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Fusion gene ID: 15220 |
FusionGeneSummary for GPLD1_BANK1 |
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Fusion gene information | Fusion gene name: GPLD1_BANK1 | Fusion gene ID: 15220 | Hgene | Tgene | Gene symbol | GPLD1 | BANK1 | Gene ID | 2822 | 55024 |
Gene name | glycosylphosphatidylinositol specific phospholipase D1 | B cell scaffold protein with ankyrin repeats 1 | |
Synonyms | GPIPLD|GPIPLDM|PIGPLD|PIGPLD1|PLD | BANK | |
Cytomap | 6p22.3 | 4q24 | |
Type of gene | protein-coding | protein-coding | |
Description | phosphatidylinositol-glycan-specific phospholipase DGPI-PLDGPI-specific phospholipase DPI-G PLDglycoprotein phospholipase D | B-cell scaffold protein with ankyrin repeats | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P80108 | Q8NDB2 | |
Ensembl transtripts involved in fusion gene | ENST00000230036, ENST00000474784, | ENST00000504592, ENST00000322953, ENST00000428908, ENST00000508653, ENST00000444316, ENST00000510950, | |
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 4 X 4 X 3=48 |
# samples | 4 | 4 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GPLD1 [Title/Abstract] AND BANK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GPLD1 | GO:0002430 | complement receptor mediated signaling pathway | 15907827|19135435 |
Hgene | GPLD1 | GO:0006507 | GPI anchor release | 2760042|15907827|19135435 |
Hgene | GPLD1 | GO:0008285 | negative regulation of cell proliferation | 19135435 |
Hgene | GPLD1 | GO:0008286 | insulin receptor signaling pathway | 18328347 |
Hgene | GPLD1 | GO:0009749 | response to glucose | 15907827 |
Hgene | GPLD1 | GO:0032869 | cellular response to insulin stimulus | 15907827 |
Hgene | GPLD1 | GO:0035690 | cellular response to drug | 17761367 |
Hgene | GPLD1 | GO:0043065 | positive regulation of apoptotic process | 19135435 |
Hgene | GPLD1 | GO:0045919 | positive regulation of cytolysis | 15907827|19135435 |
Hgene | GPLD1 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis | 17720976 |
Hgene | GPLD1 | GO:0071277 | cellular response to calcium ion | 2760042 |
Hgene | GPLD1 | GO:0071467 | cellular response to pH | 17761367 |
Hgene | GPLD1 | GO:1900076 | regulation of cellular response to insulin stimulus | 18328347 |
Tgene | BANK1 | GO:0042113 | B cell activation | 11782428 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-HC-7209-01A | GPLD1 | chr6 | 24486303 | - | BANK1 | chr4 | 102776192 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000230036 | ENST00000504592 | GPLD1 | chr6 | 24486303 | - | BANK1 | chr4 | 102776192 | + |
Frame-shift | ENST00000230036 | ENST00000322953 | GPLD1 | chr6 | 24486303 | - | BANK1 | chr4 | 102776192 | + |
Frame-shift | ENST00000230036 | ENST00000428908 | GPLD1 | chr6 | 24486303 | - | BANK1 | chr4 | 102776192 | + |
Frame-shift | ENST00000230036 | ENST00000508653 | GPLD1 | chr6 | 24486303 | - | BANK1 | chr4 | 102776192 | + |
Frame-shift | ENST00000230036 | ENST00000444316 | GPLD1 | chr6 | 24486303 | - | BANK1 | chr4 | 102776192 | + |
5CDS-intron | ENST00000230036 | ENST00000510950 | GPLD1 | chr6 | 24486303 | - | BANK1 | chr4 | 102776192 | + |
5UTR-3CDS | ENST00000474784 | ENST00000504592 | GPLD1 | chr6 | 24486303 | - | BANK1 | chr4 | 102776192 | + |
5UTR-3CDS | ENST00000474784 | ENST00000322953 | GPLD1 | chr6 | 24486303 | - | BANK1 | chr4 | 102776192 | + |
5UTR-3CDS | ENST00000474784 | ENST00000428908 | GPLD1 | chr6 | 24486303 | - | BANK1 | chr4 | 102776192 | + |
5UTR-3CDS | ENST00000474784 | ENST00000508653 | GPLD1 | chr6 | 24486303 | - | BANK1 | chr4 | 102776192 | + |
5UTR-3CDS | ENST00000474784 | ENST00000444316 | GPLD1 | chr6 | 24486303 | - | BANK1 | chr4 | 102776192 | + |
5UTR-intron | ENST00000474784 | ENST00000510950 | GPLD1 | chr6 | 24486303 | - | BANK1 | chr4 | 102776192 | + |
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FusionProtFeatures for GPLD1_BANK1 |
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Hgene | Tgene |
GPLD1 | BANK1 |
Involved in B-cell receptor (BCR)-induced Ca(2+)mobilization from intracellular stores. Promotes Lyn-mediatedphosphorylation of IP3 receptors 1 and 2.{ECO:0000269|PubMed:11782428}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPLD1_BANK1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GPLD1_BANK1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GPLD1 | APOA4, APOA1, HIF1A, EGLN1, VHL, FAM19A4 | BANK1 | LYN, ITPR1, YWHAQ |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPLD1_BANK1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GPLD1_BANK1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | BANK1 | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human |