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Fusion gene ID: 15193 |
FusionGeneSummary for GPD1L_UBE2G1 |
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Fusion gene information | Fusion gene name: GPD1L_UBE2G1 | Fusion gene ID: 15193 | Hgene | Tgene | Gene symbol | GPD1L | UBE2G1 | Gene ID | 23171 | 7326 |
Gene name | glycerol-3-phosphate dehydrogenase 1 like | ubiquitin conjugating enzyme E2 G1 | |
Synonyms | GPD1-L | E217K|UBC7|UBE2G | |
Cytomap | 3p22.3 | 17p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | glycerol-3-phosphate dehydrogenase 1-like protein | ubiquitin-conjugating enzyme E2 G1E2 ubiquitin-conjugating enzyme G1ubiquitin carrier protein G1ubiquitin conjugating enzyme E2G 1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)ub | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8N335 | P62253 | |
Ensembl transtripts involved in fusion gene | ENST00000282541, | ENST00000396981, ENST00000572484, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 7 X 4 X 5=140 |
# samples | 4 | 8 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GPD1L [Title/Abstract] AND UBE2G1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | UBE2G1 | GO:0070534 | protein K63-linked ubiquitination | 20061386 |
Tgene | UBE2G1 | GO:0070936 | protein K48-linked ubiquitination | 14593114|20061386 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF849090 | GPD1L | chr3 | 32210011 | - | UBE2G1 | chr17 | 4268537 | - | ||
ChiTaRS3.1 | BF849097 | GPD1L | chr3 | 32210011 | - | UBE2G1 | chr17 | 4268537 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000282541 | ENST00000396981 | GPD1L | chr3 | 32210011 | - | UBE2G1 | chr17 | 4268537 | - |
3UTR-intron | ENST00000282541 | ENST00000572484 | GPD1L | chr3 | 32210011 | - | UBE2G1 | chr17 | 4268537 | - |
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FusionProtFeatures for GPD1L_UBE2G1 |
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Hgene | Tgene |
GPD1L | UBE2G1 |
Plays a role in regulating cardiac sodium current;decreased enzymatic activity with resulting increased levels ofglycerol 3-phosphate activating the DPD1L-dependent SCN5Aphosphorylation pathway, may ultimately lead to decreased sodiumcurrent; cardiac sodium current may also be reduced due toalterations of NAD(H) balance induced by DPD1L.{ECO:0000269|PubMed:19666841, ECO:0000269|PubMed:19745168}. | Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May beinvolved in degradation of muscle-specific proteins. Mediatespolyubiquitination of CYP3A4. {ECO:0000269|PubMed:19103148,ECO:0000269|PubMed:20061386}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPD1L_UBE2G1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GPD1L_UBE2G1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPD1L_UBE2G1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GPD1L_UBE2G1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | GPD1L | C2673193 | Brugada Syndrome 2 | 3 | CTD_human;UNIPROT |
Hgene | GPD1L | C0038644 | Sudden infant death syndrome | 2 | UNIPROT |
Hgene | GPD1L | C0015695 | Fatty Liver | 1 | CTD_human |