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Fusion gene ID: 15158 |
FusionGeneSummary for GPBP1L1_MOB3C |
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Fusion gene information | Fusion gene name: GPBP1L1_MOB3C | Fusion gene ID: 15158 | Hgene | Tgene | Gene symbol | GPBP1L1 | MOB3C | Gene ID | 60313 | 148932 |
Gene name | GC-rich promoter binding protein 1 like 1 | MOB kinase activator 3C | |
Synonyms | SP192 | MOB1E|MOBKL2C | |
Cytomap | 1p34.1 | 1p33 | |
Type of gene | protein-coding | protein-coding | |
Description | vasculin-like protein 1 | MOB kinase activator 3CMOB1, Mps One Binder kinase activator-like 2Cmob1 homolog 2C | |
Modification date | 20180524 | 20180519 | |
UniProtAcc | Q9HC44 | Q70IA8 | |
Ensembl transtripts involved in fusion gene | ENST00000290795, ENST00000355105, ENST00000479235, | ENST00000319928, ENST00000271139, ENST00000371940, ENST00000477318, | |
Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 3 X 2 X 3=18 |
# samples | 6 | 3 | |
** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: GPBP1L1 [Title/Abstract] AND MOB3C [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | UCS | TCGA-N8-A4PQ-01A | GPBP1L1 | chr1 | 46152084 | - | MOB3C | chr1 | 47075876 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000290795 | ENST00000319928 | GPBP1L1 | chr1 | 46152084 | - | MOB3C | chr1 | 47075876 | - |
5UTR-3CDS | ENST00000290795 | ENST00000271139 | GPBP1L1 | chr1 | 46152084 | - | MOB3C | chr1 | 47075876 | - |
5UTR-3CDS | ENST00000290795 | ENST00000371940 | GPBP1L1 | chr1 | 46152084 | - | MOB3C | chr1 | 47075876 | - |
5UTR-5UTR | ENST00000290795 | ENST00000477318 | GPBP1L1 | chr1 | 46152084 | - | MOB3C | chr1 | 47075876 | - |
5UTR-3CDS | ENST00000355105 | ENST00000319928 | GPBP1L1 | chr1 | 46152084 | - | MOB3C | chr1 | 47075876 | - |
5UTR-3CDS | ENST00000355105 | ENST00000271139 | GPBP1L1 | chr1 | 46152084 | - | MOB3C | chr1 | 47075876 | - |
5UTR-3CDS | ENST00000355105 | ENST00000371940 | GPBP1L1 | chr1 | 46152084 | - | MOB3C | chr1 | 47075876 | - |
5UTR-5UTR | ENST00000355105 | ENST00000477318 | GPBP1L1 | chr1 | 46152084 | - | MOB3C | chr1 | 47075876 | - |
intron-3CDS | ENST00000479235 | ENST00000319928 | GPBP1L1 | chr1 | 46152084 | - | MOB3C | chr1 | 47075876 | - |
intron-3CDS | ENST00000479235 | ENST00000271139 | GPBP1L1 | chr1 | 46152084 | - | MOB3C | chr1 | 47075876 | - |
intron-3CDS | ENST00000479235 | ENST00000371940 | GPBP1L1 | chr1 | 46152084 | - | MOB3C | chr1 | 47075876 | - |
intron-5UTR | ENST00000479235 | ENST00000477318 | GPBP1L1 | chr1 | 46152084 | - | MOB3C | chr1 | 47075876 | - |
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FusionProtFeatures for GPBP1L1_MOB3C |
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Hgene | Tgene |
GPBP1L1 | MOB3C |
Possible transcription factor. {ECO:0000305}. | May regulate the activity of kinases. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for GPBP1L1_MOB3C |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for GPBP1L1_MOB3C |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
GPBP1L1 | EIF3E, PLEKHF2, EWSR1, ELAVL1, NXF1, XPO1, CNOT1, QRSL1, TC2N, PLCD3, KANSL2, NANOS2, PIP4K2A, SNRPF, CNOT11, AMPD2, ZBTB1, MCRS1, METAP2, PIP4K2C, UTP6, CNOT10, CNOT2, PIP4K2B, AP2A1, AP2A2, ECD, ACAD11, EIF3A, TSSC4, AP1B1, CNOT8, EPB41L5, DCAF5, EIF3C, EIF3H, AP2S1, CNOT6L, PDCD2L, SNRNP200, AP2M1, EIF3M, RQCD1, DCAF7, TRIM25 | MOB3C | LATS1, LATS2, APP, SIAH1, TDO2, TFCP2, TNIP1, NT5C2, FAM118A, ZBTB10, CMTM3, KRT40, C10orf107, MAU2, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for GPBP1L1_MOB3C |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for GPBP1L1_MOB3C |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |