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Fusion gene ID: 1523 |
FusionGeneSummary for ALG11_ZFYVE28 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ALG11_ZFYVE28 | Fusion gene ID: 1523 | Hgene | Tgene | Gene symbol | ALG11 | ZFYVE28 | Gene ID | 440138 | 57732 |
| Gene name | ALG11, alpha-1,2-mannosyltransferase | zinc finger FYVE-type containing 28 | |
| Synonyms | CDG1P|GT8 | LST2|LYST2 | |
| Cytomap | 13q14.3 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferaseGDP-Man:Man(3)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferaseasparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homologasparagine-linked glycosylation protein 11 homologgly | lateral signaling target protein 2 homologhLst2zinc finger FYVE domain-containing protein 28zinc finger, FYVE domain containing 28 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q2TAA5 | Q9HCC9 | |
| Ensembl transtripts involved in fusion gene | ENST00000523764, ENST00000521508, ENST00000519151, | ENST00000290974, ENST00000511071, ENST00000515312, ENST00000515169, ENST00000509171, ENST00000503000, ENST00000508471, ENST00000505421, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 8 X 6 X 7=336 |
| # samples | 3 | 8 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ALG11 [Title/Abstract] AND ZFYVE28 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-55-8513-01A | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000523764 | ENST00000290974 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| In-frame | ENST00000523764 | ENST00000511071 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| In-frame | ENST00000523764 | ENST00000515312 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| 5CDS-intron | ENST00000523764 | ENST00000515169 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| 5CDS-intron | ENST00000523764 | ENST00000509171 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| 5CDS-intron | ENST00000523764 | ENST00000503000 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| 5CDS-5UTR | ENST00000523764 | ENST00000508471 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| 5CDS-intron | ENST00000523764 | ENST00000505421 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| In-frame | ENST00000521508 | ENST00000290974 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| In-frame | ENST00000521508 | ENST00000511071 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| In-frame | ENST00000521508 | ENST00000515312 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| 5CDS-intron | ENST00000521508 | ENST00000515169 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| 5CDS-intron | ENST00000521508 | ENST00000509171 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| 5CDS-intron | ENST00000521508 | ENST00000503000 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| 5CDS-5UTR | ENST00000521508 | ENST00000508471 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| 5CDS-intron | ENST00000521508 | ENST00000505421 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| intron-3CDS | ENST00000519151 | ENST00000290974 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| intron-3CDS | ENST00000519151 | ENST00000511071 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| intron-3CDS | ENST00000519151 | ENST00000515312 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| intron-intron | ENST00000519151 | ENST00000515169 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| intron-intron | ENST00000519151 | ENST00000509171 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| intron-intron | ENST00000519151 | ENST00000503000 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| intron-5UTR | ENST00000519151 | ENST00000508471 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
| intron-intron | ENST00000519151 | ENST00000505421 | ALG11 | chr13 | 52586598 | + | ZFYVE28 | chr4 | 2275943 | - |
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FusionProtFeatures for ALG11_ZFYVE28 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ALG11 | ZFYVE28 |
| Mannosyltransferase involved in the last steps of thesynthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on thecytoplasmic face of the endoplasmic reticulum. Catalyzes theaddition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain. {ECO:0000269|PubMed:20080937}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ZFYVE28 | chr13:52586598 | chr4:2275943 | ENST00000290974 | - | 7 | 13 | 817_879 | 683 | 888 | Zinc finger | FYVE-type |
| Tgene | >ZFYVE28 | chr13:52586598 | chr4:2275943 | ENST00000503000 | - | 0 | 7 | 817_879 | -96 | 288 | Zinc finger | FYVE-type |
| Tgene | >ZFYVE28 | chr13:52586598 | chr4:2275943 | ENST00000509171 | - | 0 | 5 | 817_879 | -110 | 173 | Zinc finger | FYVE-type |
| Tgene | >ZFYVE28 | chr13:52586598 | chr4:2275943 | ENST00000511071 | - | 6 | 12 | 817_879 | 653 | 858 | Zinc finger | FYVE-type |
| Tgene | >ZFYVE28 | chr13:52586598 | chr4:2275943 | ENST00000515169 | - | 0 | 7 | 817_879 | -164 | 164 | Zinc finger | FYVE-type |
| Tgene | >ZFYVE28 | chr13:52586598 | chr4:2275943 | ENST00000515312 | - | 7 | 13 | 817_879 | 613 | 818 | Zinc finger | FYVE-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ALG11 | chr13:52586598 | chr4:2275943 | ENST00000521508 | + | 1 | 4 | 20_40 | 14 | 493 | Transmembrane | Helical |
| Hgene | >ALG11 | chr13:52586598 | chr4:2275943 | ENST00000521508 | + | 1 | 4 | 234_254 | 14 | 493 | Transmembrane | Helical |
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FusionGeneSequence for ALG11_ZFYVE28 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ALG11_ENST00000523764_chr13_52586598_+_ZFYVE28_ENST00000290974_chr4_2275943_-_219aa MAAGERSWCLCKLLSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEV MATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSR >In-frame_ALG11_ENST00000523764_chr13_52586598_+_ZFYVE28_ENST00000511071_chr4_2275943_-_219aa MAAGERSWCLCKLLSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEV MATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSR >In-frame_ALG11_ENST00000523764_chr13_52586598_+_ZFYVE28_ENST00000515312_chr4_2275943_-_219aa MAAGERSWCLCKLLSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEV MATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSR >In-frame_ALG11_ENST00000521508_chr13_52586598_+_ZFYVE28_ENST00000290974_chr4_2275943_-_219aa MAAGERSWCLCKLLSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEV MATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSR >In-frame_ALG11_ENST00000521508_chr13_52586598_+_ZFYVE28_ENST00000511071_chr4_2275943_-_219aa MAAGERSWCLCKLLSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEV MATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSR >In-frame_ALG11_ENST00000521508_chr13_52586598_+_ZFYVE28_ENST00000515312_chr4_2275943_-_219aa MAAGERSWCLCKLLSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEV MATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ALG11_ENST00000523764_chr13_52586598_+_ZFYVE28_ENST00000290974_chr4_2275943_-_657nt ATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCCTCAGACAAGATGGGGCCAGAG GCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGCAGCCACGACCTCATCCACCGC CTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATTCTTAAAACACTGTTTGAGGTC ATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCGGCCTTGGAGGACTGTGCACTG TGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCGGAGTGGGTGCCAGACGAGGCC TGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGTGGGAAGATCTTCTGCTCGCGC TGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGCTACATGTTCCATGTCACGCCC >In-frame_ALG11_ENST00000523764_chr13_52586598_+_ZFYVE28_ENST00000511071_chr4_2275943_-_657nt ATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCCTCAGACAAGATGGGGCCAGAG GCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGCAGCCACGACCTCATCCACCGC CTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATTCTTAAAACACTGTTTGAGGTC ATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCGGCCTTGGAGGACTGTGCACTG TGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCGGAGTGGGTGCCAGACGAGGCC TGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGTGGGAAGATCTTCTGCTCGCGC TGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGCTACATGTTCCATGTCACGCCC >In-frame_ALG11_ENST00000523764_chr13_52586598_+_ZFYVE28_ENST00000515312_chr4_2275943_-_657nt ATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCCTCAGACAAGATGGGGCCAGAG GCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGCAGCCACGACCTCATCCACCGC CTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATTCTTAAAACACTGTTTGAGGTC ATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCGGCCTTGGAGGACTGTGCACTG TGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCGGAGTGGGTGCCAGACGAGGCC TGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGTGGGAAGATCTTCTGCTCGCGC TGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGCTACATGTTCCATGTCACGCCC >In-frame_ALG11_ENST00000521508_chr13_52586598_+_ZFYVE28_ENST00000290974_chr4_2275943_-_657nt ATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCCTCAGACAAGATGGGGCCAGAG GCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGCAGCCACGACCTCATCCACCGC CTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATTCTTAAAACACTGTTTGAGGTC ATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCGGCCTTGGAGGACTGTGCACTG TGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCGGAGTGGGTGCCAGACGAGGCC TGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGTGGGAAGATCTTCTGCTCGCGC TGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGCTACATGTTCCATGTCACGCCC >In-frame_ALG11_ENST00000521508_chr13_52586598_+_ZFYVE28_ENST00000511071_chr4_2275943_-_657nt ATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCCTCAGACAAGATGGGGCCAGAG GCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGCAGCCACGACCTCATCCACCGC CTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATTCTTAAAACACTGTTTGAGGTC ATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCGGCCTTGGAGGACTGTGCACTG TGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCGGAGTGGGTGCCAGACGAGGCC TGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGTGGGAAGATCTTCTGCTCGCGC TGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGCTACATGTTCCATGTCACGCCC >In-frame_ALG11_ENST00000521508_chr13_52586598_+_ZFYVE28_ENST00000515312_chr4_2275943_-_657nt ATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCCTCAGACAAGATGGGGCCAGAG GCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGCAGCCACGACCTCATCCACCGC CTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATTCTTAAAACACTGTTTGAGGTC ATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCGGCCTTGGAGGACTGTGCACTG TGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCGGAGTGGGTGCCAGACGAGGCC TGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGTGGGAAGATCTTCTGCTCGCGC TGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGCTACATGTTCCATGTCACGCCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ALG11_ENST00000523764_chr13_52586598_+_ZFYVE28_ENST00000290974_chr4_2275943_-_1805nt GAGTTCGGGGGTCGGCGGAAGATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCC TCAGACAAGATGGGGCCAGAGGCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGC AGCCACGACCTCATCCACCGCCTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATT CTTAAAACACTGTTTGAGGTCATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCG GCCTTGGAGGACTGTGCACTGTGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCG GAGTGGGTGCCAGACGAGGCCTGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGT GGGAAGATCTTCTGCTCGCGCTGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGC TACATGTTCCATGTCACGCCCTTCTACAGCGACAAGGCCGGCCTGTGACGTGGTGCCAGGGGCAGCCCCAACCCACCCGGGCCAGGAACC CCCAGGAAGGTGGGGCCACGCTGCAGGCAGGTCTCACTGCGTCTCATGAGGCCGCTGCCGCTGCTGCAGGGGCACCCAGACCTCCAGAGC ATCCAGAGCCTCTGTCCTGCCCACGCTAGCCTCCCTGCAGGGACCCCGGGCCGGCTGCAGGGGCCAACAAGAGGTCAGCTTTGCCCAGCA GGGGACCCGGAGGAGCCTGGTGGCTGCCTCAGGGCAGGGTGCCTGGCGGAGAAGGCCTGGGCCCTCCCACTGGTCCCTCGGAGATCTGCT GGGGCTATGGGAATCGGGGCGGGTGATGGAGGTGGACAAGAGTGGGGCCACTCTGCGCCTCTGCTGTTGCGGTGAATCTGGAAGCCGGAG CAAGGGCCACTCCACAGGCTCTTTGGCACAGCAGGGCTCCCTATGTGCCTCCCAAACGTCAAATGCAGGCTACCCATTCTCCCCATCAGC TGCCCACCTCGTTCCCCAGCCCTCACCCCTCACCCCTCACCATCCTTCCTCAGGACTTGGCTAAACAACATGCATCTCATTTCTTCTTGG AGTGGGGAGATGCGGGAAGCTGACCCAGTGGTCCTCTAGGCAGGCAGGGTGCTCCTGGTGTCTGCCCACCACTGTCCCCTTGCTGATGGC ATGGGGGTCCGACCAGGCACTGACACCGCAGGCAGAGGTTGCTCGGGGCCTTGGGTCGGGTTTACCAATCAGCCAGGACGCCCGGGGCCA CCAGCTCAGCTACCACTTCCCCTTCCCTCTGCACCCTCTGGAACCCTGGCCCAATTCCTCAGACCCCAGAGTGGCCTGGGACCCAAGCTG CCGCAGCTGAGTGGCCCCAGCGGACACCTCCTCAGGCTTAAATCTCAGGCTTCACATTGCAATGACGATTGCAGTTTTATTTTTGGAGAT GACACACCTACTGCTTCTTTTCTAGGATAAATCTAATTACTGTTTACTGGTGGAGTACATATGCATAGAAACGGCTTCTGTCGGGGGGAG AGTATATAATGGAGGAAATATTATGTATTGAGATTATATTTATTTTCTAAATGCTGTAATTTGAAGCCATTTCCATAAATCTATTTAAGG >In-frame_ALG11_ENST00000523764_chr13_52586598_+_ZFYVE28_ENST00000511071_chr4_2275943_-_1064nt GAGTTCGGGGGTCGGCGGAAGATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCC TCAGACAAGATGGGGCCAGAGGCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGC AGCCACGACCTCATCCACCGCCTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATT CTTAAAACACTGTTTGAGGTCATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCG GCCTTGGAGGACTGTGCACTGTGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCG GAGTGGGTGCCAGACGAGGCCTGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGT GGGAAGATCTTCTGCTCGCGCTGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGC TACATGTTCCATGTCACGCCCTTCTACAGCGACAAGGCCGGCCTGTGACGTGGTGCCAGGGGCAGCCCCAACCCACCCGGGCCAGGAACC CCCAGGAAGGTGGGGCCACGCTGCAGGCAGGTCTCACTGCGTCTCATGAGGCCGCTGCCGCTGCTGCAGGGGCACCCAGACCTCCAGAGC ATCCAGAGCCTCTGTCCTGCCCACGCTAGCCTCCCTGCAGGGACCCCGGGCCGGCTGCAGGGGCCAACAAGAGGTCAGCTTTGCCCAGCA GGGGACCCGGAGGAGCCTGGTGGCTGCCTCAGGGCAGGGTGCCTGGCGGAGAAGGCCTGGGCCCTCCCACTGGTCCCTCGGAGATCTGCT >In-frame_ALG11_ENST00000523764_chr13_52586598_+_ZFYVE28_ENST00000515312_chr4_2275943_-_908nt GAGTTCGGGGGTCGGCGGAAGATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCC TCAGACAAGATGGGGCCAGAGGCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGC AGCCACGACCTCATCCACCGCCTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATT CTTAAAACACTGTTTGAGGTCATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCG GCCTTGGAGGACTGTGCACTGTGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCG GAGTGGGTGCCAGACGAGGCCTGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGT GGGAAGATCTTCTGCTCGCGCTGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGC TACATGTTCCATGTCACGCCCTTCTACAGCGACAAGGCCGGCCTGTGACGTGGTGCCAGGGGCAGCCCCAACCCACCCGGGCCAGGAACC CCCAGGAAGGTGGGGCCACGCTGCAGGCAGGTCTCACTGCGTCTCATGAGGCCGCTGCCGCTGCTGCAGGGGCACCCAGACCTCCAGAGC ATCCAGAGCCTCTGTCCTGCCCACGCTAGCCTCCCTGCAGGGACCCCGGGCCGGCTGCAGGGGCCAACAAGAGGTCAGCTTTGCCCAGCA >In-frame_ALG11_ENST00000521508_chr13_52586598_+_ZFYVE28_ENST00000290974_chr4_2275943_-_1789nt GGAAGATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCCTCAGACAAGATGGGGC CAGAGGCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGCAGCCACGACCTCATCC ACCGCCTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATTCTTAAAACACTGTTTG AGGTCATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCGGCCTTGGAGGACTGTG CACTGTGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCGGAGTGGGTGCCAGACG AGGCCTGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGTGGGAAGATCTTCTGCT CGCGCTGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGCTACATGTTCCATGTCA CGCCCTTCTACAGCGACAAGGCCGGCCTGTGACGTGGTGCCAGGGGCAGCCCCAACCCACCCGGGCCAGGAACCCCCAGGAAGGTGGGGC CACGCTGCAGGCAGGTCTCACTGCGTCTCATGAGGCCGCTGCCGCTGCTGCAGGGGCACCCAGACCTCCAGAGCATCCAGAGCCTCTGTC CTGCCCACGCTAGCCTCCCTGCAGGGACCCCGGGCCGGCTGCAGGGGCCAACAAGAGGTCAGCTTTGCCCAGCAGGGGACCCGGAGGAGC CTGGTGGCTGCCTCAGGGCAGGGTGCCTGGCGGAGAAGGCCTGGGCCCTCCCACTGGTCCCTCGGAGATCTGCTGGGGCTATGGGAATCG GGGCGGGTGATGGAGGTGGACAAGAGTGGGGCCACTCTGCGCCTCTGCTGTTGCGGTGAATCTGGAAGCCGGAGCAAGGGCCACTCCACA GGCTCTTTGGCACAGCAGGGCTCCCTATGTGCCTCCCAAACGTCAAATGCAGGCTACCCATTCTCCCCATCAGCTGCCCACCTCGTTCCC CAGCCCTCACCCCTCACCCCTCACCATCCTTCCTCAGGACTTGGCTAAACAACATGCATCTCATTTCTTCTTGGAGTGGGGAGATGCGGG AAGCTGACCCAGTGGTCCTCTAGGCAGGCAGGGTGCTCCTGGTGTCTGCCCACCACTGTCCCCTTGCTGATGGCATGGGGGTCCGACCAG GCACTGACACCGCAGGCAGAGGTTGCTCGGGGCCTTGGGTCGGGTTTACCAATCAGCCAGGACGCCCGGGGCCACCAGCTCAGCTACCAC TTCCCCTTCCCTCTGCACCCTCTGGAACCCTGGCCCAATTCCTCAGACCCCAGAGTGGCCTGGGACCCAAGCTGCCGCAGCTGAGTGGCC CCAGCGGACACCTCCTCAGGCTTAAATCTCAGGCTTCACATTGCAATGACGATTGCAGTTTTATTTTTGGAGATGACACACCTACTGCTT CTTTTCTAGGATAAATCTAATTACTGTTTACTGGTGGAGTACATATGCATAGAAACGGCTTCTGTCGGGGGGAGAGTATATAATGGAGGA >In-frame_ALG11_ENST00000521508_chr13_52586598_+_ZFYVE28_ENST00000511071_chr4_2275943_-_1048nt GGAAGATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCCTCAGACAAGATGGGGC CAGAGGCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGCAGCCACGACCTCATCC ACCGCCTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATTCTTAAAACACTGTTTG AGGTCATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCGGCCTTGGAGGACTGTG CACTGTGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCGGAGTGGGTGCCAGACG AGGCCTGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGTGGGAAGATCTTCTGCT CGCGCTGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGCTACATGTTCCATGTCA CGCCCTTCTACAGCGACAAGGCCGGCCTGTGACGTGGTGCCAGGGGCAGCCCCAACCCACCCGGGCCAGGAACCCCCAGGAAGGTGGGGC CACGCTGCAGGCAGGTCTCACTGCGTCTCATGAGGCCGCTGCCGCTGCTGCAGGGGCACCCAGACCTCCAGAGCATCCAGAGCCTCTGTC CTGCCCACGCTAGCCTCCCTGCAGGGACCCCGGGCCGGCTGCAGGGGCCAACAAGAGGTCAGCTTTGCCCAGCAGGGGACCCGGAGGAGC CTGGTGGCTGCCTCAGGGCAGGGTGCCTGGCGGAGAAGGCCTGGGCCCTCCCACTGGTCCCTCGGAGATCTGCTGGGGCTATGGGAATCG >In-frame_ALG11_ENST00000521508_chr13_52586598_+_ZFYVE28_ENST00000515312_chr4_2275943_-_892nt GGAAGATGGCGGCCGGCGAAAGGAGCTGGTGCCTGTGCAAGTTGTTGAGCAGCTCCACAGCTGGGTCCTGCTCCTCAGACAAGATGGGGC CAGAGGCGGCCCCAGCAGCCACGCATGCTGCCCCACAGGCCACAAGAGAGAAGATCCGGTCCAGGTTCCACGGCAGCCACGACCTCATCC ACCGCCTGTTCGTCTGCATTTCAGGTGTGGCTGACCAGCTGCAGACGAACTATGCCAGTGACCTGAGAAGTATTCTTAAAACACTGTTTG AGGTCATGGCCACCAAGCCTGAAACAGACGACAAGGAAAAGTTAAGGAAGGTCACCCAGACTCTGCGGAGTGCGGCCTTGGAGGACTGTG CACTGTGCCAGGAGACCCTGTCATCCTCTGAACTGGCAGCCAAGACCCGCGATGGGGACTTTGAAGACCCCCCGGAGTGGGTGCCAGACG AGGCCTGTGGCTTCTGCACGGCGTGCAAAGCACCCTTCACCGTCATCCGCCGGAAGCACCACTGCCGCAGCTGTGGGAAGATCTTCTGCT CGCGCTGCTCCTCGCACTCAGCACCGCTGCCCCGCTACGGGCAGGTGAAGCCGGTCCGAGTGTGCACCCACTGCTACATGTTCCATGTCA CGCCCTTCTACAGCGACAAGGCCGGCCTGTGACGTGGTGCCAGGGGCAGCCCCAACCCACCCGGGCCAGGAACCCCCAGGAAGGTGGGGC CACGCTGCAGGCAGGTCTCACTGCGTCTCATGAGGCCGCTGCCGCTGCTGCAGGGGCACCCAGACCTCCAGAGCATCCAGAGCCTCTGTC |
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FusionGenePPI for ALG11_ZFYVE28 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ALG11 | TSPAN5, HAUS7, SMPD1, TREML2, FAM63B, RAET1E, TMEM213, PVR | ZFYVE28 | EGF, RAB5A, RAB4A, RAB7A, EGFR, PRNP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ALG11_ZFYVE28 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ALG11_ZFYVE28 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ALG11 | C3150913 | CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Ip | 2 | CTD_human;ORPHANET;UNIPROT |
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