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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15318

FusionGeneSummary for GPX3_CLCN3

check button Fusion gene summary
Fusion gene informationFusion gene name: GPX3_CLCN3
Fusion gene ID: 15318
HgeneTgene
Gene symbol

GPX3

CLCN3

Gene ID

2878

1182

Gene nameglutathione peroxidase 3chloride voltage-gated channel 3
SynonymsGPx-P|GSHPx-3|GSHPx-PCLC3|ClC-3
Cytomap

5q33.1

4q33

Type of geneprotein-codingprotein-coding
Descriptionglutathione peroxidase 3GPx-3extracellular glutathione peroxidaseglutathione peroxidase 3 (plasma)plasma glutathione peroxidaseH(+)/Cl(-) exchange transporter 3chloride channel 3chloride channel protein 3chloride channel, voltage-sensitive 3chloride transporter ClC-3
Modification date2018051920180523
UniProtAcc

P22352

P51790

Ensembl transtripts involved in fusion geneENST00000388825, ENST00000521722, 
ENST00000517973, 
ENST00000513761, 
ENST00000347613, ENST00000360642, 
ENST00000504131, ENST00000506924, 
Fusion gene scores* DoF score8 X 11 X 3=26436 X 4 X 19=2736
# samples 1439
** MAII scorelog2(14/264*10)=-0.915111102413487
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(39/2736*10)=-2.81052220113629
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPX3 [Title/Abstract] AND CLCN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGPX3

GO:0051289

protein homotetramerization

3693360

TgeneCLCN3

GO:1902476

chloride transmembrane transport

11274166


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTHCATCGA-EM-A4FK-01AGPX3chr5

150408548

+CLCN3chr4

170623929

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000388825ENST00000513761GPX3chr5

150408548

+CLCN3chr4

170623929

+
5CDS-intronENST00000388825ENST00000347613GPX3chr5

150408548

+CLCN3chr4

170623929

+
5CDS-intronENST00000388825ENST00000360642GPX3chr5

150408548

+CLCN3chr4

170623929

+
5CDS-intronENST00000388825ENST00000504131GPX3chr5

150408548

+CLCN3chr4

170623929

+
5CDS-intronENST00000388825ENST00000506924GPX3chr5

150408548

+CLCN3chr4

170623929

+
intron-intronENST00000521722ENST00000513761GPX3chr5

150408548

+CLCN3chr4

170623929

+
intron-intronENST00000521722ENST00000347613GPX3chr5

150408548

+CLCN3chr4

170623929

+
intron-intronENST00000521722ENST00000360642GPX3chr5

150408548

+CLCN3chr4

170623929

+
intron-intronENST00000521722ENST00000504131GPX3chr5

150408548

+CLCN3chr4

170623929

+
intron-intronENST00000521722ENST00000506924GPX3chr5

150408548

+CLCN3chr4

170623929

+
intron-intronENST00000517973ENST00000513761GPX3chr5

150408548

+CLCN3chr4

170623929

+
intron-intronENST00000517973ENST00000347613GPX3chr5

150408548

+CLCN3chr4

170623929

+
intron-intronENST00000517973ENST00000360642GPX3chr5

150408548

+CLCN3chr4

170623929

+
intron-intronENST00000517973ENST00000504131GPX3chr5

150408548

+CLCN3chr4

170623929

+
intron-intronENST00000517973ENST00000506924GPX3chr5

150408548

+CLCN3chr4

170623929

+

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FusionProtFeatures for GPX3_CLCN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPX3

P22352

CLCN3

P51790

Protects cells and enzymes from oxidative damage, bycatalyzing the reduction of hydrogen peroxide, lipid peroxides andorganic hydroperoxide, by glutathione. Mediates the exchange of chloride ions against protons.Functions as antiporter and contributes to the acidification ofthe endosome and synaptic vesicle lumen, and may thereby affectvesicle trafficking and exocytosis. May play an important role inneuronal cell function through regulation of membrane excitabilityby protein kinase C. It could help neuronal cells to establishshort-term memory. {ECO:0000269|PubMed:11967229}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPX3_CLCN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPX3_CLCN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GPX3GPX3, UBQLN1, TP53I3CLCN3CLCN3, SLC9A3R1, PDZK1, GOPC, CFTR, LGALS3, LGALS8, LGALS9, LYPD3, HSPB1, TMEM9B, GGA1, TPCN2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPX3_CLCN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGPX3P22352DB00143GlutathioneGlutathione peroxidase 3small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for GPX3_CLCN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGPX3C0014175Endometriosis2CTD_human
HgeneGPX3C0024121Lung Neoplasms2CTD_human
HgeneGPX3C0028754Obesity2CTD_human
HgeneGPX3C0001418Adenocarcinoma1CTD_human
HgeneGPX3C0015624Fanconi Syndrome1CTD_human
HgeneGPX3C0021655Insulin Resistance1CTD_human
HgeneGPX3C0023903Liver neoplasms1CTD_human
HgeneGPX3C0033578Prostatic Neoplasms1CTD_human
HgeneGPX3C0524851Neurodegenerative Disorders1CTD_human
TgeneCLCN3C0017638Glioma1CTD_human
TgeneCLCN3C0038356Stomach Neoplasms1CTD_human
TgeneCLCN3C2931822Nasopharyngeal carcinoma1CTD_human