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Fusion gene ID: 15192 |
FusionGeneSummary for GPD1L_CNOT10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GPD1L_CNOT10 | Fusion gene ID: 15192 | Hgene | Tgene | Gene symbol | GPD1L | CNOT10 | Gene ID | 23171 | 25904 |
| Gene name | glycerol-3-phosphate dehydrogenase 1 like | CCR4-NOT transcription complex subunit 10 | |
| Synonyms | GPD1-L | - | |
| Cytomap | 3p22.3 | 3p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glycerol-3-phosphate dehydrogenase 1-like protein | CCR4-NOT transcription complex subunit 10 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8N335 | Q9H9A5 | |
| Ensembl transtripts involved in fusion gene | ENST00000282541, | ENST00000331889, ENST00000328834, ENST00000538368, ENST00000454516, ENST00000463697, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 4 X 4 X 3=48 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GPD1L [Title/Abstract] AND CNOT10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-KK-A7B1-01A | GPD1L | chr3 | 32188226 | + | CNOT10 | chr3 | 32750162 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000282541 | ENST00000331889 | GPD1L | chr3 | 32188226 | + | CNOT10 | chr3 | 32750162 | + |
| In-frame | ENST00000282541 | ENST00000328834 | GPD1L | chr3 | 32188226 | + | CNOT10 | chr3 | 32750162 | + |
| 5CDS-5UTR | ENST00000282541 | ENST00000538368 | GPD1L | chr3 | 32188226 | + | CNOT10 | chr3 | 32750162 | + |
| 5CDS-5UTR | ENST00000282541 | ENST00000454516 | GPD1L | chr3 | 32188226 | + | CNOT10 | chr3 | 32750162 | + |
| 5CDS-intron | ENST00000282541 | ENST00000463697 | GPD1L | chr3 | 32188226 | + | CNOT10 | chr3 | 32750162 | + |
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FusionProtFeatures for GPD1L_CNOT10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GPD1L | CNOT10 |
| Plays a role in regulating cardiac sodium current;decreased enzymatic activity with resulting increased levels ofglycerol 3-phosphate activating the DPD1L-dependent SCN5Aphosphorylation pathway, may ultimately lead to decreased sodiumcurrent; cardiac sodium current may also be reduced due toalterations of NAD(H) balance induced by DPD1L.{ECO:0000269|PubMed:19666841, ECO:0000269|PubMed:19745168}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GPD1L | chr3:32188226 | chr3:32750162 | ENST00000282541 | + | 5 | 8 | 12_17 | 206 | 352 | Nucleotide binding | NAD |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >GPD1L | chr3:32188226 | chr3:32750162 | ENST00000282541 | + | 5 | 8 | 271_272 | 206 | 352 | Region | Note=Substrate binding |
| Tgene | CNOT10 | chr3:32188226 | chr3:32750162 | ENST00000328834 | + | 2 | 19 | 74_107 | 93 | 745 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CNOT10 | chr3:32188226 | chr3:32750162 | ENST00000331889 | + | 2 | 18 | 74_107 | 93 | 718 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CNOT10 | chr3:32188226 | chr3:32750162 | ENST00000454516 | + | 2 | 19 | 74_107 | 153 | 805 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for GPD1L_CNOT10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_GPD1L_ENST00000282541_chr3_32188226_+_CNOT10_ENST00000331889_chr3_32750162_+_831aa MAAAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSNLSEAVQDADL LVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFK ELLQTPNFRITVVDDADTVELCGALKVHSAVEEMDGLDDVENSMLYYNQAVILYHLRQYTEAISVGEKLYQFIEPFEEKFAQAVCFLLVD LYILTYQAEKALHLLAVLEKMISQGNNNKNGKNETGNNNNKDGSNHKAESGALIEAAKSKIHQYKVRAYIQMKSLKACKREIKSVMNTAG NSAPSLFLKSNFEYLRGNYRKAVKLLNSSNIAEHPGFMKTGECLRCMFWNNLGCIHFAMSKHNLGIFYFKKALQENDNVCAQLSAGSTDP GKKFSGRPMCTLLTNKRYELLYNCGIQLLHIGRPLAAFECLIEAVQVYHANPRLWLRLAECCIAANKGTSEQETKGLPSKKGIVQSIVGQ GYHRKIVLASQSIQNTVYNDGQSSAIPVASMEFAAICLRNALLLLPEEQQDPKQENGAKNSNQLGGNTESSESSETCRCSILACSAYVAL ALGDNLMALNHADKLLQQPKLSGSLKFLGHLYAAEALISLDRISDAITHLNPENVTDVSLGISSNEQDQGSDKGENEAMESSGKRAPQCY PSSVNSARTVMLFNLGSAYCLRSEYDKARKCLHQAASMIHPKEVPPEAILLAVYLELQNGNTQLALQIIKRNQLLPAVKTHSEVRKKPVF >In-frame_GPD1L_ENST00000282541_chr3_32188226_+_CNOT10_ENST00000328834_chr3_32750162_+_858aa MAAAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSNLSEAVQDADL LVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFK ELLQTPNFRITVVDDADTVELCGALKVHSAVEEMDGLDDVENSMLYYNQAVILYHLRQYTEAISVGEKLYQFIEPFEEKFAQAVCFLLVD LYILTYQAEKALHLLAVLEKMISQGNNNKNGKNETGNNNNKDGSNHKAESGALIEAAKSKIHQYKVRAYIQMKSLKACKREIKSVMNTAG NSAPSLFLKSNFEYLRGNYRKAVKLLNSSNIAEHPGFMKTGECLRCMFWNNLGCIHFAMSKHNLGIFYFKKALQENDNVCAQLSAGSTDP GKKFSGRPMCTLLTNKRYELLYNCGIQLLHIGRPLAAFECLIEAVQVYHANPRLWLRLAECCIAANKGTSEQETKGLPSKKGIVQSIVGQ GYHRKIVLASQSIQNTVYNDGQSSAIPVASMEFAAICLRNALLLLPEEQQDPKQENGAKNSNQLGGNTESSESSETCSSKSHDGDKFIPA PPSSPLRKQELENLKCSILACSAYVALALGDNLMALNHADKLLQQPKLSGSLKFLGHLYAAEALISLDRISDAITHLNPENVTDVSLGIS SNEQDQGSDKGENEAMESSGKRAPQCYPSSVNSARTVMLFNLGSAYCLRSEYDKARKCLHQAASMIHPKEVPPEAILLAVYLELQNGNTQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_GPD1L_ENST00000282541_chr3_32188226_+_CNOT10_ENST00000331889_chr3_32750162_+_2493nt ATGGCAGCGGCGCCCCTGAAAGTGTGCATCGTGGGCTCGGGGAACTGGGGTTCAGCTGTTGCAAAAATAATTGGTAATAATGTCAAGAAA CTTCAGAAATTTGCCTCCACAGTCAAGATGTGGGTCTTTGAAGAAACAGTGAATGGCAGAAAACTGACAGACATCATAAATAATGACCAT GAAAATGTAAAATATCTTCCTGGACACAAGCTGCCAGAAAATGTGGTTGCCATGTCAAATCTTAGCGAGGCTGTGCAGGATGCAGACCTG CTGGTGTTTGTCATTCCCCACCAGTTCATTCACAGAATCTGTGATGAGATCACTGGGAGAGTGCCCAAGAAAGCGCTGGGAATCACCCTC ATCAAGGGCATAGACGAGGGCCCCGAGGGGCTGAAGCTCATTTCTGACATCATCCGTGAGAAGATGGGTATTGACATCAGTGTGCTGATG GGAGCCAACATTGCCAATGAGGTGGCTGCAGAGAAGTTCTGTGAGACCACCATCGGCAGCAAAGTAATGGAGAACGGCCTTCTCTTCAAA GAACTTCTGCAGACTCCAAATTTTCGAATTACCGTGGTTGATGATGCAGACACTGTTGAACTCTGTGGTGCGCTTAAGGTCCACTCAGCT GTTGAAGAAATGGATGGATTAGATGATGTTGAAAACAGCATGTTGTACTATAATCAAGCAGTCATTCTTTATCATCTGCGGCAGTATACA GAAGCCATATCAGTTGGTGAAAAACTTTATCAGTTCATAGAGCCTTTTGAAGAAAAATTTGCCCAAGCAGTGTGTTTTTTGCTTGTAGAC CTGTATATATTAACCTACCAAGCTGAGAAAGCTTTGCATCTTCTTGCTGTCCTAGAAAAAATGATTTCACAGGGTAACAATAACAAAAAT GGAAAGAATGAGACTGGTAATAACAACAACAAAGATGGATCTAATCATAAAGCTGAAAGTGGAGCTCTAATAGAAGCTGCAAAATCAAAG ATACATCAGTACAAAGTACGAGCTTATATCCAAATGAAGTCTCTGAAAGCATGTAAAAGGGAAATCAAGTCAGTCATGAATACAGCTGGA AATTCCGCACCCTCTCTCTTTCTTAAAAGCAATTTTGAGTACTTAAGAGGTAATTATCGAAAAGCCGTGAAGCTATTAAATAGTTCAAAC ATTGCTGAGCATCCAGGATTCATGAAAACAGGTGAATGCTTGAGATGCATGTTCTGGAATAACCTTGGTTGCATCCATTTTGCCATGAGC AAGCACAATTTGGGAATATTCTACTTTAAAAAGGCTCTGCAAGAGAATGACAATGTCTGTGCACAGCTCAGTGCAGGTAGCACTGATCCA GGTAAAAAATTTTCAGGAAGACCCATGTGTACGTTACTAACCAATAAGAGATATGAGTTGCTGTATAACTGTGGAATTCAGCTTCTTCAC ATTGGAAGGCCTCTTGCTGCCTTCGAATGTCTGATTGAAGCTGTTCAGGTTTATCATGCAAATCCTCGCCTCTGGCTACGGCTGGCTGAA TGCTGCATTGCTGCCAATAAGGGGACTTCTGAACAAGAAACTAAAGGCCTTCCCAGCAAAAAAGGAATTGTACAGTCTATTGTTGGTCAA GGCTATCATCGTAAAATAGTTTTGGCATCACAGTCTATACAGAATACTGTTTATAATGATGGGCAGTCTTCGGCCATTCCTGTAGCCAGT ATGGAGTTTGCAGCCATATGTCTCAGAAATGCCTTGTTGCTGCTACCTGAAGAACAGCAAGATCCAAAGCAGGAAAATGGGGCTAAAAAT AGTAATCAATTAGGTGGGAACACAGAGAGCAGCGAAAGCAGTGAAACTTGCAGGTGCTCCATACTTGCTTGCAGTGCCTACGTGGCTCTG GCTTTGGGTGATAACCTCATGGCTTTGAATCATGCAGATAAACTTCTTCAGCAGCCCAAGCTGTCAGGATCTCTTAAGTTTTTGGGACAT TTATATGCTGCAGAAGCCCTCATCTCTCTCGACAGAATATCTGATGCCATTACTCACTTGAACCCGGAGAATGTCACTGATGTCTCCTTA GGGATCTCTTCAAATGAGCAGGACCAAGGATCAGACAAAGGTGAAAATGAAGCAATGGAATCCTCTGGTAAGCGGGCCCCTCAGTGCTAC CCCAGTTCCGTCAACTCTGCCAGGACTGTGATGCTGTTCAACCTTGGCAGCGCTTACTGCCTGAGGAGCGAATATGACAAAGCCCGAAAG TGTCTCCACCAGGCGGCTTCAATGATCCATCCTAAAGAGGTGCCCCCTGAGGCCATCTTGCTGGCAGTCTACCTTGAACTGCAGAATGGT AATACTCAGCTGGCCTTACAGATCATCAAAAGGAATCAGCTGCTCCCTGCAGTGAAAACACACTCTGAAGTGAGAAAGAAGCCAGTGTTT >In-frame_GPD1L_ENST00000282541_chr3_32188226_+_CNOT10_ENST00000328834_chr3_32750162_+_2574nt ATGGCAGCGGCGCCCCTGAAAGTGTGCATCGTGGGCTCGGGGAACTGGGGTTCAGCTGTTGCAAAAATAATTGGTAATAATGTCAAGAAA CTTCAGAAATTTGCCTCCACAGTCAAGATGTGGGTCTTTGAAGAAACAGTGAATGGCAGAAAACTGACAGACATCATAAATAATGACCAT GAAAATGTAAAATATCTTCCTGGACACAAGCTGCCAGAAAATGTGGTTGCCATGTCAAATCTTAGCGAGGCTGTGCAGGATGCAGACCTG CTGGTGTTTGTCATTCCCCACCAGTTCATTCACAGAATCTGTGATGAGATCACTGGGAGAGTGCCCAAGAAAGCGCTGGGAATCACCCTC ATCAAGGGCATAGACGAGGGCCCCGAGGGGCTGAAGCTCATTTCTGACATCATCCGTGAGAAGATGGGTATTGACATCAGTGTGCTGATG GGAGCCAACATTGCCAATGAGGTGGCTGCAGAGAAGTTCTGTGAGACCACCATCGGCAGCAAAGTAATGGAGAACGGCCTTCTCTTCAAA GAACTTCTGCAGACTCCAAATTTTCGAATTACCGTGGTTGATGATGCAGACACTGTTGAACTCTGTGGTGCGCTTAAGGTCCACTCAGCT GTTGAAGAAATGGATGGATTAGATGATGTTGAAAACAGCATGTTGTACTATAATCAAGCAGTCATTCTTTATCATCTGCGGCAGTATACA GAAGCCATATCAGTTGGTGAAAAACTTTATCAGTTCATAGAGCCTTTTGAAGAAAAATTTGCCCAAGCAGTGTGTTTTTTGCTTGTAGAC CTGTATATATTAACCTACCAAGCTGAGAAAGCTTTGCATCTTCTTGCTGTCCTAGAAAAAATGATTTCACAGGGTAACAATAACAAAAAT GGAAAGAATGAGACTGGTAATAACAACAACAAAGATGGATCTAATCATAAAGCTGAAAGTGGAGCTCTAATAGAAGCTGCAAAATCAAAG ATACATCAGTACAAAGTACGAGCTTATATCCAAATGAAGTCTCTGAAAGCATGTAAAAGGGAAATCAAGTCAGTCATGAATACAGCTGGA AATTCCGCACCCTCTCTCTTTCTTAAAAGCAATTTTGAGTACTTAAGAGGTAATTATCGAAAAGCCGTGAAGCTATTAAATAGTTCAAAC ATTGCTGAGCATCCAGGATTCATGAAAACAGGTGAATGCTTGAGATGCATGTTCTGGAATAACCTTGGTTGCATCCATTTTGCCATGAGC AAGCACAATTTGGGAATATTCTACTTTAAAAAGGCTCTGCAAGAGAATGACAATGTCTGTGCACAGCTCAGTGCAGGTAGCACTGATCCA GGTAAAAAATTTTCAGGAAGACCCATGTGTACGTTACTAACCAATAAGAGATATGAGTTGCTGTATAACTGTGGAATTCAGCTTCTTCAC ATTGGAAGGCCTCTTGCTGCCTTCGAATGTCTGATTGAAGCTGTTCAGGTTTATCATGCAAATCCTCGCCTCTGGCTACGGCTGGCTGAA TGCTGCATTGCTGCCAATAAGGGGACTTCTGAACAAGAAACTAAAGGCCTTCCCAGCAAAAAAGGAATTGTACAGTCTATTGTTGGTCAA GGCTATCATCGTAAAATAGTTTTGGCATCACAGTCTATACAGAATACTGTTTATAATGATGGGCAGTCTTCGGCCATTCCTGTAGCCAGT ATGGAGTTTGCAGCCATATGTCTCAGAAATGCCTTGTTGCTGCTACCTGAAGAACAGCAAGATCCAAAGCAGGAAAATGGGGCTAAAAAT AGTAATCAATTAGGTGGGAACACAGAGAGCAGCGAAAGCAGTGAAACTTGCAGCAGTAAAAGCCATGATGGAGATAAATTCATTCCAGCT CCACCTTCTTCTCCATTGAGAAAACAGGAATTAGAAAACTTAAAGTGCTCCATACTTGCTTGCAGTGCCTACGTGGCTCTGGCTTTGGGT GATAACCTCATGGCTTTGAATCATGCAGATAAACTTCTTCAGCAGCCCAAGCTGTCAGGATCTCTTAAGTTTTTGGGACATTTATATGCT GCAGAAGCCCTCATCTCTCTCGACAGAATATCTGATGCCATTACTCACTTGAACCCGGAGAATGTCACTGATGTCTCCTTAGGGATCTCT TCAAATGAGCAGGACCAAGGATCAGACAAAGGTGAAAATGAAGCAATGGAATCCTCTGGTAAGCGGGCCCCTCAGTGCTACCCCAGTTCC GTCAACTCTGCCAGGACTGTGATGCTGTTCAACCTTGGCAGCGCTTACTGCCTGAGGAGCGAATATGACAAAGCCCGAAAGTGTCTCCAC CAGGCGGCTTCAATGATCCATCCTAAAGAGGTGCCCCCTGAGGCCATCTTGCTGGCAGTCTACCTTGAACTGCAGAATGGTAATACTCAG CTGGCCTTACAGATCATCAAAAGGAATCAGCTGCTCCCTGCAGTGAAAACACACTCTGAAGTGAGAAAGAAGCCAGTGTTTCAGCCTGTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_GPD1L_ENST00000282541_chr3_32188226_+_CNOT10_ENST00000331889_chr3_32750162_+_2797nt GCAGTGGTTCTTGGGAGTGGCGAAGCGGGTCCTGCCCCGCTGTCAGCTGCGGCCCCCGGCGCCGGGCGGGGGTGGCCGCGACCATTGGCG GAGAGGCGAAAGGGGCGGGGCCGCCGCCAGCCGCTGCGGGCAAGGCTGAACAGGCGGAGGTGGGCAGCCGGCCAGGGAAGCACGGTCCAG GCGGCTACATTCGGCCCGGCCATGGCAGCGGCGCCCCTGAAAGTGTGCATCGTGGGCTCGGGGAACTGGGGTTCAGCTGTTGCAAAAATA ATTGGTAATAATGTCAAGAAACTTCAGAAATTTGCCTCCACAGTCAAGATGTGGGTCTTTGAAGAAACAGTGAATGGCAGAAAACTGACA GACATCATAAATAATGACCATGAAAATGTAAAATATCTTCCTGGACACAAGCTGCCAGAAAATGTGGTTGCCATGTCAAATCTTAGCGAG GCTGTGCAGGATGCAGACCTGCTGGTGTTTGTCATTCCCCACCAGTTCATTCACAGAATCTGTGATGAGATCACTGGGAGAGTGCCCAAG AAAGCGCTGGGAATCACCCTCATCAAGGGCATAGACGAGGGCCCCGAGGGGCTGAAGCTCATTTCTGACATCATCCGTGAGAAGATGGGT ATTGACATCAGTGTGCTGATGGGAGCCAACATTGCCAATGAGGTGGCTGCAGAGAAGTTCTGTGAGACCACCATCGGCAGCAAAGTAATG GAGAACGGCCTTCTCTTCAAAGAACTTCTGCAGACTCCAAATTTTCGAATTACCGTGGTTGATGATGCAGACACTGTTGAACTCTGTGGT GCGCTTAAGGTCCACTCAGCTGTTGAAGAAATGGATGGATTAGATGATGTTGAAAACAGCATGTTGTACTATAATCAAGCAGTCATTCTT TATCATCTGCGGCAGTATACAGAAGCCATATCAGTTGGTGAAAAACTTTATCAGTTCATAGAGCCTTTTGAAGAAAAATTTGCCCAAGCA GTGTGTTTTTTGCTTGTAGACCTGTATATATTAACCTACCAAGCTGAGAAAGCTTTGCATCTTCTTGCTGTCCTAGAAAAAATGATTTCA CAGGGTAACAATAACAAAAATGGAAAGAATGAGACTGGTAATAACAACAACAAAGATGGATCTAATCATAAAGCTGAAAGTGGAGCTCTA ATAGAAGCTGCAAAATCAAAGATACATCAGTACAAAGTACGAGCTTATATCCAAATGAAGTCTCTGAAAGCATGTAAAAGGGAAATCAAG TCAGTCATGAATACAGCTGGAAATTCCGCACCCTCTCTCTTTCTTAAAAGCAATTTTGAGTACTTAAGAGGTAATTATCGAAAAGCCGTG AAGCTATTAAATAGTTCAAACATTGCTGAGCATCCAGGATTCATGAAAACAGGTGAATGCTTGAGATGCATGTTCTGGAATAACCTTGGT TGCATCCATTTTGCCATGAGCAAGCACAATTTGGGAATATTCTACTTTAAAAAGGCTCTGCAAGAGAATGACAATGTCTGTGCACAGCTC AGTGCAGGTAGCACTGATCCAGGTAAAAAATTTTCAGGAAGACCCATGTGTACGTTACTAACCAATAAGAGATATGAGTTGCTGTATAAC TGTGGAATTCAGCTTCTTCACATTGGAAGGCCTCTTGCTGCCTTCGAATGTCTGATTGAAGCTGTTCAGGTTTATCATGCAAATCCTCGC CTCTGGCTACGGCTGGCTGAATGCTGCATTGCTGCCAATAAGGGGACTTCTGAACAAGAAACTAAAGGCCTTCCCAGCAAAAAAGGAATT GTACAGTCTATTGTTGGTCAAGGCTATCATCGTAAAATAGTTTTGGCATCACAGTCTATACAGAATACTGTTTATAATGATGGGCAGTCT TCGGCCATTCCTGTAGCCAGTATGGAGTTTGCAGCCATATGTCTCAGAAATGCCTTGTTGCTGCTACCTGAAGAACAGCAAGATCCAAAG CAGGAAAATGGGGCTAAAAATAGTAATCAATTAGGTGGGAACACAGAGAGCAGCGAAAGCAGTGAAACTTGCAGGTGCTCCATACTTGCT TGCAGTGCCTACGTGGCTCTGGCTTTGGGTGATAACCTCATGGCTTTGAATCATGCAGATAAACTTCTTCAGCAGCCCAAGCTGTCAGGA TCTCTTAAGTTTTTGGGACATTTATATGCTGCAGAAGCCCTCATCTCTCTCGACAGAATATCTGATGCCATTACTCACTTGAACCCGGAG AATGTCACTGATGTCTCCTTAGGGATCTCTTCAAATGAGCAGGACCAAGGATCAGACAAAGGTGAAAATGAAGCAATGGAATCCTCTGGT AAGCGGGCCCCTCAGTGCTACCCCAGTTCCGTCAACTCTGCCAGGACTGTGATGCTGTTCAACCTTGGCAGCGCTTACTGCCTGAGGAGC GAATATGACAAAGCCCGAAAGTGTCTCCACCAGGCGGCTTCAATGATCCATCCTAAAGAGGTGCCCCCTGAGGCCATCTTGCTGGCAGTC TACCTTGAACTGCAGAATGGTAATACTCAGCTGGCCTTACAGATCATCAAAAGGAATCAGCTGCTCCCTGCAGTGAAAACACACTCTGAA GTGAGAAAGAAGCCAGTGTTTCAGCCTGTCCACCCGATCCAGCCCATCCAAATGCCGGCTTTCACCACTGTGCAGAGAAAGTGATACTTC ACTTTTGGAAAACTGTTACCTGAGACCCAGGGGAGAATTTACTGGCCATTTTAGTTGTATCACAGCAGAATGAATAAAAGATGGTGAAGG >In-frame_GPD1L_ENST00000282541_chr3_32188226_+_CNOT10_ENST00000328834_chr3_32750162_+_3039nt GCAGTGGTTCTTGGGAGTGGCGAAGCGGGTCCTGCCCCGCTGTCAGCTGCGGCCCCCGGCGCCGGGCGGGGGTGGCCGCGACCATTGGCG GAGAGGCGAAAGGGGCGGGGCCGCCGCCAGCCGCTGCGGGCAAGGCTGAACAGGCGGAGGTGGGCAGCCGGCCAGGGAAGCACGGTCCAG GCGGCTACATTCGGCCCGGCCATGGCAGCGGCGCCCCTGAAAGTGTGCATCGTGGGCTCGGGGAACTGGGGTTCAGCTGTTGCAAAAATA ATTGGTAATAATGTCAAGAAACTTCAGAAATTTGCCTCCACAGTCAAGATGTGGGTCTTTGAAGAAACAGTGAATGGCAGAAAACTGACA GACATCATAAATAATGACCATGAAAATGTAAAATATCTTCCTGGACACAAGCTGCCAGAAAATGTGGTTGCCATGTCAAATCTTAGCGAG GCTGTGCAGGATGCAGACCTGCTGGTGTTTGTCATTCCCCACCAGTTCATTCACAGAATCTGTGATGAGATCACTGGGAGAGTGCCCAAG AAAGCGCTGGGAATCACCCTCATCAAGGGCATAGACGAGGGCCCCGAGGGGCTGAAGCTCATTTCTGACATCATCCGTGAGAAGATGGGT ATTGACATCAGTGTGCTGATGGGAGCCAACATTGCCAATGAGGTGGCTGCAGAGAAGTTCTGTGAGACCACCATCGGCAGCAAAGTAATG GAGAACGGCCTTCTCTTCAAAGAACTTCTGCAGACTCCAAATTTTCGAATTACCGTGGTTGATGATGCAGACACTGTTGAACTCTGTGGT GCGCTTAAGGTCCACTCAGCTGTTGAAGAAATGGATGGATTAGATGATGTTGAAAACAGCATGTTGTACTATAATCAAGCAGTCATTCTT TATCATCTGCGGCAGTATACAGAAGCCATATCAGTTGGTGAAAAACTTTATCAGTTCATAGAGCCTTTTGAAGAAAAATTTGCCCAAGCA GTGTGTTTTTTGCTTGTAGACCTGTATATATTAACCTACCAAGCTGAGAAAGCTTTGCATCTTCTTGCTGTCCTAGAAAAAATGATTTCA CAGGGTAACAATAACAAAAATGGAAAGAATGAGACTGGTAATAACAACAACAAAGATGGATCTAATCATAAAGCTGAAAGTGGAGCTCTA ATAGAAGCTGCAAAATCAAAGATACATCAGTACAAAGTACGAGCTTATATCCAAATGAAGTCTCTGAAAGCATGTAAAAGGGAAATCAAG TCAGTCATGAATACAGCTGGAAATTCCGCACCCTCTCTCTTTCTTAAAAGCAATTTTGAGTACTTAAGAGGTAATTATCGAAAAGCCGTG AAGCTATTAAATAGTTCAAACATTGCTGAGCATCCAGGATTCATGAAAACAGGTGAATGCTTGAGATGCATGTTCTGGAATAACCTTGGT TGCATCCATTTTGCCATGAGCAAGCACAATTTGGGAATATTCTACTTTAAAAAGGCTCTGCAAGAGAATGACAATGTCTGTGCACAGCTC AGTGCAGGTAGCACTGATCCAGGTAAAAAATTTTCAGGAAGACCCATGTGTACGTTACTAACCAATAAGAGATATGAGTTGCTGTATAAC TGTGGAATTCAGCTTCTTCACATTGGAAGGCCTCTTGCTGCCTTCGAATGTCTGATTGAAGCTGTTCAGGTTTATCATGCAAATCCTCGC CTCTGGCTACGGCTGGCTGAATGCTGCATTGCTGCCAATAAGGGGACTTCTGAACAAGAAACTAAAGGCCTTCCCAGCAAAAAAGGAATT GTACAGTCTATTGTTGGTCAAGGCTATCATCGTAAAATAGTTTTGGCATCACAGTCTATACAGAATACTGTTTATAATGATGGGCAGTCT TCGGCCATTCCTGTAGCCAGTATGGAGTTTGCAGCCATATGTCTCAGAAATGCCTTGTTGCTGCTACCTGAAGAACAGCAAGATCCAAAG CAGGAAAATGGGGCTAAAAATAGTAATCAATTAGGTGGGAACACAGAGAGCAGCGAAAGCAGTGAAACTTGCAGCAGTAAAAGCCATGAT GGAGATAAATTCATTCCAGCTCCACCTTCTTCTCCATTGAGAAAACAGGAATTAGAAAACTTAAAGTGCTCCATACTTGCTTGCAGTGCC TACGTGGCTCTGGCTTTGGGTGATAACCTCATGGCTTTGAATCATGCAGATAAACTTCTTCAGCAGCCCAAGCTGTCAGGATCTCTTAAG TTTTTGGGACATTTATATGCTGCAGAAGCCCTCATCTCTCTCGACAGAATATCTGATGCCATTACTCACTTGAACCCGGAGAATGTCACT GATGTCTCCTTAGGGATCTCTTCAAATGAGCAGGACCAAGGATCAGACAAAGGTGAAAATGAAGCAATGGAATCCTCTGGTAAGCGGGCC CCTCAGTGCTACCCCAGTTCCGTCAACTCTGCCAGGACTGTGATGCTGTTCAACCTTGGCAGCGCTTACTGCCTGAGGAGCGAATATGAC AAAGCCCGAAAGTGTCTCCACCAGGCGGCTTCAATGATCCATCCTAAAGAGGTGCCCCCTGAGGCCATCTTGCTGGCAGTCTACCTTGAA CTGCAGAATGGTAATACTCAGCTGGCCTTACAGATCATCAAAAGGAATCAGCTGCTCCCTGCAGTGAAAACACACTCTGAAGTGAGAAAG AAGCCAGTGTTTCAGCCTGTCCACCCGATCCAGCCCATCCAAATGCCGGCTTTCACCACTGTGCAGAGAAAGTGATACTTCACTTTTGGA AAACTGTTACCTGAGACCCAGGGGAGAATTTACTGGCCATTTTAGTTGTATCACAGCAGAATGAATAAAAGATGGTGAAGGCTGTTAATT TTGAGTCAATTCTACCCCTGACATTTGGCCAAAAGCTTACTTAAAATTAAGGATTTACTAAGTCATCATCAGCTGTTTTTCTTAATTTCA |
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FusionGenePPI for GPD1L_CNOT10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| GPD1L | ELAVL1, BSG, FAS, PALM2, ART3, ISLR, TGOLN2, ALDOA, ALDOC, CYCS, GNPNAT1, ACO2, CKMT1A, CKMT1B, FH, GAPDH, GPT2, MYH7B, PHGDH, PYCRL, PGM1, TPI1, UPP1, GPD1, LAMP2, FAM174A, C1orf85, CCL5, DKKL1 | CNOT10 | CNOT8, USP22, CHMP1B, EPAS1, VCP, CNOT6L, CNOT6, LYN, PPP6R1, HECW2, RNF219, TNRC6A, TNRC6C, KLHL20, CT55, MMP7, CAPZA2, CNOT7, BTRC, MED4, PCM1, CEP152, CNTROB, NINL, CENPJ, CNOT2, RPL10, NUP153, CNOT1, RC3H1, DUSP6, CNOT11, NANOS2, RIBC1, TOB1, TEX13A, GPBP1L1, GADD45B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPD1L_CNOT10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GPD1L_CNOT10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GPD1L | C2673193 | Brugada Syndrome 2 | 3 | CTD_human;UNIPROT |
| Hgene | GPD1L | C0038644 | Sudden infant death syndrome | 2 | UNIPROT |
| Hgene | GPD1L | C0015695 | Fatty Liver | 1 | CTD_human |
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