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Fusion gene ID: 15223 |
FusionGeneSummary for GPLD1_TDP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPLD1_TDP2 | Fusion gene ID: 15223 | Hgene | Tgene | Gene symbol | GPLD1 | TDP2 | Gene ID | 2822 | 51567 |
| Gene name | glycosylphosphatidylinositol specific phospholipase D1 | tyrosyl-DNA phosphodiesterase 2 | |
| Synonyms | GPIPLD|GPIPLDM|PIGPLD|PIGPLD1|PLD | AD022|EAP2|EAPII|TTRAP|dJ30M3.3|hTDP2 | |
| Cytomap | 6p22.3 | 6p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phosphatidylinositol-glycan-specific phospholipase DGPI-PLDGPI-specific phospholipase DPI-G PLDglycoprotein phospholipase D | tyrosyl-DNA phosphodiesterase 25'-Tyr-DNA phosphodiesterase5'-tyrosyl-DNA phosphodiesteraseETS1-associated protein 2ETS1-associated protein IITRAF and TNF receptor-associated proteinVPg unlinkasetyr-DNA phosphodiesterase 2tyrosyl-RNA phosphodieste | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P80108 | O95551 | |
| Ensembl transtripts involved in fusion gene | ENST00000230036, ENST00000474784, | ENST00000378198, ENST00000545995, ENST00000341060, ENST00000478285, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: GPLD1 [Title/Abstract] AND TDP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GPLD1 | GO:0002430 | complement receptor mediated signaling pathway | 15907827|19135435 |
| Hgene | GPLD1 | GO:0006507 | GPI anchor release | 2760042|15907827|19135435 |
| Hgene | GPLD1 | GO:0008285 | negative regulation of cell proliferation | 19135435 |
| Hgene | GPLD1 | GO:0008286 | insulin receptor signaling pathway | 18328347 |
| Hgene | GPLD1 | GO:0009749 | response to glucose | 15907827 |
| Hgene | GPLD1 | GO:0032869 | cellular response to insulin stimulus | 15907827 |
| Hgene | GPLD1 | GO:0035690 | cellular response to drug | 17761367 |
| Hgene | GPLD1 | GO:0043065 | positive regulation of apoptotic process | 19135435 |
| Hgene | GPLD1 | GO:0045919 | positive regulation of cytolysis | 15907827|19135435 |
| Hgene | GPLD1 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis | 17720976 |
| Hgene | GPLD1 | GO:0071277 | cellular response to calcium ion | 2760042 |
| Hgene | GPLD1 | GO:0071467 | cellular response to pH | 17761367 |
| Hgene | GPLD1 | GO:1900076 | regulation of cellular response to insulin stimulus | 18328347 |
| Tgene | TDP2 | GO:0006302 | double-strand break repair | 19794497 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-76-4929-01A | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000230036 | ENST00000378198 | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
| Frame-shift | ENST00000230036 | ENST00000545995 | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
| In-frame | ENST00000230036 | ENST00000341060 | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
| 5CDS-intron | ENST00000230036 | ENST00000478285 | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
| intron-3CDS | ENST00000474784 | ENST00000378198 | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
| intron-3CDS | ENST00000474784 | ENST00000545995 | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
| intron-3CDS | ENST00000474784 | ENST00000341060 | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
| intron-intron | ENST00000474784 | ENST00000478285 | GPLD1 | chr6 | 24433415 | - | TDP2 | chr6 | 24651297 | - |
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FusionProtFeatures for GPLD1_TDP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPLD1 | TDP2 |
| DNA repair enzyme that can remove a variety of covalentadducts from DNA through hydrolysis of a 5'-phosphodiester bond,giving rise to DNA with a free 5' phosphate. Catalyzes thehydrolysis of dead-end complexes between DNA and the topoisomerase2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNAphosphodiesterase activity can enable the repair of TOP2-inducedDNA double-strand breaks/DSBs without the need for nucleaseactivity, creating a 'clean' DSB with 5'-phosphate termini thatare ready for ligation. Thereby, protects the transcription ofmany genes involved in neurological development and maintenancefrom the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damageby radiation and free radicals. Has preference for single-strandedDNA or duplex DNA with a 4 base pair overhang as substrate. Actsas a regulator of ribosome biogenesis following stress. Has also3'-tyrosyl DNA phosphodiesterase activity, but less efficientlyand much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter byparticipating in the specific activation of MAP3K7/TAK1 inresponse to TGF-beta: associates with components of the TGF-betareceptor-TRAF6-TAK1 signaling module and promotes theirubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as anegative regulator of ETS1 and may inhibit NF-kappa-B activation.{ECO:0000269|PubMed:19794497, ECO:0000269|PubMed:21030584,ECO:0000269|PubMed:21921940, ECO:0000269|PubMed:21980489,ECO:0000269|PubMed:22405347, ECO:0000269|PubMed:22822062,ECO:0000269|PubMed:24658003}. (Microbial infection) Also acts as a 5'-tyrosyl-RNAphosphodiesterase following picornavirus infection: its activityis hijacked by picornavirus and acts by specifically cleaving theprotein-RNA covalent linkage generated during the viral genomicRNA replication steps of a picornavirus infection, withoutimpairing the integrity of viral RNA.{ECO:0000269|PubMed:22908287}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPLD1_TDP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GPLD1_ENST00000230036_chr6_24433415_-_TDP2_ENST00000341060_chr6_24651297_-_906aa MSAFRLWPGLLIMLGSLCHRGSPCGLSTHVEIGHRALEFLQLHNGRVNYRELLLEHQDAYQAGIVFPDCFYPSICKGGKFHDVSESTHWT PFLNASVHYIRENYPLPWEKDTEKLVAFLFGITSHMAADVSWHSLGLEQGFLRTMGAIDFHGSYSEAHSAGDFGGDVLSQFEFNFNYLAR RWYVPVKDLLGIYEKLYGRKVITENVIVDCSHIQFLEMYGEMLAVSKLYPTYSTKSPFLVEQFQEYFLGGLDDMAFWSTNIYHLTSFMLE NGTSDCNLPENPLFIACGGQQNHTQGSKMQKNDFHRNLTTSLTESVDRNINYTERGVFFSVNSWTPDSMSFIYKALERNIRTMFIGGSQL SQKHVSSPLASYFLSFPYARLGWAMTSADLNQDGHGDLVVGAPGYSRPGHIHIGRVYLIYGNDLGLPPVDLDLDKEAHRILEGFQPSGRF GSALAVLDFNVDGVPDLAVGAPSVGSEQLTYKGAVYVYFGSKQGGMSSSPNITISCQDIYCNLGWTLLAADVNGDSEPDLVIGSPFAPGG GKQKGIVAAFYSGPSLSDKEKLNVEAANWTVRGEEDFSWFGYSLHGVTVDNRTLLLVGSPTWKNASRLGHLLHIRDEKKSLGRVYGYFPP NGQSWFTISGDKAMGKLGTSLSSGHVLMNGTLKQVLLVGAPTYDDVSKVAFLTVTLHQGGATRMYALTSDAQPLLLSTFSGDRRFSRFGG VLHLSDLDDDGLDEIIMAAPLRIADVTSGLIGGEDGRVYVYNGKETTLGDMTGKCKSWITPCPEEKAQYVLISPEASSRFGSSLITVRSK AKVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQMNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GPLD1_ENST00000230036_chr6_24433415_-_TDP2_ENST00000341060_chr6_24651297_-_2718nt ATGTCTGCTTTCAGGTTGTGGCCTGGCCTGCTGATCATGTTGGGTTCTCTCTGCCATAGAGGTTCACCGTGTGGCCTTTCAACACACGTA GAAATAGGACACAGAGCTCTGGAGTTTCTTCAGCTTCACAATGGGCGTGTTAACTACAGAGAGCTGTTACTAGAACACCAGGATGCGTAT CAGGCTGGAATCGTGTTTCCTGATTGTTTTTACCCTAGCATCTGCAAAGGAGGAAAATTCCATGATGTGTCTGAGAGCACTCACTGGACT CCGTTTCTTAATGCAAGCGTTCATTATATCCGAGAGAACTATCCCCTTCCCTGGGAGAAGGACACAGAGAAACTGGTAGCTTTCTTGTTT GGAATTACTTCTCACATGGCGGCAGATGTCAGCTGGCATAGTCTGGGCCTTGAACAAGGATTCCTTAGGACCATGGGAGCTATTGATTTT CACGGCTCCTATTCAGAGGCTCATTCGGCTGGTGATTTTGGAGGAGATGTGTTGAGCCAGTTTGAATTTAATTTTAATTACCTTGCACGA CGCTGGTATGTGCCAGTCAAAGATCTACTGGGAATTTATGAGAAACTGTATGGTCGAAAAGTCATCACCGAAAATGTAATCGTTGATTGT TCACATATCCAGTTCTTAGAAATGTATGGTGAGATGCTAGCTGTTTCCAAGTTATATCCCACTTACTCTACAAAGTCCCCGTTTTTGGTG GAACAATTCCAAGAGTATTTTCTTGGAGGACTGGATGATATGGCATTTTGGTCCACTAATATTTACCATCTAACAAGCTTCATGTTGGAG AATGGGACCAGTGACTGCAACCTGCCTGAGAACCCTCTGTTCATTGCATGTGGCGGCCAGCAAAACCACACCCAGGGCTCAAAAATGCAG AAAAATGATTTTCACAGAAATTTGACTACATCCCTAACTGAAAGTGTTGACAGGAATATAAACTATACTGAAAGAGGAGTGTTCTTTAGT GTAAATTCCTGGACCCCGGATTCCATGTCCTTTATCTACAAGGCTTTGGAAAGGAACATAAGGACAATGTTCATAGGTGGCTCTCAGTTG TCACAAAAGCACGTCTCCAGCCCCTTAGCATCTTACTTCTTGTCATTTCCTTATGCGAGGCTTGGCTGGGCAATGACCTCAGCTGACCTC AACCAGGATGGGCACGGTGACCTCGTGGTGGGCGCACCAGGCTACAGCCGCCCCGGCCACATCCACATCGGGCGCGTGTACCTCATCTAC GGCAATGACCTGGGCCTGCCACCTGTTGACCTGGACCTGGACAAGGAGGCCCACAGGATCCTTGAAGGCTTCCAGCCCTCAGGTCGGTTT GGCTCGGCCTTGGCTGTGTTGGACTTTAACGTGGACGGCGTGCCTGACCTGGCCGTGGGAGCTCCCTCGGTGGGCTCCGAGCAGCTCACC TACAAAGGTGCCGTGTATGTCTACTTTGGTTCCAAACAAGGAGGAATGTCTTCTTCCCCTAACATCACCATTTCTTGCCAGGACATCTAC TGTAACTTGGGCTGGACTCTCTTGGCTGCAGATGTGAATGGAGACAGTGAACCCGATCTGGTCATCGGCTCCCCTTTTGCACCAGGTGGA GGGAAGCAGAAGGGAATTGTGGCTGCGTTTTATTCTGGCCCCAGCCTGAGCGACAAAGAAAAACTGAACGTGGAGGCAGCCAACTGGACG GTGAGAGGCGAGGAAGACTTCTCCTGGTTTGGATATTCCCTTCACGGTGTCACTGTGGACAACAGAACCTTGCTGTTGGTTGGGAGCCCG ACCTGGAAGAATGCCAGCAGGCTGGGCCATTTGTTACACATCCGAGATGAGAAAAAGAGCCTTGGGAGGGTGTATGGCTACTTCCCACCA AACGGCCAAAGCTGGTTTACCATTTCTGGAGACAAGGCAATGGGGAAACTGGGTACTTCCCTTTCCAGTGGCCACGTACTGATGAATGGG ACTCTGAAACAAGTGCTGCTGGTTGGAGCCCCTACGTACGATGACGTGTCTAAGGTGGCATTCCTGACCGTGACCCTACACCAAGGCGGA GCCACTCGCATGTACGCACTCACATCTGACGCGCAGCCTCTGCTGCTCAGCACCTTCAGCGGAGACCGCCGCTTCTCCCGATTTGGTGGC GTTCTGCACTTGAGTGACCTGGATGATGATGGCTTAGATGAAATCATCATGGCAGCCCCCCTGAGGATAGCAGATGTAACCTCTGGACTG ATTGGGGGAGAAGACGGCCGAGTATATGTATATAATGGCAAAGAGACCACCCTTGGTGACATGACTGGCAAATGCAAATCATGGATAACT CCATGTCCAGAAGAAAAGGCCCAATATGTATTGATTTCTCCTGAAGCCAGCTCAAGGTTTGGGAGCTCCCTCATCACCGTGAGGTCCAAG GCAAAGGTTACCAGATGTGGTGGTTTACCCAACAACATTGTGGATGTCTGGGAGTTTTTGGGCAAACCTAAACATTGCCAGTATACATGG GATACACAAATGAACTCTAATCTTGGAATAACTGCTGCTTGTAAACTTCGTTTTGATCGAATATTTTTCAGAGCAGCAGCAGAAGAGGGA CACATTATTCCCCGAAGTTTGGACCTTCTTGGATTAGAAAAACTGGACTGTGGTAGATTTCCTAGTGATCACTGGGGTCTTCTGTGCAAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GPLD1_ENST00000230036_chr6_24433415_-_TDP2_ENST00000341060_chr6_24651297_-_3638nt GTGACCTGCTTAGAGAGAAGCGGTGGGTCTGCACCTGGATTTTGGAGTCCCAGTGCTGCTGCAGCTCTGAGCATTCCCACGTCACCAGAG AAGCCGGTGGGCAATGAGATCATGTCTGCTTTCAGGTTGTGGCCTGGCCTGCTGATCATGTTGGGTTCTCTCTGCCATAGAGGTTCACCG TGTGGCCTTTCAACACACGTAGAAATAGGACACAGAGCTCTGGAGTTTCTTCAGCTTCACAATGGGCGTGTTAACTACAGAGAGCTGTTA CTAGAACACCAGGATGCGTATCAGGCTGGAATCGTGTTTCCTGATTGTTTTTACCCTAGCATCTGCAAAGGAGGAAAATTCCATGATGTG TCTGAGAGCACTCACTGGACTCCGTTTCTTAATGCAAGCGTTCATTATATCCGAGAGAACTATCCCCTTCCCTGGGAGAAGGACACAGAG AAACTGGTAGCTTTCTTGTTTGGAATTACTTCTCACATGGCGGCAGATGTCAGCTGGCATAGTCTGGGCCTTGAACAAGGATTCCTTAGG ACCATGGGAGCTATTGATTTTCACGGCTCCTATTCAGAGGCTCATTCGGCTGGTGATTTTGGAGGAGATGTGTTGAGCCAGTTTGAATTT AATTTTAATTACCTTGCACGACGCTGGTATGTGCCAGTCAAAGATCTACTGGGAATTTATGAGAAACTGTATGGTCGAAAAGTCATCACC GAAAATGTAATCGTTGATTGTTCACATATCCAGTTCTTAGAAATGTATGGTGAGATGCTAGCTGTTTCCAAGTTATATCCCACTTACTCT ACAAAGTCCCCGTTTTTGGTGGAACAATTCCAAGAGTATTTTCTTGGAGGACTGGATGATATGGCATTTTGGTCCACTAATATTTACCAT CTAACAAGCTTCATGTTGGAGAATGGGACCAGTGACTGCAACCTGCCTGAGAACCCTCTGTTCATTGCATGTGGCGGCCAGCAAAACCAC ACCCAGGGCTCAAAAATGCAGAAAAATGATTTTCACAGAAATTTGACTACATCCCTAACTGAAAGTGTTGACAGGAATATAAACTATACT GAAAGAGGAGTGTTCTTTAGTGTAAATTCCTGGACCCCGGATTCCATGTCCTTTATCTACAAGGCTTTGGAAAGGAACATAAGGACAATG TTCATAGGTGGCTCTCAGTTGTCACAAAAGCACGTCTCCAGCCCCTTAGCATCTTACTTCTTGTCATTTCCTTATGCGAGGCTTGGCTGG GCAATGACCTCAGCTGACCTCAACCAGGATGGGCACGGTGACCTCGTGGTGGGCGCACCAGGCTACAGCCGCCCCGGCCACATCCACATC GGGCGCGTGTACCTCATCTACGGCAATGACCTGGGCCTGCCACCTGTTGACCTGGACCTGGACAAGGAGGCCCACAGGATCCTTGAAGGC TTCCAGCCCTCAGGTCGGTTTGGCTCGGCCTTGGCTGTGTTGGACTTTAACGTGGACGGCGTGCCTGACCTGGCCGTGGGAGCTCCCTCG GTGGGCTCCGAGCAGCTCACCTACAAAGGTGCCGTGTATGTCTACTTTGGTTCCAAACAAGGAGGAATGTCTTCTTCCCCTAACATCACC ATTTCTTGCCAGGACATCTACTGTAACTTGGGCTGGACTCTCTTGGCTGCAGATGTGAATGGAGACAGTGAACCCGATCTGGTCATCGGC TCCCCTTTTGCACCAGGTGGAGGGAAGCAGAAGGGAATTGTGGCTGCGTTTTATTCTGGCCCCAGCCTGAGCGACAAAGAAAAACTGAAC GTGGAGGCAGCCAACTGGACGGTGAGAGGCGAGGAAGACTTCTCCTGGTTTGGATATTCCCTTCACGGTGTCACTGTGGACAACAGAACC TTGCTGTTGGTTGGGAGCCCGACCTGGAAGAATGCCAGCAGGCTGGGCCATTTGTTACACATCCGAGATGAGAAAAAGAGCCTTGGGAGG GTGTATGGCTACTTCCCACCAAACGGCCAAAGCTGGTTTACCATTTCTGGAGACAAGGCAATGGGGAAACTGGGTACTTCCCTTTCCAGT GGCCACGTACTGATGAATGGGACTCTGAAACAAGTGCTGCTGGTTGGAGCCCCTACGTACGATGACGTGTCTAAGGTGGCATTCCTGACC GTGACCCTACACCAAGGCGGAGCCACTCGCATGTACGCACTCACATCTGACGCGCAGCCTCTGCTGCTCAGCACCTTCAGCGGAGACCGC CGCTTCTCCCGATTTGGTGGCGTTCTGCACTTGAGTGACCTGGATGATGATGGCTTAGATGAAATCATCATGGCAGCCCCCCTGAGGATA GCAGATGTAACCTCTGGACTGATTGGGGGAGAAGACGGCCGAGTATATGTATATAATGGCAAAGAGACCACCCTTGGTGACATGACTGGC AAATGCAAATCATGGATAACTCCATGTCCAGAAGAAAAGGCCCAATATGTATTGATTTCTCCTGAAGCCAGCTCAAGGTTTGGGAGCTCC CTCATCACCGTGAGGTCCAAGGCAAAGGTTACCAGATGTGGTGGTTTACCCAACAACATTGTGGATGTCTGGGAGTTTTTGGGCAAACCT AAACATTGCCAGTATACATGGGATACACAAATGAACTCTAATCTTGGAATAACTGCTGCTTGTAAACTTCGTTTTGATCGAATATTTTTC AGAGCAGCAGCAGAAGAGGGACACATTATTCCCCGAAGTTTGGACCTTCTTGGATTAGAAAAACTGGACTGTGGTAGATTTCCTAGTGAT CACTGGGGTCTTCTGTGCAACTTAGATATAATATTGTAAAATGCTTTTCAAGTGTGGGTTTTGCCCTGATTGTTGCAAATACAATTTCCA CCTTCTGGAAAGGTAGGTTTGCTGTGGAGGAAATAATGTACTAGATCATTGTCACAGAAAAACCAACTATGATTTATGGTTGTGTTTTCA GAATTCAACATTAAAGATTAATGTTTATTTAAACGAACACATTCCTGCATTCAGGATGTGAGGCCATTTAATAAAAAGGGCACAAAGCCT GTCAGAGTTTTCAACGGTGCTTATAGCTGCCAGCTGGATTCCAAACAGGTACCACATTGTCTCTGAGCTAATGTTTATATTTTTCCATTC AGGCACCGAAATAGTTAATATTTGAAATAAGTCTTCAAAAGAAAACATAAGAGATTATTGAGTTCTTGGGACTGGATCCTTTATTTCATA AGTTCAGATCATCTTAAATGAAAATGCCATGATTATCTGCAGTTAAGTAGATGACAGCTATTCTACATCAGACTTGATTTTTGTCAGCTA ATTACATAATTGGTAAGCTATAATTGAAACCTTATGGCTTAAAATTCCTTAACTCCTTTTTGATTCATGTTTGTAGTCATGTTGTCAACA GAGGCAAAGTTAAGCTTGATGATGGTTAAAATCGGTTTGATAGCACCATGGGACATTTTTCTAACAAAAATAAATGCATGAAGAGACATA GCCTTTTAGTTTTGCTAATTGTGAAATGGAAATGCTTTACAGGAAGTAAATGCAAATTACTTTTAAGTGTGCTTTAAAGAAAAATATTTT |
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FusionGenePPI for GPLD1_TDP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GPLD1 | APOA4, APOA1, HIF1A, EGLN1, VHL, FAM19A4 | TDP2 | UBE2I, SUMO1, ETS1, TNFRSF1B, TNFRSF8, CD40, TRAF2, TRAF3, TRAF5, TRAF6, MAPK6, PARK7, ATXN1, SKIL, JAM2, ATP5G2, TAP1, DLX3, EPS8, SMAD3, PSEN1, RAB11A, AKAP9, SNX13, C2orf88, SUMO2, SUMO3, SRPK2, AZIN1, TCEAL1, OTUB1, PLA2G10, LYPD4, GORASP1, RSBN1, WBP2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPLD1_TDP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GPLD1_TDP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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