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Fusion gene ID: 15266 |
FusionGeneSummary for GPR157_GON4L |
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Fusion gene information | Fusion gene name: GPR157_GON4L | Fusion gene ID: 15266 | Hgene | Tgene | Gene symbol | GPR157 | GON4L | Gene ID | 80045 | 54856 |
Gene name | G protein-coupled receptor 157 | gon-4 like | |
Synonyms | - | GON-4|GON4|YARP | |
Cytomap | 1p36.22 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | G-protein coupled receptor 157probable G-protein coupled receptor 157 | GON-4-like protein2610100B20RikYY1AP related proteinYY1AP-related protein1gon-4 homolog | |
Modification date | 20180329 | 20180523 | |
UniProtAcc | Q5UAW9 | Q3T8J9 | |
Ensembl transtripts involved in fusion gene | ENST00000377411, ENST00000414642, | ENST00000437809, ENST00000368331, ENST00000271883, ENST00000361040, ENST00000471341, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 7 X 6 X 6=252 |
# samples | 2 | 8 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(8/252*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GPR157 [Title/Abstract] AND GON4L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-E9-A229-01A | GPR157 | chr1 | 9188704 | - | GON4L | chr1 | 155755165 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000377411 | ENST00000437809 | GPR157 | chr1 | 9188704 | - | GON4L | chr1 | 155755165 | - |
Frame-shift | ENST00000377411 | ENST00000368331 | GPR157 | chr1 | 9188704 | - | GON4L | chr1 | 155755165 | - |
Frame-shift | ENST00000377411 | ENST00000271883 | GPR157 | chr1 | 9188704 | - | GON4L | chr1 | 155755165 | - |
Frame-shift | ENST00000377411 | ENST00000361040 | GPR157 | chr1 | 9188704 | - | GON4L | chr1 | 155755165 | - |
5CDS-5UTR | ENST00000377411 | ENST00000471341 | GPR157 | chr1 | 9188704 | - | GON4L | chr1 | 155755165 | - |
Frame-shift | ENST00000414642 | ENST00000437809 | GPR157 | chr1 | 9188704 | - | GON4L | chr1 | 155755165 | - |
Frame-shift | ENST00000414642 | ENST00000368331 | GPR157 | chr1 | 9188704 | - | GON4L | chr1 | 155755165 | - |
Frame-shift | ENST00000414642 | ENST00000271883 | GPR157 | chr1 | 9188704 | - | GON4L | chr1 | 155755165 | - |
Frame-shift | ENST00000414642 | ENST00000361040 | GPR157 | chr1 | 9188704 | - | GON4L | chr1 | 155755165 | - |
5CDS-5UTR | ENST00000414642 | ENST00000471341 | GPR157 | chr1 | 9188704 | - | GON4L | chr1 | 155755165 | - |
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FusionProtFeatures for GPR157_GON4L |
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Hgene | Tgene |
GPR157 | GON4L |
Orphan receptor that promotes neuronal differentiationof radial glial progenitors (RGPs). The activity of this receptoris mediated by a G(q)-protein that activates aphosphatidylinositol-calcium second messenger.{ECO:0000250|UniProtKB:Q8C206}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPR157_GON4L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GPR157_GON4L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GPR157 | GON4L | DHX16, PNKD, HIST1H2BA, KRAS, HIST1H2BG, CRAMP1L, H2AFX, ASB3, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPR157_GON4L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GPR157_GON4L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GON4L | C3714756 | Intellectual Disability | 1 | CTD_human |