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Fusion gene ID: 15317 |
FusionGeneSummary for GPX3_CHD4 |
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Fusion gene information | Fusion gene name: GPX3_CHD4 | Fusion gene ID: 15317 | Hgene | Tgene | Gene symbol | GPX3 | CHD4 | Gene ID | 2878 | 1108 |
Gene name | glutathione peroxidase 3 | chromodomain helicase DNA binding protein 4 | |
Synonyms | GPx-P|GSHPx-3|GSHPx-P | CHD-4|Mi-2b|Mi2-BETA|SIHIWES | |
Cytomap | 5q33.1 | 12p13.31 | |
Type of gene | protein-coding | protein-coding | |
Description | glutathione peroxidase 3GPx-3extracellular glutathione peroxidaseglutathione peroxidase 3 (plasma)plasma glutathione peroxidase | chromodomain-helicase-DNA-binding protein 4ATP-dependent helicase CHD4Mi-2 autoantigen 218 kDa protein | |
Modification date | 20180519 | 20180524 | |
UniProtAcc | P22352 | Q14839 | |
Ensembl transtripts involved in fusion gene | ENST00000388825, ENST00000521722, ENST00000517973, | ENST00000544484, ENST00000357008, ENST00000309577, ENST00000544040, ENST00000540960, | |
Fusion gene scores | * DoF score | 8 X 11 X 3=264 | 10 X 13 X 6=780 |
# samples | 14 | 16 | |
** MAII score | log2(14/264*10)=-0.915111102413487 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/780*10)=-2.28540221886225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GPX3 [Title/Abstract] AND CHD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GPX3 | GO:0051289 | protein homotetramerization | 3693360 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | THCA | TCGA-DJ-A4V2-01A | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
TCGA | RV | THCA | TCGA-FY-A3W9-01A | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000388825 | ENST00000544484 | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
3UTR-3CDS | ENST00000388825 | ENST00000357008 | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
3UTR-3CDS | ENST00000388825 | ENST00000309577 | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
3UTR-3CDS | ENST00000388825 | ENST00000544040 | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
3UTR-intron | ENST00000388825 | ENST00000540960 | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
intron-3CDS | ENST00000521722 | ENST00000544484 | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
intron-3CDS | ENST00000521722 | ENST00000357008 | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
intron-3CDS | ENST00000521722 | ENST00000309577 | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
intron-3CDS | ENST00000521722 | ENST00000544040 | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
intron-intron | ENST00000521722 | ENST00000540960 | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
intron-3CDS | ENST00000517973 | ENST00000544484 | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
intron-3CDS | ENST00000517973 | ENST00000357008 | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
intron-3CDS | ENST00000517973 | ENST00000309577 | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
intron-3CDS | ENST00000517973 | ENST00000544040 | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
intron-intron | ENST00000517973 | ENST00000540960 | GPX3 | chr5 | 150408515 | + | CHD4 | chr12 | 6710696 | - |
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FusionProtFeatures for GPX3_CHD4 |
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Hgene | Tgene |
GPX3 | CHD4 |
Protects cells and enzymes from oxidative damage, bycatalyzing the reduction of hydrogen peroxide, lipid peroxides andorganic hydroperoxide, by glutathione. | Component of the histone deacetylase NuRD complex whichparticipates in the remodeling of chromatin by deacetylatinghistones. {ECO:0000269|PubMed:17626165,ECO:0000269|PubMed:9804427}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPX3_CHD4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GPX3_CHD4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GPX3 | GPX3, UBQLN1, TP53I3 | CHD4 | XRN1, HDAC1, MTA2, MTA1, HDAC2, MBD3, ATR, IKZF1, IKZF3, IKZF2, IKZF4, USP36, NR4A1, BANF1, PML, NAB2, NAB1, TRIM27, SMARCA4, HNRNPC, SMARCC1, MCRS1, SRRM1, BCL11B, BCL11A, CBX5, MBD3L2, SMARCE1, SAP30, SIN3A, UBASH3B, RBBP4, RBBP7, H3F3A, PCNT, EMD, HIST1H3A, ATM, PARK7, UBC, MYC, CHD3, TAL1, BRD4, UBTF, CHD5, KPNA5, KPNA6, NOLC1, GATAD2A, GATAD2B, DPEP3, MLLT3, DPEP2, RAD21, SMARCAD1, SOX2, MTA3, RNF8, TWIST1, CBX1, CBX3, ELAVL1, SIRT7, CHD4, MCPH1, NR2C1, DNMT1, NR2C2, KDM1A, POLD3, SNAI2, SNAI1, TBL1XR1, ESR1, NOTCH1, VCAM1, CSNK2A1, HIST3H3, ITGA4, RPA1, RPA2, RPA3, LGR4, NACC2, DNMT3B, PHF6, ZFHX4, CUL7, OBSL1, CCDC8, SUZ12, EED, RNF2, BMI1, UBE2I, SUMO2, SIRT6, ZNF219, PHF20L1, ZNF524, MBD3L1, CLIP1, EIF5, EZH2, SUB1, NTRK1, HIST1H3E, CDK2AP1, ZMYND8, NFATC1, RBPJ, TEAD2, FOXE1, FOXG1, FOXJ2, FOXK2, FOXQ1, SNW1, NFATC2, PARP1, EP300, HSFY1, ZNF581, CPNE5, SNRNP27, CTBP1, NCL, MTNR1A, RUVBL2, PDHA1, FOXA1, TRIM25, MTF1, BRD1, ZNF827 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPX3_CHD4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | GPX3 | P22352 | DB00143 | Glutathione | Glutathione peroxidase 3 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for GPX3_CHD4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GPX3 | C0014175 | Endometriosis | 2 | CTD_human |
Hgene | GPX3 | C0024121 | Lung Neoplasms | 2 | CTD_human |
Hgene | GPX3 | C0028754 | Obesity | 2 | CTD_human |
Hgene | GPX3 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Hgene | GPX3 | C0015624 | Fanconi Syndrome | 1 | CTD_human |
Hgene | GPX3 | C0021655 | Insulin Resistance | 1 | CTD_human |
Hgene | GPX3 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | GPX3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | GPX3 | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
Tgene | CHD4 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Tgene | CHD4 | C0036341 | Schizophrenia | 1 | CTD_human |