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Fusion gene ID: 1513 |
FusionGeneSummary for ALDOA_RPL7A |
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Fusion gene information | Fusion gene name: ALDOA_RPL7A | Fusion gene ID: 1513 | Hgene | Tgene | Gene symbol | ALDOA | RPL7A | Gene ID | 226 | 6130 |
Gene name | aldolase, fructose-bisphosphate A | ribosomal protein L7a | |
Synonyms | ALDA|GSD12|HEL-S-87p | L7A|SURF3|TRUP | |
Cytomap | 16p11.2 | 9q34.2 | |
Type of gene | protein-coding | protein-coding | |
Description | fructose-bisphosphate aldolase Aaldolase A, fructose-bisphosphateepididymis secretory sperm binding protein Li 87pfructose-1,6-bisphosphate triosephosphate-lyaselung cancer antigen NY-LU-1muscle-type aldolase | 60S ribosomal protein L7aPLA-X polypeptidelarge ribosomal subunit protein eL8surfeit 3surfeit locus protein 3thyroid hormone receptor uncoupling protein | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P04075 | P62424 | |
Ensembl transtripts involved in fusion gene | ENST00000338110, ENST00000395248, ENST00000575627, ENST00000566897, ENST00000569545, ENST00000563060, ENST00000412304, ENST00000564546, ENST00000564595, ENST00000569798, ENST00000395240, | ENST00000323345, ENST00000463740, ENST00000315731, | |
Fusion gene scores | * DoF score | 17 X 7 X 10=1190 | 1 X 1 X 1=1 |
# samples | 20 | 1 | |
** MAII score | log2(20/1190*10)=-2.57288966842058 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ALDOA [Title/Abstract] AND RPL7A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ALDOA | GO:0008360 | regulation of cell shape | 9244396 |
Hgene | ALDOA | GO:0030388 | fructose 1,6-bisphosphate metabolic process | 9244396|14766013 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BLCA | TCGA-BT-A2LA-01A | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000338110 | ENST00000323345 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000338110 | ENST00000463740 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000338110 | ENST00000315731 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
Frame-shift | ENST00000395248 | ENST00000323345 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000395248 | ENST00000463740 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000395248 | ENST00000315731 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
intron-3CDS | ENST00000575627 | ENST00000323345 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
intron-3UTR | ENST00000575627 | ENST00000463740 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
intron-3UTR | ENST00000575627 | ENST00000315731 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
Frame-shift | ENST00000566897 | ENST00000323345 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000566897 | ENST00000463740 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000566897 | ENST00000315731 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
Frame-shift | ENST00000569545 | ENST00000323345 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000569545 | ENST00000463740 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000569545 | ENST00000315731 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
Frame-shift | ENST00000563060 | ENST00000323345 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000563060 | ENST00000463740 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000563060 | ENST00000315731 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
Frame-shift | ENST00000412304 | ENST00000323345 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000412304 | ENST00000463740 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000412304 | ENST00000315731 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
Frame-shift | ENST00000564546 | ENST00000323345 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000564546 | ENST00000463740 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000564546 | ENST00000315731 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
Frame-shift | ENST00000564595 | ENST00000323345 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000564595 | ENST00000463740 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000564595 | ENST00000315731 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
Frame-shift | ENST00000569798 | ENST00000323345 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000569798 | ENST00000463740 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000569798 | ENST00000315731 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
Frame-shift | ENST00000395240 | ENST00000323345 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000395240 | ENST00000463740 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
5CDS-3UTR | ENST00000395240 | ENST00000315731 | ALDOA | chr16 | 30080710 | + | RPL7A | chr9 | 136216856 | + |
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FusionProtFeatures for ALDOA_RPL7A |
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Hgene | Tgene |
ALDOA | RPL7A |
Plays a key role in glycolysis and gluconeogenesis. Inaddition, may also function as scaffolding protein (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ALDOA_RPL7A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ALDOA_RPL7A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ALDOA | XRN1, FANCA, ATP6V1E1, PLD2, USP15, OSBPL10, EGFR, TRIM63, PSMD4, H2AFX, CACNA1A, HDAC5, PCNA, PSMA3, MYC, ISG15, TERF1, CUL3, CUL4B, CUL2, CDK2, MYOC, AKT1, PGK1, ALDOC, HSPD1, LGALS1, LIG4, HSP90AA1, HSP90AB1, VCAM1, FN1, ATF2, IQCB1, MLH1, VCPKMT, ITGA4, RAD52, ALDOB, ALDOA, BCAT2, GALNT6, PIAS4, CS, TNPO3, ADRB2, HUWE1, FUS, IFNA4, SUZ12, HNRNPA1, ACAA2, ACTN4, ACO2, ADI1, ARHGDIA, ASS1, CFL1, COX4I1, ECHS1, FKBP2, GPD1L, GPX4, HSD17B10, IMPA2, ISYNA1, LMAN1, MAP2K7, MYH7B, PKM, SUMO2, TAGLN, TAGLN2, TKT, TRAP1, ATP5J, CKB, CKMT1B, CKMT1A, CKMT2, DUT, ENO1, FABP5, FH, FKBP7, GAPDH, GLO1, HSPE1, KCNAB2, LDHA, LTA4H, NDUFS4, PGAM2, PREP, SOD2, SUMO4, TALDO1, UMPS, NTRK1, HSPB2, SRPK2, AHSA1, CDK2AP1, NCSTN, NCAPH, VPS18, DRC1, MCM2, CDC73, CDH1, CARM1, DNM1L, SOAT1, SOD1, TRIM25, BRCA1 | RPL7A | POLR2M, MKNK2, SRRM2, ESR1, HDAC5, DYRK2, STAU1, VHL, ARRB1, ARRB2, SIRT7, ERG, NFX1, CUL3, CUL4A, RPL10A, RPL21, RPL6, RPL7, RPS3A, RPS3, RPL4, RPS9, RPLP0, RPL11, RPL12, RPL13, RPL14, RPL15, RPL17, RPL18A, RPL18, RPL19, RPL23, RPL27A, RPL30, RPL31, RPL5, RPL8, RPL9, RPS13, RPS15A, RPS16, RPS19, RPS20, RPS23, RPS25, RPS26, RPS28, RPS2, RPS4X, RPS5, RPS8, RPSA, RPL3, RPS6, RPS24, RPS12, RPL23A, RPL37A, RPL24, RPS11, RPL22, RPL10, RPL36, RPS14, RPL35, RPLP1, RPL38, RPS27A, RPS21, RPL32, EEF2, EEF1A1, RPL29, NCL, HNRNPU, ILF2, ILF3, SLC25A5, HSP90AB1, EEF1B2, PABPC1, HNRNPM, ACTA2, LUC7L2, RPS27L, GNB2L1, RPLP0P6, RPL10L, SLC25A6, PSMB1, MRPL12, UPF1, MAGOH, EIF4A3, FN1, VCAM1, UBL4A, ITGA4, PAN2, IGSF8, ICAM1, CTBP2, SOCS3, FBXO6, TARDBP, TRAP1, PARK2, AIMP1, DARS, EEF1E1, QARS, RPL26, EIF2S1, CEP250, TP53, HUWE1, CUL7, OBSL1, CCDC8, EED, RNF2, NPM1, LGALS3, NTRK1, DDX18, PES1, RPL26L1, RPL35A, RPL3L, BRIX1, RPL13A, RPL27, RPL34, RPS10, LOC101929876, RPS27, RPLP2, RPS15, RPS18, RPS7, SFN, EWSR1, XPO1, HIST1H3E, TTK, NOP56, MCM2, ZNF746, CDH1, RRS1, KIAA0020, MECP2, KNOP1, SART3, EBNA1BP2, ZC3HAV1, GPATCH4, MAK16, RBM34, BHLHA15, DGCR8, RRP8, ZNF2, CNBP, RPL28, H2AFY2, GLTSCR2, CYLD, INO80B, TRIM25, BRCA1, YAP1, MTF1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ALDOA_RPL7A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ALDOA | P04075 | DB01593 | Zinc | Fructose-bisphosphate aldolase A | small molecule | approved|investigational |
Hgene | ALDOA | P04075 | DB11638 | Artenimol | Fructose-bisphosphate aldolase A | small molecule | approved|investigational |
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RelatedDiseases for ALDOA_RPL7A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ALDOA | C0272066 | Glycogen Storage Disease XII | 3 | CTD_human;ORPHANET;UNIPROT |
Hgene | ALDOA | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | ALDOA | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | ALDOA | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | ALDOA | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Hgene | ALDOA | C1458155 | Mammary Neoplasms | 1 | CTD_human |