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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1529

FusionGeneSummary for ALG13_GSTM2

check button Fusion gene summary
Fusion gene informationFusion gene name: ALG13_GSTM2
Fusion gene ID: 1529
HgeneTgene
Gene symbol

ALG13

GSTM2

Gene ID

79868

2946

Gene nameALG13, UDP-N-acetylglucosaminyltransferase subunitglutathione S-transferase mu 2
SynonymsCDG1S|CXorf45|EIEE36|GLT28D1|MDS031|TDRD13|YGL047WGST4|GSTM|GSTM2-2|GTHMUS
Cytomap

Xq23

1p13.3

Type of geneprotein-codingprotein-coding
Descriptionputative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferaseUDP-N-acetylglucosamine transferase subunit ALG13 homologasparagine-linked glycosylation 13 homologgglutathione S-transferase Mu 2GST class-mu 2GST, muscleS-(hydroxyalkyl)glutathione lyase M2glutathione S-alkyltransferase M2glutathione S-aralkyltransferase M2glutathione S-aryltransferase M2glutathione S-transferase 4glutathione S-transferase M1
Modification date2018052320180519
UniProtAcc

Q9NP73

P28161

Ensembl transtripts involved in fusion geneENST00000371979, ENST00000251943, 
ENST00000394780, ENST00000470971, 
ENST00000369831, ENST00000460717, 
ENST00000369827, ENST00000442650, 
ENST00000464206, ENST00000241337, 
ENST00000414179, ENST00000369829, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 1=9
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ALG13 [Title/Abstract] AND GSTM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGSTM2

GO:0006749

glutathione metabolic process

2034681|8373352|16549767

TgeneGSTM2

GO:0010880

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

17023043

TgeneGSTM2

GO:0018916

nitrobenzene metabolic process

2034681|8373352

TgeneGSTM2

GO:0042178

xenobiotic catabolic process

2034681|8373352|16549767

TgeneGSTM2

GO:0043651

linoleic acid metabolic process

16624487

TgeneGSTM2

GO:0060315

negative regulation of ryanodine-sensitive calcium-release channel activity

17023043|22406107

TgeneGSTM2

GO:0060316

positive regulation of ryanodine-sensitive calcium-release channel activity

17023043

TgeneGSTM2

GO:0070458

cellular detoxification of nitrogen compound

2034681|8373352

TgeneGSTM2

GO:0071313

cellular response to caffeine

22406107


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1EB387269ALG13chrX

110935423

+GSTM2chr1

110220793

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000371979ENST00000369831ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000371979ENST00000460717ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000371979ENST00000369827ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000371979ENST00000442650ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000371979ENST00000464206ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000371979ENST00000241337ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000371979ENST00000414179ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000371979ENST00000369829ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000251943ENST00000369831ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000251943ENST00000460717ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000251943ENST00000369827ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000251943ENST00000442650ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000251943ENST00000464206ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000251943ENST00000241337ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000251943ENST00000414179ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000251943ENST00000369829ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000394780ENST00000369831ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000394780ENST00000460717ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000394780ENST00000369827ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000394780ENST00000442650ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000394780ENST00000464206ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000394780ENST00000241337ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000394780ENST00000414179ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000394780ENST00000369829ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000470971ENST00000369831ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000470971ENST00000460717ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000470971ENST00000369827ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000470971ENST00000442650ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000470971ENST00000464206ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000470971ENST00000241337ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000470971ENST00000414179ALG13chrX

110935423

+GSTM2chr1

110220793

-
intron-intronENST00000470971ENST00000369829ALG13chrX

110935423

+GSTM2chr1

110220793

-

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FusionProtFeatures for ALG13_GSTM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALG13

Q9NP73

GSTM2

P28161

Conjugation of reduced glutathione to a wide number ofexogenous and endogenous hydrophobic electrophiles.{ECO:0000269|PubMed:16549767}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ALG13_GSTM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ALG13_GSTM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ALG13_GSTM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGSTM2P28161DB00143GlutathioneGlutathione S-transferase Mu 2small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for ALG13_GSTM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALG13C3550904EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 362UNIPROT
TgeneGSTM2C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneGSTM2C0013080Down Syndrome1CTD_human
TgeneGSTM2C0036341Schizophrenia1PSYGENET
TgeneGSTM2C0151744Myocardial Ischemia1CTD_human
TgeneGSTM2C0524851Neurodegenerative Disorders1CTD_human
TgeneGSTM2C2609414Acute kidney injury1CTD_human
TgeneGSTM2C4277682Chemical and Drug Induced Liver Injury1CTD_human