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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15317

FusionGeneSummary for GPX3_CHD4

check button Fusion gene summary
Fusion gene informationFusion gene name: GPX3_CHD4
Fusion gene ID: 15317
HgeneTgene
Gene symbol

GPX3

CHD4

Gene ID

2878

1108

Gene nameglutathione peroxidase 3chromodomain helicase DNA binding protein 4
SynonymsGPx-P|GSHPx-3|GSHPx-PCHD-4|Mi-2b|Mi2-BETA|SIHIWES
Cytomap

5q33.1

12p13.31

Type of geneprotein-codingprotein-coding
Descriptionglutathione peroxidase 3GPx-3extracellular glutathione peroxidaseglutathione peroxidase 3 (plasma)plasma glutathione peroxidasechromodomain-helicase-DNA-binding protein 4ATP-dependent helicase CHD4Mi-2 autoantigen 218 kDa protein
Modification date2018051920180524
UniProtAcc

P22352

Q14839

Ensembl transtripts involved in fusion geneENST00000388825, ENST00000521722, 
ENST00000517973, 
ENST00000544484, 
ENST00000357008, ENST00000309577, 
ENST00000544040, ENST00000540960, 
Fusion gene scores* DoF score8 X 11 X 3=26410 X 13 X 6=780
# samples 1416
** MAII scorelog2(14/264*10)=-0.915111102413487
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/780*10)=-2.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPX3 [Title/Abstract] AND CHD4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGPX3

GO:0051289

protein homotetramerization

3693360


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTHCATCGA-DJ-A4V2-01AGPX3chr5

150408515

+CHD4chr12

6710696

-
TCGARVTHCATCGA-FY-A3W9-01AGPX3chr5

150408515

+CHD4chr12

6710696

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000388825ENST00000544484GPX3chr5

150408515

+CHD4chr12

6710696

-
3UTR-3CDSENST00000388825ENST00000357008GPX3chr5

150408515

+CHD4chr12

6710696

-
3UTR-3CDSENST00000388825ENST00000309577GPX3chr5

150408515

+CHD4chr12

6710696

-
3UTR-3CDSENST00000388825ENST00000544040GPX3chr5

150408515

+CHD4chr12

6710696

-
3UTR-intronENST00000388825ENST00000540960GPX3chr5

150408515

+CHD4chr12

6710696

-
intron-3CDSENST00000521722ENST00000544484GPX3chr5

150408515

+CHD4chr12

6710696

-
intron-3CDSENST00000521722ENST00000357008GPX3chr5

150408515

+CHD4chr12

6710696

-
intron-3CDSENST00000521722ENST00000309577GPX3chr5

150408515

+CHD4chr12

6710696

-
intron-3CDSENST00000521722ENST00000544040GPX3chr5

150408515

+CHD4chr12

6710696

-
intron-intronENST00000521722ENST00000540960GPX3chr5

150408515

+CHD4chr12

6710696

-
intron-3CDSENST00000517973ENST00000544484GPX3chr5

150408515

+CHD4chr12

6710696

-
intron-3CDSENST00000517973ENST00000357008GPX3chr5

150408515

+CHD4chr12

6710696

-
intron-3CDSENST00000517973ENST00000309577GPX3chr5

150408515

+CHD4chr12

6710696

-
intron-3CDSENST00000517973ENST00000544040GPX3chr5

150408515

+CHD4chr12

6710696

-
intron-intronENST00000517973ENST00000540960GPX3chr5

150408515

+CHD4chr12

6710696

-

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FusionProtFeatures for GPX3_CHD4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPX3

P22352

CHD4

Q14839

Protects cells and enzymes from oxidative damage, bycatalyzing the reduction of hydrogen peroxide, lipid peroxides andorganic hydroperoxide, by glutathione. Component of the histone deacetylase NuRD complex whichparticipates in the remodeling of chromatin by deacetylatinghistones. {ECO:0000269|PubMed:17626165,ECO:0000269|PubMed:9804427}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPX3_CHD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPX3_CHD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GPX3GPX3, UBQLN1, TP53I3CHD4XRN1, HDAC1, MTA2, MTA1, HDAC2, MBD3, ATR, IKZF1, IKZF3, IKZF2, IKZF4, USP36, NR4A1, BANF1, PML, NAB2, NAB1, TRIM27, SMARCA4, HNRNPC, SMARCC1, MCRS1, SRRM1, BCL11B, BCL11A, CBX5, MBD3L2, SMARCE1, SAP30, SIN3A, UBASH3B, RBBP4, RBBP7, H3F3A, PCNT, EMD, HIST1H3A, ATM, PARK7, UBC, MYC, CHD3, TAL1, BRD4, UBTF, CHD5, KPNA5, KPNA6, NOLC1, GATAD2A, GATAD2B, DPEP3, MLLT3, DPEP2, RAD21, SMARCAD1, SOX2, MTA3, RNF8, TWIST1, CBX1, CBX3, ELAVL1, SIRT7, CHD4, MCPH1, NR2C1, DNMT1, NR2C2, KDM1A, POLD3, SNAI2, SNAI1, TBL1XR1, ESR1, NOTCH1, VCAM1, CSNK2A1, HIST3H3, ITGA4, RPA1, RPA2, RPA3, LGR4, NACC2, DNMT3B, PHF6, ZFHX4, CUL7, OBSL1, CCDC8, SUZ12, EED, RNF2, BMI1, UBE2I, SUMO2, SIRT6, ZNF219, PHF20L1, ZNF524, MBD3L1, CLIP1, EIF5, EZH2, SUB1, NTRK1, HIST1H3E, CDK2AP1, ZMYND8, NFATC1, RBPJ, TEAD2, FOXE1, FOXG1, FOXJ2, FOXK2, FOXQ1, SNW1, NFATC2, PARP1, EP300, HSFY1, ZNF581, CPNE5, SNRNP27, CTBP1, NCL, MTNR1A, RUVBL2, PDHA1, FOXA1, TRIM25, MTF1, BRD1, ZNF827


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPX3_CHD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGPX3P22352DB00143GlutathioneGlutathione peroxidase 3small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for GPX3_CHD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGPX3C0014175Endometriosis2CTD_human
HgeneGPX3C0024121Lung Neoplasms2CTD_human
HgeneGPX3C0028754Obesity2CTD_human
HgeneGPX3C0001418Adenocarcinoma1CTD_human
HgeneGPX3C0015624Fanconi Syndrome1CTD_human
HgeneGPX3C0021655Insulin Resistance1CTD_human
HgeneGPX3C0023903Liver neoplasms1CTD_human
HgeneGPX3C0033578Prostatic Neoplasms1CTD_human
HgeneGPX3C0524851Neurodegenerative Disorders1CTD_human
TgeneCHD4C0014170Endometrial Neoplasms1CTD_human
TgeneCHD4C0036341Schizophrenia1CTD_human