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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15266

FusionGeneSummary for GPR157_GON4L

check button Fusion gene summary
Fusion gene informationFusion gene name: GPR157_GON4L
Fusion gene ID: 15266
HgeneTgene
Gene symbol

GPR157

GON4L

Gene ID

80045

54856

Gene nameG protein-coupled receptor 157gon-4 like
Synonyms-GON-4|GON4|YARP
Cytomap

1p36.22

1q22

Type of geneprotein-codingprotein-coding
DescriptionG-protein coupled receptor 157probable G-protein coupled receptor 157GON-4-like protein2610100B20RikYY1AP related proteinYY1AP-related protein1gon-4 homolog
Modification date2018032920180523
UniProtAcc

Q5UAW9

Q3T8J9

Ensembl transtripts involved in fusion geneENST00000377411, ENST00000414642, 
ENST00000437809, ENST00000368331, 
ENST00000271883, ENST00000361040, 
ENST00000471341, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 6 X 6=252
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPR157 [Title/Abstract] AND GON4L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A229-01AGPR157chr1

9188704

-GON4Lchr1

155755165

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000377411ENST00000437809GPR157chr1

9188704

-GON4Lchr1

155755165

-
Frame-shitENST00000377411ENST00000368331GPR157chr1

9188704

-GON4Lchr1

155755165

-
Frame-shitENST00000377411ENST00000271883GPR157chr1

9188704

-GON4Lchr1

155755165

-
Frame-shitENST00000377411ENST00000361040GPR157chr1

9188704

-GON4Lchr1

155755165

-
5CDS-5UTRENST00000377411ENST00000471341GPR157chr1

9188704

-GON4Lchr1

155755165

-
Frame-shitENST00000414642ENST00000437809GPR157chr1

9188704

-GON4Lchr1

155755165

-
Frame-shitENST00000414642ENST00000368331GPR157chr1

9188704

-GON4Lchr1

155755165

-
Frame-shitENST00000414642ENST00000271883GPR157chr1

9188704

-GON4Lchr1

155755165

-
Frame-shitENST00000414642ENST00000361040GPR157chr1

9188704

-GON4Lchr1

155755165

-
5CDS-5UTRENST00000414642ENST00000471341GPR157chr1

9188704

-GON4Lchr1

155755165

-

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FusionProtFeatures for GPR157_GON4L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPR157

Q5UAW9

GON4L

Q3T8J9

Orphan receptor that promotes neuronal differentiationof radial glial progenitors (RGPs). The activity of this receptoris mediated by a G(q)-protein that activates aphosphatidylinositol-calcium second messenger.{ECO:0000250|UniProtKB:Q8C206}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPR157_GON4L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPR157_GON4L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GPR157GON4LDHX16, PNKD, HIST1H2BA, KRAS, HIST1H2BG, CRAMP1L, H2AFX, ASB3, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPR157_GON4L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GPR157_GON4L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGON4LC3714756Intellectual Disability1CTD_human