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Fusion gene ID: 15283 |
FusionGeneSummary for GPR37L1_ELF3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPR37L1_ELF3 | Fusion gene ID: 15283 | Hgene | Tgene | Gene symbol | GPR37L1 | ELF3 | Gene ID | 9283 | 1999 |
| Gene name | G protein-coupled receptor 37 like 1 | E74 like ETS transcription factor 3 | |
| Synonyms | ET(B)R-LP-2|ETBR-LP-2|ETBRLP2 | EPR-1|ERT|ESE-1|ESX | |
| Cytomap | 1q32.1 | 1q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | prosaposin receptor GPR37L1endothelin B receptor-like protein 2endothelin type b receptor-like protein 2 | ETS-related transcription factor Elf-3E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific)E74-like factor 3 (ets domain transcription factor)E74-like factor 3 (ets domain transcription factor, epithelial-specific )epith | |
| Modification date | 20180520 | 20180523 | |
| UniProtAcc | O60883 | P78545 | |
| Ensembl transtripts involved in fusion gene | ENST00000367282, | ENST00000359651, ENST00000367284, ENST00000367283, ENST00000495848, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 7 X 6 X 3=126 |
| # samples | 3 | 8 | |
| ** MAII score | log2(3/8*10)=1.90689059560852 | log2(8/126*10)=-0.655351828612554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GPR37L1 [Title/Abstract] AND ELF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GPR37L1 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | 23690594 |
| Hgene | GPR37L1 | GO:0043410 | positive regulation of MAPK cascade | 23690594 |
| Tgene | ELF3 | GO:0045892 | negative regulation of transcription, DNA-templated | 10773884 |
| Tgene | ELF3 | GO:0045893 | positive regulation of transcription, DNA-templated | 9234700 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-VQ-A94O-01A | GPR37L1 | chr1 | 202092721 | + | ELF3 | chr1 | 201985008 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000367282 | ENST00000359651 | GPR37L1 | chr1 | 202092721 | + | ELF3 | chr1 | 201985008 | + |
| 5CDS-3UTR | ENST00000367282 | ENST00000367284 | GPR37L1 | chr1 | 202092721 | + | ELF3 | chr1 | 201985008 | + |
| 5CDS-3UTR | ENST00000367282 | ENST00000367283 | GPR37L1 | chr1 | 202092721 | + | ELF3 | chr1 | 201985008 | + |
| 5CDS-intron | ENST00000367282 | ENST00000495848 | GPR37L1 | chr1 | 202092721 | + | ELF3 | chr1 | 201985008 | + |
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FusionProtFeatures for GPR37L1_ELF3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPR37L1 | ELF3 |
| Receptor for the neuroprotective and glioprotectivefactor prosaposin. Ligand binding induces endocytosis, followed byan ERK phosphorylation cascade. {ECO:0000269|PubMed:23690594}. | Transcriptional activator that binds and transactivatesETS sequences containing the consensus nucleotide core sequenceGGA[AT]. Acts synergistically with POU2F3 to transactivate theSPRR2A promoter and with RUNX1 to transactivate the ANGPT1promoter. Also transactivates collagenase, CCL20, CLND7, FLG,KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. RepressesKRT4 promoter activity. Involved in mediating vascularinflammation. May play an important role in epithelial celldifferentiation and tumorigenesis. May be a critical downstreameffector of the ERBB2 signaling pathway. May be associated withmammary gland development and involution. Plays an important rolein the regulation of transcription with TATA-less promoters inpreimplantation embryos, which is essential in preimplantationdevelopment (By similarity). {ECO:0000250,ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:10644990,ECO:0000269|PubMed:10773884, ECO:0000269|PubMed:11036073,ECO:0000269|PubMed:11313868, ECO:0000269|PubMed:12414801,ECO:0000269|PubMed:12624109, ECO:0000269|PubMed:12682075,ECO:0000269|PubMed:12713734, ECO:0000269|PubMed:14715662,ECO:0000269|PubMed:14767472, ECO:0000269|PubMed:15075319,ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:15794755,ECO:0000269|PubMed:16307850, ECO:0000269|PubMed:17060315,ECO:0000269|PubMed:9129154, ECO:0000269|PubMed:9234700,ECO:0000269|PubMed:9336459, ECO:0000269|PubMed:9395241,ECO:0000269|PubMed:9417054}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPR37L1_ELF3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GPR37L1_ELF3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GPR37L1 | ELF3 | P4HB, DDX3X, GANAB, EHF, ATIC, KRT31, TARS, ISG15, CALR, KRT82, EEF1D, JAK1, NFKB1, MED23, ERBB2, TBP, TAF9, PAK1, BTRC, MYC, EP300, XRCC6, XRCC5, RPL6, CBR3, RELA, AR, GADD45GIP1, ELF3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPR37L1_ELF3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GPR37L1_ELF3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ELF3 | C0005426 | Biliary Tract Neoplasm | 1 | CTD_human |
| Tgene | ELF3 | C0273115 | Lung Injury | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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