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Fusion gene ID: 15211 |
FusionGeneSummary for GPI_FDPS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPI_FDPS | Fusion gene ID: 15211 | Hgene | Tgene | Gene symbol | GPI | FDPS | Gene ID | 10007 | 2224 |
| Gene name | glucosamine-6-phosphate deaminase 1 | farnesyl diphosphate synthase | |
| Synonyms | GNP1|GNPDA|GNPI|GPI|HLN | FPPS|FPS|POROK9 | |
| Cytomap | 5q31.3 | 1q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glucosamine-6-phosphate isomerase 1GNPDA 1glcN6P deaminase 1oscillin | farnesyl pyrophosphate synthase(2E,6E)-farnesyl diphosphate synthaseFPP synthaseFPP synthetasefarnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P06744 | P14324 | |
| Ensembl transtripts involved in fusion gene | ENST00000415930, ENST00000356487, ENST00000586425, | ENST00000447866, ENST00000368356, ENST00000487002, ENST00000356657, | |
| Fusion gene scores | * DoF score | 13 X 13 X 5=845 | 3 X 3 X 1=9 |
| # samples | 13 | 5 | |
| ** MAII score | log2(13/845*10)=-2.70043971814109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/9*10)=2.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: GPI [Title/Abstract] AND FDPS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CB046420 | GPI | chr19 | 34870455 | + | FDPS | chr1 | 155290342 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000415930 | ENST00000447866 | GPI | chr19 | 34870455 | + | FDPS | chr1 | 155290342 | + |
| Frame-shift | ENST00000415930 | ENST00000368356 | GPI | chr19 | 34870455 | + | FDPS | chr1 | 155290342 | + |
| 5CDS-intron | ENST00000415930 | ENST00000487002 | GPI | chr19 | 34870455 | + | FDPS | chr1 | 155290342 | + |
| 5CDS-intron | ENST00000415930 | ENST00000356657 | GPI | chr19 | 34870455 | + | FDPS | chr1 | 155290342 | + |
| In-frame | ENST00000356487 | ENST00000447866 | GPI | chr19 | 34870455 | + | FDPS | chr1 | 155290342 | + |
| Frame-shift | ENST00000356487 | ENST00000368356 | GPI | chr19 | 34870455 | + | FDPS | chr1 | 155290342 | + |
| 5CDS-intron | ENST00000356487 | ENST00000487002 | GPI | chr19 | 34870455 | + | FDPS | chr1 | 155290342 | + |
| 5CDS-intron | ENST00000356487 | ENST00000356657 | GPI | chr19 | 34870455 | + | FDPS | chr1 | 155290342 | + |
| In-frame | ENST00000586425 | ENST00000447866 | GPI | chr19 | 34870455 | + | FDPS | chr1 | 155290342 | + |
| Frame-shift | ENST00000586425 | ENST00000368356 | GPI | chr19 | 34870455 | + | FDPS | chr1 | 155290342 | + |
| 5CDS-intron | ENST00000586425 | ENST00000487002 | GPI | chr19 | 34870455 | + | FDPS | chr1 | 155290342 | + |
| 5CDS-intron | ENST00000586425 | ENST00000356657 | GPI | chr19 | 34870455 | + | FDPS | chr1 | 155290342 | + |
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FusionProtFeatures for GPI_FDPS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPI | FDPS |
| Besides it's role as a glycolytic enzyme, mammalian GPIcan function as a tumor-secreted cytokine and an angiogenic factor(AMF) that stimulates endothelial cell motility. GPI is also aneurotrophic factor (Neuroleukin) for spinal and sensory neurons.{ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381}. | Key enzyme in isoprenoid biosynthesis which catalyzesthe formation of farnesyl diphosphate (FPP), a precursor forseveral classes of essential metabolites including sterols,dolichols, carotenoids, and ubiquinones. FPP also serves assubstrate for protein farnesylation and geranylgeranylation.Catalyzes the sequential condensation of isopentenyl pyrophosphatewith the allylic pyrophosphates, dimethylallyl pyrophosphate, andthen with the resultant geranylpyrophosphate to the ultimateproduct farnesyl pyrophosphate. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPI_FDPS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GPI_ENST00000415930_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0aa >In-frame_GPI_ENST00000356487_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0aa >In-frame_GPI_ENST00000586425_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GPI_ENST00000415930_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0nt >In-frame_GPI_ENST00000356487_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0nt >In-frame_GPI_ENST00000586425_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0nt |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GPI_ENST00000415930_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0nt >In-frame_GPI_ENST00000356487_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0nt >In-frame_GPI_ENST00000586425_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0nt |
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FusionGenePPI for GPI_FDPS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPI_FDPS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | GPI | P06744 | DB11638 | Artenimol | Glucose-6-phosphate isomerase | small molecule | approved|investigational |
| Tgene | FDPS | P14324 | DB00282 | Pamidronate | Farnesyl pyrophosphate synthase | small molecule | approved |
| Tgene | FDPS | P14324 | DB00399 | Zoledronic acid | Farnesyl pyrophosphate synthase | small molecule | approved |
| Tgene | FDPS | P14324 | DB00630 | Alendronic acid | Farnesyl pyrophosphate synthase | small molecule | approved |
| Tgene | FDPS | P14324 | DB00710 | Ibandronate | Farnesyl pyrophosphate synthase | small molecule | approved|investigational |
| Tgene | FDPS | P14324 | DB00884 | Risedronate | Farnesyl pyrophosphate synthase | small molecule | approved|investigational |
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RelatedDiseases for GPI_FDPS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GPI | C3150730 | HEMOLYTIC ANEMIA, NONSPHEROCYTIC, DUE TO GLUCOSE PHOSPHATE ISOMERASE DEFICIENCY | 6 | CTD_human;ORPHANET;UNIPROT |
| Hgene | GPI | C0002878 | Anemia, Hemolytic | 1 | CTD_human |
| Hgene | GPI | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | FDPS | C4225262 | POROKERATOSIS 9, MULTIPLE TYPES | 1 | UNIPROT |
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