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Fusion gene ID: 15320 |
FusionGeneSummary for GPX3_GPX3 |
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Fusion gene information | Fusion gene name: GPX3_GPX3 | Fusion gene ID: 15320 | Hgene | Tgene | Gene symbol | GPX3 | GPX3 | Gene ID | 2878 | 2878 |
Gene name | glutathione peroxidase 3 | glutathione peroxidase 3 | |
Synonyms | GPx-P|GSHPx-3|GSHPx-P | GPx-P|GSHPx-3|GSHPx-P | |
Cytomap | 5q33.1 | 5q33.1 | |
Type of gene | protein-coding | protein-coding | |
Description | glutathione peroxidase 3GPx-3extracellular glutathione peroxidaseglutathione peroxidase 3 (plasma)plasma glutathione peroxidase | glutathione peroxidase 3GPx-3extracellular glutathione peroxidaseglutathione peroxidase 3 (plasma)plasma glutathione peroxidase | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | P22352 | P22352 | |
Ensembl transtripts involved in fusion gene | ENST00000388825, ENST00000521722, ENST00000517973, | ENST00000388825, ENST00000521722, ENST00000517973, | |
Fusion gene scores | * DoF score | 8 X 11 X 3=264 | 5 X 9 X 2=90 |
# samples | 14 | 10 | |
** MAII score | log2(14/264*10)=-0.915111102413487 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/90*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: GPX3 [Title/Abstract] AND GPX3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GPX3 | GO:0051289 | protein homotetramerization | 3693360 |
Tgene | GPX3 | GO:0051289 | protein homotetramerization | 3693360 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG430541 | GPX3 | chr5 | 150407832 | + | GPX3 | chr5 | 150406467 | + | ||
ChiTaRS3.1 | BG896291 | GPX3 | chr5 | 150407947 | - | GPX3 | chr5 | 150408072 | + | ||
ChiTaRS3.1 | BG927502 | GPX3 | chr5 | 150407992 | + | GPX3 | chr5 | 150407030 | + | ||
ChiTaRS3.1 | BF878552 | GPX3 | chr5 | 150407052 | + | GPX3 | chr5 | 150404980 | - | ||
ChiTaRS3.1 | W25873 | GPX3 | chr5 | 150407479 | - | GPX3 | chr5 | 150407726 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000388825 | ENST00000388825 | GPX3 | chr5 | 150407832 | + | GPX3 | chr5 | 150406467 | + |
3UTR-intron | ENST00000388825 | ENST00000521722 | GPX3 | chr5 | 150407832 | + | GPX3 | chr5 | 150406467 | + |
3UTR-intron | ENST00000388825 | ENST00000517973 | GPX3 | chr5 | 150407832 | + | GPX3 | chr5 | 150406467 | + |
intron-3CDS | ENST00000521722 | ENST00000388825 | GPX3 | chr5 | 150407832 | + | GPX3 | chr5 | 150406467 | + |
intron-intron | ENST00000521722 | ENST00000521722 | GPX3 | chr5 | 150407832 | + | GPX3 | chr5 | 150406467 | + |
intron-intron | ENST00000521722 | ENST00000517973 | GPX3 | chr5 | 150407832 | + | GPX3 | chr5 | 150406467 | + |
intron-3CDS | ENST00000517973 | ENST00000388825 | GPX3 | chr5 | 150407832 | + | GPX3 | chr5 | 150406467 | + |
intron-intron | ENST00000517973 | ENST00000521722 | GPX3 | chr5 | 150407832 | + | GPX3 | chr5 | 150406467 | + |
intron-intron | ENST00000517973 | ENST00000517973 | GPX3 | chr5 | 150407832 | + | GPX3 | chr5 | 150406467 | + |
3UTR-3UTR | ENST00000388825 | ENST00000388825 | GPX3 | chr5 | 150407947 | - | GPX3 | chr5 | 150408072 | + |
3UTR-intron | ENST00000388825 | ENST00000521722 | GPX3 | chr5 | 150407947 | - | GPX3 | chr5 | 150408072 | + |
3UTR-intron | ENST00000388825 | ENST00000517973 | GPX3 | chr5 | 150407947 | - | GPX3 | chr5 | 150408072 | + |
intron-3UTR | ENST00000521722 | ENST00000388825 | GPX3 | chr5 | 150407947 | - | GPX3 | chr5 | 150408072 | + |
intron-intron | ENST00000521722 | ENST00000521722 | GPX3 | chr5 | 150407947 | - | GPX3 | chr5 | 150408072 | + |
intron-intron | ENST00000521722 | ENST00000517973 | GPX3 | chr5 | 150407947 | - | GPX3 | chr5 | 150408072 | + |
intron-3UTR | ENST00000517973 | ENST00000388825 | GPX3 | chr5 | 150407947 | - | GPX3 | chr5 | 150408072 | + |
intron-intron | ENST00000517973 | ENST00000521722 | GPX3 | chr5 | 150407947 | - | GPX3 | chr5 | 150408072 | + |
intron-intron | ENST00000517973 | ENST00000517973 | GPX3 | chr5 | 150407947 | - | GPX3 | chr5 | 150408072 | + |
3UTR-3CDS | ENST00000388825 | ENST00000388825 | GPX3 | chr5 | 150407992 | + | GPX3 | chr5 | 150407030 | + |
3UTR-intron | ENST00000388825 | ENST00000521722 | GPX3 | chr5 | 150407992 | + | GPX3 | chr5 | 150407030 | + |
3UTR-intron | ENST00000388825 | ENST00000517973 | GPX3 | chr5 | 150407992 | + | GPX3 | chr5 | 150407030 | + |
intron-3CDS | ENST00000521722 | ENST00000388825 | GPX3 | chr5 | 150407992 | + | GPX3 | chr5 | 150407030 | + |
intron-intron | ENST00000521722 | ENST00000521722 | GPX3 | chr5 | 150407992 | + | GPX3 | chr5 | 150407030 | + |
intron-intron | ENST00000521722 | ENST00000517973 | GPX3 | chr5 | 150407992 | + | GPX3 | chr5 | 150407030 | + |
intron-3CDS | ENST00000517973 | ENST00000388825 | GPX3 | chr5 | 150407992 | + | GPX3 | chr5 | 150407030 | + |
intron-intron | ENST00000517973 | ENST00000521722 | GPX3 | chr5 | 150407992 | + | GPX3 | chr5 | 150407030 | + |
intron-intron | ENST00000517973 | ENST00000517973 | GPX3 | chr5 | 150407992 | + | GPX3 | chr5 | 150407030 | + |
In-frame | ENST00000388825 | ENST00000388825 | GPX3 | chr5 | 150407052 | + | GPX3 | chr5 | 150404980 | - |
5CDS-3UTR | ENST00000388825 | ENST00000521722 | GPX3 | chr5 | 150407052 | + | GPX3 | chr5 | 150404980 | - |
5CDS-intron | ENST00000388825 | ENST00000517973 | GPX3 | chr5 | 150407052 | + | GPX3 | chr5 | 150404980 | - |
intron-3CDS | ENST00000521722 | ENST00000388825 | GPX3 | chr5 | 150407052 | + | GPX3 | chr5 | 150404980 | - |
intron-3UTR | ENST00000521722 | ENST00000521722 | GPX3 | chr5 | 150407052 | + | GPX3 | chr5 | 150404980 | - |
intron-intron | ENST00000521722 | ENST00000517973 | GPX3 | chr5 | 150407052 | + | GPX3 | chr5 | 150404980 | - |
Frame-shift | ENST00000517973 | ENST00000388825 | GPX3 | chr5 | 150407052 | + | GPX3 | chr5 | 150404980 | - |
5CDS-3UTR | ENST00000517973 | ENST00000521722 | GPX3 | chr5 | 150407052 | + | GPX3 | chr5 | 150404980 | - |
5CDS-intron | ENST00000517973 | ENST00000517973 | GPX3 | chr5 | 150407052 | + | GPX3 | chr5 | 150404980 | - |
5CDS-3UTR | ENST00000388825 | ENST00000388825 | GPX3 | chr5 | 150407479 | - | GPX3 | chr5 | 150407726 | + |
5CDS-intron | ENST00000388825 | ENST00000521722 | GPX3 | chr5 | 150407479 | - | GPX3 | chr5 | 150407726 | + |
5CDS-intron | ENST00000388825 | ENST00000517973 | GPX3 | chr5 | 150407479 | - | GPX3 | chr5 | 150407726 | + |
intron-3UTR | ENST00000521722 | ENST00000388825 | GPX3 | chr5 | 150407479 | - | GPX3 | chr5 | 150407726 | + |
intron-intron | ENST00000521722 | ENST00000521722 | GPX3 | chr5 | 150407479 | - | GPX3 | chr5 | 150407726 | + |
intron-intron | ENST00000521722 | ENST00000517973 | GPX3 | chr5 | 150407479 | - | GPX3 | chr5 | 150407726 | + |
3UTR-3UTR | ENST00000517973 | ENST00000388825 | GPX3 | chr5 | 150407479 | - | GPX3 | chr5 | 150407726 | + |
3UTR-intron | ENST00000517973 | ENST00000521722 | GPX3 | chr5 | 150407479 | - | GPX3 | chr5 | 150407726 | + |
3UTR-intron | ENST00000517973 | ENST00000517973 | GPX3 | chr5 | 150407479 | - | GPX3 | chr5 | 150407726 | + |
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FusionProtFeatures for GPX3_GPX3 |
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Hgene | Tgene |
GPX3 | GPX3 |
Protects cells and enzymes from oxidative damage, bycatalyzing the reduction of hydrogen peroxide, lipid peroxides andorganic hydroperoxide, by glutathione. | Protects cells and enzymes from oxidative damage, bycatalyzing the reduction of hydrogen peroxide, lipid peroxides andorganic hydroperoxide, by glutathione. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPX3_GPX3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GPX3_GPX3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPX3_GPX3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | GPX3 | P22352 | DB00143 | Glutathione | Glutathione peroxidase 3 | small molecule | approved|investigational|nutraceutical |
Tgene | GPX3 | P22352 | DB00143 | Glutathione | Glutathione peroxidase 3 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for GPX3_GPX3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GPX3 | C0014175 | Endometriosis | 2 | CTD_human |
Hgene | GPX3 | C0024121 | Lung Neoplasms | 2 | CTD_human |
Hgene | GPX3 | C0028754 | Obesity | 2 | CTD_human |
Hgene | GPX3 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Hgene | GPX3 | C0015624 | Fanconi Syndrome | 1 | CTD_human |
Hgene | GPX3 | C0021655 | Insulin Resistance | 1 | CTD_human |
Hgene | GPX3 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | GPX3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | GPX3 | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
Tgene | GPX3 | C0014175 | Endometriosis | 2 | CTD_human |
Tgene | GPX3 | C0024121 | Lung Neoplasms | 2 | CTD_human |
Tgene | GPX3 | C0028754 | Obesity | 2 | CTD_human |
Tgene | GPX3 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Tgene | GPX3 | C0015624 | Fanconi Syndrome | 1 | CTD_human |
Tgene | GPX3 | C0021655 | Insulin Resistance | 1 | CTD_human |
Tgene | GPX3 | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | GPX3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | GPX3 | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |