FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 15257

FusionGeneSummary for GPR137_GPR137

check button Fusion gene summary
Fusion gene informationFusion gene name: GPR137_GPR137
Fusion gene ID: 15257
HgeneTgene
Gene symbol

GPR137

GPR137

Gene ID

56834

56834

Gene nameG protein-coupled receptor 137G protein-coupled receptor 137
SynonymsC11orf4|GPR137A|TM7SF1L1C11orf4|GPR137A|TM7SF1L1
Cytomap

11q13.1

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionintegral membrane protein GPR137transmembrane 7 superfamily member 1-like 1 proteinintegral membrane protein GPR137transmembrane 7 superfamily member 1-like 1 protein
Modification date2018051920180519
UniProtAcc

Q96N19

Q96N19

Ensembl transtripts involved in fusion geneENST00000411458, ENST00000539851, 
ENST00000377702, ENST00000438980, 
ENST00000313074, 		ENST00000411458, 
ENST00000539851, ENST00000377702, 
ENST00000438980, ENST00000313074, 
Fusion gene scores* DoF score2 X 3 X 2=124 X 3 X 4=48
# samples 24
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPR137 [Title/Abstract] AND GPR137 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA440013GPR137chr11

64053557

+GPR137chr11

64053507

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000411458ENST00000411458GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000411458ENST00000539851GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000411458ENST00000377702GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000411458ENST00000438980GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000411458ENST00000313074GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000539851ENST00000411458GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000539851ENST00000539851GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000539851ENST00000377702GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000539851ENST00000438980GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000539851ENST00000313074GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000377702ENST00000411458GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000377702ENST00000539851GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000377702ENST00000377702GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000377702ENST00000438980GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000377702ENST00000313074GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000438980ENST00000411458GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000438980ENST00000539851GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000438980ENST00000377702GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000438980ENST00000438980GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000438980ENST00000313074GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000313074ENST00000411458GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000313074ENST00000539851GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000313074ENST00000377702GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000313074ENST00000438980GPR137chr11

64053557

+GPR137chr11

64053507

-
intron-intronENST00000313074ENST00000313074GPR137chr11

64053557

+GPR137chr11

64053507

-

Top

FusionProtFeatures for GPR137_GPR137


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPR137

Q96N19

GPR137

Q96N19


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for GPR137_GPR137


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for GPR137_GPR137


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for GPR137_GPR137


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for GPR137_GPR137


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource