FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 1516

FusionGeneSummary for ALDOA_SLC1A3

check button Fusion gene summary
Fusion gene informationFusion gene name: ALDOA_SLC1A3
Fusion gene ID: 1516
HgeneTgene
Gene symbol

ALDOA

SLC1A3

Gene ID

226

6507

Gene namealdolase, fructose-bisphosphate Asolute carrier family 1 member 3
SynonymsALDA|GSD12|HEL-S-87pEA6|EAAT1|GLAST|GLAST1
Cytomap

16p11.2

5p13.2

Type of geneprotein-codingprotein-coding
Descriptionfructose-bisphosphate aldolase Aaldolase A, fructose-bisphosphateepididymis secretory sperm binding protein Li 87pfructose-1,6-bisphosphate triosephosphate-lyaselung cancer antigen NY-LU-1muscle-type aldolaseexcitatory amino acid transporter 1GLAST-1sodium-dependent glutamate/aspartate transporter 1solute carrier family 1 (glial high affinity glutamate transporter), member 3
Modification date2018052220180519
UniProtAcc

P04075

P43003

Ensembl transtripts involved in fusion geneENST00000338110, ENST00000395248, 
ENST00000575627, ENST00000566897, 
ENST00000569545, ENST00000563060, 
ENST00000412304, ENST00000564546, 
ENST00000564595, ENST00000569798, 
ENST00000395240, 		ENST00000265113, 
ENST00000506725, ENST00000381918, 
Fusion gene scores* DoF score17 X 7 X 10=119010 X 9 X 6=540
# samples 2012
** MAII scorelog2(20/1190*10)=-2.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALDOA [Title/Abstract] AND SLC1A3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneALDOA

GO:0008360

regulation of cell shape

9244396

HgeneALDOA

GO:0030388

fructose 1,6-bisphosphate metabolic process

9244396|14766013

TgeneSLC1A3

GO:0015813

L-glutamate transmembrane transport

26690923

TgeneSLC1A3

GO:0051938

L-glutamate import

7521911

TgeneSLC1A3

GO:0070779

D-aspartate import across plasma membrane

7521911

TgeneSLC1A3

GO:0071805

potassium ion transmembrane transport

20477940

TgeneSLC1A3

GO:0098712

L-glutamate import across plasma membrane

26690923

TgeneSLC1A3

GO:0140009

L-aspartate import across plasma membrane

20477940

TgeneSLC1A3

GO:1902476

chloride transmembrane transport

20477940


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-DU-5870-01AALDOAchr16

30081734

+SLC1A3chr5

36606541

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000338110ENST00000265113ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
5CDS-intronENST00000338110ENST00000506725ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
5CDS-intronENST00000338110ENST00000381918ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
3UTR-5UTRENST00000395248ENST00000265113ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
3UTR-intronENST00000395248ENST00000506725ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
3UTR-intronENST00000395248ENST00000381918ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
intron-5UTRENST00000575627ENST00000265113ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
intron-intronENST00000575627ENST00000506725ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
intron-intronENST00000575627ENST00000381918ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
5CDS-5UTRENST00000566897ENST00000265113ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
5CDS-intronENST00000566897ENST00000506725ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
5CDS-intronENST00000566897ENST00000381918ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
intron-5UTRENST00000569545ENST00000265113ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
intron-intronENST00000569545ENST00000506725ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
intron-intronENST00000569545ENST00000381918ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
5CDS-5UTRENST00000563060ENST00000265113ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
5CDS-intronENST00000563060ENST00000506725ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
5CDS-intronENST00000563060ENST00000381918ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
5CDS-5UTRENST00000412304ENST00000265113ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
5CDS-intronENST00000412304ENST00000506725ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
5CDS-intronENST00000412304ENST00000381918ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
3UTR-5UTRENST00000564546ENST00000265113ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
3UTR-intronENST00000564546ENST00000506725ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
3UTR-intronENST00000564546ENST00000381918ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
5CDS-5UTRENST00000564595ENST00000265113ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
5CDS-intronENST00000564595ENST00000506725ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
5CDS-intronENST00000564595ENST00000381918ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
intron-5UTRENST00000569798ENST00000265113ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
intron-intronENST00000569798ENST00000506725ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
intron-intronENST00000569798ENST00000381918ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
intron-5UTRENST00000395240ENST00000265113ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
intron-intronENST00000395240ENST00000506725ALDOAchr16

30081734

+SLC1A3chr5

36606541

+
intron-intronENST00000395240ENST00000381918ALDOAchr16

30081734

+SLC1A3chr5

36606541

+

Top

FusionProtFeatures for ALDOA_SLC1A3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALDOA

P04075

SLC1A3

P43003

Plays a key role in glycolysis and gluconeogenesis. Inaddition, may also function as scaffolding protein (Bysimilarity). {ECO:0000250}. Sodium-dependent, high-affinity amino acid transporterthat mediates the uptake of L-glutamate and also L-aspartate andD-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940,PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as asymporter that transports one amino acid molecule together withtwo or three Na(+) ions and one proton, in parallel with thecounter-transport of one K(+) ion (PubMed:20477940). MediatesCl(-) flux that is not coupled to amino acid transport; thisavoids the accumulation of negative charges due to aspartate andNa(+) symport (PubMed:20477940). Plays a redundant role in therapid removal of released glutamate from the synaptic cleft, whichis essential for terminating the postsynaptic action of glutamate(By similarity). {ECO:0000250|UniProtKB:P56564,ECO:0000269|PubMed:20477940, ECO:0000269|PubMed:26690923,ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:28424515,ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ALDOA_SLC1A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ALDOA_SLC1A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ALDOAXRN1, FANCA, ATP6V1E1, PLD2, USP15, OSBPL10, EGFR, TRIM63, PSMD4, H2AFX, CACNA1A, HDAC5, PCNA, PSMA3, MYC, ISG15, TERF1, CUL3, CUL4B, CUL2, CDK2, MYOC, AKT1, PGK1, ALDOC, HSPD1, LGALS1, LIG4, HSP90AA1, HSP90AB1, VCAM1, FN1, ATF2, IQCB1, MLH1, VCPKMT, ITGA4, RAD52, ALDOB, ALDOA, BCAT2, GALNT6, PIAS4, CS, TNPO3, ADRB2, HUWE1, FUS, IFNA4, SUZ12, HNRNPA1, ACAA2, ACTN4, ACO2, ADI1, ARHGDIA, ASS1, CFL1, COX4I1, ECHS1, FKBP2, GPD1L, GPX4, HSD17B10, IMPA2, ISYNA1, LMAN1, MAP2K7, MYH7B, PKM, SUMO2, TAGLN, TAGLN2, TKT, TRAP1, ATP5J, CKB, CKMT1B, CKMT1A, CKMT2, DUT, ENO1, FABP5, FH, FKBP7, GAPDH, GLO1, HSPE1, KCNAB2, LDHA, LTA4H, NDUFS4, PGAM2, PREP, SOD2, SUMO4, TALDO1, UMPS, NTRK1, HSPB2, SRPK2, AHSA1, CDK2AP1, NCSTN, NCAPH, VPS18, DRC1, MCM2, CDC73, CDH1, CARM1, DNM1L, SOAT1, SOD1, TRIM25, BRCA1SLC1A3CUL3, ZDHHC17, LGALS3, TCTN3, TMEM17, PDZK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ALDOA_SLC1A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneALDOAP04075DB01593ZincFructose-bisphosphate aldolase Asmall moleculeapproved|investigational
HgeneALDOAP04075DB11638ArtenimolFructose-bisphosphate aldolase Asmall moleculeapproved|investigational
TgeneSLC1A3P43003DB00142Glutamic AcidExcitatory amino acid transporter 1 {ECO:0000303|PubMed:16042756, ECO:0000303|PubMed:8647279}small moleculeapproved|nutraceutical

Top

RelatedDiseases for ALDOA_SLC1A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALDOAC0272066Glycogen Storage Disease XII3CTD_human;ORPHANET;UNIPROT
HgeneALDOAC0027626Neoplasm Invasiveness1CTD_human
HgeneALDOAC0027627Neoplasm Metastasis1CTD_human
HgeneALDOAC0151744Myocardial Ischemia1CTD_human
HgeneALDOAC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneALDOAC1458155Mammary Neoplasms1CTD_human
TgeneSLC1A3C0036341Schizophrenia4PSYGENET
TgeneSLC1A3C0004352Autistic Disorder1CTD_human
TgeneSLC1A3C0005586Bipolar Disorder1PSYGENET
TgeneSLC1A3C0014544Epilepsy1CTD_human;HPO
TgeneSLC1A3C0178417Anhedonia1PSYGENET
TgeneSLC1A3C2675211EPISODIC ATAXIA, TYPE 6 (disorder)1CTD_human;ORPHANET;UNIPROT