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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15211

FusionGeneSummary for GPI_FDPS

check button Fusion gene summary
Fusion gene informationFusion gene name: GPI_FDPS
Fusion gene ID: 15211
HgeneTgene
Gene symbol

GPI

FDPS

Gene ID

10007

2224

Gene nameglucosamine-6-phosphate deaminase 1farnesyl diphosphate synthase
SynonymsGNP1|GNPDA|GNPI|GPI|HLNFPPS|FPS|POROK9
Cytomap

5q31.3

1q22

Type of geneprotein-codingprotein-coding
Descriptionglucosamine-6-phosphate isomerase 1GNPDA 1glcN6P deaminase 1oscillinfarnesyl pyrophosphate synthase(2E,6E)-farnesyl diphosphate synthaseFPP synthaseFPP synthetasefarnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase
Modification date2018052320180523
UniProtAcc

P06744

P14324

Ensembl transtripts involved in fusion geneENST00000415930, ENST00000356487, 
ENST00000586425, 
ENST00000447866, 
ENST00000368356, ENST00000487002, 
ENST00000356657, 
Fusion gene scores* DoF score13 X 13 X 5=8453 X 3 X 1=9
# samples 135
** MAII scorelog2(13/845*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/9*10)=2.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GPI [Title/Abstract] AND FDPS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB046420GPIchr19

34870455

+FDPSchr1

155290342

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000415930ENST00000447866GPIchr19

34870455

+FDPSchr1

155290342

+
Frame-shitENST00000415930ENST00000368356GPIchr19

34870455

+FDPSchr1

155290342

+
5CDS-intronENST00000415930ENST00000487002GPIchr19

34870455

+FDPSchr1

155290342

+
5CDS-intronENST00000415930ENST00000356657GPIchr19

34870455

+FDPSchr1

155290342

+
In-frameENST00000356487ENST00000447866GPIchr19

34870455

+FDPSchr1

155290342

+
Frame-shitENST00000356487ENST00000368356GPIchr19

34870455

+FDPSchr1

155290342

+
5CDS-intronENST00000356487ENST00000487002GPIchr19

34870455

+FDPSchr1

155290342

+
5CDS-intronENST00000356487ENST00000356657GPIchr19

34870455

+FDPSchr1

155290342

+
In-frameENST00000586425ENST00000447866GPIchr19

34870455

+FDPSchr1

155290342

+
Frame-shitENST00000586425ENST00000368356GPIchr19

34870455

+FDPSchr1

155290342

+
5CDS-intronENST00000586425ENST00000487002GPIchr19

34870455

+FDPSchr1

155290342

+
5CDS-intronENST00000586425ENST00000356657GPIchr19

34870455

+FDPSchr1

155290342

+

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FusionProtFeatures for GPI_FDPS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPI

P06744

FDPS

P14324

Besides it's role as a glycolytic enzyme, mammalian GPIcan function as a tumor-secreted cytokine and an angiogenic factor(AMF) that stimulates endothelial cell motility. GPI is also aneurotrophic factor (Neuroleukin) for spinal and sensory neurons.{ECO:0000269|PubMed:11004567, ECO:0000269|PubMed:11437381}. Key enzyme in isoprenoid biosynthesis which catalyzesthe formation of farnesyl diphosphate (FPP), a precursor forseveral classes of essential metabolites including sterols,dolichols, carotenoids, and ubiquinones. FPP also serves assubstrate for protein farnesylation and geranylgeranylation.Catalyzes the sequential condensation of isopentenyl pyrophosphatewith the allylic pyrophosphates, dimethylallyl pyrophosphate, andthen with the resultant geranylpyrophosphate to the ultimateproduct farnesyl pyrophosphate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPI_FDPS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_GPI_ENST00000415930_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0aa

>In-frame_GPI_ENST00000356487_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0aa

>In-frame_GPI_ENST00000586425_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_GPI_ENST00000415930_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0nt

>In-frame_GPI_ENST00000356487_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0nt

>In-frame_GPI_ENST00000586425_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_GPI_ENST00000415930_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0nt

>In-frame_GPI_ENST00000356487_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0nt

>In-frame_GPI_ENST00000586425_chr19_34870455_+_FDPS_ENST00000447866_chr1_155290342_+_0nt


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FusionGenePPI for GPI_FDPS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPI_FDPS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGPIP06744DB11638ArtenimolGlucose-6-phosphate isomerasesmall moleculeapproved|investigational
TgeneFDPSP14324DB00282PamidronateFarnesyl pyrophosphate synthasesmall moleculeapproved
TgeneFDPSP14324DB00399Zoledronic acidFarnesyl pyrophosphate synthasesmall moleculeapproved
TgeneFDPSP14324DB00630Alendronic acidFarnesyl pyrophosphate synthasesmall moleculeapproved
TgeneFDPSP14324DB00710IbandronateFarnesyl pyrophosphate synthasesmall moleculeapproved|investigational
TgeneFDPSP14324DB00884RisedronateFarnesyl pyrophosphate synthasesmall moleculeapproved|investigational

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RelatedDiseases for GPI_FDPS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGPIC3150730HEMOLYTIC ANEMIA, NONSPHEROCYTIC, DUE TO GLUCOSE PHOSPHATE ISOMERASE DEFICIENCY6CTD_human;ORPHANET;UNIPROT
HgeneGPIC0002878Anemia, Hemolytic1CTD_human
HgeneGPIC1458155Mammary Neoplasms1CTD_human
TgeneFDPSC4225262POROKERATOSIS 9, MULTIPLE TYPES1UNIPROT