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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15220

FusionGeneSummary for GPLD1_BANK1

check button Fusion gene summary
Fusion gene informationFusion gene name: GPLD1_BANK1
Fusion gene ID: 15220
HgeneTgene
Gene symbol

GPLD1

BANK1

Gene ID

2822

55024

Gene nameglycosylphosphatidylinositol specific phospholipase D1B cell scaffold protein with ankyrin repeats 1
SynonymsGPIPLD|GPIPLDM|PIGPLD|PIGPLD1|PLDBANK
Cytomap

6p22.3

4q24

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol-glycan-specific phospholipase DGPI-PLDGPI-specific phospholipase DPI-G PLDglycoprotein phospholipase DB-cell scaffold protein with ankyrin repeats
Modification date2018052320180519
UniProtAcc

P80108

Q8NDB2

Ensembl transtripts involved in fusion geneENST00000230036, ENST00000474784, 
ENST00000504592, ENST00000322953, 
ENST00000428908, ENST00000508653, 
ENST00000444316, ENST00000510950, 
Fusion gene scores* DoF score4 X 3 X 4=484 X 4 X 3=48
# samples 44
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPLD1 [Title/Abstract] AND BANK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGPLD1

GO:0002430

complement receptor mediated signaling pathway

15907827|19135435

HgeneGPLD1

GO:0006507

GPI anchor release

2760042|15907827|19135435

HgeneGPLD1

GO:0008285

negative regulation of cell proliferation

19135435

HgeneGPLD1

GO:0008286

insulin receptor signaling pathway

18328347

HgeneGPLD1

GO:0009749

response to glucose

15907827

HgeneGPLD1

GO:0032869

cellular response to insulin stimulus

15907827

HgeneGPLD1

GO:0035690

cellular response to drug

17761367

HgeneGPLD1

GO:0043065

positive regulation of apoptotic process

19135435

HgeneGPLD1

GO:0045919

positive regulation of cytolysis

15907827|19135435

HgeneGPLD1

GO:0051044

positive regulation of membrane protein ectodomain proteolysis

17720976

HgeneGPLD1

GO:0071277

cellular response to calcium ion

2760042

HgeneGPLD1

GO:0071467

cellular response to pH

17761367

HgeneGPLD1

GO:1900076

regulation of cellular response to insulin stimulus

18328347

TgeneBANK1

GO:0042113

B cell activation

11782428


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-7209-01AGPLD1chr6

24486303

-BANK1chr4

102776192

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000230036ENST00000504592GPLD1chr6

24486303

-BANK1chr4

102776192

+
Frame-shiftENST00000230036ENST00000322953GPLD1chr6

24486303

-BANK1chr4

102776192

+
Frame-shiftENST00000230036ENST00000428908GPLD1chr6

24486303

-BANK1chr4

102776192

+
Frame-shiftENST00000230036ENST00000508653GPLD1chr6

24486303

-BANK1chr4

102776192

+
Frame-shiftENST00000230036ENST00000444316GPLD1chr6

24486303

-BANK1chr4

102776192

+
5CDS-intronENST00000230036ENST00000510950GPLD1chr6

24486303

-BANK1chr4

102776192

+
5UTR-3CDSENST00000474784ENST00000504592GPLD1chr6

24486303

-BANK1chr4

102776192

+
5UTR-3CDSENST00000474784ENST00000322953GPLD1chr6

24486303

-BANK1chr4

102776192

+
5UTR-3CDSENST00000474784ENST00000428908GPLD1chr6

24486303

-BANK1chr4

102776192

+
5UTR-3CDSENST00000474784ENST00000508653GPLD1chr6

24486303

-BANK1chr4

102776192

+
5UTR-3CDSENST00000474784ENST00000444316GPLD1chr6

24486303

-BANK1chr4

102776192

+
5UTR-intronENST00000474784ENST00000510950GPLD1chr6

24486303

-BANK1chr4

102776192

+

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FusionProtFeatures for GPLD1_BANK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPLD1

P80108

BANK1

Q8NDB2

Involved in B-cell receptor (BCR)-induced Ca(2+)mobilization from intracellular stores. Promotes Lyn-mediatedphosphorylation of IP3 receptors 1 and 2.{ECO:0000269|PubMed:11782428}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPLD1_BANK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPLD1_BANK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GPLD1APOA4, APOA1, HIF1A, EGLN1, VHL, FAM19A4BANK1LYN, ITPR1, YWHAQ


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPLD1_BANK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GPLD1_BANK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBANK1C0024141Lupus Erythematosus, Systemic1CTD_human