adenocarcinoma1CTD_human
TgeneGPX3C0015624Fanconi Syndrome1CTD_human
TgeneGPX3C0021655Insulin Resistance1CTD_human
TgeneGPX3C0023903Liver neoplasms1CTD_human
TgeneGPX3C0033578Prostatic Neoplasms1CTD_human
TgeneGPX3C0524851Neurodegenerative Disorders1CTD_human