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Fusion gene ID: 15228 |
FusionGeneSummary for GPM6A_SCLT1 |
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Fusion gene information | Fusion gene name: GPM6A_SCLT1 | Fusion gene ID: 15228 | Hgene | Tgene | Gene symbol | GPM6A | SCLT1 | Gene ID | 2823 | 132320 |
Gene name | glycoprotein M6A | sodium channel and clathrin linker 1 | |
Synonyms | GPM6|M6A | CAP-1A|CAP1A | |
Cytomap | 4q34.2 | 4q28.2 | |
Type of gene | protein-coding | protein-coding | |
Description | neuronal membrane glycoprotein M6-a | sodium channel and clathrin linker 1sodium channel-associated protein 1 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P51674 | Q96NL6 | |
Ensembl transtripts involved in fusion gene | ENST00000280187, ENST00000393658, ENST00000506894, ENST00000515090, ENST00000506219, | ENST00000281142, ENST00000434680, ENST00000439369, ENST00000503215, ENST00000502495, ENST00000506368, ENST00000511426, ENST00000503401, | |
Fusion gene scores | * DoF score | 5 X 6 X 1=30 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/30*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: GPM6A [Title/Abstract] AND SCLT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GPM6A | GO:0001764 | neuron migration | 19298174 |
Hgene | GPM6A | GO:0048863 | stem cell differentiation | 19298174 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF956714 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000280187 | ENST00000281142 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000280187 | ENST00000434680 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000280187 | ENST00000439369 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000280187 | ENST00000503215 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-5UTR | ENST00000280187 | ENST00000502495 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000280187 | ENST00000506368 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000280187 | ENST00000511426 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000280187 | ENST00000503401 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-3CDS | ENST00000393658 | ENST00000281142 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000393658 | ENST00000434680 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000393658 | ENST00000439369 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000393658 | ENST00000503215 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-5UTR | ENST00000393658 | ENST00000502495 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000393658 | ENST00000506368 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000393658 | ENST00000511426 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000393658 | ENST00000503401 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-3CDS | ENST00000506894 | ENST00000281142 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000506894 | ENST00000434680 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000506894 | ENST00000439369 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000506894 | ENST00000503215 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-5UTR | ENST00000506894 | ENST00000502495 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000506894 | ENST00000506368 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000506894 | ENST00000511426 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000506894 | ENST00000503401 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-3CDS | ENST00000515090 | ENST00000281142 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000515090 | ENST00000434680 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000515090 | ENST00000439369 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000515090 | ENST00000503215 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-5UTR | ENST00000515090 | ENST00000502495 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000515090 | ENST00000506368 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000515090 | ENST00000511426 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000515090 | ENST00000503401 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-3CDS | ENST00000506219 | ENST00000281142 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000506219 | ENST00000434680 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000506219 | ENST00000439369 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000506219 | ENST00000503215 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-5UTR | ENST00000506219 | ENST00000502495 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000506219 | ENST00000506368 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000506219 | ENST00000511426 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
intron-intron | ENST00000506219 | ENST00000503401 | GPM6A | chr4 | 176561949 | + | SCLT1 | chr4 | 129858004 | - |
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FusionProtFeatures for GPM6A_SCLT1 |
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Hgene | Tgene |
GPM6A | SCLT1 |
Involved in neuronal differentiation, includingdifferentiation and migration of neuronal stem cells. Plays a rolein neuronal plasticity and is involved in neurite and filopodiaoutgrowth, filopodia motility and probably synapse formation.GPM6A-induced filopodia formation involves mitogen-activatedprotein kinase (MAPK) and Src signaling pathways. May be involvedin neuronal NGF-dependent Ca(2+) influx. May be involved inregulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization andrecycling of mu-type opioid receptor.{ECO:0000269|PubMed:19298174}. | Adapter protein that links SCN10A to clathrin. RegulatesSCN10A channel activity, possibly by promoting channelinternalization (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPM6A_SCLT1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GPM6A_SCLT1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPM6A_SCLT1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GPM6A_SCLT1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GPM6A | C0036341 | Schizophrenia | 1 | PSYGENET |