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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 15166

FusionGeneSummary for GPBP1_GOLGA8B

check button Fusion gene summary
Fusion gene informationFusion gene name: GPBP1_GOLGA8B
Fusion gene ID: 15166
HgeneTgene
Gene symbol

GPBP1

GOLGA8B

Gene ID

65056

440270

Gene nameGC-rich promoter binding protein 1golgin A8 family member B
SynonymsGPBP|SSH6|VASCULINGOLGA5
Cytomap

5q11.2

15q14

Type of geneprotein-codingprotein-coding
Descriptionvasculinvascular wall-linked proteingolgin subfamily A member 8Bgolgi autoantigen, golgin subfamily a, 8Bgolgin-67
Modification date2018052320180523
UniProtAcc

Q86WP2

A8MQT2

Ensembl transtripts involved in fusion geneENST00000424459, ENST00000514387, 
ENST00000506184, ENST00000454432, 
ENST00000511209, ENST00000264779, 
ENST00000538707, 		ENST00000267731, 
ENST00000569811, ENST00000342314, 
ENST00000438958, 
Fusion gene scores* DoF score7 X 7 X 4=1964 X 3 X 3=36
# samples 74
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GPBP1 [Title/Abstract] AND GOLGA8B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-86-8669-01AGPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000424459ENST00000267731GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000424459ENST00000569811GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000424459ENST00000342314GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000424459ENST00000438958GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-5UTRENST00000514387ENST00000267731GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000514387ENST00000569811GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000514387ENST00000342314GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000514387ENST00000438958GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-5UTRENST00000506184ENST00000267731GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000506184ENST00000569811GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000506184ENST00000342314GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000506184ENST00000438958GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-5UTRENST00000454432ENST00000267731GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000454432ENST00000569811GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000454432ENST00000342314GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000454432ENST00000438958GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-5UTRENST00000511209ENST00000267731GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000511209ENST00000569811GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000511209ENST00000342314GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000511209ENST00000438958GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-5UTRENST00000264779ENST00000267731GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000264779ENST00000569811GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000264779ENST00000342314GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000264779ENST00000438958GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-5UTRENST00000538707ENST00000267731GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000538707ENST00000569811GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000538707ENST00000342314GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-
5CDS-intronENST00000538707ENST00000438958GPBP1chr5

56543042

+GOLGA8Bchr15

34839183

-

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FusionProtFeatures for GPBP1_GOLGA8B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPBP1

Q86WP2

GOLGA8B

A8MQT2

Functions as a GC-rich promoter-specific transactivatingtranscription factor. {ECO:0000250|UniProtKB:Q6NXH3}. May be involved in maintaining Golgi structure.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for GPBP1_GOLGA8B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for GPBP1_GOLGA8B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
GPBP1MCRS1, DNAL4, C20orf195, PLEKHF2, HNRNPD, SORT1, TSC22D2, SLX1A, PKP3, PLCD1, OTUB2, DUSP14, SELENBP1, EPB41L5, SERPINB5, HEPHL1, HIST1H1B, LRRC15, EIF3A, EIF3C, CRYABGOLGA8BCDH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for GPBP1_GOLGA8B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GPBP1_GOLGA8B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource