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Fusion gene ID: 15212 |
FusionGeneSummary for GPI_FGF2 |
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Fusion gene information | Fusion gene name: GPI_FGF2 | Fusion gene ID: 15212 | Hgene | Tgene | Gene symbol | GPI | FGF2 | Gene ID | 10007 | 2258 |
Gene name | glucosamine-6-phosphate deaminase 1 | fibroblast growth factor 13 | |
Synonyms | GNP1|GNPDA|GNPI|GPI|HLN | FGF-13|FGF2|FHF-2|FHF2 | |
Cytomap | 5q31.3 | Xq26.3-q27.1 | |
Type of gene | protein-coding | protein-coding | |
Description | glucosamine-6-phosphate isomerase 1GNPDA 1glcN6P deaminase 1oscillin | fibroblast growth factor 13fibroblast growth factor homologous factor 2 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P06744 | P09038 | |
Ensembl transtripts involved in fusion gene | ENST00000415930, ENST00000356487, ENST00000586425, | ENST00000264498, ENST00000608478, | |
Fusion gene scores | * DoF score | 13 X 13 X 5=845 | 2 X 2 X 2=8 |
# samples | 13 | 2 | |
** MAII score | log2(13/845*10)=-2.70043971814109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: GPI [Title/Abstract] AND FGF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FGF2 | GO:0000165 | MAPK cascade | 12244047 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI342169 | GPI | chr19 | 34892969 | - | FGF2 | chr4 | 123815020 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000415930 | ENST00000264498 | GPI | chr19 | 34892969 | - | FGF2 | chr4 | 123815020 | - |
3UTR-3UTR | ENST00000415930 | ENST00000608478 | GPI | chr19 | 34892969 | - | FGF2 | chr4 | 123815020 | - |
intron-3UTR | ENST00000356487 | ENST00000264498 | GPI | chr19 | 34892969 | - | FGF2 | chr4 | 123815020 | - |
intron-3UTR | ENST00000356487 | ENST00000608478 | GPI | chr19 | 34892969 | - | FGF2 | chr4 | 123815020 | - |
intron-3UTR | ENST00000586425 | ENST00000264498 | GPI | chr19 | 34892969 | - | FGF2 | chr4 | 123815020 | - |
intron-3UTR | ENST00000586425 | ENST00000608478 | GPI | chr19 | 34892969 | - | FGF2 | chr4 | 123815020 | - |
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FusionProtFeatures for GPI_FGF2 |
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Hgene | Tgene |
GPI | FGF2 |
Besides it's role as a glycolytic enzyme, mammalian GPIcan function as a tumor-secreted cytokine and an angiogenic factor(AMF) that stimulates endothelial cell motility. GPI is also aneurotrophic factor (Neuroleukin) for spinal and sensory neurons.{ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPI_FGF2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GPI_FGF2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPI_FGF2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | GPI | P06744 | DB11638 | Artenimol | Glucose-6-phosphate isomerase | small molecule | approved|investigational |
Tgene | FGF2 | P09038 | DB00364 | Sucralfate | Fibroblast growth factor 2 | small molecule | approved |
Tgene | FGF2 | P09038 | DB00686 | Pentosan Polysulfate | Fibroblast growth factor 2 | small molecule | approved |
Tgene | FGF2 | P09038 | DB00877 | Sirolimus | Fibroblast growth factor 2 | small molecule | approved|investigational |
Tgene | FGF2 | P09038 | DB01109 | Heparin | Fibroblast growth factor 2 | small molecule | approved|investigational |
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RelatedDiseases for GPI_FGF2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GPI | C3150730 | HEMOLYTIC ANEMIA, NONSPHEROCYTIC, DUE TO GLUCOSE PHOSPHATE ISOMERASE DEFICIENCY | 6 | CTD_human;ORPHANET;UNIPROT |
Hgene | GPI | C0002878 | Anemia, Hemolytic | 1 | CTD_human |
Hgene | GPI | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | FGF2 | C0525045 | Mood Disorders | 3 | PSYGENET |
Tgene | FGF2 | C0151744 | Myocardial Ischemia | 2 | CTD_human |
Tgene | FGF2 | C0008924 | Cleft Lip | 1 | CTD_human |
Tgene | FGF2 | C0008925 | Cleft Palate | 1 | CTD_human |
Tgene | FGF2 | C0011581 | Depressive disorder | 1 | CTD_human |
Tgene | FGF2 | C0014549 | Tonic-Clonic Epilepsy | 1 | CTD_human |
Tgene | FGF2 | C0017638 | Glioma | 1 | CTD_human |
Tgene | FGF2 | C0017639 | Gliosis | 1 | CTD_human |
Tgene | FGF2 | C0018800 | Cardiomegaly | 1 | CTD_human |
Tgene | FGF2 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
Tgene | FGF2 | C0021368 | Inflammation | 1 | CTD_human |
Tgene | FGF2 | C0022658 | Kidney Diseases | 1 | CTD_human |
Tgene | FGF2 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Tgene | FGF2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | FGF2 | C0025500 | Mesothelioma | 1 | CTD_human |
Tgene | FGF2 | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
Tgene | FGF2 | C0027746 | Nerve Degeneration | 1 | CTD_human |
Tgene | FGF2 | C0029172 | Oral Submucous Fibrosis | 1 | CTD_human |
Tgene | FGF2 | C0031030 | Periapical Periodontitis | 1 | CTD_human |
Tgene | FGF2 | C0033054 | Prenatal Exposure Delayed Effects | 1 | CTD_human |
Tgene | FGF2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | FGF2 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
Tgene | FGF2 | C0035126 | Reperfusion Injury | 1 | CTD_human |
Tgene | FGF2 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | FGF2 | C0036572 | Seizures | 1 | CTD_human |
Tgene | FGF2 | C0040028 | Thrombocythemia, Essential | 1 | CTD_human |
Tgene | FGF2 | C0085109 | Corneal Neovascularization | 1 | CTD_human |
Tgene | FGF2 | C0085207 | Gestational Diabetes | 1 | CTD_human |
Tgene | FGF2 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
Tgene | FGF2 | C0751955 | Brain Infarction | 1 | CTD_human |